Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 51 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
33.3 mg
37%
Vitamin D (as D3 Cholecalciferol)
8.3 mcg (333 IU)
42%
Calcium (Elemental)(from Microcrystalline Hydroxyapatite)
333.3 mg
26%
Magnesium (as Magnesium Oxide)
116.7 mg
28%
Zinc (as Zinc L-Methionine Sulfate)
3.3 mg
30%
Copper (as Copper Gluconate)
0.333 mg
37%
Manganese (as Manganese Citrate)
0.333 mg
14%
Vitamin K2 (as Natural MK-7 [Menaquinone-7])
15 mcg
†
Boron (as Boron Citrate)
1 mg
†
Top Medical Research Studies
9
We examined how hyperoside, a compound in Semen cuscutae, can combat osteoporosis in ovariectomized mice, particularly after menopause. The study revealed that hyperoside effectively increased bone density and improved bone structure by reducing the differentiation of osteoclasts—cells that break down bone.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways.
Our findings indicated that the anti-osteoporotic effects of hyperoside are linked to the estrogen receptor α, as blocking this receptor reversed its benefits. Ultimately, hyperoside shows promise in protecting against osteoporosis through its actions on specific signaling pathways.
Read More
9
Zuogui Pills improve osteoporosis outcomes
We investigated how Zuogui Pills (ZGP), an herbal formula used in Traditional Chinese Medicine, can help with osteoporosis caused by excessive iron. Our study utilized both mouse models and osteoblast cells to examine its effects.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Read More
9
Nanoparticles enhance bone healing
We examined the potential of a new nano-formulation combining rosuvastatin and calcium carbonate in encouraging bone regeneration in osteoporotic rats. By injecting this formulation directly into bone defects, we found that it not only aided in healing but also improved bone structure over 30 days.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
Read More
Most Useful Reviews
9
Normalised density
381 people found this helpful
I reversed osteopenia! I have taken Bone-Up by Jarrow Formulas for years after being diagnosed with osteopenia. I committed to taking it daily; my osteopenia eventually reversed, and my bone density is now normal. I engage in regular weight-bearing exercise which supports bone health. Despite previous thinning bone loss, I was able to reverse it through determination and consistent use of Jarrow Bone-Up. I won’t stop taking this for life!
Read More
10
Improved bone status
109 people found this helpful
As a 21-year breast cancer survivor aged 55, I discovered I had osteoporosis two years ago, despite leading a healthy lifestyle. After researching, I added Bone-Up, taking it three times a day for the last two years. I increased my Vitamin D intake upon diagnosis, and believe this, along with Bone-Up, has significantly contributed to my improving scores. I keep a close eye on my Vitamin D levels, ensuring they are within a normal range.
Read More
9
Normal bone range achieved
40 people found this helpful
I've taken Bone-Up for three years, following a back fracture. Doctors wanted me on medication, but I declined after reading about potential side effects. I previously took 6 tablets, now reduced to 3, and added Strontium for support. My bone density results have shifted from osteopenia and osteoporosis to predominantly normal ranges. I strongly recommend Bone-Up and Strontium but suggest thorough research. I've advised my daughters to begin taking it too.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9
Zuogui Pills improve osteoporosis outcomes
We investigated how Zuogui Pills (ZGP), an herbal formula used in Traditional Chinese Medicine, can help with osteoporosis caused by excessive iron. Our study utilized both mouse models and osteoblast cells to examine its effects.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Read More
9
Nanoparticles enhance bone healing
We examined the potential of a new nano-formulation combining rosuvastatin and calcium carbonate in encouraging bone regeneration in osteoporotic rats. By injecting this formulation directly into bone defects, we found that it not only aided in healing but also improved bone structure over 30 days.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
The results demonstrated that our treatment significantly boosted bone growth and stability, making it a hopeful option for osteoporosis management. This study highlights the importance of innovative approaches in enhancing bone health and regeneration.
Read More
9
We examined the effects of 1,2,3,4,6-penta--galloyl-β-D-glucose (PGG), a natural antioxidant, on osteoporosis treatment. Using an in vitro osteoblast model and a zebrafish model for osteoporosis, we found PGG significantly improved cell survival and bone formation. It also enhanced bone-building signals through estrogen receptors. By reducing cell death and strengthening bone cells, PGG shows potential as a promising option for combating osteoporosis. These findings suggest that harnessing PGG could lead to better treatment strategies for those suffering from this condition.
Read More
9
We investigated how Bu-Sui-Dan (BSD), an ancient herbal formula, affects osteoporosis, particularly in postmenopausal women. The study utilized ovariectomized rats to assess BSD’s role in encouraging bone growth and differentiation of bone marrow stem cells.
Our findings indicated that BSD effectively enhanced osteoblast activity by increasing the levels of VGLL4, which combats RUNX2 transcription suppression. This suggests BSD could be a promising therapeutic option for osteoporosis, although more research is needed to fully understand its mechanisms.
Our findings indicated that BSD effectively enhanced osteoblast activity by increasing the levels of VGLL4, which combats RUNX2 transcription suppression. This suggests BSD could be a promising therapeutic option for osteoporosis, although more research is needed to fully understand its mechanisms.
Read More
9
We explored the potential of a traditional Chinese herbal formula called Xianlinggubao (XLGB) in treating osteoporosis. In our study, we focused on a specific ingredient, XLGB28-sRNA, and found it could improve bone strength by promoting new bone formation while also reducing bone breakdown. When administered to mice, this combination significantly increased bone mineral density and enhanced bone structure. These findings suggest that XLGB28-sRNA may serve as a promising treatment for osteoporosis, although more research is needed to understand its full effects on humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 51 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normalised density
381 people found this helpful
I reversed osteopenia! I have taken Bone-Up by Jarrow Formulas for years after being diagnosed with osteopenia. I committed to taking it daily; my osteopenia eventually reversed, and my bone density is now normal. I engage in regular weight-bearing exercise which supports bone health. Despite previous thinning bone loss, I was able to reverse it through determination and consistent use of Jarrow Bone-Up. I won’t stop taking this for life!
Read More
10
Improved bone status
109 people found this helpful
As a 21-year breast cancer survivor aged 55, I discovered I had osteoporosis two years ago, despite leading a healthy lifestyle. After researching, I added Bone-Up, taking it three times a day for the last two years. I increased my Vitamin D intake upon diagnosis, and believe this, along with Bone-Up, has significantly contributed to my improving scores. I keep a close eye on my Vitamin D levels, ensuring they are within a normal range.
Read More
9
Normal bone range achieved
40 people found this helpful
I've taken Bone-Up for three years, following a back fracture. Doctors wanted me on medication, but I declined after reading about potential side effects. I previously took 6 tablets, now reduced to 3, and added Strontium for support. My bone density results have shifted from osteopenia and osteoporosis to predominantly normal ranges. I strongly recommend Bone-Up and Strontium but suggest thorough research. I've advised my daughters to begin taking it too.
Read More
10
Improved results
32 people found this helpful
Increased bone density! I've taken Bone Up for two years, complying with the 6 capsule daily recommendation after my bone density test indicated osteoporosis. At 67, I no longer take hormones and am not a fan of dairy. Preferring not to take prescription medication, I added Bone Up and walk 3 miles four to five times weekly. Following another bone density test, I discovered an 8% increase in my bone density! I now have osteopenia instead of osteoporosis. My doctor was pleased with the result and encouraged me to continue what I’m doing. I’m building bone mass!
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10
Osteoporosis reversed
31 people found this helpful
Helped my DEXA scan numbers! I officially had osteoporosis, but one year after taking this along with 10,000 units of D3, my score improved from -2.5 to -1.8, so I am now classified as having osteopenia! How wonderful is that? I highly recommend this product.
Read More
Frequently Asked Questions
7.5
Positive effects noted
This product is one of the best nutritional supplements. I always purchase it for my mother, who has osteoporosis. It produces positive effects, but it must be taken for at least six months to achieve satisfactory results.
7.5
Improved dental health
2 people found this helpful
I’ve been taking this calcium for nearly a year due to osteoporosis, and I’ve noticed slight improvement in my bone density. My nails are stronger, and my dental health has improved significantly; I no longer visit the dentist frequently.
9
Osteopenia improvement
1 people found this helpful
Osteopenia solved! I took this for a year as prescribed. My densitometry indicators improved to 94% of the norm.
9
Reduced knee pain
5 people found this helpful
I requested it for myself and my mother due to knee roughness; it has helped immensely. I cannot stop taking it, as my knee fatigue returns without it.
2
Declined bone density
This did not improve my bone mineral density. For nearly three years, I took double the recommended dose and ended up with osteoporosis. Eventually, I added other supplements, which helped improve my condition.
7.5
Magnesium supplement useful
I have tried all of Jarrow's bone supplements for osteoporosis. I take three daily to obtain 1,000 mg of calcium, lasting one month. As my daily requirement is 1,200 mg, I also include calcium-rich foods. I took an additional 120 mcg of K2 MK-7 as this formulation lacks sufficient quantity.
7.5
Awaiting bone scan results
1 people found this helpful
I switched to this product for better calcium absorption following a scan that showed my osteopenia progressed to osteoporosis. The combination of ingredients is appealing; I'll see the results in my next test.
6
Consistent use important
As an osteoporosis patient, I've taken BoneUp thrice daily for six months. They are slightly large and hard to swallow, but I've experienced no other issues.
9
Zuogui Pills improve osteoporosis outcomes
We investigated how Zuogui Pills (ZGP), an herbal formula used in Traditional Chinese Medicine, can help with osteoporosis caused by excessive iron. Our study utilized both mouse models and osteoblast cells to examine its effects.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
Through detailed experiments, we noted that ZGP has strong antioxidant and anti-apoptotic properties. It works by engaging the PI3K/AKT pathway, reducing oxidative stress, and improving bone health. These results suggest that ZGP may be a valuable treatment option for osteoporosis linked to iron overload.
7
Herbal formula aids osteoporosis treatment
We aimed to investigate whether the herbal formula Chaihu-Shugan-San (CHSG) can help alleviate osteoporosis in a mouse model that simulates depression caused by chronic stress.
Through a combination of behavioral assessments and detailed bone scans, we observed that stress-induced depression indeed led to osteoporosis in mice.
Remarkably, CHSG showed promising benefits by reducing neuroinflammation and normalizing stress-related hormonal activity, ultimately supporting healthier bones. This suggests that CHSG may present a comprehensive approach for addressing both depression and bone health.
Through a combination of behavioral assessments and detailed bone scans, we observed that stress-induced depression indeed led to osteoporosis in mice.
Remarkably, CHSG showed promising benefits by reducing neuroinflammation and normalizing stress-related hormonal activity, ultimately supporting healthier bones. This suggests that CHSG may present a comprehensive approach for addressing both depression and bone health.
9
We examined the effects of 1,2,3,4,6-penta--galloyl-β-D-glucose (PGG), a natural antioxidant, on osteoporosis treatment. Using an in vitro osteoblast model and a zebrafish model for osteoporosis, we found PGG significantly improved cell survival and bone formation. It also enhanced bone-building signals through estrogen receptors. By reducing cell death and strengthening bone cells, PGG shows potential as a promising option for combating osteoporosis. These findings suggest that harnessing PGG could lead to better treatment strategies for those suffering from this condition.
References
- Lin Y, He Q, Chen B, Li Z, Chen C, et al. Zuogui Pills alleviate iron overload-induced osteoporosis by attenuating ROS-mediated osteoblast apoptosis via the PI3K-AKT pathway and mitigating mitochondrial damage. J Ethnopharmacol. 2025;344:119455. doi:10.1016/j.jep.2025.119455
- He MC, Xia SH, Pan H, Zhou TT, Wang XL, et al. Chaihu-Shugan-San Ameliorated Osteoporosis of Mice with Depressive Behavior Caused by Chronic Unpredictable Mild Stress via Repressing Neuroinflammation and HPA Activity. Drug Des Devel Ther. 2024;18:5997. doi:10.2147/DDDT.S480077
- El-Salamouni NS, Gowayed MA, El Achy S, El Shahawy M, Ghareeb DA, et al. Rosuvastatin/calcium carbonate co-precipitated nanoparticles: A novel synergistic approach enhancing local bone regeneration in osteoporotic rat model. Int J Pharm. 2025;668:124977. doi:10.1016/j.ijpharm.2024.124977
- Zhao J, Wang Y, Wang S, Guo Q, Wang W, et al. Combining OSTA and BMR to predict osteoporosis in Chinese population. J Orthop Surg Res. 2024;19:767. doi:10.1186/s13018-024-05260-3
- Hua Y, Wang H, Chen T, Zhou Y, Chen Z, et al. Antioxidant 1,2,3,4,6-Penta--galloyl-β-D-glucose Alleviating Apoptosis and Promoting Bone Formation Is Associated with Estrogen Receptors. Molecules. 2024;29. doi:10.3390/molecules29215110
- Li M, Niu Y, Zhang T, Yang H, Tian L, et al. Wen-Shen-Tong-Luo-Zhi-Tong-Decoction inhibits bone loss in senile osteoporosis model mice by promoting testosterone production. J Ethnopharmacol. 2025;338:119033. doi:10.1016/j.jep.2024.119033
- Shen C, Deng M, Wang X, Li X, Chen X, et al. Zuogui Wan modulates macrophage polarization and promotes osteogenic differentiation through regulation of CD51-positive bone marrow mesenchymal stem cells. Sci Rep. 2024;14:26130. doi:10.1038/s41598-024-77590-5
- Tang MM, Sun LP, Song F, Chen H. Protective effects of arecanut seed phenols in retinoic acid induced osteoporosis and the potential mechanisms explored by network pharmacology. Front Endocrinol (Lausanne). 2024;15:1472146. doi:10.3389/fendo.2024.1472146
- Wei J, Dong R, Ma Y, Wang J, Tian S, et al. Single-cell sequencing reveals that specnuezhenide protects against osteoporosis via activation of METTL3 in LEPR BMSCs. Eur J Pharmacol. 2024;981:176908. doi:10.1016/j.ejphar.2024.176908
- Li C, Liu X, Chen X, Zhang J, Liao Y, et al. Bu-Sui-Dan Enhances Osteoblast Differentiation by Upregulating VGLL4 to Counteract TEAD4-Mediated RUNX2 Transcription Suppression in Ovariectomized Rats. J Ethnopharmacol. 2024;335:118690. doi:10.1016/j.jep.2024.118690
- Du X, Guo S, Mu X, Mei S, Yang R, et al. Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice. IUBMB Life. 2024;76:832. doi:10.1002/iub.2857
- Solgi S, Zayeri F, Abbasi B. Association between dietary insulin index and postmenopausal osteoporosis in Iranian women: a case-control study. BMC Womens Health. 2024;24:401. doi:10.1186/s12905-024-03248-z
- Liu H, Zhang C, Chai Y, Zhou Y, Zeng H, et al. Using broadly targeted plant metabolomics technology combined with network pharmacology to explore the mechanism of action of the Yishen Gushu formula in the treatment of postmenopausal osteoporosis in vivo. J Ethnopharmacol. 2024;333:118469. doi:10.1016/j.jep.2024.118469
- Wei Q, Ouyang M, Guo X, Fu X, Liu T, et al. Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITGβ3 signaling pathway. Eur J Pharmacol. 2024;977:176666. doi:10.1016/j.ejphar.2024.176666
- Shang G, Zhou X, Yin J, Niu X, Zhao Y, et al. Multi-omics analysis of kidney, bone and bone marrow explored potential mechanisms of Erzhi Wan against osteoporosis with kidney-Yin deficiency. J Pharm Biomed Anal. 2024;246:116211. doi:10.1016/j.jpba.2024.116211
- Xiao D, Huang S, Tang Z, Liu M, Di D, et al. Mijiao formula regulates NAT10-mediated Runx2 mRNA ac4C modification to promote bone marrow mesenchymal stem cell osteogenic differentiation and improve osteoporosis in ovariectomized rats. J Ethnopharmacol. 2024;330:118191. doi:10.1016/j.jep.2024.118191
