Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 2 Softgels
Serving Per Container: 60
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%‡
Cholesterol
11 mg
4%‡
Protein
<1 g
Fish Oil Concentrate^
2,000 mg
†
Omega-3 Fatty Acids^
1,200 mg
†
EPA (Eicosapentaenoic acid)^
800 mg
†
DHA (Docosahexaenoic acid)^
400 mg
†
Top Medical Research Studies
7
We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Read More
9
We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Read More
9
We explored how different types of polyunsaturated fatty acids (PUFAs) affect bone health. Mice with postmenopausal osteoporosis were treated with Antarctic krill oil (rich in omega-3 PUFAs) or arachidonic acid-rich oil (rich in omega-6 PUFAs) over a 120-day period.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Read More
Most Useful Reviews
9
Prevents osteoporosis
High-quality product made from natural ingredients, particularly vital for the elderly. Omega-3 fatty acids help prevent osteoporosis by maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss, reduce inflammation, lessen rheumatoid arthritis symptoms, slow cartilage destruction during arthrosis, lower bad cholesterol, hydrate skin and hair, and promote heart health.
Read More
9
Fights bone loss
Omega-3 fatty acids effectively prevent osteoporosis while maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss and reduce inflammation, ease rheumatoid arthritis symptoms, and slow cartilage destruction in arthrosis. The quality is excellent, and I am pleased with the results. I take this regularly.
Read More
9
Boosts immunity
Excellent! Omega-3 fatty acids are pivotal in preventing osteoporosis, ensuring healthy joints, and relieving pain during exacerbations. They combat bone loss and inflammation, mitigate rheumatoid arthritis symptoms, and slow cartilage destruction in arthrosis. Moreover, they enhance brain and cardiovascular function, reduce heart disease risk, and boost immunity. The clean composition and appropriate dosage of 2 capsules per serving left me very satisfied with the quality.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.5
- All Researches
9
We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Read More
9
Omega-3 benefits in osteoporosis treatment
We explored the effects of different forms of omega-3 fish oil on obesity-induced osteoporosis in mice. The study showed that DHA-enriched phosphatidylcholine (DHA-PC) had superior benefits compared to traditional DHA triglyceride (DHA-TG).
Over 120 days, DHA-PC significantly improved bone mineral density and increased new bone formation while reducing bone marrow fat more effectively than DHA-TG. This indicates that DHA-PC not only supports bone health but also encourages beneficial cell differentiation in the treatment of osteoporosis.
Over 120 days, DHA-PC significantly improved bone mineral density and increased new bone formation while reducing bone marrow fat more effectively than DHA-TG. This indicates that DHA-PC not only supports bone health but also encourages beneficial cell differentiation in the treatment of osteoporosis.
Read More
9
We explored how different types of polyunsaturated fatty acids (PUFAs) affect bone health. Mice with postmenopausal osteoporosis were treated with Antarctic krill oil (rich in omega-3 PUFAs) or arachidonic acid-rich oil (rich in omega-6 PUFAs) over a 120-day period.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Read More
9
We delved into how omega-3 fatty acids, particularly from fish oil, impact bone health in aging mice suffering from osteoporosis. Through a study involving several dietary groups, we found that those on a fish oil diet had significant improvements in bone mass and lower levels of marrow adipose tissue compared to controls.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
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9
We explored the relationship between eicosapentaenoic acid (EPA), a type of n-3 polyunsaturated fatty acid, and osteoporosis risk in postmenopausal Korean women. Our study involved fifty women diagnosed with osteoporosis and a control group of one hundred women without the condition. By measuring erythrocyte levels of EPA and examining fish intake, we aimed to see how they correlate with bone mass and the risk of osteoporosis.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevents osteoporosis
High-quality product made from natural ingredients, particularly vital for the elderly. Omega-3 fatty acids help prevent osteoporosis by maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss, reduce inflammation, lessen rheumatoid arthritis symptoms, slow cartilage destruction during arthrosis, lower bad cholesterol, hydrate skin and hair, and promote heart health.
Read More
9
Fights bone loss
Omega-3 fatty acids effectively prevent osteoporosis while maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss and reduce inflammation, ease rheumatoid arthritis symptoms, and slow cartilage destruction in arthrosis. The quality is excellent, and I am pleased with the results. I take this regularly.
Read More
9
Boosts immunity
Excellent! Omega-3 fatty acids are pivotal in preventing osteoporosis, ensuring healthy joints, and relieving pain during exacerbations. They combat bone loss and inflammation, mitigate rheumatoid arthritis symptoms, and slow cartilage destruction in arthrosis. Moreover, they enhance brain and cardiovascular function, reduce heart disease risk, and boost immunity. The clean composition and appropriate dosage of 2 capsules per serving left me very satisfied with the quality.
Read More
7.5
Strengthens health
Excellent value for money. Omega-3 polyunsaturated fatty acids are essential for tissue building, boosting the immune system, enhancing brain function, and improving metabolism among other beneficial processes. Regular intake helps prevent various diseases and promotes youthfulness, specifically benefiting women's health. Omega-3 reduces the likelihood of conditions prevalent in women, such as hypertension, osteoporosis, and hormonal imbalances. Women with cardiovascular and nervous system abnormalities, alongside skin issues, especially notice its benefits. Omega-3 has notably positive effects: it lessens skin inflammation, lowers risks of internal organ diseases, alleviates menstrual and menopause symptoms, stabilises emotions, reduces osteoporosis risk, normalises blood pressure, and supports fetal nervous system development during pregnancy.
Read More
Frequently Asked Questions
9
Fights bone loss
Omega-3 fatty acids effectively prevent osteoporosis while maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss and reduce inflammation, ease rheumatoid arthritis symptoms, and slow cartilage destruction in arthrosis. The quality is excellent, and I am pleased with the results. I take this regularly.
7.5
Strengthens health
Excellent value for money. Omega-3 polyunsaturated fatty acids are essential for tissue building, boosting the immune system, enhancing brain function, and improving metabolism among other beneficial processes. Regular intake helps prevent various diseases and promotes youthfulness, specifically benefiting women's health. Omega-3 reduces the likelihood of conditions prevalent in women, such as hypertension, osteoporosis, and hormonal imbalances. Women with cardiovascular and nervous system abnormalities, alongside skin issues, especially notice its benefits. Omega-3 has notably positive effects: it lessens skin inflammation, lowers risks of internal organ diseases, alleviates menstrual and menopause symptoms, stabilises emotions, reduces osteoporosis risk, normalises blood pressure, and supports fetal nervous system development during pregnancy.
9
Prevents osteoporosis
High-quality product made from natural ingredients, particularly vital for the elderly. Omega-3 fatty acids help prevent osteoporosis by maintaining healthy joints and alleviating pain during flare-ups. They combat bone loss, reduce inflammation, lessen rheumatoid arthritis symptoms, slow cartilage destruction during arthrosis, lower bad cholesterol, hydrate skin and hair, and promote heart health.
9
Boosts immunity
Excellent! Omega-3 fatty acids are pivotal in preventing osteoporosis, ensuring healthy joints, and relieving pain during exacerbations. They combat bone loss and inflammation, mitigate rheumatoid arthritis symptoms, and slow cartilage destruction in arthrosis. Moreover, they enhance brain and cardiovascular function, reduce heart disease risk, and boost immunity. The clean composition and appropriate dosage of 2 capsules per serving left me very satisfied with the quality.
7
We examined the effects of eicosapentaenoic acid (EPA), part of the n-3 polyunsaturated fatty acids (PUFAs), on bone health specifically in relation to osteoporosis. Our analysis included data from 12 randomized controlled trials, focusing on how EPA might enhance bone mineral density and affect key bone metabolism markers.
The findings revealed that while there was a slight positive effect on bone mineral density overall, it was postmenopausal women who showed the most notable improvement. Our analysis indicated that eicosapentaenoic acid supplementation could decrease bone resorption markers, showing a decrease in levels of CTX, a marker for bone loss, in those who received n-3 PUFAs.
However, when it came to other markers of bone formation, such as bone-specific alkaline phosphatase and osteocalcin, we found no significant changes attributable to EPA alone. This suggests while EPA may offer some benefits for bone density, it does not significantly enhance bone formation markers.
Ultimately, we can conclude that while eicosapentaenoic acid shows promise in supporting bone health, especially among specific populations like postmenopausal women, the overall benefits require further investigation to fully understand its role in osteoporosis treatment.
The findings revealed that while there was a slight positive effect on bone mineral density overall, it was postmenopausal women who showed the most notable improvement. Our analysis indicated that eicosapentaenoic acid supplementation could decrease bone resorption markers, showing a decrease in levels of CTX, a marker for bone loss, in those who received n-3 PUFAs.
However, when it came to other markers of bone formation, such as bone-specific alkaline phosphatase and osteocalcin, we found no significant changes attributable to EPA alone. This suggests while EPA may offer some benefits for bone density, it does not significantly enhance bone formation markers.
Ultimately, we can conclude that while eicosapentaenoic acid shows promise in supporting bone health, especially among specific populations like postmenopausal women, the overall benefits require further investigation to fully understand its role in osteoporosis treatment.
4
Eicosapentaenoic acid and bone density
This study aimed to explore how dietary intake of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, relates to bone mineral density (BMD) among Spanish women aged 20-79. Involving a total of 1,865 female participants, we measured BMD at various sites, including the lumbar spine and hip, using advanced dual energy X-ray absorptiometry (DXA) technology.
Our dietary assessment focused on sources of omega-3s, particularly EPA and docosahexaenoic acid (DHA), and controlled for other factors like calcium and vitamin D intake, among other influences. We found encouraging evidence that EPA and other long-chain omega-3 fatty acids were positively associated with BMD in normal and osteopenic women, suggesting that these dietary fats might play a beneficial role in maintaining bone health.
However, it's noteworthy that we did not observe any significant correlations in osteoporotic women. This indicates that while increasing EPA intake might help bolster bone density in healthier populations, it might not offer the same benefits for those already facing osteoporosis. Overall, our findings highlight the potential of eicosapentaenoic acid and other omega-3s in supporting bone health, particularly in women who are not severely osteoporotic.
Our dietary assessment focused on sources of omega-3s, particularly EPA and docosahexaenoic acid (DHA), and controlled for other factors like calcium and vitamin D intake, among other influences. We found encouraging evidence that EPA and other long-chain omega-3 fatty acids were positively associated with BMD in normal and osteopenic women, suggesting that these dietary fats might play a beneficial role in maintaining bone health.
However, it's noteworthy that we did not observe any significant correlations in osteoporotic women. This indicates that while increasing EPA intake might help bolster bone density in healthier populations, it might not offer the same benefits for those already facing osteoporosis. Overall, our findings highlight the potential of eicosapentaenoic acid and other omega-3s in supporting bone health, particularly in women who are not severely osteoporotic.
8
DHA reduces osteoclast activity
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences bone health by targeting osteoclasts, the cells responsible for bone resorption. This research specifically looked at the effects of DHA on mouse bone marrow-derived macrophages (BMMs), which are precursors to osteoclasts.
Our findings revealed that DHA can significantly reduce the proliferation of these osteoclast precursors. This happens through a dose-dependent mechanism, where DHA inhibits key signaling pathways promoted by the macrophage colony-stimulating factor (M-CSF). By selectively dampening the activation of Akt and lowering the expression of important cell cycle proteins like cyclin D1 and D2, DHA effectively curbs cell division.
Furthermore, DHA also impedes the differentiation of BMMs into mature osteoclasts that break down bone. We observed that DHA blocks various signaling pathways involved in this process, such as the JNK, ERK, and p38 MAPKs, as well as NF-κB activation. This action led to decreased expression of critical osteoclastogenic factors like c-Fos and NFATc1.
Additionally, we noted that DHA promotes the apoptosis, or programmed death, of mature osteoclasts by enhancing the expression of Bim, a key protein that modulates this cell death process. Overall, our results point to DHA's potential as a natural agent in reducing the number of bone-resorbing cells, which may contribute positively to bone health and conditions like osteoporosis.
Our findings revealed that DHA can significantly reduce the proliferation of these osteoclast precursors. This happens through a dose-dependent mechanism, where DHA inhibits key signaling pathways promoted by the macrophage colony-stimulating factor (M-CSF). By selectively dampening the activation of Akt and lowering the expression of important cell cycle proteins like cyclin D1 and D2, DHA effectively curbs cell division.
Furthermore, DHA also impedes the differentiation of BMMs into mature osteoclasts that break down bone. We observed that DHA blocks various signaling pathways involved in this process, such as the JNK, ERK, and p38 MAPKs, as well as NF-κB activation. This action led to decreased expression of critical osteoclastogenic factors like c-Fos and NFATc1.
Additionally, we noted that DHA promotes the apoptosis, or programmed death, of mature osteoclasts by enhancing the expression of Bim, a key protein that modulates this cell death process. Overall, our results point to DHA's potential as a natural agent in reducing the number of bone-resorbing cells, which may contribute positively to bone health and conditions like osteoporosis.
References
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- Casado-Díaz A, Santiago-Mora R, Dorado G, Quesada-Gómez JM. The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis. Osteoporos Int. 2013;24:1647. doi:10.1007/s00198-012-2138-z
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- Dong H, Hutchins-Wiese H, Kleppinger A, Annis K, Liva E, et al. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. Int J Vitam Nutr Res. 2014;84:124. doi:10.1024/0300-9831/a000199
- Erfanian A, Mirhosseini H, Rasti B, Hair-Bejo M, Bin Mustafa S, et al. Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats. J Agric Food Chem. 2015;63:5795. doi:10.1021/acs.jafc.5b01468
- Mirás A, Bóveda MD, Leis MR, Mera A, Aldámiz-Echevarría L, et al. Risk factors for developing mineral bone disease in phenylketonuric patients. Mol Genet Metab. 2013;108:149. doi:10.1016/j.ymgme.2012.12.008
- Moon HJ, Kim TH, Byun DW, Park Y. Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. Ann Nutr Metab. 2012;60:146. doi:10.1159/000337302
- Lappe J, Kunz I, Bendik I, Prudence K, Weber P, et al. Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study. Eur J Nutr. 2013;52:203.
- Farina EK, Kiel DP, Roubenoff R, Schaefer EJ, Cupples LA, et al. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr. 2011;93:1142. doi:10.3945/ajcn.110.005926
- Bonnet N, Ferrari SL. Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. J Nutr Biochem. 2011;22:665. doi:10.1016/j.jnutbio.2010.05.006
- Sun L, Tamaki H, Ishimaru T, Teruya T, Ohta Y, et al. Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat. Biosci Biotechnol Biochem. 2004;68:2613.
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- Li L, Wen Y, Liu D, Lan JP, Yang B. Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. Medicine (Baltimore). 2024;103:e38893. doi:10.1097/MD.0000000000038893
- Cifuentes-Mendiola SE, Moreno-Fierros L, González-Alva P, García-Hernández AL. Docosahexaenoic acid improves altered mineralization proteins, the decreased quality of hydroxyapatite crystals and suppresses oxidative stress induced by high glucose. Exp Ther Med. 2022;23:235. doi:10.3892/etm.2022.11160
- Fang-Jie W, Ting W, Fang-Mei L, Chuan-Xiang Z, Shao L. [Study on anti-osteoporosis effect of Eucommiae Cortex based on GC-MS metabonomics]. Zhongguo Zhong Yao Za Zhi. 2020;45:5555. doi:10.19540/j.cnki.cjcmm.20200624.202
- Kasonga AE, Kruger MC, Coetzee M. Free fatty acid receptor 4-β-arrestin 2 pathway mediates the effects of different classes of unsaturated fatty acids in osteoclasts and osteoblasts. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:281. doi:10.1016/j.bbalip.2018.12.009
- Kim HJ, Ohk B, Yoon HJ, Kang WY, Seong SJ, et al. Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts. Cell Signal. 2017;29:226. doi:10.1016/j.cellsig.2016.11.007
- Kruger MC, Tousen Y, Katsumata S, Tadaishi M, Kasonga AE, et al. Effects of Soy Phytoestrogens and New Zealand Functional Foods on Bone Health. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S142. doi:10.3177/jnsv.61.S142
- Akiyama M, Nakahama K, Morita I. Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. Nutrients. 2013;5:3151. doi:10.3390/nu5083151
