SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Calcium-Magnesium Inositol Hexaphosphate)
100 mg
8%
Inositol Hexaphosphate (from Calcium-Magnesium Inositol Hexaphosphate)
500 mg
†
Top Medical Research Studies
8
BZYQD enhances motility and reduces inflammation
Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats.
Moderate relevance to inositol's role
We aimed to understand the effects of Buzhongyiqi decoction (BZYQD) on constipation, particularly how it influences various metabolic pathways. In our exploration, we conducted experiments on rats experiencing loperamide-induced constipation. Following treatment with BZYQD, we observed a notable increase in the small intestinal transit rate, suggesting improved digestive movement.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Read More
9
Laxative effects of Spicatoside A
Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling.
Indirect inositol assessment noted
We examined the effects of an extract from Red Liriope platyphylla (EtRLP) on constipation in rats. Our study compared two groups of Sprague Dawley rats: one received loperamide to induce constipation while the other was treated with EtRLP alongside loperamide.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
Read More
Most Useful Reviews
10
Cured constipation entirely
Excellent! After six days of taking this, my stomach feels better, and I am no longer constipated. My IBS-M seems stable now, and I will soon check my high ferritin levels. I’ll return to review more of this fantastic IP6. Highly recommended!
Read More
8
Resolved constipation issues
IP 6 500 mg (phytic acid CaMg salt) has yielded remarkable results for me. Initially, my legs were swollen, diagnosed as lower extremity phlebitis. My feet, marked by the deposition of erythrocytes, also showed slight improvement. However, one 500 mg capsule daily led to constipation and other side effects typical of chelation therapy. Balancing my intake was challenging, even with a multi-mineral supplement. Currently, I dissolve the capsules in water and take a portion. After two months, my constipation and side effects diminished with the aid of 10 ml of super linseed oil daily. Additionally, dissolving in water aids in maintaining oral hygiene, effectively preventing and removing dental plaque.
Read More
8.8
Effective against constipation
This is a great product that effectively addresses my constipation problems. I am hopeful about lowering my iron levels in my blood as well.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
Laxative effects of Spicatoside A
Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling.
Indirect inositol assessment noted
We examined the effects of an extract from Red Liriope platyphylla (EtRLP) on constipation in rats. Our study compared two groups of Sprague Dawley rats: one received loperamide to induce constipation while the other was treated with EtRLP alongside loperamide.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
Read More
8
BZYQD enhances motility and reduces inflammation
Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats.
Moderate relevance to inositol's role
We aimed to understand the effects of Buzhongyiqi decoction (BZYQD) on constipation, particularly how it influences various metabolic pathways. In our exploration, we conducted experiments on rats experiencing loperamide-induced constipation. Following treatment with BZYQD, we observed a notable increase in the small intestinal transit rate, suggesting improved digestive movement.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
10
Cured constipation entirely
Excellent! After six days of taking this, my stomach feels better, and I am no longer constipated. My IBS-M seems stable now, and I will soon check my high ferritin levels. I’ll return to review more of this fantastic IP6. Highly recommended!
8
Resolved constipation issues
IP 6 500 mg (phytic acid CaMg salt) has yielded remarkable results for me. Initially, my legs were swollen, diagnosed as lower extremity phlebitis. My feet, marked by the deposition of erythrocytes, also showed slight improvement. However, one 500 mg capsule daily led to constipation and other side effects typical of chelation therapy. Balancing my intake was challenging, even with a multi-mineral supplement. Currently, I dissolve the capsules in water and take a portion. After two months, my constipation and side effects diminished with the aid of 10 ml of super linseed oil daily. Additionally, dissolving in water aids in maintaining oral hygiene, effectively preventing and removing dental plaque.
Read More
8.8
Effective against constipation
This is a great product that effectively addresses my constipation problems. I am hopeful about lowering my iron levels in my blood as well.
Frequently Asked Questions
No FAQs are available for this product and symptom.
