Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.3
USERS' SCORE
Good
Based on 7 Reviews
8.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
8
We explored how the treatment with JB-1—a type of probiotic bacteria—affects anxiety during chronic stress in rats. In our study, half of the twenty rats received JB-1 while the other half got a placebo over eight weeks of stress exposure.
The results were telling! Rats on JB-1 showed less anxiety and were more willing to explore their environment compared to the placebo group, which largely avoided exploration. Additionally, measurements of brain metabolites indicated that JB-1 helped maintain stability in brain chemistry, even in stressful conditions.
This suggests that lactobacillus rhamnosus might play a beneficial role in reducing anxiety during prolonged stress.
The results were telling! Rats on JB-1 showed less anxiety and were more willing to explore their environment compared to the placebo group, which largely avoided exploration. Additionally, measurements of brain metabolites indicated that JB-1 helped maintain stability in brain chemistry, even in stressful conditions.
This suggests that lactobacillus rhamnosus might play a beneficial role in reducing anxiety during prolonged stress.
Read More
8
We aimed to investigate how Lactococcus lactis subsp. LL95 affects anxiety and depression-like behaviors in mice. After administering LL95 orally for 28 days, we observed notable improvements in behavior. Mice showed less immobility in tests designed to measure depression and preferred open spaces, suggesting decreased anxiety levels. These findings highlight LL95's potential as a therapeutic probiotic, extending its benefits beyond gut health and showcasing its effects on mental well-being.
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9
We examined how Lactococcus lactis E001-B-8 impacts anxiety in female mice under chronic stress conditions. Through a series of behavioral tests, we found that this probiotic not only helped improve cognitive function but also reduced anxiety-like behaviors.
Unlike traditional treatments like FLX, L. lactis was linked to better serotonin metabolism and healthier gut microbiome composition. This suggests that enhancing gut health could be a promising approach for anxiety management.
Unlike traditional treatments like FLX, L. lactis was linked to better serotonin metabolism and healthier gut microbiome composition. This suggests that enhancing gut health could be a promising approach for anxiety management.
Read More
Most Useful Reviews
9
Improved mood
92 people found this helpful
Excellent! I suffered from mild depression and anxiety for a long time but struggled to find the right antidepressants until I started taking this. Initially, I wanted it for an energy and immunity boost, but now on my third bottle, my mood has significantly improved!
Read More
9
Anxiety reduction
This product effectively reduces my anxiety.
Read More
7.5
Reduces tension
This product relieves stress and tension, reduces anxiety, and normalises the nervous system while improving blood circulation. It's been beneficial for me overall.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.3
- All Researches
9
We investigated how probiotics, specifically Lactobacillus rhamnosus and Bifidobacterium BB-12, can affect anxiety in a mouse model of Alzheimer’s disease. In our study, we found that mice treated with these probiotics exhibited significantly reduced anxiety-like behaviors compared to those exposed to aluminum chloride alone.
Through various behavioral tests, it was evident that this probiotic combination also improved memory functions. Our results suggest that leveraging the gut-brain axis through these probiotics could offer a promising approach for alleviating anxiety and cognitive deficits in neurodegenerative conditions like Alzheimer's.
Through various behavioral tests, it was evident that this probiotic combination also improved memory functions. Our results suggest that leveraging the gut-brain axis through these probiotics could offer a promising approach for alleviating anxiety and cognitive deficits in neurodegenerative conditions like Alzheimer's.
Read More
We conducted a study to assess how well the probiotic CECT 7347 (ES1) and the heat-treated version (HT-ES1) helped alleviate diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms in adults. Over 84 days, participants took either the probiotic, the postbiotic, or a placebo, reporting significant improvement in key measures like symptom severity, quality of life, and even anxiety levels. The results demonstrated a notable reduction in IBS symptoms, making it one of the first trials to show such effectiveness in this area.
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9
Bifidobacterium longum may ease anxiety
We examined the impact of a probiotic blend, Bifidobacterium longum strains 1714® and 35642®, on anxiety and irritable bowel syndrome (IBS) symptoms in patients. Over eight weeks, we observed that the treatment helped restore the stress response and improved IBS symptoms and psychometric scores for anxiety and depression.
Interestingly, the benefits continued after stopping treatment, suggesting a lasting positive effect. The findings indicate that managing stress can significantly influence IBS symptoms and associated mood disturbances.
Interestingly, the benefits continued after stopping treatment, suggesting a lasting positive effect. The findings indicate that managing stress can significantly influence IBS symptoms and associated mood disturbances.
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9
Bifidobacterium lactis reduces anxiety significantly
We conducted a thorough investigation into the effects of Bifidobacterium lactis, known as Probio-M8, on anxiety and overall well-being in patients with coronary artery disease (CAD). Over six months, we compared a group receiving the probiotic with a placebo group.
Notably, those in the probiotic group reported significant improvements in anxiety levels and other markers of mental health. This suggests that enhancing gut health can also positively influence our mood and emotional states.
With ongoing research, it’s becoming clearer how beneficial our gut bacteria can be for our overall mental and physical wellness.
Notably, those in the probiotic group reported significant improvements in anxiety levels and other markers of mental health. This suggests that enhancing gut health can also positively influence our mood and emotional states.
With ongoing research, it’s becoming clearer how beneficial our gut bacteria can be for our overall mental and physical wellness.
Read More
9
We examined how Lactococcus lactis E001-B-8 impacts anxiety in female mice under chronic stress conditions. Through a series of behavioral tests, we found that this probiotic not only helped improve cognitive function but also reduced anxiety-like behaviors.
Unlike traditional treatments like FLX, L. lactis was linked to better serotonin metabolism and healthier gut microbiome composition. This suggests that enhancing gut health could be a promising approach for anxiety management.
Unlike traditional treatments like FLX, L. lactis was linked to better serotonin metabolism and healthier gut microbiome composition. This suggests that enhancing gut health could be a promising approach for anxiety management.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved mood
92 people found this helpful
Excellent! I suffered from mild depression and anxiety for a long time but struggled to find the right antidepressants until I started taking this. Initially, I wanted it for an energy and immunity boost, but now on my third bottle, my mood has significantly improved!
Read More
9
Anxiety reduction
This product effectively reduces my anxiety.
Read More
7.5
Reduces tension
This product relieves stress and tension, reduces anxiety, and normalises the nervous system while improving blood circulation. It's been beneficial for me overall.
Read More
7.5
Supports immunity
6 people found this helpful
Beneficial bacteria are essential for everyone, especially during travel, as they strengthen immunity. I advise those suffering from anxiety, fear, or weak immunity to take them regularly. Improvement is noticeable after consistent use, and using them on an empty stomach is best.
Read More
9
Gut health restored
5 people found this helpful
This probiotic, along with kefir, truly saved my gut. After multiple rounds of antibiotics, my gut suffered significantly. However, this combination completely transformed my gut biome, and both my heartburn and anxiety symptoms disappeared in a week, despite the initial discomfort.
Read More
Frequently Asked Questions
9
Improved mood
92 people found this helpful
Excellent! I suffered from mild depression and anxiety for a long time but struggled to find the right antidepressants until I started taking this. Initially, I wanted it for an energy and immunity boost, but now on my third bottle, my mood has significantly improved!
7.5
Supports immunity
6 people found this helpful
Beneficial bacteria are essential for everyone, especially during travel, as they strengthen immunity. I advise those suffering from anxiety, fear, or weak immunity to take them regularly. Improvement is noticeable after consistent use, and using them on an empty stomach is best.
9
Anxiety reduction
This product effectively reduces my anxiety.
7.5
Helps anxiety
1 people found this helpful
I experienced anxiety and irritability due to a stress-related ulcer. Since using this product, I’ve noticed improved stool consistency and reduced anxiety. I recommend it for those suffering similar issues.
7.5
Reduces tension
This product relieves stress and tension, reduces anxiety, and normalises the nervous system while improving blood circulation. It's been beneficial for me overall.
7.5
Less anxiety
Strains of bifidobacteria and lactobacilli have helped reduce my anxiety and depression levels while also reducing bloating. I use them for making yogurt, which has a neutral taste, unlike other brands.
9
We investigated how probiotics, specifically Lactobacillus rhamnosus and Bifidobacterium BB-12, can affect anxiety in a mouse model of Alzheimer’s disease. In our study, we found that mice treated with these probiotics exhibited significantly reduced anxiety-like behaviors compared to those exposed to aluminum chloride alone.
Through various behavioral tests, it was evident that this probiotic combination also improved memory functions. Our results suggest that leveraging the gut-brain axis through these probiotics could offer a promising approach for alleviating anxiety and cognitive deficits in neurodegenerative conditions like Alzheimer's.
Through various behavioral tests, it was evident that this probiotic combination also improved memory functions. Our results suggest that leveraging the gut-brain axis through these probiotics could offer a promising approach for alleviating anxiety and cognitive deficits in neurodegenerative conditions like Alzheimer's.
8
We investigated how the probiotic Bifidobacterium longum NCC3001 impacts anxiety in patients with Irritable Bowel Syndrome (IBS). Over six weeks, participants received either the probiotic or a placebo, allowing us to assess changes in anxiety and depression levels.
The results were promising! Patients taking the probiotic showed significant reductions in their anxiety scores and changes in brain activity related to emotional responses. Notably, higher levels of butyric acid and increased probiotic abundance in feces were linked to these improvements.
Our findings suggest that Bifidobacterium longum may play a beneficial role in managing anxiety by influencing gut-brain interactions.
The results were promising! Patients taking the probiotic showed significant reductions in their anxiety scores and changes in brain activity related to emotional responses. Notably, higher levels of butyric acid and increased probiotic abundance in feces were linked to these improvements.
Our findings suggest that Bifidobacterium longum may play a beneficial role in managing anxiety by influencing gut-brain interactions.
We conducted a clinical trial aimed at understanding the effect of caloric restriction combined with probiotic supplementation on various health factors, including anxiety, in obese men.
After 12 weeks, while the probiotic had no additional benefit on body composition or overall quality of life, we noted improvements in anxiety and depressive symptoms among those who received the probiotics.
However, there were no significant differences between the groups overall, suggesting that more research is necessary to fully understand this relationship.
After 12 weeks, while the probiotic had no additional benefit on body composition or overall quality of life, we noted improvements in anxiety and depressive symptoms among those who received the probiotics.
However, there were no significant differences between the groups overall, suggesting that more research is necessary to fully understand this relationship.
8
Lactobacillus rhamnosus shows mixed benefits
In a randomized double-blind placebo-controlled crossover trial, we investigated whether a multi-species probiotic containing Lactobacillus rhamnosus could help reduce anxiety and improve cognitive function in healthy older adults.
Over a ten-week period, participants consumed the probiotic daily and were assessed for cognitive abilities and emotional well-being.
While significant improvements were found in cognitive and emotional functions, including planning and memory, the study provided limited evidence specifically addressing anxiety benefits.
Therefore, while promising, the role of Lactobacillus rhamnosus for anxiety treatment in older adults remains uncertain.
Over a ten-week period, participants consumed the probiotic daily and were assessed for cognitive abilities and emotional well-being.
While significant improvements were found in cognitive and emotional functions, including planning and memory, the study provided limited evidence specifically addressing anxiety benefits.
Therefore, while promising, the role of Lactobacillus rhamnosus for anxiety treatment in older adults remains uncertain.
References
- Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, Alves Carrilho FB, Nakamoto FP, et al. Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Clin Nutr. 2025;45:234. doi:10.1016/j.clnu.2024.12.031
- Al Kassaa I, Fuad M. Effects of HN001 on Happiness and Mental Well-Being: Findings from a Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16172936
- Ruiz-Gonzalez C, Cardona D, Rueda-Ruzafa L, Rodriguez-Arrastia M, Ropero-Padilla C, et al. Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double-Blind Randomized Placebo-Controlled Crossover Trial. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10315-2
- Holcomb M, Marshall A, Flinn H, Lozano M, Soriano S, et al. Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice. Res Sq. 2024. doi:10.21203/rs.3.rs-4196801/v1
- Lonstein JS, Meinhardt TA, Pavlidi P, Kokras N, Dalla C, et al. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. 2024;165:107033. doi:10.1016/j.psyneuen.2024.107033
- Schmidt NP, Molz P, Fraga BS, Bondarczuk NH, Silveira PD, et al. Effect of Probiotic LB1.5 on Anxiety-like Behavior, Neuroprotection and Neuroinflammation Markers of Male Mice Fed a High-Fat Diet. Nutrients. 2024;16. doi:10.3390/nu16060879
- Schell M, Wardelmann K, Hauffe R, Rath M, Chopra S, et al. Sex-Specifically Attenuates Depressive-like Behavior and Mitigates Metabolic Consequences in Obesity. Biol Psychiatry Glob Open Sci. 2023;3:651. doi:10.1016/j.bpsgos.2023.02.011
- Jadhav G, Dudhabhate BB, Kokare DM, Sakharkar AJ. Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety. Mol Neurobiol. 2024;61:9892. doi:10.1007/s12035-023-03697-x
- Walden KE, Moon JM, Hagele AM, Allen LE, Gaige CJ, et al. A randomized controlled trial to examine the impact of a multi-strain probiotic on self-reported indicators of depression, anxiety, mood, and associated biomarkers. Front Nutr. 2023;10:1219313. doi:10.3389/fnut.2023.1219313
- Hamid M, Zahid S. Ameliorative effects of probiotics in AlCl-induced mouse model of Alzheimer's disease. Appl Microbiol Biotechnol. 2023;107:5803. doi:10.1007/s00253-023-12686-y
- Chudzik A, Słowik T, Kochalska K, Pankowska A, Łazorczyk A, et al. Continuous Ingestion of JB-1 during Chronic Stress Ensures Neurometabolic and Behavioural Stability in Rats. Int J Mol Sci. 2022;23. doi:10.3390/ijms23095173
- Wauters L, Van Oudenhove L, Accarie A, Geboers K, Geysen H, et al. CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial. Gut Microbes. 2022;14:2031695. doi:10.1080/19490976.2022.2031695
- Zhou B, Jin G, Pang X, Mo Q, Bao J, et al. Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood. Pharmacol Res. 2022;177:106090. doi:10.1016/j.phrs.2022.106090
- Liu Y, Sanderson D, Mian MF, McVey Neufeld KA, Forsythe P. Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response. Neuropharmacology. 2021;195:108682. doi:10.1016/j.neuropharm.2021.108682
- Foroozan P, Koushkie Jahromi M, Nemati J, Sepehri H, Safari MA, et al. Probiotic Supplementation and High-Intensity Interval Training Modify Anxiety-Like Behaviors and Corticosterone in High-Fat Diet-Induced Obesity Mice. Nutrients. 2021;13. doi:10.3390/nu13061762
- Quero CD, Manonelles P, Fernández M, Abellán-Aynés O, López-Plaza D, et al. Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study. Nutrients. 2021;13. doi:10.3390/nu13041321
- Tamayo M, Agusti A, Molina-Mendoza GV, Rossini V, Frances-Cuesta C, et al. Bifidobacterium longum CECT 30763 improves depressive- and anxiety-like behavior in a social defeat mouse model through the immune and dopaminergic systems. Brain Behav Immun. 2025;125:35. doi:10.1016/j.bbi.2024.12.028
- Martin FP, Cominetti O, Berger B, Combremont S, Marquis J, et al. Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic. Gut Microbes. 2024;16:2347715. doi:10.1080/19490976.2024.2347715
- Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
- Boehme M, Rémond-Derbez N, Lerond C, Lavalle L, Keddani S, et al. subsp. Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15143122
- Toh MPS, Yang CY, Lim PC, Loh HLJ, Bergonzelli G, et al. A Probiotic Intervention With Bifidobacterium longum NCC3001 on Perinatal Mood Outcomes (PROMOTE Study): Protocol for a Decentralized Randomized Controlled Trial. JMIR Res Protoc. 2023;12:e41751. doi:10.2196/41751
- Groeger D, Murphy EF, Tan HTT, Larsen IS, O'Neill I, et al. Interactions between symptoms and psychological status in irritable bowel syndrome: An exploratory study of the impact of a probiotic combination. Neurogastroenterol Motil. 2023;35:e14477. doi:10.1111/nmo.14477
- Haghighat N, Mohammadshahi M, Shayanpour S, Haghighizadeh MH, Rahmdel S, et al. The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial. Indian J Nephrol. 2021;31:149. doi:10.4103/ijn.IJN_341_19
- Ma T, Jin H, Kwok LY, Sun Z, Liong MT, et al. Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota. Neurobiol Stress. 2021;14:100294. doi:10.1016/j.ynstr.2021.100294
- Inoue T, Kobayashi Y, Mori N, Sakagawa M, Xiao JZ, et al. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. Benef Microbes. 2018;9:843. doi:10.3920/BM2017.0193
- Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, et al. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017;153:448. doi:10.1053/j.gastro.2017.05.003
- Allen AP, Hutch W, Borre YE, Kennedy PJ, Temko A, et al. Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Transl Psychiatry. 2016;6:e939. doi:10.1038/tp.2016.191
- Savignac HM, Tramullas M, Kiely B, Dinan TG, Cryan JF. Bifidobacteria modulate cognitive processes in an anxious mouse strain. Behav Brain Res. 2015;287:59. doi:10.1016/j.bbr.2015.02.044
- Savignac HM, Kiely B, Dinan TG, Cryan JF. Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterol Motil. 2014;26:1615. doi:10.1111/nmo.12427
- Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil. 2011;23:1132. doi:10.1111/j.1365-2982.2011.01796.x
- Freitas SM, Franco B, Saragiotto G, Morais MA, Simabuco FM, et al. Effect of a probiotic fermented milk supplementation on behavior and sleep. Nutr Neurosci. 2024;27:607. doi:10.1080/1028415X.2023.2240990
- Dandekar MP, Palepu MSK, Satti S, Jaiswal Y, Singh AA, et al. Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome-Brain Activity in Rats. ACS Chem Neurosci. 2022;13:1948. doi:10.1021/acschemneuro.2c00143
- Sun B, Ma T, Li Y, Yang N, Li B, et al. Bifidobacterium lactis Probio-M8 Adjuvant Treatment Confers Added Benefits to Patients with Coronary Artery Disease via Target Modulation of the Gut-Heart/-Brain Axes. mSystems. 2022;7:e0010022. doi:10.1128/msystems.00100-22
- Dong W, Wang Y, Liao S, Tang W, Peng L, et al. subsp. BB-12 Improves the State Anxiety and Sports Performance of Young Divers Under Stress Situations: A Single-Arm, Prospective Proof-of-Concept Study. Front Psychol. 2020;11:570298. doi:10.3389/fpsyg.2020.570298
- Luang-In V, Katisart T, Konsue A, Nudmamud-Thanoi S, Narbad A, et al. Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model. Food Sci Anim Resour. 2020;40:1014. doi:10.5851/kosfa.2020.e72
- Venkataraman R, Madempudi RS, Neelamraju J, Ahire JJ, Vinay HR, et al. Effect of Multi-strain Probiotic Formulation on Students Facing Examination Stress: a Double-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2021;13:12. doi:10.1007/s12602-020-09681-4
- Dawe JP, McCowan LME, Wilson J, Okesene-Gafa KAM, Serlachius AS. Probiotics and Maternal Mental Health: A Randomised Controlled Trial among Pregnant Women with Obesity. Sci Rep. 2020;10:1291. doi:10.1038/s41598-020-58129-w
- Eskandarzadeh S, Effatpanah M, Khosravi-Darani K, Askari R, Hosseini AF, et al. Efficacy of a multispecies probiotic as adjunctive therapy in generalized anxiety disorder: a double blind, randomized, placebo-controlled trial. Nutr Neurosci. 2021;24:102. doi:10.1080/1028415X.2019.1598669
- Haghighat N, Rajabi S, Mohammadshahi M. Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutr Neurosci. 2021;24:490. doi:10.1080/1028415X.2019.1646975
- Gao K, Chen C, Zheng Z, Fan Q, Wang H, et al. strains with psychobiotic properties improve cognitive and mood alterations in aged mice. Front Nutr. 2024;11:1439094. doi:10.3389/fnut.2024.1439094
- Gomes P, Laroute V, Beaufrand C, Daveran-Mingot ML, Aubry N, et al. Lactococcus lactis CNCM I-5388 versus NCDO2118 by its GABA hyperproduction ability, counteracts faster stress-induced intestinal hypersensitivity in rats. FASEB J. 2023;37:e23264. doi:10.1096/fj.202301588R
- Ma J, Wang R, Chen Y, Wang Z, Dong Y. 5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption. J Neuroinflammation. 2023;20:23. doi:10.1186/s12974-023-02693-1
- Laroute V, Beaufrand C, Gomes P, Nouaille S, Tondereau V, et al. NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract. Elife. 2022;11. doi:10.7554/eLife.77100
- Gao K, Farzi A, Ke X, Yu Y, Chen C, et al. Oral administration of WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress. Food Funct. 2022;13:957. doi:10.1039/d1fo03723d
- Surzenko N, Pjetri E, Munson CA, Friday WB, Hauser J, et al. Prenatal exposure to the probiotic Lactococcus lactis decreases anxiety-like behavior and modulates cortical cytoarchitecture in a sex specific manner. PLoS One. 2020;15:e0223395. doi:10.1371/journal.pone.0223395
- Ramalho JB, Soares MB, Spiazzi CC, Bicca DF, Soares VM, et al. In Vitro Probiotic and Antioxidant Potential of subsp. LL95 and Its Effect in Mice Behaviour. Nutrients. 2019;11. doi:10.3390/nu11040901
