Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 40 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
8
Bifidobacterium longum shows potential benefits
We investigated whether Bifidobacterium longum XZ01 could affect the progression of colon cancer in a mouse model. The results hinted that this probiotic might enhance immune responses by outcompeting harmful bacteria and protecting macrophages within tumors.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
Read More
9
We explored the effects of probiotic bacteria and their metabolites on colorectal cancer (CRC) growth through a study comparing CRC patients with healthy individuals.
Our findings revealed that beneficial strains like Bifidobacterium longum were significantly less prevalent in CRC patients. We treated cancer organoid lines with metabolites from various bacteria, including Bifidobacterium longum, and observed a notable reduction in cancer growth.
This research emphasizes how the loss of beneficial bacteria and their metabolites could contribute to cancer development and showcases the potential of these metabolites in inhibiting CRC growth.
Our findings revealed that beneficial strains like Bifidobacterium longum were significantly less prevalent in CRC patients. We treated cancer organoid lines with metabolites from various bacteria, including Bifidobacterium longum, and observed a notable reduction in cancer growth.
This research emphasizes how the loss of beneficial bacteria and their metabolites could contribute to cancer development and showcases the potential of these metabolites in inhibiting CRC growth.
Read More
9
We explored how timely liver function recovery (LFR) impacts long-term survival in hepatocellular carcinoma (HCC) patients and discovered Bifidobacterium longum, which is linked to improved recovery. In our study, we found that transferring fecal microbiota from HCC patients with delayed recovery to mice affected their recovery. Remarkably, giving these mice B. longum sped up their liver repair. In a clinical trial, a probiotic cocktail with B. longum significantly lowered recovery delays and shortened hospital stays for HCC patients, ultimately boosting their one-year survival rates.
Read More
Most Useful Reviews
7.5
Improved intestinal health
1 people found this helpful
I am pleasantly surprised. After taking 2 or 3 tablets daily for ten days, I noticed positive changes. My usual morning stool now comes out around 2 pm. Previously, I experienced painful bloating after lunch, but that discomfort has disappeared, and my bowel movements are much smoother. After my mother died of colon cancer, I feared inheriting that issue, so I started this to improve my gut health. I look forward to continuing this and hope it will benefit both my intestinal and skin health over the next three months.
Read More
7
Effective against constipation
I had high hopes for this probiotic after experiencing cancer previously. It effectively alleviates my severe constipation, and I noticed positive results within five years, even with just one a day. I will definitely repurchase!
Read More
6
Positive response noted
Good effects of lactic acid bacteria. After taking it two hours post-meal, my constipation improved, which is a welcomed relief. I also heard that maintaining bowel health may reduce the recurrence of cancer.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 40 Researches
8
- All Researches
9
Probiotic-based cancer treatment strategy
We explored how a novel approach using bifidobacterium longum combined with selenium nanoparticles might improve cancer treatment. This method targets tumor cells in oxygen-poor environments to halt their growth, while simultaneously boosting the immune response against cancer.
The therapy not only damages tumor cells but also reduces the number of immunosuppressive cells in tumors. However, there is no significant mention of direct benefits in long-term cancer outcomes. This innovative strategy aims to enhance the efficacy of traditional radiotherapy, offering a promising avenue for future treatments.
The therapy not only damages tumor cells but also reduces the number of immunosuppressive cells in tumors. However, there is no significant mention of direct benefits in long-term cancer outcomes. This innovative strategy aims to enhance the efficacy of traditional radiotherapy, offering a promising avenue for future treatments.
Read More
9
We explored the effects of probiotic bacteria and their metabolites on colorectal cancer (CRC) growth through a study comparing CRC patients with healthy individuals.
Our findings revealed that beneficial strains like Bifidobacterium longum were significantly less prevalent in CRC patients. We treated cancer organoid lines with metabolites from various bacteria, including Bifidobacterium longum, and observed a notable reduction in cancer growth.
This research emphasizes how the loss of beneficial bacteria and their metabolites could contribute to cancer development and showcases the potential of these metabolites in inhibiting CRC growth.
Our findings revealed that beneficial strains like Bifidobacterium longum were significantly less prevalent in CRC patients. We treated cancer organoid lines with metabolites from various bacteria, including Bifidobacterium longum, and observed a notable reduction in cancer growth.
This research emphasizes how the loss of beneficial bacteria and their metabolites could contribute to cancer development and showcases the potential of these metabolites in inhibiting CRC growth.
Read More
9
Probiotics may enhance immunotherapy
We investigated how Bifidobacterium longum, alongside Bifidobacterium infantis, might enhance the effectiveness of cancer immunotherapy. In a mouse study, these probiotics were administered alongside an antibiotic known to undermine the action of cancer treatments.
Surprisingly, while the antibiotic alone led to increased tumor growth, the probiotics helped to improve the anti-tumor effects of the therapy. By altering gut bacteria and boosting certain immune responses, this suggests that probiotics could be a novel approach to enhance cancer treatment, especially for patients undergoing antimicrobial therapy.
Surprisingly, while the antibiotic alone led to increased tumor growth, the probiotics helped to improve the anti-tumor effects of the therapy. By altering gut bacteria and boosting certain immune responses, this suggests that probiotics could be a novel approach to enhance cancer treatment, especially for patients undergoing antimicrobial therapy.
Read More
9
Bifidobacterium longum enhances treatment efficacy
We examined the impact of probiotics on Helicobacter pylori eradication treatment. By analyzing data from 91 randomized controlled trials with nearly 13,700 participants, we found that adding probiotics significantly improved the eradication success rate.
Specifically, a strain called Bifidobacterium longum showed remarkable results, achieving an effectiveness rate of 81%. Beyond increasing effectiveness, probiotics also reduced common side effects such as nausea, diarrhea, and abdominal pain, making treatment more manageable.
Specifically, a strain called Bifidobacterium longum showed remarkable results, achieving an effectiveness rate of 81%. Beyond increasing effectiveness, probiotics also reduced common side effects such as nausea, diarrhea, and abdominal pain, making treatment more manageable.
Read More
9
We explored how timely liver function recovery (LFR) impacts long-term survival in hepatocellular carcinoma (HCC) patients and discovered Bifidobacterium longum, which is linked to improved recovery. In our study, we found that transferring fecal microbiota from HCC patients with delayed recovery to mice affected their recovery. Remarkably, giving these mice B. longum sped up their liver repair. In a clinical trial, a probiotic cocktail with B. longum significantly lowered recovery delays and shortened hospital stays for HCC patients, ultimately boosting their one-year survival rates.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved intestinal health
1 people found this helpful
I am pleasantly surprised. After taking 2 or 3 tablets daily for ten days, I noticed positive changes. My usual morning stool now comes out around 2 pm. Previously, I experienced painful bloating after lunch, but that discomfort has disappeared, and my bowel movements are much smoother. After my mother died of colon cancer, I feared inheriting that issue, so I started this to improve my gut health. I look forward to continuing this and hope it will benefit both my intestinal and skin health over the next three months.
Read More
7
Effective against constipation
I had high hopes for this probiotic after experiencing cancer previously. It effectively alleviates my severe constipation, and I noticed positive results within five years, even with just one a day. I will definitely repurchase!
Read More
6
Positive response noted
Good effects of lactic acid bacteria. After taking it two hours post-meal, my constipation improved, which is a welcomed relief. I also heard that maintaining bowel health may reduce the recurrence of cancer.
Read More
Frequently Asked Questions
7.5
Improved intestinal health
1 people found this helpful
I am pleasantly surprised. After taking 2 or 3 tablets daily for ten days, I noticed positive changes. My usual morning stool now comes out around 2 pm. Previously, I experienced painful bloating after lunch, but that discomfort has disappeared, and my bowel movements are much smoother. After my mother died of colon cancer, I feared inheriting that issue, so I started this to improve my gut health. I look forward to continuing this and hope it will benefit both my intestinal and skin health over the next three months.
7
Effective against constipation
I had high hopes for this probiotic after experiencing cancer previously. It effectively alleviates my severe constipation, and I noticed positive results within five years, even with just one a day. I will definitely repurchase!
6
Positive response noted
Good effects of lactic acid bacteria. After taking it two hours post-meal, my constipation improved, which is a welcomed relief. I also heard that maintaining bowel health may reduce the recurrence of cancer.
8
Bifidobacterium longum shows potential benefits
We investigated whether Bifidobacterium longum XZ01 could affect the progression of colon cancer in a mouse model. The results hinted that this probiotic might enhance immune responses by outcompeting harmful bacteria and protecting macrophages within tumors.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
Notably, XZ01 appears to foster a favorable tumor immune environment, promoting immune cell activation while inhibiting certain immune suppression. By interacting with microbial communities, this treatment shows promise for potentially improving colon cancer immunotherapy strategies.
More research is necessary to confirm these effects in humans, but these findings open doors to innovative cancer treatments.
9
Probiotic-based cancer treatment strategy
We explored how a novel approach using bifidobacterium longum combined with selenium nanoparticles might improve cancer treatment. This method targets tumor cells in oxygen-poor environments to halt their growth, while simultaneously boosting the immune response against cancer.
The therapy not only damages tumor cells but also reduces the number of immunosuppressive cells in tumors. However, there is no significant mention of direct benefits in long-term cancer outcomes. This innovative strategy aims to enhance the efficacy of traditional radiotherapy, offering a promising avenue for future treatments.
The therapy not only damages tumor cells but also reduces the number of immunosuppressive cells in tumors. However, there is no significant mention of direct benefits in long-term cancer outcomes. This innovative strategy aims to enhance the efficacy of traditional radiotherapy, offering a promising avenue for future treatments.
5
We explored the connection between gut bacteria and chemotherapy outcomes in lung cancer patients. By studying stool samples from 64 individuals with locally advanced and advanced lung cancer, we compared the gut microbiota of those who responded to treatment with those who did not.
Notably, certain bacteria, like Streptococcus mutans, were more abundant in responders, while Leuconostoc lactis was associated with nonresponders. This suggests that the makeup of our gut microbiome may influence how well chemotherapy works in these patients, offering insights for more personalized treatment strategies.
Notably, certain bacteria, like Streptococcus mutans, were more abundant in responders, while Leuconostoc lactis was associated with nonresponders. This suggests that the makeup of our gut microbiome may influence how well chemotherapy works in these patients, offering insights for more personalized treatment strategies.
7
We investigated how gut microbiota influences differentiated thyroid cancer (DTC) using advanced genetic methods. By analyzing data from large genome studies, we found a significant connection between specific gut bacteria and types of thyroid cancer, particularly papillary and follicular thyroid cancer.
Notably, Bifidobacterium longum emerged as a key player for papillary thyroid cancer. Our findings also highlight that certain blood metabolites could mediate this relationship. This research helps clarify the complex links between gut health and cancer.
Notably, Bifidobacterium longum emerged as a key player for papillary thyroid cancer. Our findings also highlight that certain blood metabolites could mediate this relationship. This research helps clarify the complex links between gut health and cancer.
References
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- Zhang H, Li Y, Li L. Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis. BMC Cancer. 2025;25:368. doi:10.1186/s12885-025-13598-y
- Chen Y, Wu J, Cai K, Xiao X, Chen Y, et al. Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity. Int Immunopharmacol. 2025;150:114283. doi:10.1016/j.intimp.2025.114283
- Yu Y, Wang Y, Zhang J, Bu Q, Jiang D, et al. Anaerobic probiotics-in situ Se nanoradiosensitizers selectively anchor to tumor with immuno-regulations for robust cancer radio-immunotherapy. Biomaterials. 2025;318:123117. doi:10.1016/j.biomaterials.2025.123117
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- Fan YL, Jin JX, Zhu J, Ruan HB, Huang JQ. Extracellular vesicles of Bifidobacterium longum reverse the acquired carboplatin resistance in ovarian cancer cells via p53 phosphorylation on Ser15. Kaohsiung J Med Sci. 2024;40:530. doi:10.1002/kjm2.12837
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- Yu J, Zhu P, Shi L, Gao N, Li Y, et al. Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma. Cell Host Microbe. 2024;32:131. doi:10.1016/j.chom.2023.11.011
- Ueki H, Kitagawa K, Kato M, Yanase S, Okamura Y, et al. An oral cancer vaccine using Bifidobacterium vector augments combination of anti-PD-1 and anti-CTLA-4 antibodies in mouse renal cell carcinoma model. Sci Rep. 2023;13:9994. doi:10.1038/s41598-023-37234-6
- Chan YL, Liao JC, Li TL, Wu CJ, Chiu YH. Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions. Appl Microbiol Biotechnol. 2025;109:69. doi:10.1007/s00253-025-13445-x
- Fedosova N, Cheremshenko N, Gogol S, Bezdieniezhnykh N, Tikhonov V, et al. THE INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND LECTIN OF B. SUBTILIS IMV B-7724 ON THE ANTITUMOR IMMUNE RESPONSE OF MICE WITH EHRLICH ADENOCARCINOMA. Exp Oncol. 2024;46:228. doi:10.15407/exp-oncology.2024.03.228
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- Xiong H, He Z, Wei Y, Li Q, Xiao Q, et al. Probiotic Compounds Enhanced Recovery after Surgery for Patients with Distal Gastric Cancer: A Prospective, Controlled Clinical Trial. Ann Surg Oncol. 2024;31:5240. doi:10.1245/s10434-024-15394-7
- Kozak T, Lykhova O, Serhiichuk T, Bezdieniezhnykh N, Chekhun V. OPTIMIZATION OF EXPERIMENTAL MODEL SYSTEMS FOR EVALUATING RECIPROCAL INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND HUMAN BREAST CANCER CELLS IN VITRO. Exp Oncol. 2024;45:504. doi:10.15407/exp-oncology.2023.04.504
- Reis SK, Socca EAR, de Souza BR, Genaro SC, Durán N, et al. Effects of probiotic supplementation on chronic inflammatory process modulation in colorectal carcinogenesis. Tissue Cell. 2024;87:102293. doi:10.1016/j.tice.2023.102293
- Yang X, Cao Q, Ma B, Xia Y, Liu M, et al. Probiotic powder ameliorates colorectal cancer by regulating Bifidobacterium animalis, Clostridium cocleatum, and immune cell composition. PLoS One. 2023;18:e0277155. doi:10.1371/journal.pone.0277155
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- Holkem AT, Favaro-Trindade CS, Lacroix M. Study of anticancer properties of proanthocyanidin-rich cinnamon extract in combination with Bifidobacterium animalis subsp. lactis BLC1 and resistance of these free and co-encapsulated materials under in vitro simulated gastrointestinal conditions. Food Res Int. 2020;134:109274. doi:10.1016/j.foodres.2020.109274
- An J, Kim H, Yang KM. An Aqueous Extract of a Species Induces Apoptosis and Inhibits Invasiveness of Non-Small Cell Lung Cancer Cells. J Microbiol Biotechnol. 2020;30:885. doi:10.4014/jmb.1912.12054
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