Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 16 Reviews
8.4
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
7
We investigated the effects of acetyl-L-carnitine (ALCAR) on anxiety-like behaviors in rats, using a systematic approach with control groups. Our findings revealed that chronic doses of 50 and 75 mg/kg significantly reduced anxiety, while doses of 10 and 100 mg/kg showed no effect. In an interesting twist, an acute dose of 100 mg/kg led to increased anxiety. This suggests a complex relationship where ALCAR may work differently depending on the dosage and timing. More research is needed to clarify how ALCAR influences anxiety in these cases.
Read More
8
ALC shows promise for anxiety treatment
We evaluated how acetyl-L-carnitine (ALC) can influence anxiety-like behaviors in zebrafish under stress. Using a protocol that simulated unpredictable chronic stress, we saw that the fish exhibited increased anxiety and oxidative stress.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Read More
8
We explored how acetyl-l-carnitine (LAC) treatment affects anxiety linked to stress. In our study, mice experiencing chronic stress showed structural changes in the medial amygdala, a brain area crucial for anxiety responses.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
Read More
Most Useful Reviews
9
Reduced social fear
8 people found this helpful
Six stars out of five! This is the best supplement I've used so far. It significantly reduces stress and improves mood, making it ideal for anyone facing social anxiety or fear of public speaking.
Read More
9
Life-changing energy
Resolved no energy, lack of clarity, and depression! I have Fibromyalgia with chronic fatigue. I did research on ALC before trying it, and I asked my doctor for advice. Initially, I took 3 capsules in the morning and 2 in the afternoon. The first day brought great energy, clarity, and improved mood. However, I noticed a rash and did not take the second dose. After a day of just one dose, my energy and mood returned! I continue taking 3 a day without further issues. I highly recommend ALC for anyone struggling with fatigue, memory problems, anxiety, or depression.
Read More
9
Helps with multiple issues
I have AuDHD and various autoimmune problems; taking one daily helps ease my anxiety, depression, and obsessive thoughts. It works well, especially in conjunction with NAC and L-Theanine.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
- All Researches
9
We checked how acetyl-L-carnitine (ALC) affects patients with minimal hepatic encephalopathy (MHE), a condition that can lower quality of life. Through a rigorous, randomized, double-blind study with 67 participants, half received ALC while the other half got a placebo for 90 days.
By the end, those on ALC reported notable improvements in energy and mental health, correlating with lower anxiety and depression levels. This suggests that ALC could be a valuable treatment option for enhancing well-being in patients facing this challenging condition.
By the end, those on ALC reported notable improvements in energy and mental health, correlating with lower anxiety and depression levels. This suggests that ALC could be a valuable treatment option for enhancing well-being in patients facing this challenging condition.
Read More
8
ALC shows promise for anxiety treatment
We evaluated how acetyl-L-carnitine (ALC) can influence anxiety-like behaviors in zebrafish under stress. Using a protocol that simulated unpredictable chronic stress, we saw that the fish exhibited increased anxiety and oxidative stress.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Read More
8
We explored how acetyl-l-carnitine (LAC) treatment affects anxiety linked to stress. In our study, mice experiencing chronic stress showed structural changes in the medial amygdala, a brain area crucial for anxiety responses.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
We introduced LAC shortly before the stress period ended, and we saw some promising results. Treatment with LAC improved social interaction and reduced passive behaviors in stressful situations, indicating enhanced resilience. However, while LAC influenced some brain structures positively, it did not entirely reverse stress-related changes in all neuron types.
Read More
8
Antidepressant and carnitine effective
We examined how combining acetyl-L-carnitine with modern antidepressants affects anxiety and depression in elderly patients. In our study involving two groups of older individuals, we compared those receiving solo antidepressant treatment to those receiving a combination with carnitine over eight weeks.
The results showed that the combination therapy led to quicker improvements in anxiety and other symptoms, while also causing fewer side effects. Thus, we recommend this approach for better managing depression in older adults.
The results showed that the combination therapy led to quicker improvements in anxiety and other symptoms, while also causing fewer side effects. Thus, we recommend this approach for better managing depression in older adults.
Read More
8
We analyzed randomized controlled trials to see how effective different treatments for persistent depressive disorder are.
Our study included data from over 8,000 patients across multiple interventions, including medications, psychotherapy, and combinations of both.
Notably, acetyl-l-carnitine showed significant effectiveness, with an odds ratio that indicates it performs better than a placebo.
However, while various treatments stand out, we also found important differences in their acceptability and effectiveness.
Our study included data from over 8,000 patients across multiple interventions, including medications, psychotherapy, and combinations of both.
Notably, acetyl-l-carnitine showed significant effectiveness, with an odds ratio that indicates it performs better than a placebo.
However, while various treatments stand out, we also found important differences in their acceptability and effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced social fear
8 people found this helpful
Six stars out of five! This is the best supplement I've used so far. It significantly reduces stress and improves mood, making it ideal for anyone facing social anxiety or fear of public speaking.
Read More
9
Life-changing energy
Resolved no energy, lack of clarity, and depression! I have Fibromyalgia with chronic fatigue. I did research on ALC before trying it, and I asked my doctor for advice. Initially, I took 3 capsules in the morning and 2 in the afternoon. The first day brought great energy, clarity, and improved mood. However, I noticed a rash and did not take the second dose. After a day of just one dose, my energy and mood returned! I continue taking 3 a day without further issues. I highly recommend ALC for anyone struggling with fatigue, memory problems, anxiety, or depression.
Read More
9
Helps with multiple issues
I have AuDHD and various autoimmune problems; taking one daily helps ease my anxiety, depression, and obsessive thoughts. It works well, especially in conjunction with NAC and L-Theanine.
Read More
9
Life-changing supplement
53 people found this helpful
Best supplement out there. Carnitine has transformed my life. I've struggled with anxiety, depression, and low energy, but this has changed everything. I have tried numerous anxiety medications and antidepressants without success. Give it a few weeks to adjust, and you'll notice a difference. I like to take these before exercising as they give me an extra boost.
Read More
9
Increased motivation
13 people found this helpful
This product worked for me as I dealt with issues of poor energy, motivation, and anxiety. Now I feel much better after dietary changes and stopping smoking and caffeine. Whatever it is, don’t give up!
Read More
Frequently Asked Questions
9
Life-changing energy
Resolved no energy, lack of clarity, and depression! I have Fibromyalgia with chronic fatigue. I did research on ALC before trying it, and I asked my doctor for advice. Initially, I took 3 capsules in the morning and 2 in the afternoon. The first day brought great energy, clarity, and improved mood. However, I noticed a rash and did not take the second dose. After a day of just one dose, my energy and mood returned! I continue taking 3 a day without further issues. I highly recommend ALC for anyone struggling with fatigue, memory problems, anxiety, or depression.
7.5
Improved mood
The supplement is from a reputable brand, and I've always relied on Acetyl-L-Carnitine for managing anxiety and improving focus. After one month of use, I feel a noticeable improvement in my mood and calmness.
6
Initial anxiety increase
I had to start slowly as it initially increased my anxiety. However, after a couple of weeks, things levelled out, and I noticed a slight improvement in my energy.
7.5
Improved conversation confidence
1 people found this helpful
I have ADHD and struggle with severe anxiety and fatigue that affect my daily communication. After taking these supplements, I found myself able to engage in conversations without anxiety. I'm more focused and energetic now. It's been a subtle yet significant improvement compared to other options.
7.5
Reduced anxiety levels
Great value for money. I have been using Acetyl-L-Carnitine for a while now, from a more expensive brand! This supplement has helped to reduce my anxiety levels and at the same time enables me to maintain a high level of energy.
7
Increased energy
I’ve noticed significant improvements; I have more energy and less anxiety. The pain in my pancreas has also disappeared.
9
Helps with multiple issues
I have AuDHD and various autoimmune problems; taking one daily helps ease my anxiety, depression, and obsessive thoughts. It works well, especially in conjunction with NAC and L-Theanine.
9
Increased motivation
13 people found this helpful
This product worked for me as I dealt with issues of poor energy, motivation, and anxiety. Now I feel much better after dietary changes and stopping smoking and caffeine. Whatever it is, don’t give up!
7
We explored how different factors contribute to our ability to cope with social stress. In a study involving mice, we looked at behaviors, immune responses, and brain structure to understand who might be more susceptible or resilient to stress.
We found that certain characteristics, like anxiety and changes in the brain, marked those more likely to struggle after stress exposure. Interestingly, when we administered acetyl-L-carnitine, it seemed to help those affected show resilience in the face of stress. However, further research is needed to confirm these promising results.
We found that certain characteristics, like anxiety and changes in the brain, marked those more likely to struggle after stress exposure. Interestingly, when we administered acetyl-L-carnitine, it seemed to help those affected show resilience in the face of stress. However, further research is needed to confirm these promising results.
8
ALC shows promise for anxiety treatment
We evaluated how acetyl-L-carnitine (ALC) can influence anxiety-like behaviors in zebrafish under stress. Using a protocol that simulated unpredictable chronic stress, we saw that the fish exhibited increased anxiety and oxidative stress.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
Remarkably, after ALC treatment, these anxiety-like behaviors and signs of oxidative damage were significantly reduced in the stressed group. However, ALC showed negligible effects on the control animals.
Although our findings highlight ALC’s potential as a neuroprotective agent for stress-related psychiatric disorders, more research is necessary to fully understand how it works and confirm its effectiveness.
7
ALC shows limited anxiety benefits
We aimed to assess how acetyl-L-carnitine (ALC) affects pain and anxiety linked to acute pancreatitis in a mouse model. Over several weeks, mice received injections to induce pancreatitis, and then were treated with ALC.
Results showed that while ALC reduced certain types of pain sensitivity, it did not seem to alleviate the anxiety-like behaviors associated with the condition. This indicates that ALC may not effectively treat anxiety related to acute pancreatitis.
Results showed that while ALC reduced certain types of pain sensitivity, it did not seem to alleviate the anxiety-like behaviors associated with the condition. This indicates that ALC may not effectively treat anxiety related to acute pancreatitis.
9
We checked how acetyl-L-carnitine (ALC) affects patients with minimal hepatic encephalopathy (MHE), a condition that can lower quality of life. Through a rigorous, randomized, double-blind study with 67 participants, half received ALC while the other half got a placebo for 90 days.
By the end, those on ALC reported notable improvements in energy and mental health, correlating with lower anxiety and depression levels. This suggests that ALC could be a valuable treatment option for enhancing well-being in patients facing this challenging condition.
By the end, those on ALC reported notable improvements in energy and mental health, correlating with lower anxiety and depression levels. This suggests that ALC could be a valuable treatment option for enhancing well-being in patients facing this challenging condition.
8
Antidepressant and carnitine effective
We examined how combining acetyl-L-carnitine with modern antidepressants affects anxiety and depression in elderly patients. In our study involving two groups of older individuals, we compared those receiving solo antidepressant treatment to those receiving a combination with carnitine over eight weeks.
The results showed that the combination therapy led to quicker improvements in anxiety and other symptoms, while also causing fewer side effects. Thus, we recommend this approach for better managing depression in older adults.
The results showed that the combination therapy led to quicker improvements in anxiety and other symptoms, while also causing fewer side effects. Thus, we recommend this approach for better managing depression in older adults.
7
We investigated the effects of acetyl-L-carnitine (ALCAR) on anxiety-like behaviors in rats, using a systematic approach with control groups. Our findings revealed that chronic doses of 50 and 75 mg/kg significantly reduced anxiety, while doses of 10 and 100 mg/kg showed no effect. In an interesting twist, an acute dose of 100 mg/kg led to increased anxiety. This suggests a complex relationship where ALCAR may work differently depending on the dosage and timing. More research is needed to clarify how ALCAR influences anxiety in these cases.
References
- McIlwrath SL, Starr ME, High AE, Saito H, Westlund KN. Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain's pain circuitry. World J Gastroenterol. 2021;27:794. 10.3748/wjg.v27.i9.794
- Nasca C, Menard C, Hodes G, Bigio B, Pena C, et al. Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress. Biol Psychiatry. 2019;86:483. 10.1016/j.biopsych.2019.06.030
- Marcon M, Mocelin R, de Oliveira DL, da Rosa Araujo AS, Herrmann AP, et al. Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model. Neuropharmacology. 2019;150:145. 10.1016/j.neuropharm.2019.03.024
- Lau T, Bigio B, Zelli D, McEwen BS, Nasca C. Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. Mol Psychiatry. 2017;22:227. 10.1038/mp.2016.68
- Gavrilova SI, Kalyn YB, Safarova TP, Yakovleva OB, Sheshenin VS, et al. [Optimization of the efficacy and safety of antidepressant therapy in patients of a geriatric psychiatric unit]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115:24. 10.17116/jnevro20151156124-32
- Kriston L, von Wolff A, Westphal A, Hölzel LP, Härter M. Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis. Depress Anxiety. 2014;31:621. 10.1002/da.22236
- Malaguarnera M, Bella R, Vacante M, Giordano M, Malaguarnera G, et al. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Scand J Gastroenterol. 2011;46:750. 10.3109/00365521.2011.565067
- Levine J, Kaplan Z, Pettegrew JW, McClure RJ, Gershon S, et al. Effect of intraperitoneal acetyl-L-carnitine (ALCAR) on anxiety-like behaviours in rats. Int J Neuropsychopharmacol. 2005;8:65.
