' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 3 Researches
8.7
USERS' SCORE
Very Good
Based on 112 Reviews
8.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
9
Pediatric anemia treatment evaluation
Oral lactoferrin as a treatment of pediatrics' anemia resulted from chronic kidney diseases: a randomized controlled trial.
Relevant comparison of treatments
We explored an important question regarding anemia management in children with chronic kidney disease (CKD). In a randomized clinical trial, we compared the effectiveness of oral lactoferrin and intravenous iron dextran in treating anemia related to CKD in pediatrics.
The study involved 60 children who were divided into two groups: one received 100 mg of oral lactoferrin daily for three months, while the other group was treated with IV iron dextran three times a week. After the treatment period, we observed significant changes in several blood parameters among those taking oral lactoferrin, specifically in hemoglobin, red blood cells, and various other indicators related to anemia.
However, while both treatments proved effective, we found no significant differences between the two groups overall in improving anemia symptoms after three months. Ultimately, while oral lactoferrin showed promising results, it did not outperform IV iron dextran to a degree that would change treatment choices.
The study involved 60 children who were divided into two groups: one received 100 mg of oral lactoferrin daily for three months, while the other group was treated with IV iron dextran three times a week. After the treatment period, we observed significant changes in several blood parameters among those taking oral lactoferrin, specifically in hemoglobin, red blood cells, and various other indicators related to anemia.
However, while both treatments proved effective, we found no significant differences between the two groups overall in improving anemia symptoms after three months. Ultimately, while oral lactoferrin showed promising results, it did not outperform IV iron dextran to a degree that would change treatment choices.
Read More
8
Valpalf improves anemia treatment
Valpalf: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity.
Study highlights lactoferrin's impact
We explored how lactoferrin, particularly in a new formulation called Valpalf, can help with anemia. This study highlighted the properties of bovine lactoferrin (bLf) as an iron-binding protein that supports our immune system and has various beneficial effects. Notably, many people tolerate bLf well, even at higher doses.
Valpalf combines bLf with sodium citrate and sodium bicarbonate, leading to improved iron-binding abilities and greater effectiveness in reducing inflammation markers, like interleukin-6 (IL-6). When tested in macrophages and monocytes, Valpalf showed a more potent capacity to impact antioxidant enzyme expression compared to standard bLf.
Not only did Valpalf demonstrate these promising effects in laboratory settings, but it also produced favorable results in a retrospective study. This study looked at how Valpalf influenced anemia in pregnant and non-pregnant women with hereditary thrombophilia. We observed that using Valpalf led to better hematological outcomes and a notable reduction in IL-6 levels compared to traditional bLf alone.
Valpalf combines bLf with sodium citrate and sodium bicarbonate, leading to improved iron-binding abilities and greater effectiveness in reducing inflammation markers, like interleukin-6 (IL-6). When tested in macrophages and monocytes, Valpalf showed a more potent capacity to impact antioxidant enzyme expression compared to standard bLf.
Not only did Valpalf demonstrate these promising effects in laboratory settings, but it also produced favorable results in a retrospective study. This study looked at how Valpalf influenced anemia in pregnant and non-pregnant women with hereditary thrombophilia. We observed that using Valpalf led to better hematological outcomes and a notable reduction in IL-6 levels compared to traditional bLf alone.
Read More
9
Lactoferrin improves anemia in CKD
Effectiveness of Lactoferrin in the Treatment of Anemia in Chronic Kidney Disease: A Single-Center Pilot Study.
Lower relevance due to combined effects
We aimed to understand how lactoferrin, a protein known for its potential health benefits, affects anemia in patients suffering from chronic kidney disease (CKD). Our study included 46 adults with stage 5 CKD who were experiencing anemia despite being on stable doses of erythropoietin, a common treatment for this condition.
Participants received 100 mg of oral lactoferrin twice a day for one month, and some also received iron supplements. We measured how their hemoglobin levels changed over this period and looked at inflammatory markers, which can indicate how the body reacts to illness.
From our findings, we observed significant improvements in hemoglobin levels by the end of the study. Initially, participants had a mean hemoglobin level of 8.18 g/dl, and by four weeks, it had risen to 8.96 g/dl. Interestingly, we noted that women experienced a greater increase in hemoglobin than men, and those who received iron supplements alongside lactoferrin showed an even better response.
However, when looking at inflammatory markers, the results were less clear. There appeared to be a decrease in the erythrocyte sedimentation rate, which was not significant, along with a slight, not meaningful increase in C-reactive protein levels. This suggests that while lactoferrin might improve hemoglobin levels for patients with advanced CKD and anemia, its impact on inflammation remains uncertain.
Participants received 100 mg of oral lactoferrin twice a day for one month, and some also received iron supplements. We measured how their hemoglobin levels changed over this period and looked at inflammatory markers, which can indicate how the body reacts to illness.
From our findings, we observed significant improvements in hemoglobin levels by the end of the study. Initially, participants had a mean hemoglobin level of 8.18 g/dl, and by four weeks, it had risen to 8.96 g/dl. Interestingly, we noted that women experienced a greater increase in hemoglobin than men, and those who received iron supplements alongside lactoferrin showed an even better response.
However, when looking at inflammatory markers, the results were less clear. There appeared to be a decrease in the erythrocyte sedimentation rate, which was not significant, along with a slight, not meaningful increase in C-reactive protein levels. This suggests that while lactoferrin might improve hemoglobin levels for patients with advanced CKD and anemia, its impact on inflammation remains uncertain.
Read More
Most Useful Reviews
9.5
Ferritin has risen
I am truly grateful that I discovered Lactoferrin! I have chronic anaemia and struggled to increase my ferritin levels. After ceasing iron supplements, my ferritin dropped to 3. Thankfully, Lactoferrin raised it to 56! My health has greatly improved; my depression has lifted, my sleep quality has enhanced, and I've gained warmth in my limbs. This supplement has remarkable properties against various viruses and aids in cell oxygenation, boosting stamina and recovery from illness.
Read More
8.8
Helps iron absorption
Thanks to Lactoferrin, I could finally increase my ferritin levels. Initially, I struggled with absorbing iron due to my anaemia. Lactoferrin, a protein found in blood plasma, transports iron to cells and regulates its levels. I trust Jarrow's high-quality products. My energy levels have improved significantly now that I take this alongside iron supplements, and it is gluten-free, which is essential for those with intolerances.
Read More
9.5
Fights yeast infections
I experienced symptoms of an intestinal yeast infection while taking iron for my anaemia. I discovered that Lactoferrin binds to iron, making it unavailable to yeast while effectively transporting it into my cells. I am thankful to iHerb for this affordable product and excellent service.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 3 Researches
8.7
9
Pediatric anemia treatment evaluation
Oral lactoferrin as a treatment of pediatrics' anemia resulted from chronic kidney diseases: a randomized controlled trial.
Relevant comparison of treatments
We explored an important question regarding anemia management in children with chronic kidney disease (CKD). In a randomized clinical trial, we compared the effectiveness of oral lactoferrin and intravenous iron dextran in treating anemia related to CKD in pediatrics.
The study involved 60 children who were divided into two groups: one received 100 mg of oral lactoferrin daily for three months, while the other group was treated with IV iron dextran three times a week. After the treatment period, we observed significant changes in several blood parameters among those taking oral lactoferrin, specifically in hemoglobin, red blood cells, and various other indicators related to anemia.
However, while both treatments proved effective, we found no significant differences between the two groups overall in improving anemia symptoms after three months. Ultimately, while oral lactoferrin showed promising results, it did not outperform IV iron dextran to a degree that would change treatment choices.
The study involved 60 children who were divided into two groups: one received 100 mg of oral lactoferrin daily for three months, while the other group was treated with IV iron dextran three times a week. After the treatment period, we observed significant changes in several blood parameters among those taking oral lactoferrin, specifically in hemoglobin, red blood cells, and various other indicators related to anemia.
However, while both treatments proved effective, we found no significant differences between the two groups overall in improving anemia symptoms after three months. Ultimately, while oral lactoferrin showed promising results, it did not outperform IV iron dextran to a degree that would change treatment choices.
Read More
9
Lactoferrin improves anemia in CKD
Effectiveness of Lactoferrin in the Treatment of Anemia in Chronic Kidney Disease: A Single-Center Pilot Study.
Lower relevance due to combined effects
We aimed to understand how lactoferrin, a protein known for its potential health benefits, affects anemia in patients suffering from chronic kidney disease (CKD). Our study included 46 adults with stage 5 CKD who were experiencing anemia despite being on stable doses of erythropoietin, a common treatment for this condition.
Participants received 100 mg of oral lactoferrin twice a day for one month, and some also received iron supplements. We measured how their hemoglobin levels changed over this period and looked at inflammatory markers, which can indicate how the body reacts to illness.
From our findings, we observed significant improvements in hemoglobin levels by the end of the study. Initially, participants had a mean hemoglobin level of 8.18 g/dl, and by four weeks, it had risen to 8.96 g/dl. Interestingly, we noted that women experienced a greater increase in hemoglobin than men, and those who received iron supplements alongside lactoferrin showed an even better response.
However, when looking at inflammatory markers, the results were less clear. There appeared to be a decrease in the erythrocyte sedimentation rate, which was not significant, along with a slight, not meaningful increase in C-reactive protein levels. This suggests that while lactoferrin might improve hemoglobin levels for patients with advanced CKD and anemia, its impact on inflammation remains uncertain.
Participants received 100 mg of oral lactoferrin twice a day for one month, and some also received iron supplements. We measured how their hemoglobin levels changed over this period and looked at inflammatory markers, which can indicate how the body reacts to illness.
From our findings, we observed significant improvements in hemoglobin levels by the end of the study. Initially, participants had a mean hemoglobin level of 8.18 g/dl, and by four weeks, it had risen to 8.96 g/dl. Interestingly, we noted that women experienced a greater increase in hemoglobin than men, and those who received iron supplements alongside lactoferrin showed an even better response.
However, when looking at inflammatory markers, the results were less clear. There appeared to be a decrease in the erythrocyte sedimentation rate, which was not significant, along with a slight, not meaningful increase in C-reactive protein levels. This suggests that while lactoferrin might improve hemoglobin levels for patients with advanced CKD and anemia, its impact on inflammation remains uncertain.
Read More
8
Valpalf improves anemia treatment
Valpalf: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity.
Study highlights lactoferrin's impact
We explored how lactoferrin, particularly in a new formulation called Valpalf, can help with anemia. This study highlighted the properties of bovine lactoferrin (bLf) as an iron-binding protein that supports our immune system and has various beneficial effects. Notably, many people tolerate bLf well, even at higher doses.
Valpalf combines bLf with sodium citrate and sodium bicarbonate, leading to improved iron-binding abilities and greater effectiveness in reducing inflammation markers, like interleukin-6 (IL-6). When tested in macrophages and monocytes, Valpalf showed a more potent capacity to impact antioxidant enzyme expression compared to standard bLf.
Not only did Valpalf demonstrate these promising effects in laboratory settings, but it also produced favorable results in a retrospective study. This study looked at how Valpalf influenced anemia in pregnant and non-pregnant women with hereditary thrombophilia. We observed that using Valpalf led to better hematological outcomes and a notable reduction in IL-6 levels compared to traditional bLf alone.
Valpalf combines bLf with sodium citrate and sodium bicarbonate, leading to improved iron-binding abilities and greater effectiveness in reducing inflammation markers, like interleukin-6 (IL-6). When tested in macrophages and monocytes, Valpalf showed a more potent capacity to impact antioxidant enzyme expression compared to standard bLf.
Not only did Valpalf demonstrate these promising effects in laboratory settings, but it also produced favorable results in a retrospective study. This study looked at how Valpalf influenced anemia in pregnant and non-pregnant women with hereditary thrombophilia. We observed that using Valpalf led to better hematological outcomes and a notable reduction in IL-6 levels compared to traditional bLf alone.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 112 Reviews
8.9
10
Ferritin recovery
After discovering my anaemia, I took iron, folate, and vitamin C, but my ferritin levels increased slowly. Upon starting lactoferrin, my ferritin rose dramatically within a month, and I’m thrilled with the result!
10
Iron levels improved
I used lactoferrin after struggling with anaemia, where my levels went from 7 to 13, thanks to this supplement. I attribute my recovery to it and feel grateful for the positive change it brought.
10
Energetic and healthy
I took this alongside Hema-Plex to raise my ferritin during terrible anemia. This winter, I didn't suffer from herpes outbreaks, and my ferritin is now at its peak. I'm energetic and no longer experience dizziness or darkening of vision. Huge thanks to the manufacturer!
10
Health improvement
On my doctor’s recommendation, I purchased Jarrow Formulas lactoferrin for my iron deficiency anaemia. After a month of taking it with iron, my tests improved, and I felt much better. I definitely noticed the benefits.
9.5
Ferritin has risen
I am truly grateful that I discovered Lactoferrin! I have chronic anaemia and struggled to increase my ferritin levels. After ceasing iron supplements, my ferritin dropped to 3. Thankfully, Lactoferrin raised it to 56! My health has greatly improved; my depression has lifted, my sleep quality has enhanced, and I've gained warmth in my limbs. This supplement has remarkable properties against various viruses and aids in cell oxygenation, boosting stamina and recovery from illness.
Read More
