Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 13 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
9
We investigated how lactoferrin, particularly from bovine sources, affects herpes simplex virus type 2 (HSV-2) infection. Through experiments using monkey kidney cells, we found that bovine lactoferrin effectively inhibits HSV-2 without relying on glycosaminoglycans (GAGs), which are often involved in viral entry. Interestingly, human lactoferrin showed sensitivity differences with mutant strains, suggesting unique interactions. Overall, the study highlights bovine lactoferrin as a promising option for treating herpes infections, potentially offering more than previously understood.
Read More
8
We investigated how human lactoferrin (hLf) affects herpes simplex virus type 1 (HSV-1) and compared its action to that of lysozyme. Our findings revealed that hLf effectively blocked HSV-1 infection at various stages, significantly reducing viral spread between cells. In contrast, lysozyme showed no anti-HSV effect. It seems that lactoferrin plays a vital role in controlling HSV-1 in mucosal environments, making it a potential candidate for future treatments against this virus.
Read More
8
We investigated how bovine lactoferrin (BLf) and its derivative lactoferricin (BLfcin) combat the Herpes simplex virus-1 (HSV-1). Using advanced microscopy techniques, we found that both BLf and BLfcin significantly reduced the virus's ability to enter host cells compared to untreated controls. Moreover, the limited virus particles that did enter exhibited delayed movement within the cells. This indicates that both compounds not only prevent viral entry but also disrupt its subsequent activity inside the cells.
Read More
Most Useful Reviews
9
Blessing for pets
68 people found this helpful
After five years of searching for a solution, this product is it! I mixed it with L-Lysine in my pet's wet food, and together they have stopped all the sneezing and coughing from feline herpes. My cats are getting along better now, and he is feeling well. It’s a blessing!
Read More
9
Shortens duration
38 people found this helpful
I read online that this can help shorten the duration of cold sores by inhibiting the herpes simplex 1 virus. When I felt the familiar tingling, I took a couple of pills, and the next morning the cold sore didn’t develop fully. It seems to do the job for what I intended!
Read More
9
Reduced herpes instances
6 people found this helpful
My cat suffers from the herpes virus, experiencing keratitis up to three times a year. Since I started using this product, the frequency has decreased markedly, and her recovery is much quicker. I've realised it's beneficial for cats, and I'm pleased to share this information. For dosage, mixing half a capsule with food twice a week is sufficient.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We investigated the potential of lactoferrin, a powerful natural compound, to inhibit herpes simplex viruses, specifically HSV-2. Our approach involved testing silver and gold nanoparticles modified with lactoferrin, known as LF-Ag/AuNPs, to see if they could serve as novel treatments or microbicides for genital herpes.
In our experiments with human skin and vaginal cells, we observed that LF-Ag/AuNPs were much more effective than lactoferrin on its own at preventing the virus from attaching to and entering cells. Notably, when we pretreated cells with LF-AgNPs, they were better protected from infection.
In tests with infected mice, those treated with LF-Ag/AuNPs had significantly lower virus levels in vaginal tissues and spinal cords compared to those treated with just lactoferrin. The immune response appeared to be enhanced too, as evidenced by increased counts of specific immune cells.
Overall, our findings suggest that LF-Ag/AuNPs not only fight the virus but may also boost immune function, highlighting their potential as effective new antiviral treatments targeting mucosal surfaces.
In our experiments with human skin and vaginal cells, we observed that LF-Ag/AuNPs were much more effective than lactoferrin on its own at preventing the virus from attaching to and entering cells. Notably, when we pretreated cells with LF-AgNPs, they were better protected from infection.
In tests with infected mice, those treated with LF-Ag/AuNPs had significantly lower virus levels in vaginal tissues and spinal cords compared to those treated with just lactoferrin. The immune response appeared to be enhanced too, as evidenced by increased counts of specific immune cells.
Overall, our findings suggest that LF-Ag/AuNPs not only fight the virus but may also boost immune function, highlighting their potential as effective new antiviral treatments targeting mucosal surfaces.
Read More
9
We investigated how lactoferrin, particularly from bovine sources, affects herpes simplex virus type 2 (HSV-2) infection. Through experiments using monkey kidney cells, we found that bovine lactoferrin effectively inhibits HSV-2 without relying on glycosaminoglycans (GAGs), which are often involved in viral entry. Interestingly, human lactoferrin showed sensitivity differences with mutant strains, suggesting unique interactions. Overall, the study highlights bovine lactoferrin as a promising option for treating herpes infections, potentially offering more than previously understood.
Read More
9
We investigated how bovine lactoferrin (bLf) can inhibit herpes simplex virus type 1 (HSV-1) in Green Monkey Kidney cells. Our findings showed that bLf effectively prevents the virus from entering cells and spreading from one infected cell to another. By binding to specific proteins found on the virus and cell receptors, bLf disrupts the typical infection process. This key activity makes bLf a promising candidate for treating herpes infections, possibly reducing not just initial infections but also helping control viral spread within the body.
Read More
9
Lactoferrin inhibits feline herpesvirus
We explored the effects of bovine lactoferrin on the replication of feline herpesvirus in a controlled lab setting. Using Crandell-Reese feline kidney cells, we tested various concentrations of lactoferrin at different stages of infection.
The results showed that lactoferrin significantly inhibited the virus's ability to attach to and enter cells when applied before or during infection. However, it didn’t have any beneficial effect after the virus had already entered.
This research opens the door for further studies on using topical lactoferrin to treat herpes outbreaks in cats.
The results showed that lactoferrin significantly inhibited the virus's ability to attach to and enter cells when applied before or during infection. However, it didn’t have any beneficial effect after the virus had already entered.
This research opens the door for further studies on using topical lactoferrin to treat herpes outbreaks in cats.
Read More
8
We investigated how human lactoferrin (hLf) affects herpes simplex virus type 1 (HSV-1) and compared its action to that of lysozyme. Our findings revealed that hLf effectively blocked HSV-1 infection at various stages, significantly reducing viral spread between cells. In contrast, lysozyme showed no anti-HSV effect. It seems that lactoferrin plays a vital role in controlling HSV-1 in mucosal environments, making it a potential candidate for future treatments against this virus.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Blessing for pets
68 people found this helpful
After five years of searching for a solution, this product is it! I mixed it with L-Lysine in my pet's wet food, and together they have stopped all the sneezing and coughing from feline herpes. My cats are getting along better now, and he is feeling well. It’s a blessing!
Read More
9
Shortens duration
38 people found this helpful
I read online that this can help shorten the duration of cold sores by inhibiting the herpes simplex 1 virus. When I felt the familiar tingling, I took a couple of pills, and the next morning the cold sore didn’t develop fully. It seems to do the job for what I intended!
Read More
9
Reduced herpes instances
6 people found this helpful
My cat suffers from the herpes virus, experiencing keratitis up to three times a year. Since I started using this product, the frequency has decreased markedly, and her recovery is much quicker. I've realised it's beneficial for cats, and I'm pleased to share this information. For dosage, mixing half a capsule with food twice a week is sufficient.
Read More
9
Impressive outcomes for immunity
1 people found this helpful
Absolutely fantastic! I have chronic sinusitis and low immunity due to a high viral load (herpes). Following Dr. Chernousov's advice, I took Zovirax (Acyclovir) and then added Lactoferrin. The results are remarkable; I feel almost normal again!
Read More
9
Less sneezing
It really helps my cat with feline herpes. He sneezes significantly less and can breathe more easily. It effectively manages the URI.
Read More
Frequently Asked Questions
9
Reduced herpes instances
6 people found this helpful
My cat suffers from the herpes virus, experiencing keratitis up to three times a year. Since I started using this product, the frequency has decreased markedly, and her recovery is much quicker. I've realised it's beneficial for cats, and I'm pleased to share this information. For dosage, mixing half a capsule with food twice a week is sufficient.
9
Impressive outcomes for immunity
1 people found this helpful
Absolutely fantastic! I have chronic sinusitis and low immunity due to a high viral load (herpes). Following Dr. Chernousov's advice, I took Zovirax (Acyclovir) and then added Lactoferrin. The results are remarkable; I feel almost normal again!
9
Less sneezing
It really helps my cat with feline herpes. He sneezes significantly less and can breathe more easily. It effectively manages the URI.
9
Combats herpes effectively
6 people found this helpful
Lactoferrin, a protein from the transferrin family, enhances iron absorption in the body. It's present in breast milk and helps combat pathogenic bacteria, displaying antibacterial properties while also fighting herpes viruses. I've observed significant benefits in my child; I give one capsule daily. Among various options, I find Jarrow's lactoferrin to be the most effective based on price and quality. It consistently delivers good outcomes; I wholeheartedly recommend it.
8
We investigated how bovine lactoferrin (BLf) and its derivative lactoferricin (BLfcin) combat the Herpes simplex virus-1 (HSV-1). Using advanced microscopy techniques, we found that both BLf and BLfcin significantly reduced the virus's ability to enter host cells compared to untreated controls. Moreover, the limited virus particles that did enter exhibited delayed movement within the cells. This indicates that both compounds not only prevent viral entry but also disrupt its subsequent activity inside the cells.
9
We investigated how lactoferrin, particularly from bovine sources, affects herpes simplex virus type 2 (HSV-2) infection. Through experiments using monkey kidney cells, we found that bovine lactoferrin effectively inhibits HSV-2 without relying on glycosaminoglycans (GAGs), which are often involved in viral entry. Interestingly, human lactoferrin showed sensitivity differences with mutant strains, suggesting unique interactions. Overall, the study highlights bovine lactoferrin as a promising option for treating herpes infections, potentially offering more than previously understood.
9
We investigated how bovine lactoferrin (bLf) can inhibit herpes simplex virus type 1 (HSV-1) in Green Monkey Kidney cells. Our findings showed that bLf effectively prevents the virus from entering cells and spreading from one infected cell to another. By binding to specific proteins found on the virus and cell receptors, bLf disrupts the typical infection process. This key activity makes bLf a promising candidate for treating herpes infections, possibly reducing not just initial infections but also helping control viral spread within the body.
7
We explored how lactoferrin (LF) and its peptide lactoferricin (Lfcin) can fight Herpes simplex viruses 1 and 2. This study measured their antiviral effects against various strains, including those resistant to acyclovir (ACV).
Interestingly, we found that combining LF or Lfcin with ACV significantly boosted effectiveness. The necessary concentration of both LF or Lfcin was reduced two- to sevenfold when used alongside ACV, highlighting a potential new strategy for herpes treatment.
Interestingly, we found that combining LF or Lfcin with ACV significantly boosted effectiveness. The necessary concentration of both LF or Lfcin was reduced two- to sevenfold when used alongside ACV, highlighting a potential new strategy for herpes treatment.
4
We evaluated how lactoferrin, a milk protein, impacts herpes simplex virus type 1 (HSV-1) infections in mice. After feeding mice bovine lactoferrin, we later infected them with HSV-1. While lactoferrin didn't clear the virus, it helped reduce skin lesions and prevent weight loss. Furthermore, it increased certain immune responses, indicating a protective role during the infection. Though lactoferrin may not eliminate HSV-1, it aids in maintaining body stability and boosting immune reactions.
8
Our exploration into lactoferrin's role against herpes simplex virus (HSV) revealed promising findings. Lactoferrin and its peptide fragment, lactoferricin, effectively block the virus from entering host cells, which is key in preventing infection.
Additionally, while it's suggested that these components may boost the immune response, this idea still needs more clarity. Overall, these insights could lead to developing new, targeted treatments for HSV.
Additionally, while it's suggested that these components may boost the immune response, this idea still needs more clarity. Overall, these insights could lead to developing new, targeted treatments for HSV.
References
- Krzyzowska M, Chodkowski M, Janicka M, Dmowska D, Tomaszewska E, et al. Lactoferrin-Functionalized Noble Metal Nanoparticles as New Antivirals for HSV-2 Infection. Microorganisms. 2022;10. doi:10.3390/microorganisms10010110
- Shust GF, Cho S, Kim M, Madan RP, Guzman EM, et al. Female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception. Am J Reprod Immunol. 2010;63:110. doi:10.1111/j.1600-0897.2009.00768.x
- Välimaa H, Tenovuo J, Waris M, Hukkanen V. Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread. Virol J. 2009;6:53. doi:10.1186/1743-422X-6-53
- Marr AK, Jenssen H, Moniri MR, Hancock RE, Panté N. Bovine lactoferrin and lactoferricin interfere with intracellular trafficking of Herpes simplex virus-1. Biochimie. 2009;91:160. doi:10.1016/j.biochi.2008.05.016
- Marchetti M, Ammendolia MG, Superti F. Glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin. Biochimie. 2009;91:155. doi:10.1016/j.biochi.2008.04.015
- Jenssen H, Sandvik K, Andersen JH, Hancock RE, Gutteberg TJ. Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin. Antiviral Res. 2008;79:192. doi:10.1016/j.antiviral.2008.03.004
- Ammendolia MG, Marchetti M, Superti F. Bovine lactoferrin prevents the entry and intercellular spread of herpes simplex virus type 1 in Green Monkey Kidney cells. Antiviral Res. 2007;76:252.
- Jenssen H. Anti herpes simplex virus activity of lactoferrin/lactoferricin -- an example of antiviral activity of antimicrobial protein/peptide. Cell Mol Life Sci. 2005;62:3002.
- Jenssen H, Gutteberg TJ, Lejon T. Modelling of anti-HSV activity of lactoferricin analogues using amino acid descriptors. J Pept Sci. 2005;11:97.
- Andersen JH, Jenssen H, Sandvik K, Gutteberg TJ. Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface. J Med Virol. 2004;74:262.
- Wakabayashi H, Kurokawa M, Shin K, Teraguchi S, Tamura Y, et al. Oral lactoferrin prevents body weight loss and increases cytokine responses during herpes simplex virus type 1 infection of mice. Biosci Biotechnol Biochem. 2004;68:537.
- Marchetti M, Trybala E, Superti F, Johansson M, Bergström T. Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans. Virology. 2004;318:405.
- Jenssen H, Andersen JH, Uhlin-Hansen L, Gutteberg TJ, Rekdal Ø. Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate. Antiviral Res. 2004;61:101.
- Beaumont SL, Maggs DJ, Clarke HE. Effects of bovine lactoferrin on in vitro replication of feline herpesvirus. Vet Ophthalmol. 2003;6:245.
- Andersen JH, Jenssen H, Gutteberg TJ. Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir. Antiviral Res. 2003;58:209.
- Seganti L, Di Biase AM, Rega B, De Giulio B, Nicoletti M, et al. Involvement of bovine lactoferrin moieties in the inhibition of herpes simplex virus type 1 infection. Int J Immunopathol Pharmacol. 2001;14:71.
