Overview

SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
USERS' SCORE
Moderately Good
Based on 38 Reviews
7.9
Supplement Facts
Serving Size: 3 Capsules
Serving Per Container:  30
Amount Per Serving
%DV
Magnesium (from 2,000 mg Magnesium L-Threonate)
144 mg
34%

Top Medical Research Studies

8
Magnesium treats anxiety in MS
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.

We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.

Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.

In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Read More
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.

Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.

Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
Read More
5
Magnesium's effects on anxiety examined
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.

Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.

This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
Read More

Most Useful Reviews

9
Immensely helpful for sleep
64 people found this helpful
I was referred to purchase this by my brother-in-law. I struggle with anxiety around sleeping and have difficulty focusing during the day due to my hypothyroid disease. This product has significantly helped me; over the month of use, my sleep has improved, and I no longer toss and turn. At work, I find I can stay focused throughout the day. Be warned, the pills are large, but I’m fine with that.
Read More
9
Significant calm achieved
59 people found this helpful
My anxiety is quite severe, and I often struggle daily. After being recommended this product, I felt no effect after my first dose in store, but after a second, I experienced the calmest feeling I've had in ages. I’m so grateful as it’s helping me with my new job. I’ve now ordered more.
Read More
7.5
Reduces panic effectively
58 people found this helpful
If you're using nootropics, this is essential. If you're choline sensitive, a choline supplement is needed. I took aniracetam without one, and though I was fine for a few days, I began to experience headaches. After research, I started using Alpha GPC, and I noticed an immediate improvement in my concentration and a reduction in anxiety. This product is fantastic for anyone considering -racetams and suffering from choline sensitivity.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
  • All Researches
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.

The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.

However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.

Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
Read More
8
Magnesium's role in anxiety treatment
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.

Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.

However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
Read More
8
Magnesium aids post-surgery anxiety
This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.

Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.

While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.

Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
Read More
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.

Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.

This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
Read More
8
Magnesium treats anxiety in MS
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.

We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.

Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.

In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 38 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Immensely helpful for sleep
64 people found this helpful
I was referred to purchase this by my brother-in-law. I struggle with anxiety around sleeping and have difficulty focusing during the day due to my hypothyroid disease. This product has significantly helped me; over the month of use, my sleep has improved, and I no longer toss and turn. At work, I find I can stay focused throughout the day. Be warned, the pills are large, but I’m fine with that.
Read More
9
Significant calm achieved
59 people found this helpful
My anxiety is quite severe, and I often struggle daily. After being recommended this product, I felt no effect after my first dose in store, but after a second, I experienced the calmest feeling I've had in ages. I’m so grateful as it’s helping me with my new job. I’ve now ordered more.
Read More
7.5
Reduces panic effectively
58 people found this helpful
If you're using nootropics, this is essential. If you're choline sensitive, a choline supplement is needed. I took aniracetam without one, and though I was fine for a few days, I began to experience headaches. After research, I started using Alpha GPC, and I noticed an immediate improvement in my concentration and a reduction in anxiety. This product is fantastic for anyone considering -racetams and suffering from choline sensitivity.
Read More
7.5
Pain relief achieved
55 people found this helpful
This vitamin has restored my life. I've dealt with anxiety and stress symptoms that brought me immense pain. At first, I doubted this product would help, but I quickly noticed a difference within days; my heart palpitations and overall discomfort lessened. Anxiety can affect you physically, and this product may be all you need to get back on track.
Read More
7.5
Improved mood drastically
49 people found this helpful
Hopeful and excited! I absolutely love this product. I have PTSD, depression with suicidal tendencies, Lyme disease, and ADHD. The PTSD causes me to sleepwalk. I've only been taking this product for a few weeks, but after the first week, I noticed a significant improvement in my mood and memory. I can actually remember what I did from one day to the next even better than my husband. I feel so much better. The suicidal thoughts have almost vanished. I still have anxiety, but I feel better. I'm actually dreaming and remembering my dreams too, and I'm sleeping through the night without waking up screaming due to my PTSD.
Read More

Frequently Asked Questions

9
Enhanced productivity
4 people found this helpful
Highly recommended! After just three days of using this product, I noticed a difference in my brain fog caused by fibromyalgia and anxiety. I'm more productive and my mood has improved; I hope it continues to help me with fatigue as well.
7.5
Reduced anxiety
2 people found this helpful
Excellent! Within a week, I noticed a decrease in my anxiety and improvement in my mood.
9
Mind relaxation
After about three weeks, my mind feels much more relaxed. It helps strengthen memory and supports sleep quality, effectively relieving anxiety.
9
Quick anxiety relief
8 people found this helpful
Excellent magnesium threonate! Unlike others, this one has a gentle effect. It alleviates magnesium deficiency in the brain, enhancing cognitive functions and providing support during anxiety and nervous states. I have used it for severe anxiety post-trauma and can attest to its efficacy. Despite the higher cost, I consider it essential.
9
Insomnia relief
3 people found this helpful
This product helped eliminate my awakenings and anxiety. I recommend it for those with insomnia related to anxiety.
9
Mental clarity
3 people found this helpful
This is an affordable version of magnesium L-threonate! It uniquely crosses the blood-brain barrier, aiding anxiety and mental clarity. I definitely notice a difference!
5
Mildly calming
If you suffer from significant anxiety, this isn't a miracle cure. While the benefits are overstated and it didn't help my insomnia, it does offer some calming effect on the body and mind. I would suggest it as part of a broader routine, including sleep hygiene and other supplements.
7.5
Headache relief
6 people found this helpful
Powerful magnesium! This form, L-threonate by Jarrow formulas, effectively addresses headaches and brain fog, while also helping with anxiety and muscle spasms. I combine it with magnesium glycinate and potassium glycinate during meals.
7.5
Quality sleep
I started this for sleep during a high-anxiety period, and it improved my sleep quality significantly. However, it is rather expensive, so I switched to other products that worked similarly.
9
Reduced anxiety
17 people found this helpful
Best magnesium for brain health from a reputable brand! I've noticed improvements in my sleep and nerve issues since taking Magtein. One capsule in the morning and one at bedtime work well for me. Jarrow uses minimal fillers and offers competitive pricing. I highly recommend it!
7.5
Deep sleep
1 people found this helpful
It is effective, but remember the daily allowance is three capsules. The shape is beneficial for the brain, offering deep sleep and reducing sleep anxiety, especially in children.
7
Magnesium shows potential for anxiety
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.

Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.

Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.

Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.

Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.

Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
7
Magnesium's transient anxiety relief
In our quest to understand how magnesium influences anxiety, we conducted a randomized double-blind controlled trial involving 120 adults diagnosed with major depressive disorder (MDD). Participants took either a combination of probiotics, magnesium orotate, and coenzyme Q10 or a placebo for eight weeks.

At the end of the treatment period, we observed that those taking the combination showed significantly lower rates of major depressive episodes compared to those taking the placebo. However, this difference did not persist by the 8-week follow-up. While there was a notable reduction in self-reported symptoms of anxiety and stress during the treatment, this result also lacks long-term significance.

Ultimately, while our findings suggest that magnesium in combination with probiotics and coenzyme Q10 might help alleviate anxiety symptoms for a brief period, the persistent effects are unclear as we found no enduring benefits in the longer term.

References

  1. Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. 10.1038/s41598-024-71093-z
  2. Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. 10.3390/microorganisms12071429
  3. Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. 10.7759/cureus.59317
  4. Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. 10.5152/alphapsychiatry.2024.231342
  5. Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. 10.23736/S0375-9393.24.17868-6
  6. Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. 10.1080/01616412.2024.2352234
  7. Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. 10.3390/life14030306
  8. Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. 10.1038/s41591-023-02705-w
  9. Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
  10. Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. 10.1080/1354750X.2023.2246104
  11. Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
  12. Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. 10.3390/metabo13010073
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