Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
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7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
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5
Magnesium's effects on anxiety examined
The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms.
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
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Most Useful Reviews
9
Immensely helpful for sleep
64 people found this helpful
I was referred to purchase this by my brother-in-law. I struggle with anxiety around sleeping and have difficulty focusing during the day due to my hypothyroid disease. This product has significantly helped me; over the month of use, my sleep has improved, and I no longer toss and turn. At work, I find I can stay focused throughout the day. Be warned, the pills are large, but I’m fine with that.
Read More
9
Significant calm achieved
59 people found this helpful
My anxiety is quite severe, and I often struggle daily. After being recommended this product, I felt no effect after my first dose in store, but after a second, I experienced the calmest feeling I've had in ages. I’m so grateful as it’s helping me with my new job. I’ve now ordered more.
Read More
7.5
Reduces panic effectively
58 people found this helpful
If you're using nootropics, this is essential. If you're choline sensitive, a choline supplement is needed. I took aniracetam without one, and though I was fine for a few days, I began to experience headaches. After research, I started using Alpha GPC, and I noticed an immediate improvement in my concentration and a reduction in anxiety. This product is fantastic for anyone considering -racetams and suffering from choline sensitivity.
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
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8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
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8
Magnesium aids post-surgery anxiety
Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study.
This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
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8
Magnesium reduces anxiety symptoms
Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat.
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.
Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.
This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
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8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
I was referred to purchase this by my brother-in-law. I struggle with anxiety around sleeping and have difficulty focusing during the day due to my hypothyroid disease. This product has significantly helped me; over the month of use, my sleep has improved, and I no longer toss and turn. At work, I find I can stay focused throughout the day. Be warned, the pills are large, but I’m fine with that.
Read More
9
Significant calm achieved
59 people found this helpful
My anxiety is quite severe, and I often struggle daily. After being recommended this product, I felt no effect after my first dose in store, but after a second, I experienced the calmest feeling I've had in ages. I’m so grateful as it’s helping me with my new job. I’ve now ordered more.
Read More
7.5
Reduces panic effectively
58 people found this helpful
If you're using nootropics, this is essential. If you're choline sensitive, a choline supplement is needed. I took aniracetam without one, and though I was fine for a few days, I began to experience headaches. After research, I started using Alpha GPC, and I noticed an immediate improvement in my concentration and a reduction in anxiety. This product is fantastic for anyone considering -racetams and suffering from choline sensitivity.
Read More
7.5
Pain relief achieved
55 people found this helpful
This vitamin has restored my life. I've dealt with anxiety and stress symptoms that brought me immense pain. At first, I doubted this product would help, but I quickly noticed a difference within days; my heart palpitations and overall discomfort lessened. Anxiety can affect you physically, and this product may be all you need to get back on track.
Read More
7.5
Improved mood drastically
49 people found this helpful
Hopeful and excited! I absolutely love this product. I have PTSD, depression with suicidal tendencies, Lyme disease, and ADHD. The PTSD causes me to sleepwalk. I've only been taking this product for a few weeks, but after the first week, I noticed a significant improvement in my mood and memory. I can actually remember what I did from one day to the next even better than my husband. I feel so much better. The suicidal thoughts have almost vanished. I still have anxiety, but I feel better. I'm actually dreaming and remembering my dreams too, and I'm sleeping through the night without waking up screaming due to my PTSD.
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium has been studied for its potential role in alleviating symptoms of anxiety, and some evidence suggests it may be beneficial. Magnesium plays a critical role in brain function and the regulation of neurotransmitters, which are essential for mood stability. Some studies have indicated that low levels of magnesium may be linked to increased anxiety symptoms, and supplementation could work to help improve overall mental health by restoring adequate magnesium levels. While it's not a standalone treatment for anxiety disorders, integrating magnesium into a balanced diet with other treatment modalities could provide additional support.
That said, it's important to approach magnesium supplementation thoughtfully. Overuse can lead to adverse effects, and individual needs may vary widely depending on dietary intake and overall health status. Before starting any new supplement, especially for managing anxiety, consulting with a healthcare professional is advisable to tailor an approach that aligns with your personal health needs. In summary, while magnesium can play a role in supporting anxiety management, it should complement traditional treatments rather than serve as a primary solution.
Based on user reviews, the timeframe for experiencing noticeable effects from magnesium L-threonate for anxiety varies by individual. Many users report improvements within a short period, with some seeing changes as quickly as three days after starting the supplement Read Review. Others have noted positive effects within one week, indicating a decrease in anxiety and an uplifted mood Read Review.
However, it's worth mentioning that certain users have indicated it may take longer to fully appreciate the benefits, with some reporting enhancements in mood and relaxation after about three weeks Read Review. It seems that while some may experience immediate relief, others might need a bit more time for the supplement to exert its calming effects. Thus, patience and consistent use may be crucial in determining personal effectiveness.
Current scientific research presents a mixed picture regarding the use of magnesium as a supplement for alleviating anxiety. Several studies indicate promising short-term benefits of magnesium supplementation, particularly in relation to mild anxiety conditions. For instance, a systematic review encompassing 15 studies indicated improvements in self-reported anxiety levels in five out of seven studies focused on anxiety outcomes, suggesting that magnesium could benefit those with anxiety, particularly if they initially have low magnesium levels [3]. Additionally, studies involving mice showed that magnesium oxide may help in reducing anxiety-like behavior, highlighting its potential role in modifying gut bacteria dynamics that contribute to anxiety [2].
However, it is essential to approach these findings with caution. The effects of magnesium appear to be more significant in the short term and depend heavily on individual circumstances, such as dosage and the presence of other health conditions [3]. Some studies noted that the benefits did not persist beyond certain follow-up periods, indicating a lack of long-term efficacy [1]. While magnesium shows potential as a supplemental aid for managing anxiety, more rigorous and extensive research is necessary to fully understand its capabilities and determine optimal dosages for effectiveness.
Based on user reviews, many have reported significant improvements in a variety of symptoms after using Magnesium L-threonate. A common theme among users is its effectiveness in alleviating anxiety; individuals have noted considerable reductions in anxiety levels, with some stating it has provided support during particularly stressful periods, such as post-trauma experiences Read Review. Notably, one user highlighted that they experienced a decrease in anxiety and an improvement in mood within just a week of use Read Review. Additionally, users have mentioned enhanced sleep quality, with some reporting more restful nights and fewer awakenings due to anxiety Read Review.
Moreover, the supplement seems to aid in reducing cognitive issues such as brain fog, especially among those dealing with chronic conditions like fibromyalgia Read Review. Many users have also expressed an overall boost in cognitive functions and memory improvement, which they attribute to the magnesium's ability to cross the blood-brain barrier effectively Read Review. However, it’s important to note that individual experiences can vary greatly; some have found it less effective or noted only mild improvements in their symptoms Read Review. Thus, while Magnesium L-threonate appears beneficial for many, results will differ based on individual health circumstances and expectations.
Based on user reviews, many individuals have found that combining Magnesium L-threonate with other supplements can enhance its efficacy in managing anxiety. One user specifically mentioned using Magnesium L-threonate in conjunction with magnesium glycinate and potassium glycinate during meals, noting that this combination effectively addresses issues like brain fog and anxiety, in addition to physical symptoms such as headaches Read Review. Another user reported that Magnesium L-threonate helped them during a period of severe anxiety post-trauma, indicating its complementary effects when integrated into a broader supplement regimen Read Review.
However, it is important to note that while many users endorse the benefits of this magnesium form, some have expressed that it should not be seen as a standalone solution for severe anxiety and suggested it works best as part of a comprehensive approach, including other supplements and good sleep hygiene Read Review. Although results can vary, users generally find value in exploring combinations that cater to their specific needs and experiences with anxiety Read Review.
Based on user reviews, the optimal dosage for Magnesium, particularly Magnesium L-threonate, seems to vary among individuals, but several users reported positive experiences with specific quantities. A common approach includes taking one capsule in the morning and one at night, which users found to be effective for enhancing sleep and alleviating anxiety symptoms Read Review. Others mentioned taking up to three capsules daily to achieve the desired calming effects and improved cognitive functions Read Review.
Additionally, some users highlighted the necessity of consistency and patience, noting that benefits emerged after a few days or weeks of regular use Read Review. It is important to keep in mind that while many experienced notable reductions in anxiety, others reported mixed results, suggesting that finding the right dosage may require personal experimentation and possibly guidance from a healthcare professional Read Review.
9
Enhanced productivity
4 people found this helpful
Highly recommended! After just three days of using this product, I noticed a difference in my brain fog caused by fibromyalgia and anxiety. I'm more productive and my mood has improved; I hope it continues to help me with fatigue as well.
7.5
Reduced anxiety
2 people found this helpful
Excellent! Within a week, I noticed a decrease in my anxiety and improvement in my mood.
9
Mind relaxation
After about three weeks, my mind feels much more relaxed. It helps strengthen memory and supports sleep quality, effectively relieving anxiety.
9
Quick anxiety relief
8 people found this helpful
Excellent magnesium threonate! Unlike others, this one has a gentle effect. It alleviates magnesium deficiency in the brain, enhancing cognitive functions and providing support during anxiety and nervous states. I have used it for severe anxiety post-trauma and can attest to its efficacy. Despite the higher cost, I consider it essential.
9
Insomnia relief
3 people found this helpful
This product helped eliminate my awakenings and anxiety. I recommend it for those with insomnia related to anxiety.
9
Mental clarity
3 people found this helpful
This is an affordable version of magnesium L-threonate! It uniquely crosses the blood-brain barrier, aiding anxiety and mental clarity. I definitely notice a difference!
5
Mildly calming
If you suffer from significant anxiety, this isn't a miracle cure. While the benefits are overstated and it didn't help my insomnia, it does offer some calming effect on the body and mind. I would suggest it as part of a broader routine, including sleep hygiene and other supplements.
7.5
Headache relief
6 people found this helpful
Powerful magnesium! This form, L-threonate by Jarrow formulas, effectively addresses headaches and brain fog, while also helping with anxiety and muscle spasms. I combine it with magnesium glycinate and potassium glycinate during meals.
7.5
Quality sleep
I started this for sleep during a high-anxiety period, and it improved my sleep quality significantly. However, it is rather expensive, so I switched to other products that worked similarly.
9
Reduced anxiety
17 people found this helpful
Best magnesium for brain health from a reputable brand! I've noticed improvements in my sleep and nerve issues since taking Magtein. One capsule in the morning and one at bedtime work well for me. Jarrow uses minimal fillers and offers competitive pricing. I highly recommend it!
7.5
Deep sleep
1 people found this helpful
It is effective, but remember the daily allowance is three capsules. The shape is beneficial for the brain, offering deep sleep and reducing sleep anxiety, especially in children.
7
Magnesium shows potential for anxiety
Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.
Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.
Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.
Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
7
Magnesium's transient anxiety relief
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.
In our quest to understand how magnesium influences anxiety, we conducted a randomized double-blind controlled trial involving 120 adults diagnosed with major depressive disorder (MDD). Participants took either a combination of probiotics, magnesium orotate, and coenzyme Q10 or a placebo for eight weeks.
At the end of the treatment period, we observed that those taking the combination showed significantly lower rates of major depressive episodes compared to those taking the placebo. However, this difference did not persist by the 8-week follow-up. While there was a notable reduction in self-reported symptoms of anxiety and stress during the treatment, this result also lacks long-term significance.
Ultimately, while our findings suggest that magnesium in combination with probiotics and coenzyme Q10 might help alleviate anxiety symptoms for a brief period, the persistent effects are unclear as we found no enduring benefits in the longer term.
References
Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. 10.1038/s41598-024-71093-z
Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. 10.3390/microorganisms12071429
Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. 10.7759/cureus.59317
Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. 10.5152/alphapsychiatry.2024.231342
Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. 10.23736/S0375-9393.24.17868-6
Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. 10.1080/01616412.2024.2352234
Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. 10.3390/life14030306
Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. 10.1038/s41591-023-02705-w
Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. 10.1080/1354750X.2023.2246104
Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. 10.3390/metabo13010073