Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.9
USERS' SCORE
Good
Based on 31 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
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9.5
We observed that Vitamin B6 (VB6) plays a crucial role in preventing certain types of anemia, particularly in individuals undergoing treatment for Parkinson's disease. In this case, a 75-year-old man who was receiving levodopa/carbidopa intestinal gel therapy developed severe VB6 deficiency anemia. This condition is characterized by microcytic, hypochromic, and sideroblastic blood profiles, which can resemble myelodysplastic syndrome.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
Read More
9
We explored the intriguing link between vitamin B12 deficiency and anemia, particularly through a rare condition known as pseudo-thrombotic microangiopathy. This condition mimics other thrombotic microangiopathies and could lead to unnecessary treatments such as plasmapheresis.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
Read More
Most Useful Reviews
9
Lowered homocysteine
8 people found this helpful
The best. These vitamins are excellent; the taste, dosage, and form are perfect for assimilation. They helped to reduce my homocysteine levels from 9 to 4.5, and my haemoglobin rose after more than 10 years of dealing with anaemia. I took them alongside D3, C, and iron. I definitely recommend them!
Read More
9
Enjoyable daily intake
2 people found this helpful
Rrss1122. Very, very excellent. It tastes like sweet cherry, which I enjoyed. I loved it so much that I ordered it again, as a doctor prescribed it for my anaemia. I take it every day and truly enjoy using it. Iron pills no longer nauseate me, thanks to these wonderful pills.
Read More
10
Eliminated anemia effectively
Well tolerated. It is an excellent form of methylcobalamin and folate, effectively eliminating anemia (due to B12 and folate deficiency) and aiding with neuropathy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.9
- All Researches
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Read More
9.5
We observed that Vitamin B6 (VB6) plays a crucial role in preventing certain types of anemia, particularly in individuals undergoing treatment for Parkinson's disease. In this case, a 75-year-old man who was receiving levodopa/carbidopa intestinal gel therapy developed severe VB6 deficiency anemia. This condition is characterized by microcytic, hypochromic, and sideroblastic blood profiles, which can resemble myelodysplastic syndrome.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
Read More
9.5
We observed the influence of nutrition education and iron-folic acid (IFA) supplementation on the levels of anemia among pregnant women in Butajira, Ethiopia. Through a quasi-experimental design over three months, we provided pregnant women with health education based on the Health Belief Model, alongside IFA supplements over a six-week period.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
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9.5
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
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9.5
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 31 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lowered homocysteine
8 people found this helpful
The best. These vitamins are excellent; the taste, dosage, and form are perfect for assimilation. They helped to reduce my homocysteine levels from 9 to 4.5, and my haemoglobin rose after more than 10 years of dealing with anaemia. I took them alongside D3, C, and iron. I definitely recommend them!
Read More
9
Enjoyable daily intake
2 people found this helpful
Rrss1122. Very, very excellent. It tastes like sweet cherry, which I enjoyed. I loved it so much that I ordered it again, as a doctor prescribed it for my anaemia. I take it every day and truly enjoy using it. Iron pills no longer nauseate me, thanks to these wonderful pills.
Read More
10
Eliminated anemia effectively
Well tolerated. It is an excellent form of methylcobalamin and folate, effectively eliminating anemia (due to B12 and folate deficiency) and aiding with neuropathy.
Read More
9
Improved health significantly
Good for anaemia. Taking Vitamin B12 with methylfolate has greatly improved my overall health. I now feel less fatigued and notice increased energy. My nervous system functions better, with fewer episodes of irritability. I highly recommend Vitamin B12 with Methylfolate for anyone seeking a natural way to support their health and replenish these essential vitamins.
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9
Excellent result
Quick effect for anemia. I took it during my pregnancy, and the results were excellent!
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Frequently Asked Questions
9
Significant improvement
Best therapeutic dosage! If you’re deficient in these vitamins, try it! Within a week of taking it, I noticed improvements, and after a month, my anemia receded!
7.5
Increased energy levels
One of the best. This is not my first order, and I really enjoy the boost I feel after using them. An hour later, I have more energy and my mood lifts. A relative who I ordered them for shares this experience. For those with anaemia, they’re essential! Though I experienced nausea with a smaller dosage, I believe taking them daily for at least a month and less frequently afterwards, based on personal condition, works well.
9
Excellent result
Quick effect for anemia. I took it during my pregnancy, and the results were excellent!
9
Lowered homocysteine
8 people found this helpful
The best. These vitamins are excellent; the taste, dosage, and form are perfect for assimilation. They helped to reduce my homocysteine levels from 9 to 4.5, and my haemoglobin rose after more than 10 years of dealing with anaemia. I took them alongside D3, C, and iron. I definitely recommend them!
9
Improved health significantly
Good for anaemia. Taking Vitamin B12 with methylfolate has greatly improved my overall health. I now feel less fatigued and notice increased energy. My nervous system functions better, with fewer episodes of irritability. I highly recommend Vitamin B12 with Methylfolate for anyone seeking a natural way to support their health and replenish these essential vitamins.
7.5
Pleasant results
A fantastic sublingual complex with B6, B9, and B12 in active forms. The results are pleasing, and I monitored my anemia effectively through my blood tests.
9
Effective methylation
The Vitamin B12 methyl formula is one of the best I’ve used for anemia. It needs to be methylated for effectiveness. I mistakenly took a non-methylated version before, which did not help me. Methylation is vital, especially for those with diabetes. This formula has excellent quality and taste.
8
We explored the case of a 10-year-old boy diagnosed with congenital sideroblastic anemia (CSA). This condition can lead to severe anemia due to the body’s ineffective production of red blood cells. As part of the investigation, we performed various blood tests and conducted gene mutation analysis to identify any underlying causes.
We identified a novel genetic variant (c.1102C > T:p. Arg368Trp) that seemed to play a significant role in this boy's anemia. Notably, the treatment regimen included vitamin B6, known to help in certain cases of sideroblastic anemia, along with another medication called deferasirox. After six months of treatment, the patient saw significant improvement; his hemoglobin levels rose significantly, and iron overload was managed effectively.
While our findings suggest that vitamin B6 can be beneficial for some patients with CSA, it was combined with deferasirox in this instance. Consequently, isolating the exact impact of vitamin B6 on the anemia proves challenging. Nevertheless, this case highlights the importance of mutational analysis and tailored treatments in managing inherited blood disorders.
We identified a novel genetic variant (c.1102C > T:p. Arg368Trp) that seemed to play a significant role in this boy's anemia. Notably, the treatment regimen included vitamin B6, known to help in certain cases of sideroblastic anemia, along with another medication called deferasirox. After six months of treatment, the patient saw significant improvement; his hemoglobin levels rose significantly, and iron overload was managed effectively.
While our findings suggest that vitamin B6 can be beneficial for some patients with CSA, it was combined with deferasirox in this instance. Consequently, isolating the exact impact of vitamin B6 on the anemia proves challenging. Nevertheless, this case highlights the importance of mutational analysis and tailored treatments in managing inherited blood disorders.
9
We examined how vitamin B6, also known as pyridoxine, affects different types of anemia through innovative animal models. Specifically, we focused on conditions like X-linked sideroblastic anemia (XLSA) and X-linked protoporphyria (XLPP), which are linked to mutations in a specific enzyme involved in heme biosynthesis.
Our research utilized advanced gene editing techniques to create mouse models that mimic these anemic conditions. This approach allowed us to explore how adjusting dietary vitamin B6 levels impacts symptoms such as anemia and porphyria in these models.
Interestingly, our findings revealed that while XLSA patients often benefit from vitamin B6 supplementation, XLPP showed less sensitivity to this treatment. We also discovered that other related conditions, like congenital sideroblastic anemia (SLC25A38-CSA), reacted extremely negatively to vitamin B6 deficiency—something not seen in a different mouse model of anemia we studied. This unexpected sensitivity suggests that vitamin B6 plays a crucial role in managing specific types of anemia, paving the way for potential new treatment strategies.
Our research utilized advanced gene editing techniques to create mouse models that mimic these anemic conditions. This approach allowed us to explore how adjusting dietary vitamin B6 levels impacts symptoms such as anemia and porphyria in these models.
Interestingly, our findings revealed that while XLSA patients often benefit from vitamin B6 supplementation, XLPP showed less sensitivity to this treatment. We also discovered that other related conditions, like congenital sideroblastic anemia (SLC25A38-CSA), reacted extremely negatively to vitamin B6 deficiency—something not seen in a different mouse model of anemia we studied. This unexpected sensitivity suggests that vitamin B6 plays a crucial role in managing specific types of anemia, paving the way for potential new treatment strategies.
9
We explored the effectiveness of vitamin B6 in treating anemia, particularly within the context of congenital sideroblastic anemia (CSA). CSA is caused by genetic mutations that disrupt iron utilization and lead to ineffective red blood cell production. While vitamin B6 is a common initial treatment for some types of anemia, we observed that it does not work for everyone. Specifically, some patients with CSA had been treated with vitamin B6 and iron chelators, yet they remained unresponsive.
In our review of two cases involving patients with mutations in the ALAS2 and SLC25A38 genes, we noted that after failing to respond to vitamin B6, these individuals turned to a newer treatment known as luspatercept. This medication helped them attain transfusion independence and significantly reduced their spleen size. Therefore, while vitamin B6 might be effective for some, this study highlights its limitations, showing that it does not provide adequate solutions for all patients with CSA.
In our review of two cases involving patients with mutations in the ALAS2 and SLC25A38 genes, we noted that after failing to respond to vitamin B6, these individuals turned to a newer treatment known as luspatercept. This medication helped them attain transfusion independence and significantly reduced their spleen size. Therefore, while vitamin B6 might be effective for some, this study highlights its limitations, showing that it does not provide adequate solutions for all patients with CSA.
9.5
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
7
We observed that vitamin B6 plays a significant role in the treatment of certain types of anemia, particularly in cases related to congenital sideroblastic anemia. In these instances, vitamin B6 can help spur the body's ability to produce healthy red blood cells, which are essential for transporting oxygen throughout our bodies.
However, it's important to note that the effects of vitamin B6 aren't universally effective for all anemia types. Its use primarily appears beneficial as a part of a broader supportive treatment strategy. For those with conditions like myelodysplastic syndromes, the treatment approach is more complex and may not rely primarily on vitamin B6 alone.
Despite these limitations, vitamin B6 remains a key player in managing specific cases of anemia, showing effectiveness that can often lead to improved outcomes for patients. It highlights how personalized treatment plans are crucial, as the situation can vary significantly from one individual to another.
However, it's important to note that the effects of vitamin B6 aren't universally effective for all anemia types. Its use primarily appears beneficial as a part of a broader supportive treatment strategy. For those with conditions like myelodysplastic syndromes, the treatment approach is more complex and may not rely primarily on vitamin B6 alone.
Despite these limitations, vitamin B6 remains a key player in managing specific cases of anemia, showing effectiveness that can often lead to improved outcomes for patients. It highlights how personalized treatment plans are crucial, as the situation can vary significantly from one individual to another.
References
- Cai J, Liu T, Huang Y, Chen H, Yu M, et al. A novel and apparent missense variant associated with congenital sideroblastic anemia. Front Pediatr. 2024;12:1411676. 10.3389/fped.2024.1411676
- Ducamp S, Sendamarai AK, Campagna DR, Chin DWL, Fujiwara Y, et al. Murine models of erythroid 5ALA synthesis disorders and their conditional synthetic lethal dependency on pyridoxine. Blood. 2024;144:1418. 10.1182/blood.2023023078
- Shao Y, He L, Ding S, Fu R. Luspatercept for the treatment of congenital sideroblastic anemia: Two case reports. Curr Res Transl Med. 2024;72:103438. 10.1016/j.retram.2024.103438
- Mohamed S, Ibrahim F, Alasafar MN, Alshurafa A, Akiki S, et al. Recurrent sideroblastic anemia during pregnancy. Clin Case Rep. 2023;11:e6814. 10.1002/ccr3.6814
- Yasuda H, Hatano T, Honda T, Tsutsui M, Hattori N, et al. Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy for Parkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts. Intern Med. 2022;61:3719. 10.2169/internalmedicine.9577-22
- Abu-Zeinah G, DeSancho MT. Understanding Sideroblastic Anemia: An Overview of Genetics, Epidemiology, Pathophysiology and Current Therapeutic Options. J Blood Med. 2020;11:305. 10.2147/JBM.S232644
- Merga RT, Birhane M, Dhinsa M, Muleta B, Jemal J, et al. Determinants of compliance with iron-folic acid supplementation among pregnant mothers in Bule Hora district, Southern Ethiopia: unmatched case-control study. BMC Public Health. 2025;25:832. 10.1186/s12889-025-22005-x
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. 10.1016/S2214-109X(24)00559-X
- Weeks CJ, Mian M, Stokes M, Gold M, Shah A, et al. The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma. Hematol Rep. 2025;17. 10.3390/hematolrep17010005
- Taye M, Mohammed T, Taye W, Glagn M, Yihune M. Compliance with iron-folate supplementation among pregnant women in Southern Ethiopia: a multi-center cross-sectional study. Reprod Health. 2025;22:22. 10.1186/s12978-025-01944-z
- Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. 10.1038/s41598-025-87957-x
- Kant SB, Bashir R, Khan B, Shabbir NA, Nizami AA, et al. A Cross-Sectional Study of the Maternal Health Factors: The Interplay Between Breastfeeding Patterns, Gut Microbiota, Anemia, and Cardiovascular Risk in Lactating Mothers. Cureus. 2024;16:e76316. 10.7759/cureus.76316
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. 10.1016/j.tracli.2025.01.006
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. 10.7759/cureus.75676
- Kataria S, Kataria S, Chougule D, Bharti B, Rastogi A. Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India. Cureus. 2024;16:e75608. 10.7759/cureus.75608
- Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. 10.1177/03795721241304475
- Chillo SL, Woldesemayat EM, Dangisso MH. Intermittent versus daily oral iron folic acid supplementation and pregnancy outcome in low- and middle-income countries: a systematic review and meta-analysis of experimental studies. Reprod Health. 2025;22:2. 10.1186/s12978-024-01917-8
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. 10.7759/cureus.75257
- Contreras R, Méndez GP, Mujica J, Padilla C, Selamé ME, et al. [Paroxysmal Nocturnal Hemoglobinuria: A Rare but Treatable Cause of Acute Kidney Injury. Case Report]. Rev Med Chil. 2024;152:627. 10.4067/s0034-98872024000500627
- Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. 10.4103/ijph.ijph_844_23
- Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. 10.1021/acsami.4c15206
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. 10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. 10.1007/s13668-025-00622-7
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. 10.5692/clinicalneurol.cn-002023
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. 10.7759/cureus.75800
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. 10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. 10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. 10.1155/2024/3258227
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