Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.8
USERS' SCORE
Moderately Good
Based on 72 Reviews
7.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9.5
Family education improves anemia treatment
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Read More
8
Preconception nutrition helps reduce anemia
We examined various trials that focused on how preconception nutrition supplements affect maternal anemia, using hemoglobin levels as a key indicator. Our review suggests these supplements can significantly lower anemia rates among expectant mothers.
However, the benefits regarding fetal growth remain unclear. While data shows promise, the overall quality of evidence is low, signaling a need for more robust studies in this area. Future research should aim to evaluate comprehensive nutrition packages containing essential nutrients.
However, the benefits regarding fetal growth remain unclear. While data shows promise, the overall quality of evidence is low, signaling a need for more robust studies in this area. Future research should aim to evaluate comprehensive nutrition packages containing essential nutrients.
Read More
8
We synthesized specialized iron oxide nanoparticles enhanced with folic acid to tackle cancer-related anemia and improve tumor imaging. Through innovative strategies, these nanoparticles not only showed superior imaging capabilities but also significantly increased red blood cell counts and hemoglobin levels in mice with anemia, offering a safer alternative to blood transfusions. This dual function suggests that these nanoparticles could play a pivotal role in both diagnosing and treating anemia in cancer patients, helping to address a major concern in cancer care.
Read More
Most Useful Reviews
9
Combatting folate deficiency
113 people found this helpful
After being diagnosed with folate anaemia, my doctor recommended this methylfolate, which has excellent digestibility and performance.
Read More
9
Improved anemia treatment
113 people found this helpful
Excellent folic acid in the form of methylfolate, easily absorbed, especially for those with folate cycle gene polymorphism. I take one capsule daily after breakfast. Methylfolate plays a crucial role in DNA formation, fetal development, and reducing the risk of anaemia. It’s particularly important for pregnant women. This supplement has an increased dose to effectively address folic acid deficiency. I recommend checking homocysteine levels; it's inexpensive and beneficial.
Read More
9
Suitable for pregnant women
69 people found this helpful
Methylfolate is a well-absorbed form of folic acid I take daily. It's safe for pregnant women and energises while helping with anaemia. You must know your genetic mutations, as standard folic acid may not be effective for everyone.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.8
- All Researches
9.5
We assessed how nutrition education, combined with iron-folic acid supplementation, impacts hemoglobin levels and adherence to supplementation among pregnant women in Ethiopia. Over three months, pregnant women received community-based education and were given supplements for six weeks.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
Read More
9.5
Family education improves anemia treatment
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Read More
9.5
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Read More
9
We evaluated the effectiveness of a grassroots organization’s iron and folic acid (IFA) supplementation program aimed at improving anemia levels among school-age and adolescent females in India. The program implemented a peer network approach to educate young females about anemia and encourage compliance with supplementation.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Read More
8
Preconception nutrition helps reduce anemia
We examined various trials that focused on how preconception nutrition supplements affect maternal anemia, using hemoglobin levels as a key indicator. Our review suggests these supplements can significantly lower anemia rates among expectant mothers.
However, the benefits regarding fetal growth remain unclear. While data shows promise, the overall quality of evidence is low, signaling a need for more robust studies in this area. Future research should aim to evaluate comprehensive nutrition packages containing essential nutrients.
However, the benefits regarding fetal growth remain unclear. While data shows promise, the overall quality of evidence is low, signaling a need for more robust studies in this area. Future research should aim to evaluate comprehensive nutrition packages containing essential nutrients.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 72 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Combatting folate deficiency
113 people found this helpful
After being diagnosed with folate anaemia, my doctor recommended this methylfolate, which has excellent digestibility and performance.
Read More
9
Improved anemia treatment
113 people found this helpful
Excellent folic acid in the form of methylfolate, easily absorbed, especially for those with folate cycle gene polymorphism. I take one capsule daily after breakfast. Methylfolate plays a crucial role in DNA formation, fetal development, and reducing the risk of anaemia. It’s particularly important for pregnant women. This supplement has an increased dose to effectively address folic acid deficiency. I recommend checking homocysteine levels; it's inexpensive and beneficial.
Read More
9
Suitable for pregnant women
69 people found this helpful
Methylfolate is a well-absorbed form of folic acid I take daily. It's safe for pregnant women and energises while helping with anaemia. You must know your genetic mutations, as standard folic acid may not be effective for everyone.
Read More
9
Prevented pregnancy complications
40 people found this helpful
For those planning a pregnancy, I recommend 400 mcg of methylfolate daily, as it significantly reduces the risk of anaemia and neural tube defects. Essential for reproductive health.
Read More
9
Improved nerve inflammation
15 people found this helpful
This folic acid supplement supports heart and brain health and treats anaemia effectively. It contains methylfolate, which is absorbed quickly. My parents have benefitted greatly, addressing nerve pain and sleep issues.
Read More
Frequently Asked Questions
10
Fast absorption for anaemia
4 people found this helpful
I have folic anaemia, and within a month, this supplement greatly helped me. It has excellent absorption, and my body responds well to this formula.
9
Improved child's anaemia
4 people found this helpful
I take this with my child, who sees a haematologist. We also use iron and vitamin C. Our tests have improved, and my child's anaemia has finally resolved.
9
Life-saving against anaemia
5 people found this helpful
This supplement, combined with B12 injections and iron, saved my father's life. Anaemia in the elderly can be dangerous, affecting heart function and causing lethargy. We started with two per day for two weeks, then reduced to one daily. Don't underestimate B12; it can lead to severe brain damage if deficient.
9
Raised vitamin B9 levels
2 people found this helpful
In the treatment of my anemia, this vitamin has successfully raised my blood vitamin B9 levels.
9
Anemia treatment success
7 people found this helpful
Methylfolate is vital for treating my anaemia. I take 800 mcg daily, and it significantly improved my condition. It's also known to positively affect liver health, particularly important during pregnancy.
9
Addresses iron deficiency
1 people found this helpful
This year has made me realise the importance of folic acid, especially for treating my iron deficiency anemia. It supports blood vessel health and iron absorption, vital for all.
9
Prevented pregnancy complications
40 people found this helpful
For those planning a pregnancy, I recommend 400 mcg of methylfolate daily, as it significantly reduces the risk of anaemia and neural tube defects. Essential for reproductive health.
9
Normalised blood levels
9 people found this helpful
Methylfolate plays a vital role in treating anaemia, and I noticed my levels normalising after treatment. I take 800 mcg daily, which has positively affected my liver health as well.
9
Enhances absorption
3 people found this helpful
This methylfolate is absorbed better than standard folic acid. I find it beneficial for addressing anaemia and for those planning a pregnancy.
8
We looked into the effects of daily oral iron supplementation during pregnancy, both alone and with folic acid. Findings suggest that iron can significantly lower the risk of maternal anemia—going from 7.4% to just 4%.
Adding folic acid further enhances this effect, reducing anemia rates from 25.5% to 12.1%. However, when it comes to infant outcomes, results are mixed with limited evidence on improvements in birth weight and little change in preterm births or other complications.
Overall, daily iron intake helps fight anemia, but further studies are needed to explore its broader benefits for mothers and babies.
Adding folic acid further enhances this effect, reducing anemia rates from 25.5% to 12.1%. However, when it comes to infant outcomes, results are mixed with limited evidence on improvements in birth weight and little change in preterm births or other complications.
Overall, daily iron intake helps fight anemia, but further studies are needed to explore its broader benefits for mothers and babies.
9.5
We assessed how nutrition education, combined with iron-folic acid supplementation, impacts hemoglobin levels and adherence to supplementation among pregnant women in Ethiopia. Over three months, pregnant women received community-based education and were given supplements for six weeks.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
2
Folic acid plus micronutrients ineffective
We conducted a trial in rural India to see if adding multiple micronutrients to iron-folic acid improves anemia in young children. Over 1,300 children with mild-to-moderate anemia were divided into two groups: one received iron-folic acid alone, while the other got iron-folic acid plus micronutrients.
After 90 days, both groups showed no significant differences in hemoglobin levels or anemia cure rates. While compliance was high in both groups, our findings suggest that focusing on iron-folic acid alone may be sufficient for effective anemia recovery in these children.
After 90 days, both groups showed no significant differences in hemoglobin levels or anemia cure rates. While compliance was high in both groups, our findings suggest that focusing on iron-folic acid alone may be sufficient for effective anemia recovery in these children.
References
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Engidaw MT, Lee P, Ahmed F. Iron and folic acid supplementation compliance during pregnancy and its effect on post-pregnancy anaemia among reproductive-age women in East Africa. Womens Health (Lond). 2025;21:17455057251317547. doi:10.1177/17455057251317547
- Williams BA, McCartney H, Singer J, Devlin AM, Vercauteren S, et al. Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial. Am J Clin Nutr. 2025;121:910. doi:10.1016/j.ajcnut.2025.02.001
- Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. doi:10.1038/s41598-025-87957-x
- Aziz Ali S, Genkinger J, Kahe K, Valeri L, Khowaja N, et al. Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2025;14:11. doi:10.1186/s13643-024-02726-7
- Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. doi:10.1177/03795721241304475
- Chillo SL, Woldesemayat EM, Dangisso MH. Intermittent versus daily oral iron folic acid supplementation and pregnancy outcome in low- and middle-income countries: a systematic review and meta-analysis of experimental studies. Reprod Health. 2025;22:2. doi:10.1186/s12978-024-01917-8
- Zhou J, Wang Q, Yu Y, Chen L, Shi J, et al. A rare case report of severe aplastic anaemia caused by long-term use of zidovudine. BMC Infect Dis. 2024;24:1421. doi:10.1186/s12879-024-09875-z
- Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. doi:10.4103/ijph.ijph_844_23
- Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. doi:10.1021/acsami.4c15206
- Behera DK, Rahut DB, Tripathy S, Negi S. Burden and causes of anemia in Vietnam: insights from the global burden of disease data. BMC Public Health. 2024;24:3026. doi:10.1186/s12889-024-20497-7
- Finkelstein JL, Cuthbert A, Weeks J, Venkatramanan S, Larvie DY, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2024;8:CD004736. doi:10.1002/14651858.CD004736.pub6
- Merga RT, Birhane M, Dhinsa M, Muleta B, Jemal J, et al. Determinants of compliance with iron-folic acid supplementation among pregnant mothers in Bule Hora district, Southern Ethiopia: unmatched case-control study. BMC Public Health. 2025;25:832. doi:10.1186/s12889-025-22005-x
- Weeks CJ, Mian M, Stokes M, Gold M, Shah A, et al. The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma. Hematol Rep. 2025;17. doi:10.3390/hematolrep17010005
- Taye M, Mohammed T, Taye W, Glagn M, Yihune M. Compliance with iron-folate supplementation among pregnant women in Southern Ethiopia: a multi-center cross-sectional study. Reprod Health. 2025;22:22. doi:10.1186/s12978-025-01944-z
- Kant SB, Bashir R, Khan B, Shabbir NA, Nizami AA, et al. A Cross-Sectional Study of the Maternal Health Factors: The Interplay Between Breastfeeding Patterns, Gut Microbiota, Anemia, and Cardiovascular Risk in Lactating Mothers. Cureus. 2024;16:e76316. doi:10.7759/cureus.76316
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Kataria S, Kataria S, Chougule D, Bharti B, Rastogi A. Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India. Cureus. 2024;16:e75608. doi:10.7759/cureus.75608
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. doi:10.7759/cureus.75257
- Contreras R, Méndez GP, Mujica J, Padilla C, Selamé ME, et al. [Paroxysmal Nocturnal Hemoglobinuria: A Rare but Treatable Cause of Acute Kidney Injury. Case Report]. Rev Med Chil. 2024;152:627. doi:10.4067/s0034-98872024000500627
