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SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
USERS' SCORE
Good
Based on 72 Reviews
8.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Folate supplementation improves anemia
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
Study shows significant benefits
We conducted a study to understand how a school-based program offering weekly iron and folic acid supplements affects anemia, particularly focusing on the serum folate levels in adolescent girls aged 10 to 19 in the Sidama Region of Southern Ethiopia.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Read More
9
Folate's role in cancer anemia
Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis.
Study highlights folate's impact
We explored how functionalized iron oxide nanoparticles, specifically those enhanced with folate, can play a crucial role in improving anemia related to cancer. This innovative approach aimed at offering both effective imaging solutions for tumors as well as addressing cancer-related anemia in patients.
Our focus was on nanoparticles modified with protoporphyrin IX and folate, which allowed for both magnetic resonance imaging and fluorescence imaging to assist in cancer diagnostics. The study showed that the nanoparticles collected in targeted tumor areas efficiently, which is helpful for imaging and treatment purposes. Interestingly, we also observed a significant improvement in erythropoiesis, with an increase of up to 20% in red blood cell counts and hemoglobin levels in mice suffering from cancer-related anemia.
This finding provides a potential alternative to traditional blood transfusions, which can be burdensome for patients requiring frequent treatments. While we recognize that the isolated effects of folate itself may not be easily determined due to the combined treatment methods, the contribution of folate in this context relates directly to our quest to understand how to effectively combat anemia in cancer patients. Overall, this study positions functionalized iron oxide nanoparticles as a promising tool in the intersection of cancer treatment and anemia management.
Our focus was on nanoparticles modified with protoporphyrin IX and folate, which allowed for both magnetic resonance imaging and fluorescence imaging to assist in cancer diagnostics. The study showed that the nanoparticles collected in targeted tumor areas efficiently, which is helpful for imaging and treatment purposes. Interestingly, we also observed a significant improvement in erythropoiesis, with an increase of up to 20% in red blood cell counts and hemoglobin levels in mice suffering from cancer-related anemia.
This finding provides a potential alternative to traditional blood transfusions, which can be burdensome for patients requiring frequent treatments. While we recognize that the isolated effects of folate itself may not be easily determined due to the combined treatment methods, the contribution of folate in this context relates directly to our quest to understand how to effectively combat anemia in cancer patients. Overall, this study positions functionalized iron oxide nanoparticles as a promising tool in the intersection of cancer treatment and anemia management.
Read More
8
Folate improves anemia after COVID-19
Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection.
Significant but not isolated effect
We explored the case of a patient experiencing severe anemia following a COVID-19 infection, where we observed the presence of both cold agglutinin and cryoglobulin. Interestingly, direct antiglobulin testing revealed that while the patient had positivity for C3d, immunoglobulin G was negative, meaning there was no sign of hemolytic anemia or thrombosis.
The key highlight was the patient’s response to folic acid supplementation. We noted that the anemia improved significantly with this treatment, and there was a corresponding decrease in the cold agglutination titer. Eventually, the direct antiglobulin test turned negative, indicating the resolution of the cold agglutinin’s effects.
Despite ongoing positivity for cryoglobulinemia, the patient showed no clinical symptoms related to thrombosis, suggesting that not all laboratory findings lead to significant health concerns. This case emphasizes the careful consideration needed regarding immunosuppressive therapy for cold-related hematologic disorders after a COVID-19 infection.
The key highlight was the patient’s response to folic acid supplementation. We noted that the anemia improved significantly with this treatment, and there was a corresponding decrease in the cold agglutination titer. Eventually, the direct antiglobulin test turned negative, indicating the resolution of the cold agglutinin’s effects.
Despite ongoing positivity for cryoglobulinemia, the patient showed no clinical symptoms related to thrombosis, suggesting that not all laboratory findings lead to significant health concerns. This case emphasizes the careful consideration needed regarding immunosuppressive therapy for cold-related hematologic disorders after a COVID-19 infection.
Read More
Most Useful Reviews
9.5
Combatting folate deficiency
After being diagnosed with folate anaemia, my doctor recommended this methylfolate, which has excellent digestibility and performance.
Read More
9.5
Improved anemia treatment
Excellent folic acid in the form of methylfolate, easily absorbed, especially for those with folate cycle gene polymorphism. I take one capsule daily after breakfast. Methylfolate plays a crucial role in DNA formation, fetal development, and reducing the risk of anaemia. It’s particularly important for pregnant women. This supplement has an increased dose to effectively address folic acid deficiency. I recommend checking homocysteine levels; it's inexpensive and beneficial.
Read More
9.5
Suitable for pregnant women
Methylfolate is a well-absorbed form of folic acid I take daily. It's safe for pregnant women and energises while helping with anaemia. You must know your genetic mutations, as standard folic acid may not be effective for everyone.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
9.5
Nutrition education reduces anemia
Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study.
Effectiveness in anemia reduction
We observed the influence of nutrition education and iron-folic acid (IFA) supplementation on the levels of anemia among pregnant women in Butajira, Ethiopia. Through a quasi-experimental design over three months, we provided pregnant women with health education based on the Health Belief Model, alongside IFA supplements over a six-week period.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
Read More
9.5
Folate's limited role in anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Moderate connection to folate research
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Read More
9
Grassroots program improves compliance
Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India.
Folate's impact on anemia unclear
We evaluated the effectiveness of a grassroots organization’s iron and folic acid (IFA) supplementation program aimed at improving anemia levels among school-age and adolescent females in India. The program implemented a peer network approach to educate young females about anemia and encourage compliance with supplementation.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Read More
9
Folate supplementation improves anemia
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
Study shows significant benefits
We conducted a study to understand how a school-based program offering weekly iron and folic acid supplements affects anemia, particularly focusing on the serum folate levels in adolescent girls aged 10 to 19 in the Sidama Region of Southern Ethiopia.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Read More
9
Effective health education for anemia
Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study.
Addresses folate in anemia reduction
We conducted a community-based program focusing on how family-centered health education can impact iron and folic acid adherence, along with an examination of anemia in pregnant women. Our research specifically targeted women in rural Jodhpur who were at 14-16 weeks of gestation and suffering from mild to moderate anemia. This approach utilized a quasi-experimental design, which allowed us to compare outcomes between an intervention group and a control group.
Throughout the study, we aimed to boost not just the adherence to iron and folic acid supplements, but also to increase knowledge, attitudes, and practices surrounding anemia. The results were promising. In the intervention group, we noticed notable improvements in all areas assessed, including adherence to iron supplements and actual anemia status. For instance, the percentage of participants with moderate anemia dropped significantly, showing that education and support had a concrete effect on health outcomes.
Moreover, we observed a significant increase in hemoglobin levels and serum ferritin, suggesting that our educational efforts were indeed effective. Overall, our findings indicate that involving family members in health education can lead to better health practices and improved outcomes for pregnant women experiencing anemia. This study underscores the importance of community-based interventions and education in reversing anemia trends and promoting better maternal health.
Throughout the study, we aimed to boost not just the adherence to iron and folic acid supplements, but also to increase knowledge, attitudes, and practices surrounding anemia. The results were promising. In the intervention group, we noticed notable improvements in all areas assessed, including adherence to iron supplements and actual anemia status. For instance, the percentage of participants with moderate anemia dropped significantly, showing that education and support had a concrete effect on health outcomes.
Moreover, we observed a significant increase in hemoglobin levels and serum ferritin, suggesting that our educational efforts were indeed effective. Overall, our findings indicate that involving family members in health education can lead to better health practices and improved outcomes for pregnant women experiencing anemia. This study underscores the importance of community-based interventions and education in reversing anemia trends and promoting better maternal health.
Read More
User Reviews
USERS' SCORE
Good
Based on 72 Reviews
8.9
10
Fast absorption for anaemia
I have folic anaemia, and within a month, this supplement greatly helped me. It has excellent absorption, and my body responds well to this formula.
10
Preconception necessity
Methylfolate, a key form of vitamin B9, is essential for women planning a pregnancy to prevent fetal malformations like spina bifida and for preventing anaemia.
9.5
Combatting folate deficiency
After being diagnosed with folate anaemia, my doctor recommended this methylfolate, which has excellent digestibility and performance.
9.5
Improved anemia treatment
Excellent folic acid in the form of methylfolate, easily absorbed, especially for those with folate cycle gene polymorphism. I take one capsule daily after breakfast. Methylfolate plays a crucial role in DNA formation, fetal development, and reducing the risk of anaemia. It’s particularly important for pregnant women. This supplement has an increased dose to effectively address folic acid deficiency. I recommend checking homocysteine levels; it's inexpensive and beneficial.
Read More
9.5
Suitable for pregnant women
Methylfolate is a well-absorbed form of folic acid I take daily. It's safe for pregnant women and energises while helping with anaemia. You must know your genetic mutations, as standard folic acid may not be effective for everyone.
