Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
7
We investigated the impact of folic acid (FA) on anxiety and ovarian function in female mice exposed to radiation. By dividing the mice into groups treated with FA and others that weren’t, we observed that those receiving FA showed significantly reduced anxiety levels alongside improvements in ovarian health. The findings highlighted that FA not only supports reproductive performance by preserving ovarian function but may also help manage emotional symptoms linked to radiation exposure. This suggests that folic acid could be a beneficial aid for women undergoing radiation therapy.
Read More
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
Read More
Most Useful Reviews
9
Controls anxiety effectively
112 people found this helpful
This supplement has been instrumental in maintaining my anxiety levels. Its effects were subtle at first, but when I skipped several days, the anxiety returned, reminding me of its efficacy. I ensure I take it daily as it helps manage my anxiety better than anything else I've tried, alongside a balanced diet.
Read More
9
Effective for anxiety
67 people found this helpful
MTHFR QUADFECTA is a remarkable supplement I’ve combined with P5P, Methyl B-12, and TMG to address MTHFR symptoms over my ten-year journey. Initially, I focused solely on physical symptoms, achieving success. However, as I explored the mental implications of MTHFR, I discovered its role in my lifelong struggles with anxiety and depression. Following advice, I introduced TMG, believing it could fully combat MTHFR’s effects. I urge others suffering with MTHFR to consider including TMG in their regimen for noticeable mental relief. This supplement can be conveniently purchased in bulk, being both efficient and economical. I hope my experience encourages others to pursue similar solutions.
Read More
9
Great for anxiety
15 people found this helpful
This product is simply fantastic for alleviating depression and anxiety. I recently went a few days without it and instantly noticed the impact. I won't make the mistake of running out again!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
- All Researches
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
8
We explored the effects of chlorzoxazone and folic acid on anxiety and cognitive functions in mice suffering from spinocerebellar ataxia type 3 (SCA3).
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
Read More
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
Read More
7
Folic acid alleviates nicotine withdrawal symptoms
We explored how folic acid (FA) could ease anxiety and depression in adolescent male rats going through nicotine withdrawal.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
Read More
7
We explored how folate supplementation might counteract anxiety-like behaviors caused by prenatal ethanol exposure in rodents. Administering folate alongside ethanol during crucial developmental days showed promising results.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Controls anxiety effectively
112 people found this helpful
This supplement has been instrumental in maintaining my anxiety levels. Its effects were subtle at first, but when I skipped several days, the anxiety returned, reminding me of its efficacy. I ensure I take it daily as it helps manage my anxiety better than anything else I've tried, alongside a balanced diet.
Read More
9
Effective for anxiety
67 people found this helpful
MTHFR QUADFECTA is a remarkable supplement I’ve combined with P5P, Methyl B-12, and TMG to address MTHFR symptoms over my ten-year journey. Initially, I focused solely on physical symptoms, achieving success. However, as I explored the mental implications of MTHFR, I discovered its role in my lifelong struggles with anxiety and depression. Following advice, I introduced TMG, believing it could fully combat MTHFR’s effects. I urge others suffering with MTHFR to consider including TMG in their regimen for noticeable mental relief. This supplement can be conveniently purchased in bulk, being both efficient and economical. I hope my experience encourages others to pursue similar solutions.
Read More
9
Great for anxiety
15 people found this helpful
This product is simply fantastic for alleviating depression and anxiety. I recently went a few days without it and instantly noticed the impact. I won't make the mistake of running out again!
Read More
9
Lowered anxiety
7 people found this helpful
My doctor suggested I take 5-MTHF to address high homocysteine levels in my family, which are linked to anxiety and insomnia. Within just three days of taking this supplement, I found myself sleeping through the night.
Read More
9
Controlled anxiety
3 people found this helpful
This supplement has been effective in managing my anxiety. I didn’t realise its impact until I skipped taking it for a few days and felt extremely edgy. Now, I ensure I take it daily, which helps me remain calm.
Read More
Frequently Asked Questions
9
Lowered anxiety
7 people found this helpful
My doctor suggested I take 5-MTHF to address high homocysteine levels in my family, which are linked to anxiety and insomnia. Within just three days of taking this supplement, I found myself sleeping through the night.
9
Controlled anxiety
3 people found this helpful
This supplement has been effective in managing my anxiety. I didn’t realise its impact until I skipped taking it for a few days and felt extremely edgy. Now, I ensure I take it daily, which helps me remain calm.
9
Reduced anxiety
1 people found this helpful
This product has noticeably helped with my anxiety and depression. I could tell it was effective within a couple of weeks.
7.5
Less anxiety
3 people found this helpful
I’ve tried numerous Methylfolate brands, but this low-dose option works best for me. Higher doses overstimulated my nervous system, leading to heightened anxiety, whereas this brand provides only positive effects.
9
Confidence boost
My anxiety has decreased significantly, and I feel calmer and more confident. Sleep has normalised, and I've had fewer headaches. magnesium helps with vascular spasms. I recommend it to everyone!
0
Anxiety worsened
3 people found this helpful
Be cautious if you have anxiety, as this can exacerbate it. I found others with similar issues regarding folate.
6
Dosage adjustment
I believe this works but found the full dose too much for me, which increased my anxiety. I reduced it to half a pill, and now it’s fine.
9
Reduced anxiety
3 people found this helpful
Methylfolate combined with vitamin B12 significantly aids in managing my anxiety and alleviating depression symptoms.
7.5
Supports anxiety
1 people found this helpful
I generally use Jarrow's B-complex but chose this supplement for additional folate. Folate is crucial for liver health and its deficiency is linked with anxiety and depression. Alongside B12, these vitamins help metabolise serotonin, promoting better mood.
0
Severe anxiety spikes
As I carry one of the MTHFR mutations, this was recommended to me. However, I suffered greatly, experiencing extreme anxiety, panic attacks, and overwhelming stress after taking it for two months. I developed migraines too. Discontinuing it took two weeks for my symptoms to improve.
7.5
Alleviated anxiety
1 people found this helpful
Folate is key for serotonin and dopamine production, helping to relieve anxiety. This product is easily digestible, and I highly recommend it.
0
Worsened anxiety
I had a terrible reaction to this supplement and don't recommend it. My anxiety increased dramatically.
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
7
Folic acid alleviates nicotine withdrawal symptoms
We explored how folic acid (FA) could ease anxiety and depression in adolescent male rats going through nicotine withdrawal.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
7
We explored how folate supplementation might counteract anxiety-like behaviors caused by prenatal ethanol exposure in rodents. Administering folate alongside ethanol during crucial developmental days showed promising results.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
7
We observed that optimal folate intake is linked to reduced future-oriented worry but has no connection to past-oriented rumination, which relates to anxiety. Our genome-wide association study, incorporating over 72,000 participants, revealed that specific biological processes underlying worry may differ based on folate levels. Notably, individuals with adequate folate showed a unique genetic background associated with their concerns. This points to the potential benefits of folate in addressing anxiety, suggesting that a personalized approach considering both genetic and environmental factors could enhance treatment strategies.
References
- Ni WH, Wang K, Wang Y, Lu J, Lu CT, et al. Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats. Neuropharmacology. 2025;269:110352. 10.1016/j.neuropharm.2025.110352
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. 10.1093/hmg/ddae079
- Rezaei Moghadam M, Khoshrou A, Kakhki S, Hosseini SH, Shirinzadeh Feizabadi A, et al. Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats. Nicotine Tob Res. 2024;26:733. 10.1093/ntr/ntad227
- Marengo L, Barey A, Salguero A, Fabio MC, Cendán CM, et al. Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration. Dev Psychobiol. 2023;65:e22426. 10.1002/dev.22426
- Kakhki S, Goodarzi M, Abbaszade-Cheragheali A, Rajabi M, Masoumipour AH, et al. Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring. Int J Dev Neurosci. 2023;83:615. 10.1002/jdn.10289
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Zhang Q, Wei Z, Weng H, Chen Y, Zhang J, et al. Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice. Front Nutr. 2022;9:854655. 10.3389/fnut.2022.854655
- Ono T, Hino K, Kimura T, Uchimura Y, Ashihara T, et al. Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles. Congenit Anom (Kyoto). 2022;62:169. 10.1111/cga.12472
- Zhao T, Wu D, Du J, Liu G, Ji G, et al. Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation. Front Pharmacol. 2022;13:818423. 10.3389/fphar.2022.818423
- Eszlari N, Bruncsics B, Millinghoffer A, Hullam G, Petschner P, et al. Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake. Nutrients. 2021;13. 10.3390/nu13124396
- Zhang Q, Huang Q, Yao L, Liu W, Ruan J, et al. Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice. Front Pharmacol. 2021;12:701009. 10.3389/fphar.2021.701009
- Mahdavifar B, Hosseinzadeh M, Salehi-Abargouei A, Mirzaei M, Vafa M. Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. J Affect Disord. 2021;288:92. 10.1016/j.jad.2021.03.055
- de Carvalho J, Lerner A, Feingold D. Management of Hyperhomocysteinemia, Low Vitamin Levels, and Low Cortisol in Cannabis Users: A Report of 2 Cases. J Chiropr Med. 2022;21:322. 10.1016/j.jcm.2022.03.001
