Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
Most Useful Reviews
9
Eliminated injections
35 people found this helpful
I'm unsure why others find these lozenges slow to dissolve; they are meant to melt gradually. With pernicious anaemia, I can't absorb B12 in my stomach, so I keep the lozenge between my gum and lip for absorption through the mouth. After using one daily, I no longer require injectable B12.
Read More
10
No more anaemia
14 people found this helpful
This vitamin is excellent and easily digested. Since I started taking it, I no longer have anaemia, as confirmed by my tests.
Read More
9
Relief from symptoms
12 people found this helpful
Excellent, the best I've found. This is the finest B12 I’ve encountered. In my health profession, I usually administer it via injection, but sublingual is also effective for absorption. I previously tried another ineffective brand and stopped taking B12 but started experiencing fasciculations, which worsened over time. Following my B12 treatment, the PVCs and fasciculations improved significantly. Initially, I took it daily but now I use it almost daily at night, resolving my B12-related symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
- All Researches
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9.5
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Read More
9
We explored a case of a 3-year-old girl diagnosed with Imerslund-Gräsbeck syndrome, a condition that causes vitamin B12 malabsorption and leads to anemia. After identifying novel mutations in the AMN gene, we initiated long-term oral vitamin B12 therapy.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 42 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eliminated injections
35 people found this helpful
I'm unsure why others find these lozenges slow to dissolve; they are meant to melt gradually. With pernicious anaemia, I can't absorb B12 in my stomach, so I keep the lozenge between my gum and lip for absorption through the mouth. After using one daily, I no longer require injectable B12.
Read More
10
No more anaemia
14 people found this helpful
This vitamin is excellent and easily digested. Since I started taking it, I no longer have anaemia, as confirmed by my tests.
Read More
9
Relief from symptoms
12 people found this helpful
Excellent, the best I've found. This is the finest B12 I’ve encountered. In my health profession, I usually administer it via injection, but sublingual is also effective for absorption. I previously tried another ineffective brand and stopped taking B12 but started experiencing fasciculations, which worsened over time. Following my B12 treatment, the PVCs and fasciculations improved significantly. Initially, I took it daily but now I use it almost daily at night, resolving my B12-related symptoms.
Read More
9
Enhanced sleep quality
6 people found this helpful
B12 is a great option as it dissolves under the tongue for quick absorption. Suggested dosages range from 300-1000 mcg, enhancing sleep quality and supporting nerve health. High doses can combat anaemia and support overall health, especially for those with conditions that hinder absorption.
Read More
7.5
Localized discomfort
6 people found this helpful
I have anaemia and take this B12 with iron. After a few days, unpleasant leg sensations during PMS significantly improved and are now only felt in my toes. My menstrual symptoms are also much less severe than before.
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Frequently Asked Questions
7.5
Localized discomfort
6 people found this helpful
I have anaemia and take this B12 with iron. After a few days, unpleasant leg sensations during PMS significantly improved and are now only felt in my toes. My menstrual symptoms are also much less severe than before.
9
Felt much better
This methylcobalamin vitamin B12 is highly absorbable and effective against B12 deficiency, which causes health issues like anemia. After a month of using these small, tasty tablets, I felt more energetic and less fatigued. I'll retake my tests at the end of my treatment.
9
Improved indicators
I was prescribed B12 by a nutritionist due to anemia caused by its deficiency. I only took folic acid and B12 tablets, which were convenient and had a pleasant sour taste. I started with two tablets daily, then moved to every other day, and eventually to 2-3 times a week. My indicators improved significantly. Previously, I used a B12 spray, which was convenient, but this drug is a good alternative and very affordable.
9
Eliminated injections
35 people found this helpful
I'm unsure why others find these lozenges slow to dissolve; they are meant to melt gradually. With pernicious anaemia, I can't absorb B12 in my stomach, so I keep the lozenge between my gum and lip for absorption through the mouth. After using one daily, I no longer require injectable B12.
10
No more anaemia
14 people found this helpful
This vitamin is excellent and easily digested. Since I started taking it, I no longer have anaemia, as confirmed by my tests.
7.5
Boosted energy levels
5 people found this helpful
This vitamin works well for me. Despite having low ferritin levels, I’ve noticed remarkable improvements in sleep quality and mental clarity. My symptoms of anaemia seem to have improved significantly, contributing to a healthier feeling overall.
7.5
Fighting anemia
5 people found this helpful
I used this vitamin with vitamin C and calcium to combat my anemia. I took iron separately, as it doesn't absorb well with vitamin B12, even though both are essential for blood health.
7.5
Nervous system support
36 people found this helpful
As a pharmacist and naturopath, I highly recommend this supplement. B12 is crucial for the nervous system and particularly beneficial for diabetics. Certain anemias stem from B12 deficiency. If you experience numbness, fatigue, muscle spasms, or lack of concentration, B12 could be vital for you alongside other vitamins and minerals.
8
We explored a case involving a 51-year-old Ugandan man who experienced recurring lower limb weakness and was ultimately diagnosed with pernicious anemia. His condition stemmed from vitamin B12 deficiency, confirmed by blood tests showing macrocytic anemia and low cobalamin levels.
With treatment using methylcobalamin injections, he showed significant improvement. This case emphasizes the need for heightened awareness of vitamin B12 deficiency in diagnosing anemia, especially in areas with limited health resources.
With treatment using methylcobalamin injections, he showed significant improvement. This case emphasizes the need for heightened awareness of vitamin B12 deficiency in diagnosing anemia, especially in areas with limited health resources.
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
We conducted a study to explore how effective different vitamin B12 supplements are at increasing levels of this crucial vitamin in people with a deficiency. This clinical trial involved healthy adults who were found to have low B12 levels.
Our research spanned across three centers in Pakistan, where participants received either a new formulation of Sucrosomial vitamin B12 or conventional B12 supplements. They took a daily dose for seven days, and we measured their serum B12 levels at various points before and after the treatment.
What we found was quite significant: the Sucrosomial vitamin B12 was notably better at elevating and maintaining higher B12 levels in the bloodstream compared to traditional options. This is important because low vitamin B12 can lead to serious health issues, like megaloblastic anemia and neurological problems.
Overall, this innovative supplement could offer a valuable solution for individuals with B12 deficiency, especially those who may have absorption issues. Our findings support the potential of Sucrosomial vitamin B12 in enhancing health through improved nutrient bioavailability.
Our research spanned across three centers in Pakistan, where participants received either a new formulation of Sucrosomial vitamin B12 or conventional B12 supplements. They took a daily dose for seven days, and we measured their serum B12 levels at various points before and after the treatment.
What we found was quite significant: the Sucrosomial vitamin B12 was notably better at elevating and maintaining higher B12 levels in the bloodstream compared to traditional options. This is important because low vitamin B12 can lead to serious health issues, like megaloblastic anemia and neurological problems.
Overall, this innovative supplement could offer a valuable solution for individuals with B12 deficiency, especially those who may have absorption issues. Our findings support the potential of Sucrosomial vitamin B12 in enhancing health through improved nutrient bioavailability.
8
This case explores the journey of a 40-year-old woman who suffered from various nonspecific symptoms, mistakenly attributed to other health issues, for ten years. Her vitamin B12 levels were critically low, ultimately diagnosed as pernicious anemia.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
9
We explored how vitamin B12 affects anemia, specifically through its role in correcting deficiencies. The research analyzes oral B12 intake and its absorption, particularly in individuals showing signs of deficiency.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
9
We explored the impact of vitamin B12 treatment on anemia through the case of a 41-year-old man diagnosed with autoimmune polyglandular syndrome type 3 (APS-3). This syndrome included conditions like Hashimoto's thyroiditis and pernicious anemia due to autoimmune gastritis. The patient was admitted to the hospital due to severe fatigue and macrocytic anemia, which prompted a detailed evaluation.
Upon diagnosis, we observed that the patient's pernicious anemia was directly linked to his autoimmune issues. The treatment plan involved administering parenteral vitamin B12, which successfully improved his anemia symptoms. Interestingly, this case highlights how anemia can be overlooked in patients with autoimmune conditions, yet it's crucial for our understanding of APS-3.
While anemia isn't typically seen as a key feature of autoimmune syndromes, we found that in this instance, addressing the anemia with vitamin B12 was vital. The case illustrates the significance of thorough evaluations and the role of vitamin B12 as a potential lifeline for patients suffering from pernicious anemia linked to autoimmune gastritis.
Upon diagnosis, we observed that the patient's pernicious anemia was directly linked to his autoimmune issues. The treatment plan involved administering parenteral vitamin B12, which successfully improved his anemia symptoms. Interestingly, this case highlights how anemia can be overlooked in patients with autoimmune conditions, yet it's crucial for our understanding of APS-3.
While anemia isn't typically seen as a key feature of autoimmune syndromes, we found that in this instance, addressing the anemia with vitamin B12 was vital. The case illustrates the significance of thorough evaluations and the role of vitamin B12 as a potential lifeline for patients suffering from pernicious anemia linked to autoimmune gastritis.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. doi:10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x
- Shen M, Luo X, Wu C, Wang J, Wang Z, et al. Pernicious anemia is a common cause of cobalamin deficiency-caused megaloblastic anemia in Hainan, China. Hematology. 2024;29:2399375. doi:10.1080/16078454.2024.2399375
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. doi:10.1007/s00277-024-05878-7
- Song JH, Park SH, Cho M, Kim YM, Hyung WJ, et al. Proximal Gastrectomy Is Associated with Lower Incidence of Anemia and Vitamin B12 Deficiency Compared to Total Gastrectomy in Patients with Upper Gastric Cancer. Cancer Res Treat. 2025;57:174. doi:10.4143/crt.2024.319
- Lacombe V, Vinatier E, Roquin G, Copin MC, Delattre E, et al. Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study. Am J Clin Nutr. 2024;120:217. doi:10.1016/j.ajcnut.2024.05.019
- Chakrabarti S, Ajjampur SSR, Waddington HS, Kishore A, Nguyen PH, et al. Deworming and micronutrient status by community open defecation prevalence: An observational study using nationally representative data from India, 2016-2018. PLoS Med. 2024;21:e1004402. doi:10.1371/journal.pmed.1004402
- Sawada Y, Sakamoto K, Tsukamura A, Sawai C. Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet. Int J Hematol. 2024;119:613. doi:10.1007/s12185-024-03759-3
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. doi:10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. doi:10.1007/s13668-025-00622-7
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. doi:10.7759/cureus.75800
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. doi:10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. doi:10.3389/fnut.2024.1493593
