Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Good
Based on 14 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Most Useful Reviews
9
Improves anxiety response
16 people found this helpful
With both ADHD and anxiety, I previously relied on meditation and meditation techniques. Upon reading about natural treatments for anxiety, I incorporated Methylcobalamin and Folinic Acid into my routine. The results have been remarkable; I haven't needed Xanax during the day, and my anxiety has significantly decreased. My husband, unaware of the supplements, has also noticed improved handling of daily stresses, which confirms their effectiveness.
9
Significant relief for anxiety
5 people found this helpful
I have dealt with Rheumatoid Arthritis for 45 years and was recently diagnosed with severe anaemia and a B12 deficiency. Following three months of taking 9,000 mcg of Methyl B12 daily, I’ve seen drastic improvements—my neuralgia pain has vanished, and my balance and speech have improved dramatically. Understanding the difference between Methyl B12 and Cyanocobalamin has changed my health for the better.
7.5
Improved sleep quality
287 people found this helpful
After being a raw foodist and vegan for three years, my B12 levels were critically low at 99 units. I started taking a bioavailable B12 supplement, and after a month, my levels rose to nearly 600 units. I noticed a significant improvement in my sleep and a reduction in my anxiety. I highly recommend this.
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
- All Researches
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
7
We set out to understand how Vitamin B affects behavior and brain chemistry in rats experiencing depression due to stress. In our study, 72 rats were divided into three groups: a control group, a group under stress, and a group under stress receiving Vitamin B injections.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves anxiety response
16 people found this helpful
With both ADHD and anxiety, I previously relied on meditation and meditation techniques. Upon reading about natural treatments for anxiety, I incorporated Methylcobalamin and Folinic Acid into my routine. The results have been remarkable; I haven't needed Xanax during the day, and my anxiety has significantly decreased. My husband, unaware of the supplements, has also noticed improved handling of daily stresses, which confirms their effectiveness.
9
Significant relief for anxiety
5 people found this helpful
I have dealt with Rheumatoid Arthritis for 45 years and was recently diagnosed with severe anaemia and a B12 deficiency. Following three months of taking 9,000 mcg of Methyl B12 daily, I’ve seen drastic improvements—my neuralgia pain has vanished, and my balance and speech have improved dramatically. Understanding the difference between Methyl B12 and Cyanocobalamin has changed my health for the better.
7.5
Improved sleep quality
287 people found this helpful
After being a raw foodist and vegan for three years, my B12 levels were critically low at 99 units. I started taking a bioavailable B12 supplement, and after a month, my levels rose to nearly 600 units. I noticed a significant improvement in my sleep and a reduction in my anxiety. I highly recommend this.
9
Vitamin solution for anxiety
81 people found this helpful
After battling social anxiety disorder my entire life, I discovered that my anxiety stemmed from B-6 and B-12 deficiencies. This revelation came after trying various medications. Thankfully, these inexpensive B vitamins have transformed my life; I now enjoy a more normal existence after years of expenditure on ineffective treatments. It is crucial to select the right type of B-12, avoiding those containing cyanide.
6
Mood and anxiety boost
11 people found this helpful
I began taking this to address a B12 deficiency due to my strict vegetarian diet. Immediately, it elevated my mood and energy levels. Over a month of daily use resolved my symptoms, including a modest reduction in my anxiety. I realise missing a dose results in noticeable differences; however, the benefits are evident and clearly effective.
Frequently Asked Questions
9
Fatigue vanquished
After taking this for a month, I experienced massive improvements. The numbness in my arms and legs subsided, and my anxiety completely disappeared.
7.5
Improved sleep quality
287 people found this helpful
After being a raw foodist and vegan for three years, my B12 levels were critically low at 99 units. I started taking a bioavailable B12 supplement, and after a month, my levels rose to nearly 600 units. I noticed a significant improvement in my sleep and a reduction in my anxiety. I highly recommend this.
9
Anxiety symptom relief
1 people found this helpful
Vitamin B12 (methylcobalamin) offers neuroprotective and immunomodulatory benefits. This chewable form works quickly and significantly alleviated my symptoms of anxiety, breathlessness, and fatigue.
7.5
Anxiety support restored
2 people found this helpful
After three years of strict veganism, my B12 levels were alarmingly low. Upon starting a supplement, my levels improved significantly, and I noticed reduced anxiety and improved sleep.
7.5
Enhanced mood levels
2 people found this helpful
This supplement has significantly boosted my energy and mood throughout the day. It helps reduce anxiety and makes my brain much more active, aiding memorisation. It's suitable for vegans and has a pleasant lemon flavour.
0
Increased anxiety levels
Unfortunately, instead of feeling energised, this product caused me to experience increased anxiety, which was the opposite of what I was hoping for.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
4
We explored the impact of high-dose Vitamin B6 and B12 supplementation on anxiety in a double-blind study involving 478 young adults. Participants reported their anxiety and depression levels before and after taking the supplements for a month.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
4
We explored the impact of vitamin B12 on anxiety symptoms in adolescents. In a study involving outpatients aged 12 to 18 with anxiety or depressive symptoms, we measured the severity of their conditions and checked various health markers, including serum vitamin B12 and folate levels.
Our findings indicated that lower levels of vitamin B12 were associated with a higher risk of experiencing severe anxiety and depressive symptoms. Interestingly, we also observed that vitamin B12, folate, and total homocysteine levels were interconnected, suggesting that deficiencies in these vitamins might be related.
However, while we found these associations, the correlations between vitamin levels and anxiety symptoms were generally weak.
In summary, while vitamin B12 might play a role in anxiety severity, the relationships are complex and influenced by other factors. Overall, this study underscores the importance of considering nutritional factors in mental health, but we should be cautious not to overstate the benefits of vitamin B12 alone.
Our findings indicated that lower levels of vitamin B12 were associated with a higher risk of experiencing severe anxiety and depressive symptoms. Interestingly, we also observed that vitamin B12, folate, and total homocysteine levels were interconnected, suggesting that deficiencies in these vitamins might be related.
However, while we found these associations, the correlations between vitamin levels and anxiety symptoms were generally weak.
In summary, while vitamin B12 might play a role in anxiety severity, the relationships are complex and influenced by other factors. Overall, this study underscores the importance of considering nutritional factors in mental health, but we should be cautious not to overstate the benefits of vitamin B12 alone.
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
- Al Jassem O, Kheir K, Ismail A, Abou-Abbas L, Masri A, et al. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores. PLoS One. 2024;19:e0297976. 10.1371/journal.pone.0297976
- Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. 10.1186/s12879-023-08925-2
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Young LM, Gauci S, Arnoldy L, Martin L, Perry N, et al. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients. 2022;14. 10.3390/nu14235079
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. 10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. 10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. 10.2147/NDT.S399378
