We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
9
Vitamin B shows anxiety relief potential
Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats.
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
B12 improves fibromyalgia-related anxiety
Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study.
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
Most Useful Reviews
9
Improves anxiety response
16 people found this helpful
With both ADHD and anxiety, I previously relied on meditation and meditation techniques. Upon reading about natural treatments for anxiety, I incorporated Methylcobalamin and Folinic Acid into my routine. The results have been remarkable; I haven't needed Xanax during the day, and my anxiety has significantly decreased. My husband, unaware of the supplements, has also noticed improved handling of daily stresses, which confirms their effectiveness.
Read More
9
Significant relief for anxiety
5 people found this helpful
I have dealt with Rheumatoid Arthritis for 45 years and was recently diagnosed with severe anaemia and a B12 deficiency. Following three months of taking 9,000 mcg of Methyl B12 daily, I’ve seen drastic improvements—my neuralgia pain has vanished, and my balance and speech have improved dramatically. Understanding the difference between Methyl B12 and Cyanocobalamin has changed my health for the better.
Read More
7.5
Improved sleep quality
287 people found this helpful
After being a raw foodist and vegan for three years, my B12 levels were critically low at 99 units. I started taking a bioavailable B12 supplement, and after a month, my levels rose to nearly 600 units. I noticed a significant improvement in my sleep and a reduction in my anxiety. I highly recommend this.
Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats.
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
B12 improves fibromyalgia-related anxiety
Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study.
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
7
Vitamin B improves anxiety-related behaviors
[Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats].
We set out to understand how Vitamin B affects behavior and brain chemistry in rats experiencing depression due to stress. In our study, 72 rats were divided into three groups: a control group, a group under stress, and a group under stress receiving Vitamin B injections.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Read More
7
B12 treatment showed no significant anxiety benefit
Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb).
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
With both ADHD and anxiety, I previously relied on meditation and meditation techniques. Upon reading about natural treatments for anxiety, I incorporated Methylcobalamin and Folinic Acid into my routine. The results have been remarkable; I haven't needed Xanax during the day, and my anxiety has significantly decreased. My husband, unaware of the supplements, has also noticed improved handling of daily stresses, which confirms their effectiveness.
Read More
9
Significant relief for anxiety
5 people found this helpful
I have dealt with Rheumatoid Arthritis for 45 years and was recently diagnosed with severe anaemia and a B12 deficiency. Following three months of taking 9,000 mcg of Methyl B12 daily, I’ve seen drastic improvements—my neuralgia pain has vanished, and my balance and speech have improved dramatically. Understanding the difference between Methyl B12 and Cyanocobalamin has changed my health for the better.
Read More
7.5
Improved sleep quality
287 people found this helpful
After being a raw foodist and vegan for three years, my B12 levels were critically low at 99 units. I started taking a bioavailable B12 supplement, and after a month, my levels rose to nearly 600 units. I noticed a significant improvement in my sleep and a reduction in my anxiety. I highly recommend this.
Read More
9
Vitamin solution for anxiety
81 people found this helpful
After battling social anxiety disorder my entire life, I discovered that my anxiety stemmed from B-6 and B-12 deficiencies. This revelation came after trying various medications. Thankfully, these inexpensive B vitamins have transformed my life; I now enjoy a more normal existence after years of expenditure on ineffective treatments. It is crucial to select the right type of B-12, avoiding those containing cyanide.
Read More
6
Mood and anxiety boost
11 people found this helpful
I began taking this to address a B12 deficiency due to my strict vegetarian diet. Immediately, it elevated my mood and energy levels. Over a month of daily use resolved my symptoms, including a modest reduction in my anxiety. I realise missing a dose results in noticeable differences; however, the benefits are evident and clearly effective.
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in several vital functions in the human body. It is essential for red blood cell formation, neurological function, and DNA synthesis. Naturally occurring in animal products, the vitamin can be found in high concentrations in meat, fish, eggs, and dairy, making it particularly important for those following a vegetarian or vegan diet, as plant-based sources of B12 are limited and often require supplementation.
A deficiency in vitamin B12 can lead to serious health issues, including anemia, fatigue, memory problems, and nerve damage. Due to its significance, it's crucial for individuals, particularly those at risk of deficiency, to ensure adequate intake through diet or supplementation. For most adults, the recommended daily allowance (RDA) is around 2.4 micrograms, though pregnant or breastfeeding women may require higher amounts. If you're considering B12 supplements, it's advisable to consult with a healthcare provider to determine the best option for your specific needs and health status.
Vitamin B12 plays a crucial role in maintaining overall brain health and is involved in the production of neurotransmitters that regulate mood, such as serotonin and dopamine. While some studies have indicated that individuals with low levels of B12 may experience higher rates of anxiety and depression, research specifically linking B12 supplementation directly to significant anxiety relief is limited. It’s important to note that a balanced diet rich in B12, which can be found in foods like meat, fish, eggs, and dairy, may support proper brain function and potentially help mitigate anxiety symptoms.
If you are considering B12 supplements for anxiety management, it's best to consult with a healthcare professional first. They can assess your B12 levels and provide personalized recommendations. While supplementation may help those who are deficient in this vital nutrient, relying solely on B12 without addressing other aspects of mental health, such as therapy or lifestyle changes, may not be an effective strategy for anxiety management.
Based on user reviews, most individuals report noticing improvements in their anxiety levels within a month of starting the B12 supplement. For instance, one reviewer mentioned that after taking the supplement for a month, they experienced significant improvements, including the complete disappearance of their anxiety (Read Review). Another user noted a marked reduction in anxiety and improvements in sleep after a month of use (Read Review).
Additionally, several users have highlighted quick results, indicating that they felt reduced anxiety shortly after beginning the supplementation. One review emphasized that the chewable B12 worked rapidly to alleviate symptoms of anxiety, breathlessness, and fatigue (Read Review). Therefore, while experiences can vary, it seems that a timeframe of around one month is common for seeing noticeable improvements in anxiety levels.
Research surrounding the use of Vitamin B for anxiety reveals mixed results. Some studies suggest that Vitamin B can be beneficial, particularly in specific populations such as those with fibromyalgia. For instance, a study found that daily doses of 1000 mcg of vitamin B12 resulted in significant improvements in anxiety scores among patients with fibromyalgia, indicating its potential role as a complementary therapy for those struggling with anxiety related to chronic conditions [8]. Additionally, vitamins B6 and B12 have been examined for their impact on anxiety, with some evidence pointing to B6's effectiveness in reducing anxiety levels during supplementation [9].
However, other studies highlight the complexity of the relationship between Vitamin B and anxiety. For example, while lower levels of vitamin B12 were linked to higher anxiety levels in adolescents, the strength of these associations was generally weak [12]. Moreover, research on B12's use in Post-COVID anxiety did not yield significant benefits specifically for managing anxiety symptoms, suggesting that more research is needed to clarify these findings and establish effective treatments [3]. As such, while there is some support for the role of Vitamin B in managing anxiety among specific demographics, the overall evidence remains inconclusive and necessitates further investigation.
Based on user reviews, many individuals have reported significant improvements in symptoms after starting a B12 supplement. For example, one user mentioned that after a month of supplementation, their anxiety completely disappeared, and they also saw a reduction in numbness in their limbs (Read Review). Others have noted that their anxiety levels diminished alongside improved sleep quality, indicating that the supplement has multifaceted benefits for mental and emotional well-being (Read Review; Read Review).
Additionally, users have reported enhancements in mood and energy levels, with several highlighting that they felt a noticeable boost in their day-to-day functioning and cognitive abilities (Read Review). However, it is important to note that individual results can vary; one user did express experiencing increased anxiety instead of relief, showing that not every experience is uniformly positive (Read Review). Overall, while feedback suggests that many people find B12 supplements beneficial for anxiety and mood improvement, individual responses may differ significantly.
Based on user reviews, individuals who combine the B12 supplement with other supplements for anxiety management often report positive outcomes. For instance, one user noted that after starting B12, not only did their energy levels and mood improve, but they also experienced a significant reduction in anxiety, showcasing the supplement's multifaceted benefits (Read Review). Another user emphasized the neuroprotective benefits of methylcobalamin, reporting that it quickly alleviated their symptoms of anxiety, breathlessness, and fatigue, hinting at compatibility with other anxiety-relief supplements (Read Review).
However, the experience is not uniformly positive for everyone. One reviewer reported an increase in anxiety instead of relief, indicating that responses can vary when combining B12 with other supplements (Read Review). Overall, while many users advocate for the effectiveness of B12 in conjunction with other supplements to manage anxiety, individual results do differ, suggesting that trying out combinations mindfully is advisable.
The research indicates that a daily dose of 1000 mcg (micrograms) of vitamin B12 may be beneficial for alleviating anxiety, particularly in individuals with conditions such as fibromyalgia. In a study focusing on fibromyalgia patients, participants who took this dosage experienced significant improvements in both their anxiety scores and overall symptoms after 50 days of treatment [8]. This suggests that incorporating vitamin B12 into treatment plans could be a viable option for those facing anxiety issues related to fibromyalgia.
9
Fatigue vanquished
After taking this for a month, I experienced massive improvements. The numbness in my arms and legs subsided, and my anxiety completely disappeared.
7.5
Improved sleep quality
287 people found this helpful
After being a raw foodist and vegan for three years, my B12 levels were critically low at 99 units. I started taking a bioavailable B12 supplement, and after a month, my levels rose to nearly 600 units. I noticed a significant improvement in my sleep and a reduction in my anxiety. I highly recommend this.
9
Anxiety symptom relief
1 people found this helpful
Vitamin B12 (methylcobalamin) offers neuroprotective and immunomodulatory benefits. This chewable form works quickly and significantly alleviated my symptoms of anxiety, breathlessness, and fatigue.
7.5
Anxiety support restored
2 people found this helpful
After three years of strict veganism, my B12 levels were alarmingly low. Upon starting a supplement, my levels improved significantly, and I noticed reduced anxiety and improved sleep.
7.5
Enhanced mood levels
2 people found this helpful
This supplement has significantly boosted my energy and mood throughout the day. It helps reduce anxiety and makes my brain much more active, aiding memorisation. It's suitable for vegans and has a pleasant lemon flavour.
0
Increased anxiety levels
Unfortunately, instead of feeling energised, this product caused me to experience increased anxiety, which was the opposite of what I was hoping for.
8
B12 improves fibromyalgia-related anxiety
Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study.
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
We explored the impact of high-dose Vitamin B6 and B12 supplementation on anxiety in a double-blind study involving 478 young adults. Participants reported their anxiety and depression levels before and after taking the supplements for a month.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
4
Vitamin B12's role in anxiety
Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms.
We explored the impact of vitamin B12 on anxiety symptoms in adolescents. In a study involving outpatients aged 12 to 18 with anxiety or depressive symptoms, we measured the severity of their conditions and checked various health markers, including serum vitamin B12 and folate levels.
Our findings indicated that lower levels of vitamin B12 were associated with a higher risk of experiencing severe anxiety and depressive symptoms. Interestingly, we also observed that vitamin B12, folate, and total homocysteine levels were interconnected, suggesting that deficiencies in these vitamins might be related.
However, while we found these associations, the correlations between vitamin levels and anxiety symptoms were generally weak.
In summary, while vitamin B12 might play a role in anxiety severity, the relationships are complex and influenced by other factors. Overall, this study underscores the importance of considering nutritional factors in mental health, but we should be cautious not to overstate the benefits of vitamin B12 alone.
7
B12 treatment showed no significant anxiety benefit
Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb).
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
References
Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
Al Jassem O, Kheir K, Ismail A, Abou-Abbas L, Masri A, et al. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores. PLoS One. 2024;19:e0297976. 10.1371/journal.pone.0297976
Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. 10.1186/s12879-023-08925-2
Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
Young LM, Gauci S, Arnoldy L, Martin L, Perry N, et al. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients. 2022;14. 10.3390/nu14235079
Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. 10.1080/00207454.2024.2398564
Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. 10.3390/nu16131986
Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. 10.2147/NDT.S399378