Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 15 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We explored the effects of vitamin B12 deficiency on neurological health in elderly patients. In a case study involving two patients, we observed that even with normal B12 levels, symptoms like fatigue and cognitive impairment persisted, especially in those with significant medical histories.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
Treatment with hydroxocobalamin injections led to notable improvements in both patients’ cognitive and motor functions. This highlights the importance of recognizing vitamin B12 deficiency in older adults, even when traditional tests suggest adequate levels.
7
We explored a case involving a 41-year-old woman who experienced unstable walking due to a vitamin B12 deficiency. Her symptoms were related to subacute combined degeneration of the spinal cord, which affected her nerve health.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Most Useful Reviews
10
Numbness alleviated
7 people found this helpful
B12 improves peripheral neuropathy. After taking the first tablet, the numbness in my right foot, which persisted for over three years, has almost completely disappeared. I was surprised by its immediate effect, and I believe my previous diet influenced my condition.
10
Miracle for pain
1 people found this helpful
I give this to my mother for her foot pain. She developed diabetes at age 90 and suffered from burning feet every night. After taking 4 tablets (4000 mcg) at dinner, it has been a miracle worker. I love the methyl form of B12 for better absorption, and Jarrow provides great products at a good price.
9
Effective for neuropathy
1 people found this helpful
If anyone experiences burning, zips, zaps, or symptoms of neuropathy, I recommend trying this product. It works effectively for me.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
We examined a unique case involving a 33-year-old woman with HIV who experienced sudden vision loss linked to vitamin B12 deficiency. Initially treated with B12 tablets for severe peripheral neuropathy, her condition escalated to optic neuritis. Upon diagnosis, she received prednisolone and daily B12 injections. After five months of this treatment, she reported a significant recovery in her vision. This case highlights the importance of recognizing vitamin B12 deficiency’s potential eye-related symptoms, especially in patients with underlying health conditions like HIV, to ensure timely intervention.
9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
8
We examined the case of a 40-year-old woman suffering from a decade of vague symptoms, including pain and cognitive issues, before being diagnosed with vitamin B12 deficiency due to pernicious anemia.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
Despite low B12 levels showing no typical signs of anemia, the use of parenteral B12 treatment led to her neurological improvement. This case reinforces how vital it is to recognize B12 deficiency even when classic symptoms aren't present, ensuring timely treatment to avoid serious complications.
8
We explored the effectiveness of steroid treatment versus vitamin B12 therapy for improving diabetic ocular nerve palsy. Our study involved fifty participants, with half receiving steroids and the other half vitamin B12 injections.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
8
We explored the connection between nitrous oxide use and vitamin B12 deficiency, specifically focusing on neurological issues like peripheral neuropathy. Through a reported case of nitrous oxide-induced subacute combined degeneration of the spinal cord, we identified a functional B12 deficiency despite normal serum levels.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Numbness alleviated
7 people found this helpful
B12 improves peripheral neuropathy. After taking the first tablet, the numbness in my right foot, which persisted for over three years, has almost completely disappeared. I was surprised by its immediate effect, and I believe my previous diet influenced my condition.
10
Miracle for pain
1 people found this helpful
I give this to my mother for her foot pain. She developed diabetes at age 90 and suffered from burning feet every night. After taking 4 tablets (4000 mcg) at dinner, it has been a miracle worker. I love the methyl form of B12 for better absorption, and Jarrow provides great products at a good price.
9
Effective for neuropathy
1 people found this helpful
If anyone experiences burning, zips, zaps, or symptoms of neuropathy, I recommend trying this product. It works effectively for me.
9
Good absorption
Even though it is the same vitamin 12, it is the active form, meaning it has a better absorption rate and is beneficial for peripheral neuropathy and nerve damage. It is also helpful for diabetic neuropathy. People on diabetes medication should consider taking it.
9
Relieves foot pain
This is good for neuropathy foot pain. It melts under the tongue for quick absorption and alleviates foot pain immediately. However, it's advisable not to use it for extended periods, as B12 can accumulate in the system.
Frequently Asked Questions
10
Numbness alleviated
7 people found this helpful
B12 improves peripheral neuropathy. After taking the first tablet, the numbness in my right foot, which persisted for over three years, has almost completely disappeared. I was surprised by its immediate effect, and I believe my previous diet influenced my condition.
7.5
Effective for neuropathy
They are very tasty and seem to work exceptionally well for my neuropathy.
9
Relieves foot pain
This is good for neuropathy foot pain. It melts under the tongue for quick absorption and alleviates foot pain immediately. However, it's advisable not to use it for extended periods, as B12 can accumulate in the system.
7.5
Helps my symptoms
1 people found this helpful
I have been using Jarrow Formulas, Methyl B-12 for years, and it helps my neuropathy symptoms significantly.
10
Miracle for pain
1 people found this helpful
I give this to my mother for her foot pain. She developed diabetes at age 90 and suffered from burning feet every night. After taking 4 tablets (4000 mcg) at dinner, it has been a miracle worker. I love the methyl form of B12 for better absorption, and Jarrow provides great products at a good price.
7.5
Reduces tingling
2 people found this helpful
My family suffers from diabetes and poor blood circulation. I have had sole pain and occasional tinnitus. After taking methylcobalamin, it has helped relieve the tingling in my feet and even reduced tinnitus. We will continue to use this product as it has good absorption without the need for biotransformation.
6
Cognitive improvement
This product helps with neuropathy and brain fog. I was recommended it at my local health food store. Always consult with your doctor or healthcare team to ensure that a supplement or dosage is appropriate for you. Heal well! :)
9
Good absorption
Even though it is the same vitamin 12, it is the active form, meaning it has a better absorption rate and is beneficial for peripheral neuropathy and nerve damage. It is also helpful for diabetic neuropathy. People on diabetes medication should consider taking it.
8
We explored the effectiveness of steroid treatment versus vitamin B12 therapy for improving diabetic ocular nerve palsy. Our study involved fifty participants, with half receiving steroids and the other half vitamin B12 injections.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
After assessing ocular movements at various intervals, we found that the vitamin B12 group experienced a greater improvement than the steroid group. This suggests that vitamin therapy could play a significant role in enhancing eye movement and addressing underlying nutritional deficiencies.
Ultimately, vitamin B12 therapy presents a promising option for those with diabetic mononeuropathies.
8
We explored the connection between nitrous oxide use and vitamin B12 deficiency, specifically focusing on neurological issues like peripheral neuropathy. Through a reported case of nitrous oxide-induced subacute combined degeneration of the spinal cord, we identified a functional B12 deficiency despite normal serum levels.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
The good news is that treatment with intramuscular vitamin B12 showed notable clinical improvement. This suggests that B12 may be beneficial for those with similar deficiencies related to nitrous oxide exposure.
7
We explored a case involving a 41-year-old woman who experienced unstable walking due to a vitamin B12 deficiency. Her symptoms were related to subacute combined degeneration of the spinal cord, which affected her nerve health.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
After starting vitamin B12 treatment, we observed significant improvements in her limb weakness and overall muscle strength, recovering to a notable level. This case highlights the critical importance of early diagnosis and intervention for vitamin deficiencies to prevent irreversible nerve damage.
7
We conducted a cross-sectional study with 130 type-2 diabetic patients to explore the connection between diabetic peripheral neuropathy (DPN) and various micronutrients. Using a well-defined screening tool, we identified 28 patients with DPN.
Our results showed a significant association between DPN and both zinc and vitamin B12 levels. However, there was no significant correlation with copper or magnesium levels. This suggests that while zinc and vitamin B12 may play a role in neuropathy among diabetic patients, other micronutrients do not appear to have the same impact.
Our results showed a significant association between DPN and both zinc and vitamin B12 levels. However, there was no significant correlation with copper or magnesium levels. This suggests that while zinc and vitamin B12 may play a role in neuropathy among diabetic patients, other micronutrients do not appear to have the same impact.
4
Vitamin B12's limited neuropathy effects
We explored the impact of vitamin B12 on neuropathy in the context of a unique case presenting with symptoms resembling POEMS syndrome. The patient, a man in his 40s, initially showed signs such as fatigue, imbalance, and painful numbness, which led to a diagnosis focused on vitamin B12 deficiency after initial evaluations.
After a month of treatment, his vitamin B12 levels improved, but unfortunately, there wasn't any significant relief in his neuropathic symptoms. Further investigation revealed he also had a deficiency in vitamin B6, as well as an IgA lambda monoclonal spike, which ultimately contributed to a diagnosis of POEMS syndrome.
This case highlights a vital consideration: while vitamin B12 treatment is essential, it may not always lead to expected improvements in neuropathy symptoms, especially in complex cases involving multiple deficiencies or syndromes like POEMS. Our findings emphasize the importance of a thorough evaluation and management for symptoms that mimic neuropathy, indicating that simply supplementing B12 might not suffice alone.
After a month of treatment, his vitamin B12 levels improved, but unfortunately, there wasn't any significant relief in his neuropathic symptoms. Further investigation revealed he also had a deficiency in vitamin B6, as well as an IgA lambda monoclonal spike, which ultimately contributed to a diagnosis of POEMS syndrome.
This case highlights a vital consideration: while vitamin B12 treatment is essential, it may not always lead to expected improvements in neuropathy symptoms, especially in complex cases involving multiple deficiencies or syndromes like POEMS. Our findings emphasize the importance of a thorough evaluation and management for symptoms that mimic neuropathy, indicating that simply supplementing B12 might not suffice alone.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- El-Najjar SE, Naser IA, Al-Wahidi KM. Is Functional Vitamin B12 Deficiency a Risk Factor for the Development of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients?. Asian Pac J Cancer Prev. 2025;26:375. 10.31557/APJCP.2025.26.2.375
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. 10.7759/cureus.75656
- Kyaw KY, Lwin MT, Lwin ZT. Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report. Cureus. 2024;16:e74383. 10.7759/cureus.74383
- Bandara P, Wijenayake W, Fernando S, Padeniya P, Mettananda S. Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report. BMC Pediatr. 2024;24:622. 10.1186/s12887-024-05106-1
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. 10.11604/pamj.2024.47.164.43048
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. 10.1177/03795721241226886
- Pino S, Vega E, Fragoso M, Salazar G. Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report. Cureus. 2024;16:e63003. 10.7759/cureus.63003
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. 10.59556/japi.72.0493
- Zhu M, Yu C, Xu Z, Zhang H, Huang H. Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report. Medicine (Baltimore). 2024;103:e37605. 10.1097/MD.0000000000037605
- Hu S, Brown-Kunin S, Martin P, Wang Y. Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report. BMC Neurol. 2025;25:54. 10.1186/s12883-025-04069-9
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. 10.1111/1753-0407.70045
- Kulkantrakorn K, Chunhachatrachai P, Kulkantrakorn W. Nitrous oxide abuse and associated neurological diseases. BMC Neurol. 2024;24:461. 10.1186/s12883-024-03966-9
- Hotta K, Mano Y. Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma. J Pharmacol Toxicol Methods. 2024;129:107552. 10.1016/j.vascn.2024.107552
