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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
The product is found useful for the following medical conditions
Anemia
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.8
USERS' SCORE
Good
Based on 8 Reviews
8.8
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Most Relevant Research
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
9.5
Essential for health
Most Useful Review
This high-quality cherry-flavoured supplement supports red blood cell production and helps convert homocysteine to methionine, necessary for DNA synthesis and nerve function. Vitamin B12 prevents pernicious anemia, heart conditions, and aids in treating depression and other ailments. I find the ingredients excellent.
Autoimmune Disorder
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.8
USERS' SCORE
Good
Based on 13 Reviews
8.8
9
Pernicious anemia treatment effectiveness
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
Most Relevant Research
We explored the impact of vitamin B12 treatment on individuals suffering from pernicious anemia, an autoimmune disorder that affects the body’s ability to absorb this essential vitamin. In a recent case report, a 51-year-old man from Uganda presented with lower limb weakness, which had returned after an earlier bout of vitamin B12 deficiency.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
Upon investigation, he was diagnosed with pernicious anemia, a condition that can cause a range of symptoms due to the body’s inability to produce intrinsic factor, crucial for vitamin B12 absorption. After starting parenteral methylcobalamin therapy, we observed significant improvements in his symptoms, highlighting how effective vitamin B12 can be in managing this disorder.
This case emphasizes the need for awareness and timely diagnosis of vitamin B12 deficiency among healthcare providers, especially in resource-limited settings. Such proactive management can lead to recovery and improved quality of life for those affected.
9.5
Pain relief
Most Useful Review
I have rheumatoid arthritis and, in 2010, my pain worsened significantly. I discovered that a gluten-free diet alleviated most of my pain, but I still faced severe discomfort in my feet and hands. After researching B12 deficiency, I started taking Jarrow methyl B12 and I now experience minimal pain. I'm regaining my life.
Back Pain
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
9.5
Pain reduction
Most Useful Review
Changing my life! I have chronic nerve pain, and instead of painkillers, I now use Jarrow B-12 lozenges. Within a week, I've seen a huge increase in my pain tolerance and a noticeable decrease in nerve pain. Jarrow is definitely the superior brand for B-12.
Chronic Fatigue Syndrome
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 14 Reviews
8.7
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Most Relevant Research
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
7.5
Aids absorption
Most Useful Review
I took this vitamin B12 due to a deficiency from gastrointestinal issues. It's delicious with a strawberry flavour, and I’m now repeating at 1000 mcg to help with my chronic fatigue syndrome and overall nutrient absorption.
Depression
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 7 Reviews
8.7
2
Vitamin B12 shows no benefit for depression
Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
Most Relevant Research
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
9.5
Memory improvement
Most Useful Review
My husband had severe memory problems and depression, with low B12 levels. After taking two 5000 B12 a week, we saw a major improvement in his memory and energy levels.
Leg Cramps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Cramps alleviated
Most Useful Review
I am not diabetic, but since taking metformin, I believe my B12 levels have depleted, leading to constant burning in my feet. My restless leg syndrome was at its worst. After a few days of receiving Jarrow B12 5000, I experienced complete relief from the burning within two days of taking one or two tablets daily, and my restless legs improved significantly, allowing me to sleep peacefully. I am extremely grateful for this product—it’s the only thing that has worked!
Arthritis
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.6
USERS' SCORE
Good
Based on 1 Reviews
8.6
9
Vitamin B12 may improve arthritis
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice.
Most Relevant Research
We investigated the effects of vitamin B12 on rheumatoid arthritis, particularly focusing on its impact on peptidylarginine deiminase isoform 4 (PADI-4), an enzyme linked to the disease's progression. Our study revealed that vitamin B12 effectively inhibited this enzyme more than another related enzyme, PADI-2, highlighting its potential as a therapeutic agent.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
We observed that vitamin B12 treatment led to lower overall levels of citrullination, which is important since unregulated citrullination is a common issue in rheumatoid arthritis. Additionally, when hydroxocobalamin, a form of vitamin B12, was administered to mice, it significantly reduced the severity of arthritis symptoms in those with collagen type II antibody induced arthritis (CAIA).
Importantly, we found that vitamin B12 also decreased the expression of various pro-inflammatory factors and cytokines often elevated in rheumatoid arthritis, including IL17A, TNFα, and IL-6. These findings suggest that vitamin B12 may have a beneficial role in managing rheumatoid arthritis, warranting further exploration of its therapeutic potential.
9.5
Pain relief
Most Useful Review
I have suffered from rheumatoid arthritis for over ten years. After discovering that avoiding gluten significantly reduces my pain, I researched further and found a link between peripheral neuropathy, B12 deficiency, and arthritis. I started taking Jarrow methyl B12 from iHerb, and within days, my excruciating pain subsided, allowing me to walk almost pain-free. I've also identified intolerances to other foods, such as tomatoes and strawberries.
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.6
9.5
Health improvement
Most Useful Review
This excellent product helps me stay healthy and fend off the common cold and illnesses. The price is fantastic, and even with delivery to Australia, they are cheaper than what we find here. Thank you so much for your service, providing such wonderful products at great prices.
Dizziness
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Good
Based on 1 Reviews
8.6
9
Vitamin B12 improves dizziness symptoms
Acute presentation of dizziness in vitamin B12 deficient old patient of cardiac disease: a case report.
Most Relevant Research
We observed a fascinating case involving an elderly patient who experienced acute dizziness, ataxia, and imbalance shortly after receiving a pacemaker. Upon investigation, we discovered that her symptoms were linked to a significant deficiency in vitamin B12.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
The patient's vitamin B12 levels were notably low, accompanied by increased plasma homocysteine and methylmalonic acid levels. Despite her neurological symptoms suggesting peripheral neuropathy, her brain scan returned normal results. What stood out to us was the absence of the typical hematological signs often associated with vitamin B12 deficiency.
Importantly, the patient responded remarkably well to treatment with parenteral vitamin B12, leading to a resolution of her dizziness. This case underscores the importance of considering vitamin B12 deficiency, especially in elderly patients who present with neuropsychiatric symptoms. As we reflected on this, it became clear that proper recognition and treatment of vitamin B12 deficiency can significantly influence patient outcomes.
9.5
Dizziness relief
Most Useful Review
A must-have for improving and preventing dizziness!
Fibromyalgia
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin B12 aids fibromyalgia symptoms
Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study.
Most Relevant Research
We aimed to investigate how vitamin B12 can affect the symptoms and overall well-being of fibromyalgia patients. In our study, we worked with individuals diagnosed with fibromyalgia based on established criteria. Participants were given a daily dose of 1000 mcg of oral vitamin B12 to take for fifty days.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
Before and after the treatment period, we assessed the patients' conditions using various questionnaires designed to measure pain severity, anxiety, and overall health. Our findings revealed that this short course of vitamin B12 significantly reduced the severity of fibromyalgia symptoms and improved anxiety levels.
Such results suggest that vitamin B12 could play an important role as an adjunctive therapy for managing fibromyalgia. We believe there is potential for further research in this area to enhance treatment options for individuals living with this condition.
9.5
Vital supplement
Most Useful Review
Excellent product. It’s an essential supplement for managing my Chronic Fatigue and fibromyalgia. I can't live without it.
Insomnia
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Vitamin B12 promotes sleep in rats
Effects of intravenously administered vitamin B12 on sleep in the rat.
Most Relevant Research
We sought to determine the impact of vitamin B12 (VB12) on sleep patterns in rats, particularly considering its potential benefits for those struggling with insomnia. By giving rats a daily intravenous dose of VB12, we monitored their sleep using polysomnographic recordings over a four-day period.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
During our observations, we noticed a significant increase in non-rapid eye movement (NREM) sleep on the second and third days of VB12 administration. Interestingly, REM sleep also showed a notable boost on the second day. The enhancements in sleep were particularly evident during the light period, indicating that vitamin B12 could play a role in promoting sleep at those times.
Additionally, we found that the rats receiving vitamin B12 exhibited serum levels that were 40 times higher than those in control rats, suggesting a robust absorption and impact of the vitamin. Overall, our findings indicate that administering VB12 peripherally does have positive effects on sleep in rats, especially during the light hours.
9.5
Improved sleep quality
Most Useful Review
Great product! I noticed that my brain felt more alert almost immediately. I experienced fewer minor headaches and began sleeping better, despite my insomnia. Plus, it tastes good too!
Ulcer
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.7
USERS' SCORE
Good
Based on 1 Reviews
8.6
9
Genetic insights into ulcer healing
Phenotype puzzle: the role of novel LMBRD1 gene variant in Cbl deficiency causing Dyskeratosis Congenita-like clinical manifestations.
Most Relevant Research
We delved into the complexities surrounding a specific genetic mutation in the LMBRD1 gene, which is linked to a variant form of cobalamin (vitamin B12) deficiency. This study highlighted a 15-year-old male with symptoms typical of Dyskeratosis Congenita, including skin hyperpigmentation and ulcers. After identifying a novel splice site deletion in the gene, we learned that this alteration can heavily impact vitamin B12 metabolism and lead to various clinical manifestations, including ulcers.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
Importantly, we observed the effects of administering intravenous hydroxocobalamin therapy. Following treatment, our findings indicated a notable improvement in the patient's skin hyperpigmentation, angular cheilitis, and the painful aphthous ulcers. While the study primarily focused on genetic factors and treatment responses, the results suggested that vitamin B12 therapy plays a valuable role in alleviating ulcer symptoms. We encourage further exploration to expand our understanding of these relationships and optimize treatment approaches.
9.5
Effective treatment
Most Useful Review
Very helpful for ulcers; after I used it, the ulcers improved significantly.
Anxiety
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
Most Relevant Research
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9.5
Helps reduce anxiety
Most Useful Review
I've swapped my afternoon coffee for this B-12 chewable, which has helped alleviate my anxiety and gastrointestinal issues. It energises me for the afternoon without the jitters or acidity of caffeine. Joy!
Athlete’s Foot
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.3
Neuropathy relief
Most Useful Review
I ordered this to assist with neuropathy in my feet caused by chemotherapy. It has truly helped, and I plan to continue purchasing and using it.
Bone Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.5
7.5
Alleviates bone pain
Most Useful Review
I have consistently used this product. My legs hurt, making it hard to walk. However, since I started taking one tablet each morning and evening, my bone pain has eased significantly. I hope to continue using it for a long time, though a lower price would be great.
Breast Cancer
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.1
USERS' SCORE
Good
Based on 1 Reviews
8.5
7
Vitamin B12 may reduce breast cancer
Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study.
Most Relevant Research
We explored the impact of vitamin B12 supplement use on breast cancer risk among women with BRCA mutations. In a case-control study involving 129 breast cancer patients and 271 healthy controls, we evaluated the relationship between dietary supplements, including folic acid and vitamin B12, and breast cancer incidence.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
Our findings revealed that women who took vitamin B12 supplements showed a significant decrease in breast cancer risk when compared to those who did not use these supplements. Specifically, moderate B12 intake was linked to a 52% reduction in risk.
Importantly, this association was most pronounced in women carrying the BRCA1 mutation. These results suggest that vitamin B12, in conjunction with folic acid supplements, may contribute to a lower risk of developing breast cancer among those genetically predisposed to the disease.
However, we recommend further studies to confirm these findings, as more extensive research with larger participant groups would help solidify our understanding of vitamin B12's benefits in this context.
8
Vitamin B12 support
Most Useful Review
Recommended by my nutritionist to manage low vitamin B12 levels due to breast cancer, and also for my daughter who had bariatric surgery.
Cancer
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 1 Reviews
8.5
7
Vitamin B12 and lymphoma association
Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization.
Most Relevant Research
We aimed to understand how levels of vitamin B12 might influence the risk of developing lymphoma, a type of cancer that affects the lymphatic system. Using data from comprehensive genome-wide association studies, we assessed the potential genetic links between circulating vitamin levels and lymphoma.
Our analysis particularly focused on vitamin B12 along with other vitamins, utilizing robust methods to ensure reliable results. We discovered that higher levels of vitamin B12 showed a noticeable association with a lower risk of lymphoma, indicating that it might play a beneficial role in cancer prevention. Interestingly, we also found similar results for folic acid, suggesting that these vitamins could have important implications for lymphoma risk overall.
However, it's essential to note that while our findings are promising, the evidence isn't definitive. Further research is needed to explore these relationships in greater depth and to understand the mechanisms behind them. Understanding how vitamins like B12 affect cancer could lead to better preventive strategies in the future.
Our analysis particularly focused on vitamin B12 along with other vitamins, utilizing robust methods to ensure reliable results. We discovered that higher levels of vitamin B12 showed a noticeable association with a lower risk of lymphoma, indicating that it might play a beneficial role in cancer prevention. Interestingly, we also found similar results for folic acid, suggesting that these vitamins could have important implications for lymphoma risk overall.
However, it's essential to note that while our findings are promising, the evidence isn't definitive. Further research is needed to explore these relationships in greater depth and to understand the mechanisms behind them. Understanding how vitamins like B12 affect cancer could lead to better preventive strategies in the future.
8
Controls vitamin B12
Most Useful Review
Recommended by my nutritionist to manage low vitamin B12 levels due to cancer and also for my daughter following her bariatric surgery.
Heart Attack
SCIENTIFIC SCORE
Likely Ineffective
Based on 2 Researches
3
USERS' SCORE
Good
Based on 2 Reviews
8.5
4
Vitamin B12 shows no heart attack benefit
Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial.
Most Relevant Research
In a recent study, we delved into the role of homocysteine thiolactone, a metabolite linked to heart disease, in predicting the risk of acute myocardial infarction (AMI). Conducted with a sizable group of 2049 patients suspected of having coronary artery disease (CAD), the trial was meticulously designed as a double-blind clinical intervention.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
Participants were divided randomly into four distinct groups, receiving a combination of folic acid and other B vitamins or a placebo. Notably, we measured urinary levels of homocysteine thiolactone at different points throughout the study to draw correlations with heart attack incidents.
Our analysis revealed that while the homocysteine thiolactone/creatinine ratio was a significant predictor of AMI risk, there was no observable effect from the vitamin B treatments received by participants. This suggests that vitamin B12, when part of a group of B vitamins, did not independently influence the likelihood of having a heart attack.
Ultimately, we found that higher levels of homocysteine thiolactone correlated with a greater risk of AMI, but the combination of vitamin B treatments did not alter this outcome. This points to the potential of homocysteine thiolactone as an important marker in understanding cardiovascular health.
8.8
Prevents heart attack
Most Useful Review
This high-quality supplement has a beneficial composition. The cherry flavour is pleasant, and it aids in improving red blood cell production and reducing homocysteine levels, which are linked to conditions like heart attack. Vitamin B12 is crucial as it eliminates pain and helps prevent pernicious anaemia, heart attack, stroke, and nervous diseases. I find the ingredients to be excellent.
Heart Disease
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 1 Reviews
8.5
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Most Relevant Research
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
8.8
Supports heart health
Most Useful Review
High-quality supplement with a good composition. The cherry flavour is pleasant. I find that it improves haematopoiesis and increases my red blood cell count. Vitamin B12 is crucial; it aids in converting homocysteine to methionine for DNA production and helps prevent heart disease. It also alleviates pain and reduces the risk of pernicious anaemia, heart attack, and stroke. Overall, it supports my treatment for various conditions, including heart disease, and I appreciate the quality of the ingredients.
Sciatica
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Reviews
8.5
9
Vitamin B12 helps alleviate sciatica
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Most Relevant Research
We conducted a double-blind, randomized, placebo-controlled study to explore the effectiveness of intramuscular vitamin B12 in treating low back pain, including cases of sciatica. A total of 60 patients between the ages of 18 and 65, all suffering from mechanical lumbago or sciatic neuritis, participated in the study over a period of time. Each patient had a solid medical history of back pain lasting from 6 months to 5 years, with significant pain intensity measured on a scale.
Throughout the study, both groups showed notable reductions in pain and disability. However, when we compared the active treatment with the placebo, the results favored vitamin B12 significantly; the differences were strikingly marked in measurement tools used for assessing pain and disability. Furthermore, the placebo group reported higher consumption of paracetamol compared to those receiving vitamin B12, indicating that this vitamin could effectively alleviate pain and the need for additional pain relief medications.
Overall, our findings support the potential of vitamin B12 injections in managing low back pain and sciatica for those without signs of nutritional deficiency.
Throughout the study, both groups showed notable reductions in pain and disability. However, when we compared the active treatment with the placebo, the results favored vitamin B12 significantly; the differences were strikingly marked in measurement tools used for assessing pain and disability. Furthermore, the placebo group reported higher consumption of paracetamol compared to those receiving vitamin B12, indicating that this vitamin could effectively alleviate pain and the need for additional pain relief medications.
Overall, our findings support the potential of vitamin B12 injections in managing low back pain and sciatica for those without signs of nutritional deficiency.
8.8
Helps with sciatica
Most Useful Review
I truly enjoy this brand of methylcobalamin. The taste is delightful, making it a hit with the kids. I experience twitchy toes due to my nerves, and this product significantly alleviates that discomfort. I also believe it aids with my sciatica.
Sinusitis
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.8
Eases sinusitis symptoms
Most Useful Review
This product effectively alleviates my chronic rhinitis and sinusitis symptoms. I occasionally take one lozenge as needed, which also gives a subtle boost of clean energy. I've tried other brands but find this one the tastiest and reasonably priced for its high dose.
Stroke
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 1 Reviews
8.5
9
Vitamin B12 alleviates stroke effects
Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.
Most Relevant Research
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
8.8
Reduced homocysteine levels
Most Useful Review
I found it great for lowering levels of an amino acid called homocysteine, which has been associated with chronic issues like heart disease, stroke, and Alzheimer's.
Alzheimer
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6
USERS' SCORE
Good
Based on 3 Reviews
8.4
4
Vitamin B12's limited effect on Alzheimer's
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials.
Most Relevant Research
We explored the potential role of vitamin B12, alongside folic acid, in slowing the progression of Alzheimer's disease (AD) through a meta-analysis of randomized control trials. Our aim was to determine whether these supplements might improve cognitive function, daily life activities, and influence blood homocysteine levels in individuals diagnosed with AD.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
After carefully sifting through studies, we found five that met our criteria. These studies assessed the cognitive changes in participants through the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Additionally, they examined the impact on daily functioning as well as blood homocysteine levels.
The results showed that after six months of treatment, participants taking vitamin B12 and folic acid did experience a slight improvement in MMSE scores compared to those on a placebo. However, there was no significant change in the ADAS-Cog scores, which means some cognitive aspects didn’t show marked improvement. Likewise, daily life functioning did not see any benefits from the supplements.
Importantly, we also noted a significant reduction in blood homocysteine levels following the supplementation, suggesting a biochemical effect of the treatment. Overall, while vitamin B12 shows promise in enhancing some cognitive measures, it does not translate directly into broader cognitive or daily functioning improvements in Alzheimer's patients.
7.8
Quality recommendation
Most Useful Review
This is a very high-quality product. I recommend it for my patients who exhibit mild Alzheimer’s and neurological issues.
Tinnitus
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
8.8
Effective treatment
Most Useful Review
I take vitamin B12 for tinnitus. It is effective as it is hard to supplement through food.
Ear Infection
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.1
5.8
Energy support
Most Useful Review
Excellent for cellular energy and aiding in the formation of red blood cells. I bought this for my nerve and tinnitus issues from a while back. A mate suggested this supplement would assist with my tinnitus. After a month, I feel better; the ringing has reduced somewhat, but tinnitus still persists. I will carry on with the supplements.
Allergies
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8
7
Vitamin B12 hypersensitivity studied
Vitamin B Hypersensitivity: A Retrospective Multicenter Study.
Most Relevant Research
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
9.5
Effective ingredient choices
Most Useful Review
This is an excellent quality product. The carefully selected ingredients did not cause any allergies or negative reactions. The large package size lasts long, with average-sized capsules that have a neutral taste. I noticed improvements within a week; my intestinal function and metabolism have enhanced while my nervous system feels more stable. I have no doubts about its effectiveness in treating allergies.
Sleep Apnea
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 1 Reviews
7.9
2.3
Unsure effect
Most Useful Review
I mentioned it was good for sleep disorder, but it hasn't worked yet. The delivery was faster than expected, taking 2-3 days. I'm uncertain of its effects at this point, as I have been using it for about half a week now. I plan to continue for three months.
Headache
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Researches
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.2
8
Vitamin B12 deficiency linked to migraines
The correlation between vitamin B12 serum levels and migraine: a case-control study.
Most Relevant Research
We conducted a case-control study to investigate the link between vitamin B12 serum levels and migraine, which affects so many people but lacks a fully understood cause. Our research included 90 individuals experiencing migraines—split into those with chronic migraines and those with episodic migraines—matched against 90 healthy participants.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
We measured vitamin B12 serum levels using a reliable testing method and explored how these levels correlated with migraine intensity, as assessed by two measuring scales. Notably, we found that migraine sufferers had significantly lower levels of vitamin B12 compared to those without migraines.
Chronic migraine patients specifically had even lower vitamin B12 levels than their episodic counterparts. Additionally, there was a noteworthy negative correlation; as vitamin B12 levels decreased, the severity of migraine attacks increased. These findings suggest that vitamin B12 deficiency may have an important relationship with migraine experiences, emphasizing the need for further studies to explore this connection in detail.
7.5
Positive effect
Most Useful Review
So far, so good. My husband and I are using these every 3 to 4 days and we both like them. They do take a while to dissolve, but overall, we’ve felt well, and I believe they have been helping my husband with his headaches. All in all, we like this product.
