Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
Most Useful Reviews
9
Bloodwork normalised
9 people found this helpful
I could not find a source for my macrocytic anaemia, so I started taking the Jarrow formula before breakfast every day for better absorption. Six weeks later, my bloodwork was normal for the first time in years. I feel less irritable and have more energy. I take it whole for maximum effect since B12 isn't easily absorbed.
Read More
10
Effective B12
2 people found this helpful
Worked fast for me. I ordered this product because my doctor said I was anaemic and needed B12. I wanted to avoid shots. Within a week, I had my blood tested and the analysis showed my hemoglobin was normal. After a couple of months, my B12 level was off the charts at 2000mcg—very impressed with the absorbability.
Read More
9
Essential for health
1 people found this helpful
This high-quality cherry-flavoured supplement supports red blood cell production and helps convert homocysteine to methionine, necessary for DNA synthesis and nerve function. Vitamin B12 prevents pernicious anemia, heart conditions, and aids in treating depression and other ailments. I find the ingredients excellent.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
- All Researches
9.5
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9.5
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Read More
9
We explored a case of a 3-year-old girl diagnosed with Imerslund-Gräsbeck syndrome, a condition that causes vitamin B12 malabsorption and leads to anemia. After identifying novel mutations in the AMN gene, we initiated long-term oral vitamin B12 therapy.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
Read More
9
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Bloodwork normalised
9 people found this helpful
I could not find a source for my macrocytic anaemia, so I started taking the Jarrow formula before breakfast every day for better absorption. Six weeks later, my bloodwork was normal for the first time in years. I feel less irritable and have more energy. I take it whole for maximum effect since B12 isn't easily absorbed.
Read More
10
Effective B12
2 people found this helpful
Worked fast for me. I ordered this product because my doctor said I was anaemic and needed B12. I wanted to avoid shots. Within a week, I had my blood tested and the analysis showed my hemoglobin was normal. After a couple of months, my B12 level was off the charts at 2000mcg—very impressed with the absorbability.
Read More
9
Essential for health
1 people found this helpful
This high-quality cherry-flavoured supplement supports red blood cell production and helps convert homocysteine to methionine, necessary for DNA synthesis and nerve function. Vitamin B12 prevents pernicious anemia, heart conditions, and aids in treating depression and other ailments. I find the ingredients excellent.
Read More
9
Life-changing effects
1 people found this helpful
This product has positively transformed my life. I suffer from chronic nerve pain, and turning to Jarrow B-12 lozenges instead of painkillers has significantly increased my pain tolerance and decreased my discomfort after just a week. I have already noticed a substantial improvement.
Read More
9
Enhanced vitality
1 people found this helpful
After being diagnosed with anemia and having low B12 absorption, I felt lethargic and unwell. Switching to this product has made a remarkable difference; I now have more energy and can breathe easier. After four months, my B12 levels improved significantly, allowing me to reduce my dosage.
Read More
Frequently Asked Questions
7.5
Improved hemoglobin
16 people found this helpful
Anemia has significantly improved within a month of starting this supplement. My previous hemoglobin levels were 12.8, now they are 14.0, and red blood cell count increased from 358 to 390. Since the iron supplement showed no effect, this product came as a surprise. I plan to continue using it.
9
Life-changing effects
1 people found this helpful
This product has positively transformed my life. I suffer from chronic nerve pain, and turning to Jarrow B-12 lozenges instead of painkillers has significantly increased my pain tolerance and decreased my discomfort after just a week. I have already noticed a substantial improvement.
7.5
Quick improvement
1 people found this helpful
I take this supplement with my anemia medication, and my levels seem to improve rapidly. It's proving to be effective.
9
Enhanced vitality
1 people found this helpful
After being diagnosed with anemia and having low B12 absorption, I felt lethargic and unwell. Switching to this product has made a remarkable difference; I now have more energy and can breathe easier. After four months, my B12 levels improved significantly, allowing me to reduce my dosage.
7.5
Vital for energy
2 people found this helpful
B vitamins, particularly B9 and B12, must be monitored. The methylcobalamin form has excellent bioavailability and is beneficial alongside iron for those with anemia. B12 energises our cells, making it a vital nutrient.
8
This case explores the journey of a 40-year-old woman who suffered from various nonspecific symptoms, mistakenly attributed to other health issues, for ten years. Her vitamin B12 levels were critically low, ultimately diagnosed as pernicious anemia.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
8
We explored a case involving a 51-year-old Ugandan man who experienced recurring lower limb weakness and was ultimately diagnosed with pernicious anemia. His condition stemmed from vitamin B12 deficiency, confirmed by blood tests showing macrocytic anemia and low cobalamin levels.
With treatment using methylcobalamin injections, he showed significant improvement. This case emphasizes the need for heightened awareness of vitamin B12 deficiency in diagnosing anemia, especially in areas with limited health resources.
With treatment using methylcobalamin injections, he showed significant improvement. This case emphasizes the need for heightened awareness of vitamin B12 deficiency in diagnosing anemia, especially in areas with limited health resources.
7
We sought to understand how effective vitamin B12 is in treating anemia in children. Our focus was on comparing two different methods of supplementation: parenteral (injections) and oral (pills). While previous studies in adults suggested both methods might have similar benefits, we found limited data for children, prompting our thorough investigation.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
8
We investigated the prevalence of pernicious anemia (PA) as a cause of cobalamin (vitamin B12) deficiency in patients with megaloblastic anemia in Hainan, China. By testing 90 patients, we found that over 80% were diagnosed with PA.
During the follow-up period, those receiving consistent B12 therapy showed no relapse, while interruptions led to a significant relapse rate. Our findings suggest that screening for PA is crucial and highlight the importance of ongoing B12 supplementation for affected patients.
During the follow-up period, those receiving consistent B12 therapy showed no relapse, while interruptions led to a significant relapse rate. Our findings suggest that screening for PA is crucial and highlight the importance of ongoing B12 supplementation for affected patients.
9.5
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
9
We explored how vitamin B12 affects anemia, specifically through its role in correcting deficiencies. The research analyzes oral B12 intake and its absorption, particularly in individuals showing signs of deficiency.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. doi:10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x
- Shen M, Luo X, Wu C, Wang J, Wang Z, et al. Pernicious anemia is a common cause of cobalamin deficiency-caused megaloblastic anemia in Hainan, China. Hematology. 2024;29:2399375. doi:10.1080/16078454.2024.2399375
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. doi:10.1007/s00277-024-05878-7
- Song JH, Park SH, Cho M, Kim YM, Hyung WJ, et al. Proximal Gastrectomy Is Associated with Lower Incidence of Anemia and Vitamin B12 Deficiency Compared to Total Gastrectomy in Patients with Upper Gastric Cancer. Cancer Res Treat. 2025;57:174. doi:10.4143/crt.2024.319
- Lacombe V, Vinatier E, Roquin G, Copin MC, Delattre E, et al. Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study. Am J Clin Nutr. 2024;120:217. doi:10.1016/j.ajcnut.2024.05.019
- Chakrabarti S, Ajjampur SSR, Waddington HS, Kishore A, Nguyen PH, et al. Deworming and micronutrient status by community open defecation prevalence: An observational study using nationally representative data from India, 2016-2018. PLoS Med. 2024;21:e1004402. doi:10.1371/journal.pmed.1004402
- Sawada Y, Sakamoto K, Tsukamura A, Sawai C. Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet. Int J Hematol. 2024;119:613. doi:10.1007/s12185-024-03759-3
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. doi:10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. doi:10.1007/s13668-025-00622-7
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. doi:10.7759/cureus.75800
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. doi:10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. doi:10.3389/fnut.2024.1493593
