Reviewed By
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Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
USERS' SCORE
Good
Based on 10 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
Most Useful Reviews
9
Normalcy restored
100 people found this helpful
This worked wonders for my anxiety! After switching to a vegan diet, my anxiety grew worse until I started taking Methyl-B12. Nearly immediately, my stress diminished, allowing me to sleep better and enjoy life again. I'm incredibly grateful for this supplement's impact on my daily motivation and general wellbeing.
Read More
9
Vanquished depression
64 people found this helpful
This absolutely eliminated my depression. Upon recognising symptoms of low histamine, I tried numerous treatments without success. After deciding to switch to the B12 route, I felt immediate happiness and motivation. It's so surprising how quickly this worked, improving my energy and joy in life. If you have similar low histamine issues, I highly recommend it.
Read More
7.5
Better sleep quality
8 people found this helpful
This is a great natural sleep aid and anxiety reducer, especially for those who avoid meat. I did my research before trying Jarrow B12 and found it effectively improves my profound sleep and helps control my anxiety the next day. It doesn't make me groggy, unlike some alternatives, and truly supports restful sleep.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.4
- All Researches
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
Read More
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
7
We set out to understand how Vitamin B affects behavior and brain chemistry in rats experiencing depression due to stress. In our study, 72 rats were divided into three groups: a control group, a group under stress, and a group under stress receiving Vitamin B injections.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Read More
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normalcy restored
100 people found this helpful
This worked wonders for my anxiety! After switching to a vegan diet, my anxiety grew worse until I started taking Methyl-B12. Nearly immediately, my stress diminished, allowing me to sleep better and enjoy life again. I'm incredibly grateful for this supplement's impact on my daily motivation and general wellbeing.
Read More
9
Vanquished depression
64 people found this helpful
This absolutely eliminated my depression. Upon recognising symptoms of low histamine, I tried numerous treatments without success. After deciding to switch to the B12 route, I felt immediate happiness and motivation. It's so surprising how quickly this worked, improving my energy and joy in life. If you have similar low histamine issues, I highly recommend it.
Read More
7.5
Better sleep quality
8 people found this helpful
This is a great natural sleep aid and anxiety reducer, especially for those who avoid meat. I did my research before trying Jarrow B12 and found it effectively improves my profound sleep and helps control my anxiety the next day. It doesn't make me groggy, unlike some alternatives, and truly supports restful sleep.
Read More
0
Risk of anxiety
3 people found this helpful
This caused extreme anxiety and heart palpitations. I experienced serious side effects, including a spike in blood pressure leading my doctor to suggest anxiety medication. After discontinuing, my pulse and anxiety levels returned to normal. My experience may warn others about potential adverse effects.
Read More
7.5
Anxiety relief
1 people found this helpful
Helps with anxiety. It hasn't eliminated it entirely but has undoubtedly made a difference.
Read More
Frequently Asked Questions
9
Best for anxiety
This is my third purchase and it truly lives up to the reputation. Taking it first thing in the morning helps manage my stress and anxiety effectively.
9
Helps reduce anxiety
I've swapped my afternoon coffee for this B-12 chewable, which has helped alleviate my anxiety and gastrointestinal issues. It energises me for the afternoon without the jitters or acidity of caffeine. Joy!
4
Reduces anxiety
I purchased this to lower homocysteine and noticed a reduction in anxiety alongside other supplements like TMG and garlic. It effectively lowers homocysteine, although I experienced side effects like anxiety and depression, leading me to consider adjusting the dose due to possible hypermethylation.
7.5
Supports anxiety relief
This product is beneficial for anxiety. It supports health, provides energy, and notably tastes good too.
7
B12 in supplement shows promise
We explored the effect of a supplement known as Mg-Teadiola, which includes magnesium and B vitamins, on anxiety in people experiencing chronic stress. Over 28 days, 40 participants took either the supplement or a placebo.
Our findings revealed that those who took Mg-Teadiola showed a notable reduction in anxiety-related symptoms and changes in brain activity in response to stress. The group taking the supplement reported improved quality of life and a decrease in their stress scores, though further research is needed to fully understand its benefits on anxiety.
Our findings revealed that those who took Mg-Teadiola showed a notable reduction in anxiety-related symptoms and changes in brain activity in response to stress. The group taking the supplement reported improved quality of life and a decrease in their stress scores, though further research is needed to fully understand its benefits on anxiety.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
4
We explored the impact of high-dose Vitamin B6 and B12 supplementation on anxiety in a double-blind study involving 478 young adults. Participants reported their anxiety and depression levels before and after taking the supplements for a month.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
7
We set out to explore the role of serum vitamin B12 levels in relation to anxiety disorders, using a robust methodology that involved genetic data analysis. By pulling information from large-scale genome-wide association studies, we focused on identifying potential causal relationships between vitamin B12 and anxiety symptoms.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
7
B12 treatment showed no significant anxiety benefit
We evaluated the effectiveness of B12, along with other B vitamins, in managing anxiety symptoms in patients suffering from Post-COVID-19 syndrome (PC19S). The PreVitaCOV trial was carefully designed as a phase IIIb study with a double-blind, placebo-controlled structure. While over half of participants showed a notable improvement in other symptoms, B12 treatment did not demonstrate significant benefits specifically for anxiety.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
This highlights the need for further research into effective anxiety treatments following COVID-19 infections.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
- Al Jassem O, Kheir K, Ismail A, Abou-Abbas L, Masri A, et al. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores. PLoS One. 2024;19:e0297976. 10.1371/journal.pone.0297976
- Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. 10.1186/s12879-023-08925-2
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Young LM, Gauci S, Arnoldy L, Martin L, Perry N, et al. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients. 2022;14. 10.3390/nu14235079
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. 10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. 10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. 10.2147/NDT.S399378
