' 
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
Vitamin B12 aids colitis treatment
Vitamin B12 ameliorates gut epithelial injury via modulating the HIF-1 pathway and gut microbiota.
High relevance to IBD management
We constructed a Drosophila model that simulates the recurrent intestinal injuries seen in inflammatory bowel diseases (IBDs) to explore the potential benefits of vitamin B12 (VB12) in treating colitis. Our findings showed that VB12 can effectively protect the intestinal barrier and reduce damage caused by factors like dextran sulfate sodium.
Additionally, we observed that VB12 helps restore balance in gut microbiota, reducing the growth of harmful gram-negative bacteria. This improvement in gut health appears to be linked to the activation of the hypoxia-inducible factor-1 (HIF-1) signaling pathway, which VB12 seems to influence during injury.
To further validate our results, we also tested VB12's protective effects in a murine acute colitis model, showing consistent beneficial impacts. Overall, we provide new insights on how vitamin B12 could play a supportive role in managing flare-ups of recurrent IBDs, particularly colitis.
Additionally, we observed that VB12 helps restore balance in gut microbiota, reducing the growth of harmful gram-negative bacteria. This improvement in gut health appears to be linked to the activation of the hypoxia-inducible factor-1 (HIF-1) signaling pathway, which VB12 seems to influence during injury.
To further validate our results, we also tested VB12's protective effects in a murine acute colitis model, showing consistent beneficial impacts. Overall, we provide new insights on how vitamin B12 could play a supportive role in managing flare-ups of recurrent IBDs, particularly colitis.
Read More
5
Vitamin B12's effects on colitis
Protective role of vitamin B12 on acetic acid induced colitis in rats.
Directly investigates vitamin B12
We examined the effects of vitamin B12 on colitis induced by acetic acid in a structured study with control groups, allowing us to observe its potential protective benefits. After inducing colitis in rats, we administered vitamin B12 at a dose of 1 mg/kg for three consecutive days.
After four days, we sacrificed the rats to analyze their colonic tissues for both macroscopic and microscopic damage. While we noticed some improvement in the colon tissues of those treated with vitamin B12, the inflammation severity was reduced but not significantly compared to the control group.
Biochemical analysis showed that levels of certain inflammatory markers did not change between groups, which suggests that vitamin B12 may not have a strong therapeutic effect for colitis overall. However, we did find significant differences in levels of IL-6 and GSH, indicating some potential interaction.
Ultimately, our findings imply that while vitamin B12 is often discussed for its nutritional benefits, its role in treating inflammatory bowel disease remains controversial and may need further investigation.
After four days, we sacrificed the rats to analyze their colonic tissues for both macroscopic and microscopic damage. While we noticed some improvement in the colon tissues of those treated with vitamin B12, the inflammation severity was reduced but not significantly compared to the control group.
Biochemical analysis showed that levels of certain inflammatory markers did not change between groups, which suggests that vitamin B12 may not have a strong therapeutic effect for colitis overall. However, we did find significant differences in levels of IL-6 and GSH, indicating some potential interaction.
Ultimately, our findings imply that while vitamin B12 is often discussed for its nutritional benefits, its role in treating inflammatory bowel disease remains controversial and may need further investigation.
Read More
4
Vitamin B12's complex gut effects
Vitamin B12 Deficiency Alters the Gut Microbiota in a Murine Model of Colitis.
Focused study on vitamin B12
We explored how vitamin B12 influences gut health, particularly in the context of colitis. Using a murine model, we divided young mice into three groups based on their dietary intake of vitamin B12: sufficient, deficient, and supplemented. After supplementing with varying levels of vitamin B12 for four weeks, we induced colitis using a common agent called dextran sodium sulfate.
Despite our thorough investigation, we found no significant changes in the gut microbiota composition among healthy mice based on their vitamin B12 levels. However, in mice that experienced DSS-induced colitis, a substantial number of bacterial genera were altered in those that were vitamin B12 deficient. Intriguingly, while vitamin B12 levels did not noticeably affect colitis severity scores, the mice on a B12-deficient diet displayed less epithelial tissue damage following colitis induction.
In conclusion, while vitamin B12 supplementation did not change the gut microbiota in healthy conditions, it played a role in how the gut responded to inflammation caused by colitis. This suggests that while B12 might not prevent colitis, it could influence microbial reactions post-injury.
Despite our thorough investigation, we found no significant changes in the gut microbiota composition among healthy mice based on their vitamin B12 levels. However, in mice that experienced DSS-induced colitis, a substantial number of bacterial genera were altered in those that were vitamin B12 deficient. Intriguingly, while vitamin B12 levels did not noticeably affect colitis severity scores, the mice on a B12-deficient diet displayed less epithelial tissue damage following colitis induction.
In conclusion, while vitamin B12 supplementation did not change the gut microbiota in healthy conditions, it played a role in how the gut responded to inflammation caused by colitis. This suggests that while B12 might not prevent colitis, it could influence microbial reactions post-injury.
Read More
Most Useful Reviews
10
B12 levels normalised
It works – I have the numbers to prove it. I have ulcerative colitis, which prevents me from absorbing B12 properly. Last year my B12 was very low (136) and I received injections to bring it up to 1100. I didn't realise I needed to keep taking B12 and stopped, resulting in a level of 214 after nine months. Wanting to avoid injections again, I asked my doctor about oral supplements. He was sceptical but I decided to try these pills daily for three months. When tested again, my level was at 1350! I couldn’t believe it and intend to take these permanently. The injection therapy cost around $800, so I'm thrilled these work!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.8
- All Researches
9
Vitamin B12 aids colitis treatment
Vitamin B12 ameliorates gut epithelial injury via modulating the HIF-1 pathway and gut microbiota.
High relevance to IBD management
We constructed a Drosophila model that simulates the recurrent intestinal injuries seen in inflammatory bowel diseases (IBDs) to explore the potential benefits of vitamin B12 (VB12) in treating colitis. Our findings showed that VB12 can effectively protect the intestinal barrier and reduce damage caused by factors like dextran sulfate sodium.
Additionally, we observed that VB12 helps restore balance in gut microbiota, reducing the growth of harmful gram-negative bacteria. This improvement in gut health appears to be linked to the activation of the hypoxia-inducible factor-1 (HIF-1) signaling pathway, which VB12 seems to influence during injury.
To further validate our results, we also tested VB12's protective effects in a murine acute colitis model, showing consistent beneficial impacts. Overall, we provide new insights on how vitamin B12 could play a supportive role in managing flare-ups of recurrent IBDs, particularly colitis.
Additionally, we observed that VB12 helps restore balance in gut microbiota, reducing the growth of harmful gram-negative bacteria. This improvement in gut health appears to be linked to the activation of the hypoxia-inducible factor-1 (HIF-1) signaling pathway, which VB12 seems to influence during injury.
To further validate our results, we also tested VB12's protective effects in a murine acute colitis model, showing consistent beneficial impacts. Overall, we provide new insights on how vitamin B12 could play a supportive role in managing flare-ups of recurrent IBDs, particularly colitis.
Read More
8
Vitamin B12 aids colitis recovery
Vitamin B is a limiting factor for induced cellular plasticity and tissue repair.
Vitamin B's effects are unclear
Our exploration of vitamin B12's effect on colitis treatment reveals important insights. Through our research, we observed that vitamin B12 supplementation increased the overall effectiveness of reprogramming in mice, leading to enhanced recovery from ulcerative colitis.
Although the study emphasized the impact of vitamin B, it did not specifically isolate vitamin B12 from other contributing factors that may have influenced treatment outcomes. This means while we can appreciate the potential benefits of vitamin B in supporting tissue repair, particularly in cases of ulcerative colitis, we must acknowledge that more focused studies are needed to determine the specific role of vitamin B12.
Overall, the relationship between vitamin B levels and efficient tissue repair suggests a promising area of study, especially as we seek to better understand how we can support healing processes in inflammatory bowel diseases.
Although the study emphasized the impact of vitamin B, it did not specifically isolate vitamin B12 from other contributing factors that may have influenced treatment outcomes. This means while we can appreciate the potential benefits of vitamin B in supporting tissue repair, particularly in cases of ulcerative colitis, we must acknowledge that more focused studies are needed to determine the specific role of vitamin B12.
Overall, the relationship between vitamin B levels and efficient tissue repair suggests a promising area of study, especially as we seek to better understand how we can support healing processes in inflammatory bowel diseases.
Read More
8
Acquired ichthyosis and colitis link
Acquired Ichthyosis Revealing Lymphocytic Colitis.
Moderate relevance to colitis treatment
We observed a fascinating case involving a 69-year-old man who initially presented with severe skin dryness known as acquired ichthyosis, along with changes in bowel habits. After experiencing intense itching and skin scaling, he also reported watery diarrhea and mild steatorrhea. Our investigation included skin biopsies that confirmed the ichthyosis diagnosis, but we also uncovered signs of lymphocytic colitis through further testing.
In our examination of his condition, laboratory tests showed a low serum vitamin B12 level alongside mild anemia and hypoalbuminemia, but notably, we found that other autoimmune markers were normal. Despite the low vitamin B12, we did not find evidence that it played a direct role in improving the colitis symptoms. His treatment included salazopyrin, which resulted in a significant improvement in both his diarrhea and skin condition over four weeks.
This case is intriguing as it connects two seemingly unrelated conditions, and it highlights the importance of comprehensive evaluations in dermatology and gastroenterology. While the vitamin B12 level was low, our findings suggest no significant benefit directly attributed to its treatment in alleviating colitis symptoms. Rather, it was the salazopyrin that led to marked improvement.
In our examination of his condition, laboratory tests showed a low serum vitamin B12 level alongside mild anemia and hypoalbuminemia, but notably, we found that other autoimmune markers were normal. Despite the low vitamin B12, we did not find evidence that it played a direct role in improving the colitis symptoms. His treatment included salazopyrin, which resulted in a significant improvement in both his diarrhea and skin condition over four weeks.
This case is intriguing as it connects two seemingly unrelated conditions, and it highlights the importance of comprehensive evaluations in dermatology and gastroenterology. While the vitamin B12 level was low, our findings suggest no significant benefit directly attributed to its treatment in alleviating colitis symptoms. Rather, it was the salazopyrin that led to marked improvement.
Read More
7
Vitamin B12's mixed colitis effects
Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats.
Combination effects limit assessment
We explored the effects of various B vitamins, including vitamin B12, on acute colitis induced in rats. The study involved administering high doses of thiamine, riboflavin, pyridoxine, and cyanocobalamin—vitamin B12—intraperitoneally over a period of five days. Additionally, a lower dose of these vitamins was given for a longer duration to see if this change influenced the inflammation associated with colitis.
Although we observed some benefits in reducing inflammation and healing properties with the B vitamins combined, vitamin B12's effects were hard to isolate due to its use in combination with other vitamins. While it showed some therapeutic potential, vitamin B12 alone didn’t stand out significantly in improving the pathological features of colitis compared to other treatments.
Overall, the findings suggest that these selected B vitamins may help alleviate symptoms of colitis, but further research is needed to clarify how much vitamin B12, specifically, contributes to these improvements in the context of this condition.
Although we observed some benefits in reducing inflammation and healing properties with the B vitamins combined, vitamin B12's effects were hard to isolate due to its use in combination with other vitamins. While it showed some therapeutic potential, vitamin B12 alone didn’t stand out significantly in improving the pathological features of colitis compared to other treatments.
Overall, the findings suggest that these selected B vitamins may help alleviate symptoms of colitis, but further research is needed to clarify how much vitamin B12, specifically, contributes to these improvements in the context of this condition.
Read More
5
Vitamin B12's effects on colitis
Protective role of vitamin B12 on acetic acid induced colitis in rats.
Directly investigates vitamin B12
We examined the effects of vitamin B12 on colitis induced by acetic acid in a structured study with control groups, allowing us to observe its potential protective benefits. After inducing colitis in rats, we administered vitamin B12 at a dose of 1 mg/kg for three consecutive days.
After four days, we sacrificed the rats to analyze their colonic tissues for both macroscopic and microscopic damage. While we noticed some improvement in the colon tissues of those treated with vitamin B12, the inflammation severity was reduced but not significantly compared to the control group.
Biochemical analysis showed that levels of certain inflammatory markers did not change between groups, which suggests that vitamin B12 may not have a strong therapeutic effect for colitis overall. However, we did find significant differences in levels of IL-6 and GSH, indicating some potential interaction.
Ultimately, our findings imply that while vitamin B12 is often discussed for its nutritional benefits, its role in treating inflammatory bowel disease remains controversial and may need further investigation.
After four days, we sacrificed the rats to analyze their colonic tissues for both macroscopic and microscopic damage. While we noticed some improvement in the colon tissues of those treated with vitamin B12, the inflammation severity was reduced but not significantly compared to the control group.
Biochemical analysis showed that levels of certain inflammatory markers did not change between groups, which suggests that vitamin B12 may not have a strong therapeutic effect for colitis overall. However, we did find significant differences in levels of IL-6 and GSH, indicating some potential interaction.
Ultimately, our findings imply that while vitamin B12 is often discussed for its nutritional benefits, its role in treating inflammatory bowel disease remains controversial and may need further investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
B12 levels normalised
It works – I have the numbers to prove it. I have ulcerative colitis, which prevents me from absorbing B12 properly. Last year my B12 was very low (136) and I received injections to bring it up to 1100. I didn't realise I needed to keep taking B12 and stopped, resulting in a level of 214 after nine months. Wanting to avoid injections again, I asked my doctor about oral supplements. He was sceptical but I decided to try these pills daily for three months. When tested again, my level was at 1350! I couldn’t believe it and intend to take these permanently. The injection therapy cost around $800, so I'm thrilled these work!
Read More
