Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.7
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 2 Capsule
Amount Per Serving
%DV
Sulforaphane Glucosinolate(from Broccoli Seed Extract [Brassica oleracea L. Italica] in a Proprietary Blend Containing Myrosinase Enzyme)
35 mg
†
Top Medical Research Studies
9.5
We examined how broccoli, specifically its sprouts and bioactive compounds, might help in cancer prevention, particularly against aggressive brain tumors known as gliomas. Utilizing a C6 rat glioma model, we discovered that administering broccoli sprout extracts significantly slowed tumor growth when given before cancer introduction.
While the results are encouraging for future research, it's important to note that these findings stem from animal studies and not humans. Nonetheless, this study advocates for the inclusion of broccoli in our diets due to its potential health benefits.
While the results are encouraging for future research, it's important to note that these findings stem from animal studies and not humans. Nonetheless, this study advocates for the inclusion of broccoli in our diets due to its potential health benefits.
Read More
8
We explored the connection between broccoli consumption and cancer risk through a detailed meta-analysis of observational studies. By reviewing multiple databases and assessing potential biases, we found that people diagnosed with cancer generally consumed less broccoli.
The results indicate a protective effect, particularly highlighted in case-control studies, suggesting that higher broccoli intake may lower cancer risk. However, we acknowledge that these findings aren't definitive and further cohort studies are needed to fully understand broccoli's impact on various types of cancer.
The results indicate a protective effect, particularly highlighted in case-control studies, suggesting that higher broccoli intake may lower cancer risk. However, we acknowledge that these findings aren't definitive and further cohort studies are needed to fully understand broccoli's impact on various types of cancer.
Read More
8
Cooking enhances broccoli's anti-cancer properties
We investigated how heating broccoli affects its health benefits, particularly focusing on a compound called indole-3-carbinol (I3C). This study revealed that cooking promotes unique transformations of I3C into various beneficial indole compounds. Among these, a novel compound known as DIM-1 showed promise in inhibiting cancer cell growth. Despite these findings, it’s important to note that further research is needed to fully understand the implications of DIM-1 as an anti-cancer agent. This study enhances our knowledge about the potential health benefits of cooking broccoli.
Read More
Most Useful Reviews
9
Promising for prostate
61 people found this helpful
Prostate Cancer Sufferers. This is a great product for prostate cancer sufferers. It shows promise in eradicating prostate cancer cells and lowering PSA levels. pcspes.net will address all your queries regarding alternative therapy for prostate cancer, and I have faith in them. Undoubtedly, PCSPES and POMI10x are the most effective supplements I’ve encountered.
Read More
9
Success against cancer
36 people found this helpful
Broccomax. I have experienced great success in combating my stage IV cancer over the past two years. Why is it so difficult to find these at a reasonable price now?
Read More
9
Effective for breast cancer
34 people found this helpful
I've been taking this supplement since early 2018 after researching alternative therapies for breast cancer. Recommended to control cancer-causing estrogens, I’ve adjusted my dosage to adapt to my stomach. Taking three doses before meals, I've had clear scans and attribute my well-being to this product alongside healthy eating and exercise.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.7
- All Researches
9.5
We examined how broccoli, specifically its sprouts and bioactive compounds, might help in cancer prevention, particularly against aggressive brain tumors known as gliomas. Utilizing a C6 rat glioma model, we discovered that administering broccoli sprout extracts significantly slowed tumor growth when given before cancer introduction.
While the results are encouraging for future research, it's important to note that these findings stem from animal studies and not humans. Nonetheless, this study advocates for the inclusion of broccoli in our diets due to its potential health benefits.
While the results are encouraging for future research, it's important to note that these findings stem from animal studies and not humans. Nonetheless, this study advocates for the inclusion of broccoli in our diets due to its potential health benefits.
Read More
8
Broccoli compound alters cancer metabolism
We explored how a sulfur compound found in broccoli, called S-methyl methanethiosulfonate (MMTSO), affects prostate cancer cells. In our study, we cultured prostate cancer cells in varying glucose environments while introducing MMTSO. We found that MMTSO reduces certain metabolic processes in the cancer cells, steering them towards a less aggressive state. Despite this, S-methyl-L-cysteine-sulfoxide (SMCSO), another compound associated with broccoli, did not show similar effects. Our findings suggest potential health benefits of a broccoli-rich diet in terms of energy metabolism and cancer treatment.
Read More
8
We explored the effects of sulforaphane (SFN), a compound found in broccoli, on multiple myeloma (MM) cell-induced osteoclast differentiation. Using conditional mediums from MM cells, we noticed that SFN inhibited the processes that lead to osteoclast formation and macrophage proliferation.
Our findings suggest that SFN elevates ferroportin1 levels, reducing iron overload linked to osteoclast differentiation. This research points to SFN as a potential therapeutic strategy for managing osteolysis in MM patients, showcasing broccoli's promising role in cancer treatment.
Our findings suggest that SFN elevates ferroportin1 levels, reducing iron overload linked to osteoclast differentiation. This research points to SFN as a potential therapeutic strategy for managing osteolysis in MM patients, showcasing broccoli's promising role in cancer treatment.
Read More
8
Whey protein enhances sulforaphane stability
We observed that sulforaphane, a key compound in broccoli known for its anticancer properties, can be difficult to use clinically due to its instability. To tackle this, we focused on enhancing its stability and absorption through microencapsulation with whey and pea protein.
Our findings revealed that sulforaphane's bioaccessibility and bioavailability were significantly higher when encapsulated with whey protein compared to pea protein or dried broccoli. Whey protein made sulforaphane 67.7% bioaccessible and 54.4% bioavailable, indicating its potential in developing effective cancer-fighting nutraceuticals.
Our findings revealed that sulforaphane's bioaccessibility and bioavailability were significantly higher when encapsulated with whey protein compared to pea protein or dried broccoli. Whey protein made sulforaphane 67.7% bioaccessible and 54.4% bioavailable, indicating its potential in developing effective cancer-fighting nutraceuticals.
Read More
8
Broccoli-based bionanocomposite against cancer
We explored the effectiveness of a new bionanocomposite made from chitosan, broccoli extract, and zinc oxide nanoparticles in combating human osteosarcoma. Using several techniques, we thoroughly examined its properties and tested its cytotoxic effects on bone cancer cells.
The results were promising, demonstrating that our bionanocomposite effectively reduces cancer cell viability. It showed an IC50 value of 115 μg/mL, indicating its potential as a valuable chemotherapeutic agent in treating osteosarcoma.
This innovative approach highlights the possibilities for using natural extracts in cancer therapies, paving the way for future biological applications.
The results were promising, demonstrating that our bionanocomposite effectively reduces cancer cell viability. It showed an IC50 value of 115 μg/mL, indicating its potential as a valuable chemotherapeutic agent in treating osteosarcoma.
This innovative approach highlights the possibilities for using natural extracts in cancer therapies, paving the way for future biological applications.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Promising for prostate
61 people found this helpful
Prostate Cancer Sufferers. This is a great product for prostate cancer sufferers. It shows promise in eradicating prostate cancer cells and lowering PSA levels. pcspes.net will address all your queries regarding alternative therapy for prostate cancer, and I have faith in them. Undoubtedly, PCSPES and POMI10x are the most effective supplements I’ve encountered.
Read More
9
Success against cancer
36 people found this helpful
Broccomax. I have experienced great success in combating my stage IV cancer over the past two years. Why is it so difficult to find these at a reasonable price now?
Read More
9
Effective for breast cancer
34 people found this helpful
I've been taking this supplement since early 2018 after researching alternative therapies for breast cancer. Recommended to control cancer-causing estrogens, I’ve adjusted my dosage to adapt to my stomach. Taking three doses before meals, I've had clear scans and attribute my well-being to this product alongside healthy eating and exercise.
Read More
9
Healthy cell replication
Sulforaphane, found in Broccoli, induces liver enzymes crucial for detoxification, aiding cell replication and promoting liver health. It is a source of vital nutrients and helps prevent various cancers, including gastrointestinal and breast cancer. Each capsule has sustained-release sulforaphane, essential for protecting DNA and combating free radicals.
Read More
9
Life-saving recommendation
110 people found this helpful
Great stuff! I credit it with helping to keep me alive as I battle stage IV prostate cancer. I recommended it to a friend with a different cancer, and it has helped her too.
Read More
Frequently Asked Questions
9
Healthy cell replication
Sulforaphane, found in Broccoli, induces liver enzymes crucial for detoxification, aiding cell replication and promoting liver health. It is a source of vital nutrients and helps prevent various cancers, including gastrointestinal and breast cancer. Each capsule has sustained-release sulforaphane, essential for protecting DNA and combating free radicals.
7.5
Anti-cancer effects
Broccomax offers impressive antioxidant, anti-aging, and anti-cancer benefits. It’s a valuable supplement for overall health.
8
We explored the effects of sulforaphane (SFN), a compound found in broccoli, on multiple myeloma (MM) cell-induced osteoclast differentiation. Using conditional mediums from MM cells, we noticed that SFN inhibited the processes that lead to osteoclast formation and macrophage proliferation.
Our findings suggest that SFN elevates ferroportin1 levels, reducing iron overload linked to osteoclast differentiation. This research points to SFN as a potential therapeutic strategy for managing osteolysis in MM patients, showcasing broccoli's promising role in cancer treatment.
Our findings suggest that SFN elevates ferroportin1 levels, reducing iron overload linked to osteoclast differentiation. This research points to SFN as a potential therapeutic strategy for managing osteolysis in MM patients, showcasing broccoli's promising role in cancer treatment.
8
Broccoli-based bionanocomposite against cancer
We explored the effectiveness of a new bionanocomposite made from chitosan, broccoli extract, and zinc oxide nanoparticles in combating human osteosarcoma. Using several techniques, we thoroughly examined its properties and tested its cytotoxic effects on bone cancer cells.
The results were promising, demonstrating that our bionanocomposite effectively reduces cancer cell viability. It showed an IC50 value of 115 μg/mL, indicating its potential as a valuable chemotherapeutic agent in treating osteosarcoma.
This innovative approach highlights the possibilities for using natural extracts in cancer therapies, paving the way for future biological applications.
The results were promising, demonstrating that our bionanocomposite effectively reduces cancer cell viability. It showed an IC50 value of 115 μg/mL, indicating its potential as a valuable chemotherapeutic agent in treating osteosarcoma.
This innovative approach highlights the possibilities for using natural extracts in cancer therapies, paving the way for future biological applications.
7
Nanoparticles enhance broccoli for cancer
We investigated how silk fibroin nanoparticles (SFPNPs) can deliver the beneficial compounds from broccoli sprout extract (BSE) for cancer therapy. These specially designed nanoparticles not only encapsulated sulforaphane but were also stable, with an average size of 88.5 nm.
We found that the SFPNPs showed promising results in targeting breast cancer cells, with significant cytotoxic effects observed. However, while the nanoparticles appeared safe for normal cells, the concentration needed for effective cancer treatment was higher than the free extract alone.
Overall, these findings support the potential of using broccoli extract-loaded nanoparticles as a way to improve cancer therapies.
We found that the SFPNPs showed promising results in targeting breast cancer cells, with significant cytotoxic effects observed. However, while the nanoparticles appeared safe for normal cells, the concentration needed for effective cancer treatment was higher than the free extract alone.
Overall, these findings support the potential of using broccoli extract-loaded nanoparticles as a way to improve cancer therapies.
8
We explored the connection between broccoli consumption and cancer risk through a detailed meta-analysis of observational studies. By reviewing multiple databases and assessing potential biases, we found that people diagnosed with cancer generally consumed less broccoli.
The results indicate a protective effect, particularly highlighted in case-control studies, suggesting that higher broccoli intake may lower cancer risk. However, we acknowledge that these findings aren't definitive and further cohort studies are needed to fully understand broccoli's impact on various types of cancer.
The results indicate a protective effect, particularly highlighted in case-control studies, suggesting that higher broccoli intake may lower cancer risk. However, we acknowledge that these findings aren't definitive and further cohort studies are needed to fully understand broccoli's impact on various types of cancer.
8
Cooking enhances broccoli's anti-cancer properties
We investigated how heating broccoli affects its health benefits, particularly focusing on a compound called indole-3-carbinol (I3C). This study revealed that cooking promotes unique transformations of I3C into various beneficial indole compounds. Among these, a novel compound known as DIM-1 showed promise in inhibiting cancer cell growth. Despite these findings, it’s important to note that further research is needed to fully understand the implications of DIM-1 as an anti-cancer agent. This study enhances our knowledge about the potential health benefits of cooking broccoli.
8
We explored the impact of broccoli extracellular vesicles (BEVs) on colon cancer, particularly in overcoming the challenges of the chemotherapy drug 5-fluorouracil (5-FU). Through our study, we found that BEVs from broccoli juice were taken up by colorectal cancer cells and, when combined with 5-FU, they significantly slowed the cancer cell growth and movement. Moreover, this combination helped trigger cell death and improved the effectiveness of 5-FU by addressing its resistance mechanisms. Overall, our findings suggest a promising new approach for enhancing colon cancer therapy using broccoli compounds.
References
- Beasy G, Bernuzzi F, Day-Walsh P, Tronsco-Rey P, Defernez M, et al. S-Methyl Methanethiosulfonate, the Main Human Metabolite of S-Methyl-L-Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells. Mol Nutr Food Res. 2025. doi:10.1002/mnfr.70008
- Sun W, Sun J, Hu W, Luo C, Lu Z, et al. Sulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1. Cancer Chemother Pharmacol. 2024;95:3. doi:10.1007/s00280-024-04736-7
- Ali Redha A, Torquati L, Bows JR, Gidley MJ, Cozzolino D. Microencapsulation of broccoli sulforaphane using whey and pea protein: dynamic gastrointestinal digestion and intestinal absorption by Caco-2-HT29-MTX-E12 cells. Food Funct. 2025;16:71. doi:10.1039/d4fo03446e
- Sanchez-Guzman X, Alvarez-Domínguez L, Ramírez-Torres MF, Montes-Alvarado JB, Garcia-Ibañez P, et al. Cruciferous Plant Extracts, Their Isothyocianate or Indol Derivatives, and Their Effect on Cellular Viability of Breast Cancer Cell Lines. J Med Food. 2024;27:1183. doi:10.1089/jmf.2023.0199
- Hussein MO, Abdulhameed AS. Design of Bionanomaterial of Chitosan Carbohydrate Polymer Composited with Broccoli Extract and Zinc Oxide Nanoparticles: Anticancer Activity in Human Osteosarcoma. Appl Biochem Biotechnol. 2025;197:1073. doi:10.1007/s12010-024-05066-3
- Baladia E, Moñino M, Pleguezuelos E, Russolillo G, Garnacho-Castaño MV. Broccoli Consumption and Risk of Cancer: An Updated Systematic Review and Meta-Analysis of Observational Studies. Nutrients. 2024;16. doi:10.3390/nu16111583
- Qian JC, Zhang HP, Wang Y, Liu D. Heating conversion of indole-3-carbinol into -substituted oligomers with anti-melanoma effect. Food Chem X. 2024;22:101410. doi:10.1016/j.fochx.2024.101410
- Ghanbari Hassan Kiadeh S, Rahaiee S, Azizi H, Govahi M. The synthesis of broccoli sprout extract-loaded silk fibroin nanoparticles as efficient drug delivery vehicles: development and characterization. Pharm Dev Technol. 2024;29:359. doi:10.1080/10837450.2024.2336101
- Cao Y, Hou L, Li M, Zhang J, Wang L, et al. Broccoli extracellular vesicles enhance the therapeutic effects and restore the chemosensitivity of 5-fluorouracil on colon cancer. Food Chem Toxicol. 2024;186:114563. doi:10.1016/j.fct.2024.114563
- Lee YJ, Pan Y, Lim D, Park SH, Sin SI, et al. Broccoli Cultivated with Deep Sea Water Mineral Fertilizer Enhances Anti-Cancer and Anti-Inflammatory Effects of AOM/DSS-Induced Colorectal Cancer in C57BL/6N Mice. Int J Mol Sci. 2024;25. doi:10.3390/ijms25031650
- Liu X, Chang Y, Li Y, Zhang X, Li F, et al. Prospective cohort study of broccoli consumption frequency and all-cause and cause-specific mortality risks. Front Nutr. 2023;10:1286658. doi:10.3389/fnut.2023.1286658
- Ren HG, Luu HN, Liu Y, Wang DW, Guo X. High intake of cruciferous vegetables reduces the risk of gastrointestinal cancers: results from observational studies. Crit Rev Food Sci Nutr. 2024;64:8493. doi:10.1080/10408398.2023.2271070
- Baenas N, Vega-García A, Manjarrez-Marmolejo J, Moreno DA, Feria-Romero IA. The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model. Biomed Pharmacother. 2023;168:115720. doi:10.1016/j.biopha.2023.115720
- Hwang JW, Park JS, Jo EH, Kim SJ, Yoon BS, et al. Chinese cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases. J Agric Food Chem. 2005;53:8205.
