We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
8
Eicosapentaenoic acid reduces arrhythmia
Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Read More
Most Useful Reviews
9
Cholesterol regulation
267 people found this helpful
This dietary supplement, made from anchovy and sardines, has easy-to-swallow capsules with a pleasant strawberry flavour. It helps normalise cholesterol levels and reduces the risk of cardiovascular disease. Taking two capsules after meals improves hair and nail health. Focus on nutrition and health!
Read More
9
Brain function boost
160 people found this helpful
I chose this fish oil for its ideal EPA and DHA ratio (2:1). Omega-3 alleviates depression, improves vision, and plays a key role in brain function while reducing cardiovascular disease risks. This oil, from smaller fish, is tasty with no unpleasant smell, and I've ordered it multiple times.
Read More
9
Youthful vitality
19 people found this helpful
A remarkable product available at a reasonable price in Ukraine. It’s recommended for those recovering from operations or with chronic diseases to prevent cardiovascular diseases. You can taste the contents by biting the capsules, ensuring health and vitality!
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Read More
9
Omega-3 levels reduce heart failure
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Krill oil may improve heart health
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We delved into how Antarctic krill oil, rich in eicosapentaenoic acid (EPA), can influence cardiovascular health, specifically in the context of obesity. Our focus centered on its effects in mice fed a high-fat diet, which typically leads to increased cholesterol levels and oxidative stress—conditions that can heighten cardiovascular disease risk.
Through our research methods, including molecular docking and analysis of liver histology, we discovered that Antarctic krill oil appears to play a beneficial role in combating these adverse effects. We observed that the oil reduced oxidative stress and fat accumulation in these obese mice. This was associated with improved metabolic parameters that contribute to heart health, primarily through its action on molecules involved in cholesterol metabolism.
Notably, we found that krill oil helped lower the levels of harmful low-density lipoprotein cholesterol and activated pathways that support good cholesterol management in the body. These findings suggest that incorporating Antarctic krill oil, with its high EPA content, might be a promising strategy for addressing obesity-related cardiovascular issues.
Overall, our study points to the potential of eicosapentaenoic acid from krill oil as a natural approach to improving heart health, particularly for those struggling with obesity and its challenges.
Read More
8
Omega-3s are safer for hearts
EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines.
This study examined how different fatty acids affect heart health, particularly focusing on long-chain acylcarnitines. We found that saturated and monounsaturated acylcarnitines, especially one type called trans-elaidoylcarnitine, can significantly harm heart function and cell viability.
On the other hand, omega-3 derived acylcarnitines like eicosapentaenoylcarnitine and docosahexaenoylcarnitine showed minimal negative effects. In fact, they did not impair heart function or cell viability, suggesting that omega-3 fish oil might be a safer option for people with heart issues compared to other fatty acid sources.
This dietary supplement, made from anchovy and sardines, has easy-to-swallow capsules with a pleasant strawberry flavour. It helps normalise cholesterol levels and reduces the risk of cardiovascular disease. Taking two capsules after meals improves hair and nail health. Focus on nutrition and health!
Read More
9
Brain function boost
160 people found this helpful
I chose this fish oil for its ideal EPA and DHA ratio (2:1). Omega-3 alleviates depression, improves vision, and plays a key role in brain function while reducing cardiovascular disease risks. This oil, from smaller fish, is tasty with no unpleasant smell, and I've ordered it multiple times.
Read More
9
Youthful vitality
19 people found this helpful
A remarkable product available at a reasonable price in Ukraine. It’s recommended for those recovering from operations or with chronic diseases to prevent cardiovascular diseases. You can taste the contents by biting the capsules, ensuring health and vitality!
Read More
9
Cognitive improvement
5 people found this helpful
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are crucial omega-3 fatty acids. As our bodies cannot produce them, we must obtain them through diet. EPA and DHA assist in enhancing cognitive processes and reducing cardiovascular disease risks. Fish oil was unappealing to me, so I opted for Jarrow Formulas’ products. After a three-month course, my cholesterol improved, and I felt mentally sharper.
Read More
9
Convenient dosage
3 people found this helpful
I continuously take omega-3, which has improved my blood pressure and cardiovascular health. This supplement has also alleviated joint issues. Its dosage is convenient, and I recommend it to my family and friends for overall wellness.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has long been touted for its potential cardiovascular benefits, and numerous studies support the notion that it can be helpful in managing overall heart health. Rich in EPA and DHA, the primary active components in fish oil, omega-3 fatty acids are known to reduce triglyceride levels, lower blood pressure, and may even decrease the risk of arrhythmias. Some research suggests that regular consumption of omega-3s can lead to a reduced risk of heart disease and stroke by improving vascular health and reducing inflammation in the body.
However, it's essential to approach this topic with a balanced perspective. While omega-3 supplements can be beneficial, they should not be seen as a standalone solution for cardiovascular disease. Incorporating omega-3s through diet—such as fatty fish like salmon, sardines, and mackerel—is preferable to relying solely on supplements. Moreover, if you're considering adding fish oil supplements to your routine, it's advisable to consult with a healthcare provider to ensure they fit within your complete cardiovascular health strategy, which should also include a nutritious diet, regular exercise, and other heart-healthy lifestyle choices.
Based on user reviews, the timeframe for seeing results from omega-3 supplements, particularly for cardiovascular health, can vary among individuals. Many users report noticeable improvements within a few weeks to a few months. For instance, one user mentioned an enhancement in their cholesterol levels and mental sharpness after a three-month course of a specific supplement Read Review. Another reviewer observed improvements in memory and triglyceride levels after two months of consistent intake Read Review.
Users frequently emphasize the importance of consistent usage for optimal benefits, suggesting daily intake as a standard practice. Some even noted immediate benefits, such as improved energy and stability in blood pressure within weeks Read Review. Overall, while experiences can vary, many users agree that with regular consumption, enhancements in cardiovascular health are often felt within several weeks to three months.
Research consistently supports the use of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in promoting cardiovascular health. Various studies have demonstrated that these essential fatty acids can lower triglyceride levels, improve lipid profiles, and reduce the risk of major cardiovascular events such as heart attacks and strokes. For instance, a clinical trial showed that EPA supplementation can significantly lower the occurrence of serious cardiovascular issues in high-risk individuals, suggesting that it could effectively serve as an additional treatment alongside statins for those managing elevated triglycerides [5]. Research also indicates that higher plasma levels of omega-3s are associated with a decreased risk of conditions like heart failure and sudden cardiac death, reinforcing their cardioprotective properties [29].
Moreover, dietary sources of omega-3 fatty acids have been linked to reduced inflammation and blood pressure, further contributing to their beneficial effects on heart health. A study found that individuals consuming a diet rich in omega-3s experienced improvements in cardiovascular metrics, while another highlighted how genetically predisposed individuals benefitted more from fish oil supplementation [2]. Additionally, higher chronic inflammation markers were inversely related to omega-3 levels, indicating potential anti-inflammatory effects [21]. However, it is vital to approach the supplementation of omega-3s cautiously, as some may experience adverse effects at high doses [21]. In conclusion, the accumulation of scientific evidence positions omega-3 supplementation as a promising strategy for enhancing cardiovascular health.
Users report a range of improvements in symptoms after taking omega-3 supplements, particularly regarding cardiovascular health, cognitive function, and overall well-being. Many reviewers highlighted benefits such as normalized cholesterol levels and reduced blood pressure, with one user noting a marked enhancement in cardiovascular health after consistent use Read Review. Others have observed improvements in memory and mental sharpness, as illustrated by a reviewer who experienced enhanced concentration and better triglyceride levels after two months Read Review. There are also reports of users experiencing less joint pain and improved skin and hair health, indicating a holistic benefit from the regular intake of omega-3s Read Review.
Beyond cardiovascular advantages, users have cited psychological benefits as well. Multiple reviews attest to reductions in symptoms of depression and stress, reinforcing omega-3’s pivotal role in mental health Read Review. It's important to highlight that while many users express satisfaction with their results, individual outcomes may vary based on factors like dosage and personal health conditions. Regular consumption appears to be a common recommendation among users for achieving these benefits effectively Read Review.
Users report positive experiences when combining omega-3 supplements with other dietary supplements for managing cardiovascular disease. Many have noted that these omega-3 capsules, especially those with an ideally balanced EPA and DHA ratio, significantly contribute to heart health and blood pressure stabilization. For instance, one user shared that taking omega-3s helped improve their blood pressure and overall cardiovascular health Read Review. Others also emphasized that regular usage not only benefited their cardiovascular system but also improved joint and cognitive functions, demonstrating a holistic impact on wellness Read Review.
Additionally, some users have highlighted the importance of consulting healthcare professionals before combining supplements, particularly for those with specific health conditions or dietary restrictions, to ensure compatibility and avoid potential side effects Read Review. Overall, the consensus suggests that users appreciate the synergy of omega-3s with other supplements, which might enhance their effectiveness in managing cardiovascular health and promoting overall vitality Read Review.
Based on recent research, the optimal dose for omega-3 fish oil in treating cardiovascular disease appears to be in the range of 2,000 to 4,000 mg per day, particularly when taken over a period of at least one year. A comprehensive network meta-analysis highlighted that this dosage range significantly improved heart function, including metrics like left ventricular ejection fraction and peak oxygen consumption in patients with heart failure [7]. Moreover, individuals already diagnosed with heart conditions benefited from higher omega-3 intake, which is crucial for enhancing overall cardiovascular health.
9
Cognitive improvement
5 people found this helpful
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are crucial omega-3 fatty acids. As our bodies cannot produce them, we must obtain them through diet. EPA and DHA assist in enhancing cognitive processes and reducing cardiovascular disease risks. Fish oil was unappealing to me, so I opted for Jarrow Formulas’ products. After a three-month course, my cholesterol improved, and I felt mentally sharper.
7.5
Improved memory function
1 people found this helpful
This EPA-DHA balance supplement has been ideal for me. The ratio is good, supporting both physical and mental health. The soft gels are easy to take without a fishy smell. After two months, I noticed improvements in my concentration, memory, and skin, along with better triglyceride levels. I recommend it for cardiovascular disease prevention.
7.5
Feeling cheerful
3 people found this helpful
I take omega-3 to enhance cardiovascular health and it has successfully stabilised my blood pressure. I feel more alert and energetic. I recommend it to everyone!
9
Convenient dosage
3 people found this helpful
I continuously take omega-3, which has improved my blood pressure and cardiovascular health. This supplement has also alleviated joint issues. Its dosage is convenient, and I recommend it to my family and friends for overall wellness.
7.5
Stabilises cholesterol levels
1 people found this helpful
My husband and I regularly take Omega-3s. This product provides the perfect EPA and DHA ratio from small fish to avoid heavy metals. It normalises cholesterol levels, reduces the risk of cardiovascular disease, and improves hair and nail health, with no fish burps!
9
Brain function boost
160 people found this helpful
I chose this fish oil for its ideal EPA and DHA ratio (2:1). Omega-3 alleviates depression, improves vision, and plays a key role in brain function while reducing cardiovascular disease risks. This oil, from smaller fish, is tasty with no unpleasant smell, and I've ordered it multiple times.
7.5
Effective source recommended
6 people found this helpful
I chose EPA-DHA Balance by Jarrow Formulas, due to its optimal ratio of omega-3 components. Omega-3 deficiencies can lead to various health issues. The product comes in a large plastic jar containing 240 soft capsules, with no unpleasant fishy smell. I recommend it as a strong source of omega-3, but do keep in mind the contraindications. Consulting a doctor beforehand is wise.
9
Cholesterol regulation
267 people found this helpful
This dietary supplement, made from anchovy and sardines, has easy-to-swallow capsules with a pleasant strawberry flavour. It helps normalise cholesterol levels and reduces the risk of cardiovascular disease. Taking two capsules after meals improves hair and nail health. Focus on nutrition and health!
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
8
DHA's protective role in heart health
A cohort study reveals shared and distinct serum metabolic biomarkers for major adverse cardiovascular events in middle-aged and older adults.
We assessed the relationship between various serum metabolites and the occurrence of major adverse cardiovascular events (MACE) in middle-aged and elderly adults. One of the key metabolites we looked at was docosahexaenoic acid (DHA), which has been noted for its potential cardiovascular benefits.
Throughout our study involving over 54,000 UK Biobank participants, we found that DHA and some other metabolic markers were linked to MACE risk, particularly among middle-aged individuals. Interestingly, in the elderly, DHA showcased a protective role, revealing how certain metabolic factors may play a different part in heart health as we age.
Our research highlighted that while middle-aged adults exhibited various metabolic indicators associated with increased risk of cardiovascular issues, the elderly had fewer markers that correlated with heightened risk. DHA, in particular, seemed to stand out among the compounds that may help protect against MACE in older adults, as indicated by our findings.
Overall, this research sheds light on the complexity of how dietary components like DHA interact with age-related cardiovascular risks, suggesting a need for further studies into personalized approaches for preventing cardiovascular events tailored to different age groups.
4
Genetics influence omega-3 effectiveness
The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation.
We explored the potential connection between eicosapentaenoic acid (EPA), which is an omega-3 fatty acid, and its role in reducing inflammation related to cardiovascular disease (CVD) in older adults. In our study, we measured the plasma levels of various omega-3 fatty acids and their specialized pro-resolving lipid mediators (SPMs) in a group of 21 older participants who exhibited low-grade chronic inflammation.
The findings were intriguing. We observed that higher levels of docosahexaenoic acid (DHA) were linked to lower concentrations of several inflammatory markers, including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Additionally, certain SPMs derived from EPA and DHA were also associated with reductions in inflammation levels, suggesting that these omega-3-derived substances might support the body's natural ability to resolve inflammation.
However, while the association between omega-3 fatty acids and inflammation was apparent, our study did not isolate the effects of EPA alone. This means we cannot definitively conclude the unique impact of eicosapentaenoic acid on cardiovascular health.
Overall, this research sheds light on how dietary intake of omega-3 fatty acids, particularly from sources rich in DHA and EPA, may benefit inflammation regulation—an important aspect of cardiovascular well-being.
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
References
Liepinsh E, Gukalova B, Krims-Davis K, Kuka J, Leduskrasta A, et al. EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines. Biofactors. 2025;51:e70014. 10.1002/biof.70014
Medoro A, Graziano F, Cardinale G, Voccola S, Zotti T, et al. The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation. Lipids Health Dis. 2025;24:102. 10.1186/s12944-025-02513-w
Horii K, Ono K, Sumi T, Higashihara M, Zaima N, et al. Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice. J Physiol Sci. 2025;75:100014. 10.1016/j.jphyss.2025.100014
Dawczynski C, Drobner T, Weidauer T, Schlattmann P, Kiehntopf M, et al. Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study. Lipids Health Dis. 2025;24:88. 10.1186/s12944-025-02500-1
Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
Mao Q, Tian X, Wang X, Xu H, Zhang Y, et al. Global burden of cardiovascular diseases attributable to diet low in seafood omega-3 fatty acids from 1990~2021 and forecasting the future trends: A population-based study. PLoS One. 2025;20:e0316767. 10.1371/journal.pone.0316767
Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. 10.1515/jcim-2024-0427
Wang Y, Wu G, Wang Y, Rehman A, Yu L, et al. Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases. Food Chem. 2025;470:142498. 10.1016/j.foodchem.2024.142498
Dong S, Wang Y, Bian J, Chen H, Dong J, et al. The effect of omega-3 Polyunsaturated Fatty Acid (PUFA) prescription preparations on the prevention of clinical cardiovascular disease: a meta-analysis of RCTs. Nutr J. 2024;23:157. 10.1186/s12937-024-01051-y
Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. 10.1016/j.mayocp.2024.08.007
Brosolo G, Da Porto A, Marcante S, Capilupi F, Bertin N, et al. The role for ω-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota. Eur J Pharmacol. 2024;985:177107. 10.1016/j.ejphar.2024.177107
Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. 10.1017/S0007114524002708
Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
Li ZH, Song WQ, Qiu CS, Li HM, Tang XL, et al. Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension. Prev Med. 2024;189:108152. 10.1016/j.ypmed.2024.108152
Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.028
Liboriussen C, Nygaard L, Jensen JD, Schmidt EB, Glerup RI, et al. Low Plasma Marine N-3 Polyunsaturated Fatty Acids are Associated with Increased Risk of Cardiovascular Events in Patients Treated with Maintenance Hemodialysis. J Ren Nutr. 2025. 10.1053/j.jrn.2025.02.001
Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. 10.3390/jcdd12020060
Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. 10.1007/s40261-024-01417-4
Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. 10.3390/jcm14010026
Lamon-Fava S. Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. Prostaglandins Other Lipid Mediat. 2025;176:106948. 10.1016/j.prostaglandins.2025.106948
Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. 10.7759/cureus.73417
O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. 10.1016/j.pcad.2024.11.003
Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. 10.3390/nu16213614
So J, Yao JH, Magadmi R, Matthan NR, Lamon-Fava S. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2024;203:102655. 10.1016/j.plefa.2024.102655
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. 10.3389/fnut.2024.1423228
Follonier C, Rabassa G, Branca M, Carballo D, Koskinas K, et al. Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes. Atheroscler Plus. 2024;58:1. 10.1016/j.athplu.2024.09.002
Koutsaliaris IK, Pantazi D, Tsouka AN, Argyropoulou O, Tellis CC, et al. Differential Effect of Omega-3 Fatty Acids on Platelet Inhibition by Antiplatelet Drugs In Vitro. Int J Mol Sci. 2024;25. 10.3390/ijms251810136
Ren Y, Chen B, Zhang H, Xu S. A cohort study reveals shared and distinct serum metabolic biomarkers for major adverse cardiovascular events in middle-aged and older adults. Geroscience. 2025. 10.1007/s11357-025-01544-6
Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. 10.1007/s13668-024-00602-3
Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. 10.1039/d4fo04961f
Berkowitz L, Echeverría G, Salazar C, Faúndez C, Coe CL, et al. Lipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults. Nutrients. 2024;16. 10.3390/nu16233995
Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. 10.1093/eurjpc/zwae315