Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
USERS' SCORE
Good
Based on 18 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Quercetin
500 mg
†
Top Medical Research Studies
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
We explored the effects of quercetin, a plant flavonoid, on KON oral cancer cells. Our aim was to understand how quercetin could potentially fight cancer by assessing its anti-growth, anti-migrative, and anti-invasive properties. Using various assays, we treated KON cells with quercetin and observed its impact on their viability compared to normal fibroblast cells.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
Read More
8
Quercetin reduces oral cancer cell viability
We explored the effects of quercetin, a natural flavonoid, on oral cancer during a systematic review of existing studies. Our investigation included a thorough screening process, where we analyzed 193 articles and selected 18 that met our inclusion criteria.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Read More
Most Useful Reviews
9
Cancer resistance
56 people found this helpful
Quercetin is a unique and irreplaceable substance that effectively fights against various cancers, including breast and pancreatic cancer. It enhances vascular tone, combats atherosclerosis, allergies, and regulates blood pressure. Additionally, it helps in reducing inflammation and boosts immune response. However, it is vital to know the correct dosage, as excessive intake may be harmful.
Read More
9
Trusted brand
17 people found this helpful
My oncologist recommended Jarrow brand Quercetin for my prostate cancer treatment, asserting it accurately represents its label.
Read More
9
Cancer fighting
8 people found this helpful
Quercetin is a vital natural substance that effectively combats various cancers and enhances vascular function. It regulates blood pressure, reduces inflammation, and boosts immune activity. However, knowing the right dosage is crucial, as high amounts may have adverse effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
- All Researches
9.5
Quercetin enhances cancer treatment efficacy
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Read More
9
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Read More
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
Quercetin combats cancer drug resistance
We explored the potential of quercetin, a natural compound found in various fruits and vegetables, in combating resistance to the cancer drug trastuzumab, particularly in patients with HER2-positive gastric cancer. Our study investigated how quercetin, as part of a mixture known as Jian Pi Hua Tan Fang (JPHTF), could enhance the effectiveness of this treatment.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Read More
9
Our research delved into the effects of quercetin, a flavonoid commonly found in plants, on hepatocellular carcinoma (HCC), a prevalent form of liver cancer. We focused on the role of the Farnesoid X receptor (FXR), which is crucial for maintaining liver health and metabolism. By investigating how quercetin influences the glycolysis pathway through FXR signaling, we sought to uncover its anti-cancer properties.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cancer resistance
56 people found this helpful
Quercetin is a unique and irreplaceable substance that effectively fights against various cancers, including breast and pancreatic cancer. It enhances vascular tone, combats atherosclerosis, allergies, and regulates blood pressure. Additionally, it helps in reducing inflammation and boosts immune response. However, it is vital to know the correct dosage, as excessive intake may be harmful.
Read More
9
Trusted brand
17 people found this helpful
My oncologist recommended Jarrow brand Quercetin for my prostate cancer treatment, asserting it accurately represents its label.
Read More
9
Cancer fighting
8 people found this helpful
Quercetin is a vital natural substance that effectively combats various cancers and enhances vascular function. It regulates blood pressure, reduces inflammation, and boosts immune activity. However, knowing the right dosage is crucial, as high amounts may have adverse effects.
Read More
9
Lung cancer
2 people found this helpful
Quercetin has greatly assisted individuals with lung cancer, effectively dilating blood vessels and addressing pulmonary nodules. I continue to use it, and it also facilitates the uptake of vitamin C and zinc when taken together. Highly recommend Geno’s Quercetin.
Read More
10
Cancer protection
1 people found this helpful
Quercetin disrupts cancer cell growth and enhances chemotherapy effects while protecting normal cells. Studies indicate that consuming onions twice weekly can significantly reduce the risk of various cancers. It also acts as a powerful antioxidant, safeguarding cells from damage and gene mutations.
Read More
Frequently Asked Questions
9
Lung cancer
2 people found this helpful
Quercetin has greatly assisted individuals with lung cancer, effectively dilating blood vessels and addressing pulmonary nodules. I continue to use it, and it also facilitates the uptake of vitamin C and zinc when taken together. Highly recommend Geno’s Quercetin.
7.5
Prostate cancer inhibition
1 people found this helpful
Quercetin combined with other extracts has shown positive effects on prostatitis symptoms and quality of life. It inhibits prostate cancer by disrupting cell survival mechanisms.
9
Cancer resistance
56 people found this helpful
Quercetin is a unique and irreplaceable substance that effectively fights against various cancers, including breast and pancreatic cancer. It enhances vascular tone, combats atherosclerosis, allergies, and regulates blood pressure. Additionally, it helps in reducing inflammation and boosts immune response. However, it is vital to know the correct dosage, as excessive intake may be harmful.
10
Cancer protection
1 people found this helpful
Quercetin disrupts cancer cell growth and enhances chemotherapy effects while protecting normal cells. Studies indicate that consuming onions twice weekly can significantly reduce the risk of various cancers. It also acts as a powerful antioxidant, safeguarding cells from damage and gene mutations.
7.5
Allergy relief
4 people found this helpful
I was amazed by Quercetin's benefits, particularly its ability to help with allergies and potentially support blood cancer treatment. It reduces histamine effects, allowing for safer dining experiences, especially with histamine-rich foods. I take two before meals to mitigate risks.
9
Immune boost
1 people found this helpful
Quercetin provides numerous benefits, including being a strong antioxidant, reducing cancer risk, and boosting the immune system. During Covid, my husband and I took it and believe it helped maintain our immunity. We remain committed to taking Quercetin daily.
6
Cancer prevention
6 people found this helpful
Quercetin is cost-effective and potentially useful for lung cancer prevention. Consuming onion skins can maximise its benefits, and combining it with soy lecithin increases its effectiveness.
9
Cancer fighting
8 people found this helpful
Quercetin is a vital natural substance that effectively combats various cancers and enhances vascular function. It regulates blood pressure, reduces inflammation, and boosts immune activity. However, knowing the right dosage is crucial, as high amounts may have adverse effects.
9
Trusted brand
17 people found this helpful
My oncologist recommended Jarrow brand Quercetin for my prostate cancer treatment, asserting it accurately represents its label.
7.5
Reduced risk of cancer
Quercetin is a common dietary supplement linked to decreased inflammation, normalised blood sugar, improved brain function, and higher endurance levels. However, it should be combined with digestive enzymes or vitamin C for better absorption. This flavonoid can significantly lower cancer risk and alleviate allergy symptoms.
9.5
Quercetin enhances cancer treatment efficacy
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
9
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
8
Quercetin reduces oral cancer cell viability
We explored the effects of quercetin, a natural flavonoid, on oral cancer during a systematic review of existing studies. Our investigation included a thorough screening process, where we analyzed 193 articles and selected 18 that met our inclusion criteria.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
8
Quercetin induces cancer cell apoptosis
We explored how the natural herb Bryophyllum pinnatum affects colorectal cancer cells, with a special focus on one of its key components, quercetin. The study highlighted that B. pinnatum leaf extract caused significant cell death in HCT116 colorectal cancer cells, showing a remarkable cytotoxic effect even at low concentrations.
In addition to inducing cancer cell death, we also observed that the extract led to an increase in reactive oxygen species (ROS) inside the cells. This buildup of ROS seems to play a crucial role in triggering apoptosis, or programmed cell death, facilitated by the upregulation of various proteins including p53, which is known for its tumor-suppressing functions. Moreover, we found that quercetin—one of the active compounds in the extract—was integral to these effects, suggesting that it could be a promising candidate for further research in cancer treatment.
Our findings demonstrate that B. pinnatum and its bioactive components, particularly quercetin, may offer a natural approach to enhancing cancer therapy. This research opens the door for developing new plant-based treatments that could be used alongside traditional chemotherapy methods, potentially reducing side effects and increasing efficacy in treating colorectal cancer.
In addition to inducing cancer cell death, we also observed that the extract led to an increase in reactive oxygen species (ROS) inside the cells. This buildup of ROS seems to play a crucial role in triggering apoptosis, or programmed cell death, facilitated by the upregulation of various proteins including p53, which is known for its tumor-suppressing functions. Moreover, we found that quercetin—one of the active compounds in the extract—was integral to these effects, suggesting that it could be a promising candidate for further research in cancer treatment.
Our findings demonstrate that B. pinnatum and its bioactive components, particularly quercetin, may offer a natural approach to enhancing cancer therapy. This research opens the door for developing new plant-based treatments that could be used alongside traditional chemotherapy methods, potentially reducing side effects and increasing efficacy in treating colorectal cancer.
7
We explored the role of quercetin, a flavonoid celebrated for its antioxidant and anti-inflammatory properties, in cancer therapy. The review highlights how quercetin targets critical molecular pathways, including those linked to tumor growth and immune response.
By inhibiting key signaling pathways, quercetin may help promote cancer cell death while leaving healthy cells unharmed. Moreover, its potential for enhancing immune recognition of tumor cells and reducing inflammation is particularly promising.
The study also examines innovative nanoformulations that could boost quercetin's effectiveness in treatment, suggesting a bright future for its combined use with traditional therapies.
By inhibiting key signaling pathways, quercetin may help promote cancer cell death while leaving healthy cells unharmed. Moreover, its potential for enhancing immune recognition of tumor cells and reducing inflammation is particularly promising.
The study also examines innovative nanoformulations that could boost quercetin's effectiveness in treatment, suggesting a bright future for its combined use with traditional therapies.
9
We investigated the potential of quercetin, a natural flavonoid known for its cancer-fighting properties, and how we can enhance its effectiveness using specialized nanoparticles. The study focused on making these nanoparticles from whey protein isolate, pectin, and triphenylphosphonium bromide, which work together to increase quercetin’s bioavailability, a common hurdle for many treatments.
During our research, we found that these nanoparticles encapsulated 82.64% of quercetin and measured about 261.7 nm in size, with a zeta potential indicating they were stable. More importantly, this formulation allowed quercetin to better target mitochondria in cancer cells, specifically HepG-2 liver cancer cells, leading to a significant increase in apoptosis, or programmed cell death, with an impressive rate of 83.6%.
Overall, our findings suggest that using pectin-modified nanoparticles could greatly improve how quercetin is administered, increasing its effectiveness against cancer. This study opens the door to new and potentially more successful treatments by improving the delivery of important compounds like quercetin to cancer cells.
During our research, we found that these nanoparticles encapsulated 82.64% of quercetin and measured about 261.7 nm in size, with a zeta potential indicating they were stable. More importantly, this formulation allowed quercetin to better target mitochondria in cancer cells, specifically HepG-2 liver cancer cells, leading to a significant increase in apoptosis, or programmed cell death, with an impressive rate of 83.6%.
Overall, our findings suggest that using pectin-modified nanoparticles could greatly improve how quercetin is administered, increasing its effectiveness against cancer. This study opens the door to new and potentially more successful treatments by improving the delivery of important compounds like quercetin to cancer cells.
8
We investigated how quercetin, a natural compound with potential cancer-fighting abilities, can be more effective when delivered using specially designed nanoparticles.
By loading quercetin onto magnetic iron oxide nanoparticles, we enhanced its effectiveness while targeting human breast cancer cells. The results were promising, with higher rates of cancer cell death and noticeable changes in cell structure when treated with our nanoparticle system.
Overall, this innovative approach may improve quercetin’s bioavailability and effectiveness in breast cancer treatment, giving us hope for better therapeutic options.
By loading quercetin onto magnetic iron oxide nanoparticles, we enhanced its effectiveness while targeting human breast cancer cells. The results were promising, with higher rates of cancer cell death and noticeable changes in cell structure when treated with our nanoparticle system.
Overall, this innovative approach may improve quercetin’s bioavailability and effectiveness in breast cancer treatment, giving us hope for better therapeutic options.
References
- Verma M, Yadav K, Parihar R, Dutta D, Chaudhuri S, et al. Active tumor targeting by core-shell PDMS-HA nanoparticles with sequential delivery of doxorubicin and quercetin to overcome P-glycoprotein efflux pump. Nanoscale. 2025;17:5033. doi:10.1039/d4nr03040k
- Wang J, Yang JH, Xiong D, Chen L. Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma. Hum Exp Toxicol. 2025;44:9603271251323753. doi:10.1177/09603271251323753
- Saadh MJ, Ahmed HH, Chandra M, Al-Hussainy AF, Hamid JA, et al. Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis. Cancer Cell Int. 2025;25:66. doi:10.1186/s12935-025-03694-1
- Mukherjee S, Banik SK, Chakraborty S, Das T, Choudhury MD, et al. Bryophyllum pinnatum Induces p53-Dependent Apoptosis of Colorectal Cancer Cells via Increased Intracellular ROS and G2/M Cell-Cycle Arrest In Vitro and Validated in Silico by Molecular Docking. Cell Biol Int. 2025. doi:10.1002/cbin.70004
- Alsaab J, Sarawi WS, Alhusaini AM, Hasan IH, Alturaif S, et al. Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways. Food Chem Toxicol. 2025;199:115341. doi:10.1016/j.fct.2025.115341
- Sun J, Sha M, Zhou J, Huang Y. Quercetin affects apoptosis and autophagy in pediatric acute myeloid leukaemia cells by inhibiting PI3K/AKT signaling pathway activation through regulation of miR-224-3p/PTEN axis. BMC Cancer. 2025;25:318. doi:10.1186/s12885-025-13709-9
- Han S, Yi YW, Kim H, Lee MY, Choi H, et al. Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells. Biomed Pharmacother. 2025;184:117930. doi:10.1016/j.biopha.2025.117930
- Martínez-Esquivias F, Guzmán-Flores JM, Pech-Santiago EO, Guerrero-Barrera AL, Delgadillo-Aguirre CK, et al. Therapeutic Role of Quercetin in Prostate Cancer: A Study of Network Pharmacology, Molecular Docking, and Dynamics Simulation. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01697-3
- Chuang CH, Tai YA, Wu TJ, Ho YJ, Yeh SL. Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling. Front Nutr. 2025;12:1530132. doi:10.3389/fnut.2025.1530132
- Singh T, Rastogi M, Thakur K. Network pharmacology and in silico approach to study the mechanism of quercetin against breast cancer. In Silico Pharmacol. 2025;13:22. doi:10.1007/s40203-025-00306-8
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