Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
USERS' SCORE
Good
Based on 35 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
9.5
We explored the effectiveness of a specially engineered probiotic yeast, Saccharomyces boulardii, aimed at treating colitis. By cleverly binding this probiotic to proteins in the gut, we managed to significantly extend its stay in the gastrointestinal tract. This allowed us to observe a noteworthy increase in probiotic levels in the colon.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Read More
9
Saccharomyces boulardii reduces colitis cancer
We examined how Saccharomyces boulardii impacts ulcerative colitis and its related cancer development in mice. In this study, mice underwent a specific treatment to create a model of ulcerative colitis, followed by 12 weeks of S. boulardii treatment.
The results showed a significant reduction in tumor development as well as lower levels of inflammatory markers, TNF-α and IL-6. Additionally, S. boulardii positively influenced the composition of intestinal bacteria. Overall, the findings suggest that saccharomyces boulardii may have protective effects against colitis-related cancer.
The results showed a significant reduction in tumor development as well as lower levels of inflammatory markers, TNF-α and IL-6. Additionally, S. boulardii positively influenced the composition of intestinal bacteria. Overall, the findings suggest that saccharomyces boulardii may have protective effects against colitis-related cancer.
Read More
9
We investigated whether Saccharomyces boulardii could protect mice from experimental colitis. Over three weeks, treated mice showed less weight loss, reduced colon damage, and improved gut barrier function compared to untreated ones.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
Read More
Most Useful Reviews
9
Successful treatment
187 people found this helpful
I was battling C. difficile after taking Clindamycin. After starting this probiotic along with my treatment, I had a follow-up colonoscopy and found no trace of C. diff. I plan to take this every day as it has been instrumental in my recovery.
Read More
9
Symptom relief
89 people found this helpful
This will take care of gas and diarrhoea. It subdues all the symptoms of C-Diff and colitis. I have tried many probiotics, but this one significantly improves my life. I take it continually for relief.
Read More
7.5
Feeling better now
34 people found this helpful
I suffer from ulcerative colitis and always wish to try something that helps me feel like a "normal healthy" person. My doctor recommended this product, and I had read positive reviews and scientific studies. I have been using it for a few weeks now and feel better; my bowel movements are regular, cramps have diminished, and I no longer feel bloated. I have also noticed an improvement in my skin, though I am unsure if it's related. This product contains MOS - prebiotics that can block harmful bacteria, which is an added advantage! Wishing everyone good health and please give me a like if you find this helpful.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
- All Researches
9.5
We explored the effectiveness of a specially engineered probiotic yeast, Saccharomyces boulardii, aimed at treating colitis. By cleverly binding this probiotic to proteins in the gut, we managed to significantly extend its stay in the gastrointestinal tract. This allowed us to observe a noteworthy increase in probiotic levels in the colon.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Read More
9
Probiotic shows anti-inflammatory efficacy
We explored the potential of Saccharomyces boulardii, a probiotic, to ease gut inflammation. This study developed a unique system that displayed specific anti-inflammatory proteins on the probiotic. By optimizing these proteins' expression, the engineered S. boulardii samples were tested on a colitis mouse model.
The results indicated a notably lower disease activity and a reduction in inflammation markers, suggesting that this innovative approach could be effective in improving intestinal health. Overall, our findings highlight the probiotic's promise in managing inflammatory conditions.
The results indicated a notably lower disease activity and a reduction in inflammation markers, suggesting that this innovative approach could be effective in improving intestinal health. Overall, our findings highlight the probiotic's promise in managing inflammatory conditions.
Read More
9
Saccharomyces boulardii as a postbiotic
We explored the impact of Saccharomyces boulardii on colitis, aiming to understand its potential benefits for gut health. Our findings revealed that an oral dose of S. boulardii supernatant helped ease intestinal inflammation and reinforced the gut barrier.
A key player in this process is thioredoxin (Trx), a protein that activated important pathways to reduce inflammation and oxidative stress. By promoting the activation of the epidermal growth factor receptor, Trx showed promise as a new postbiotic treatment for colitis.
However, while these results are encouraging, more research is needed to fully comprehend its long-term effects.
A key player in this process is thioredoxin (Trx), a protein that activated important pathways to reduce inflammation and oxidative stress. By promoting the activation of the epidermal growth factor receptor, Trx showed promise as a new postbiotic treatment for colitis.
However, while these results are encouraging, more research is needed to fully comprehend its long-term effects.
Read More
9
This study delved into the effects of heat-killed Saccharomyces boulardii on ulcerative colitis, aiming to uncover its potential as a treatment option. We observed that this treatment significantly restored body weight, reduced inflammation, and improved gut barrier function in mice with colitis. It also effectively modulated gut microbiota, outperforming other treatments like β-glucan.
Overall, heat-killed Saccharomyces boulardii presents a promising new approach for those suffering from ulcerative colitis, enhancing their quality of life.
Overall, heat-killed Saccharomyces boulardii presents a promising new approach for those suffering from ulcerative colitis, enhancing their quality of life.
Read More
9
We investigated whether Saccharomyces boulardii could protect mice from experimental colitis. Over three weeks, treated mice showed less weight loss, reduced colon damage, and improved gut barrier function compared to untreated ones.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
Read More
User Reviews
USERS' SCORE
Good
Based on 35 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Successful treatment
187 people found this helpful
I was battling C. difficile after taking Clindamycin. After starting this probiotic along with my treatment, I had a follow-up colonoscopy and found no trace of C. diff. I plan to take this every day as it has been instrumental in my recovery.
Read More
9
Symptom relief
89 people found this helpful
This will take care of gas and diarrhoea. It subdues all the symptoms of C-Diff and colitis. I have tried many probiotics, but this one significantly improves my life. I take it continually for relief.
Read More
7.5
Feeling better now
34 people found this helpful
I suffer from ulcerative colitis and always wish to try something that helps me feel like a "normal healthy" person. My doctor recommended this product, and I had read positive reviews and scientific studies. I have been using it for a few weeks now and feel better; my bowel movements are regular, cramps have diminished, and I no longer feel bloated. I have also noticed an improvement in my skin, though I am unsure if it's related. This product contains MOS - prebiotics that can block harmful bacteria, which is an added advantage! Wishing everyone good health and please give me a like if you find this helpful.
Read More
9
C-Diff recovery
33 people found this helpful
Five years ago, I had a traumatic experience with C-Diff after an antibiotic treatment. After taking Florastor and changing my diet, my colitis has stayed at bay. I now use Jarrow Formulas, which is similar and much more affordable. This probiotic has changed my life and helped in my recovery from C-Diff.
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9
Life-changing experience
29 people found this helpful
This product has truly changed my life following years of suffering from colitis and C. Diff. I was frequently needing the restroom, which induced anxiety and impacted my social life. After adding S. Boulardii to my existing regimen, I noticed a remarkable difference within days. My anxiety has greatly diminished, and I can finally enjoy life without worrying about restroom accessibility.
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Frequently Asked Questions
9
Significant improvement
2 people found this helpful
Great for those who have ulcerative colitis. After a week of use, I feel much better, as I have a chronic illness like diarrhoea, and this probiotic is excellent! I highly recommend it!
9
Symptoms stabilised
1 people found this helpful
After my first use, my symptoms vastly decreased. I have ulcerative colitis with problems including bloating, cramps, and abdominal pain. Within days of using this product, my symptoms started to disappear, stabilising my condition. During a crisis, I take two pills daily, and for maintenance, one a day. I highly recommend it!
6
Slight improvement
I have ulcerative colitis, and after nearly a month of taking these probiotics, I've noticed a slight improvement.
7.5
Feeling better now
34 people found this helpful
I suffer from ulcerative colitis and always wish to try something that helps me feel like a "normal healthy" person. My doctor recommended this product, and I had read positive reviews and scientific studies. I have been using it for a few weeks now and feel better; my bowel movements are regular, cramps have diminished, and I no longer feel bloated. I have also noticed an improvement in my skin, though I am unsure if it's related. This product contains MOS - prebiotics that can block harmful bacteria, which is an added advantage! Wishing everyone good health and please give me a like if you find this helpful.
7.5
Quick results
11 people found this helpful
Best probiotic I’ve ever tried! My doctor recommended using two capsules each morning and evening to manage excess gas and diarrhoea. It has worked wonders for my gastroparisis and also for my husband’s colitis. I have even given it to the dogs and cats in smaller doses when they faced problems. It begins to work immediately and often negates the need for other medications. Just a note, it shouldn't be taken if you have yeast infection issues, as it's yeast-derived.
7.5
Hospital-free success
3 people found this helpful
My father has had numerous bowel obstruction surgeries due to his ulcerative colitis, celiac disease, and lactose allergy. After using Saccharomyces Boulardii+MOS, alongside a strict gluten and lactose-free diet, he has maintained good health and has been hospital-free for 20 months. Our gastroenterologist approves of this product, and we are truly pleased with the results. Thank you.
9
Effective symptom control
2 people found this helpful
I suffer from ulcerative colitis and use the Saccharomyces Boulardii veggie caps on an "as needed" basis. It effectively controls the diarrhoea associated with UC. This product acts faster than regular acidophilus and is less likely to cause a floral overgrowth.
8
Saccharomyces boulardii aids colitis treatment
We investigated how Saccharomyces boulardii supernatant (SbS) could help alleviate ulcerative colitis (UC) using a murine model. By examining the FXR-NLRP3 signaling pathway, we found that SbS activates FXR and suppresses the NLRP3 inflammasome, reducing macrophage pyroptosis.
Our results indicated that SbS significantly improved symptoms of colitis, making it a promising treatment approach.
Our results indicated that SbS significantly improved symptoms of colitis, making it a promising treatment approach.
9
We explored how the probiotic yeast, Saccharomyces boulardii, helps treat ulcerative colitis in mice. After administering it for three weeks, we observed that it protected the mice from weight loss, diarrhea, and intestinal damage caused by a substance that simulates the condition.
Saccharomyces boulardii helped strengthen the intestinal barrier, reduced inflammation, and boosted antioxidant levels. The study suggests that it works by blocking inflammatory pathways while encouraging protective mechanisms in the gut. Overall, it shows promising potential in managing ulcerative colitis symptoms in this animal model.
Saccharomyces boulardii helped strengthen the intestinal barrier, reduced inflammation, and boosted antioxidant levels. The study suggests that it works by blocking inflammatory pathways while encouraging protective mechanisms in the gut. Overall, it shows promising potential in managing ulcerative colitis symptoms in this animal model.
9
This study delved into the effects of heat-killed Saccharomyces boulardii on ulcerative colitis, aiming to uncover its potential as a treatment option. We observed that this treatment significantly restored body weight, reduced inflammation, and improved gut barrier function in mice with colitis. It also effectively modulated gut microbiota, outperforming other treatments like β-glucan.
Overall, heat-killed Saccharomyces boulardii presents a promising new approach for those suffering from ulcerative colitis, enhancing their quality of life.
Overall, heat-killed Saccharomyces boulardii presents a promising new approach for those suffering from ulcerative colitis, enhancing their quality of life.
8
In our investigation, we analyzed the potential of various yeast strains as probiotics for treating ulcerative colitis (UC). The strain QHNLD8L1 stood out for its ability to alleviate symptoms linked to DSS-induced colitis in mice.
This was evident through improvements in body weight, colon length, and reduced inflammation markers. Additionally, QHNLD8L1 helped restore the intestinal barrier and change the gut microbiome by increasing beneficial bacteria and reducing harmful ones.
Overall, we observed strong evidence suggesting that QHNLD8L1 could be a valuable option for preventing and easing UC symptoms.
This was evident through improvements in body weight, colon length, and reduced inflammation markers. Additionally, QHNLD8L1 helped restore the intestinal barrier and change the gut microbiome by increasing beneficial bacteria and reducing harmful ones.
Overall, we observed strong evidence suggesting that QHNLD8L1 could be a valuable option for preventing and easing UC symptoms.
References
- Culpepper T, Senthil K, Vlcek J, Hazelton A, Heavey MK, et al. Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice. Dig Dis Sci. 2025. 10.1007/s10620-025-09008-9
- Yang L, Li W, Zhao Q, Mo Q, Liu T, et al. Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis. J Inflamm Res. 2025;18:3161. 10.2147/JIR.S504957
- Han K, Park JS, Kim YW, Lee W, Park K, et al. Efficient surface display of single-chain variable fragments against tumor necrosis factor α on engineered probiotic Saccharomyces boulardii and its application in alleviating intestinal inflammation in vivo. N Biotechnol. 2025;86:107. 10.1016/j.nbt.2025.02.003
- Qin X, Zhao Q, Zhao Q, Yang L, Li W, et al. A Saccharomyces boulardii-derived antioxidant protein, thioredoxin, ameliorates intestinal inflammation through transactivating epidermal growth factor receptor. Pharmacol Res. 2024;208:107372. 10.1016/j.phrs.2024.107372
- Heavey MK, Hazelton A, Wang Y, Garner M, Anselmo AC, et al. Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis. Nat Commun. 2024;15:3784. 10.1038/s41467-024-48128-0
- Jin Y, Wu J, Huang K, Liang Z. Heat-Killed Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis by Restoring the Intestinal Barrier, Reducing Inflammation, and Modulating the Gut Microbiota. Nutrients. 2024;16. 10.3390/nu16050702
- Gao H, Li Y, Xu J, Zuo X, Yue T, et al. protects against murine experimental colitis by reshaping the gut microbiome and its metabolic profile. Front Microbiol. 2023;14:1204122. 10.3389/fmicb.2023.1204122
- Hu Q, Yu L, Zhai Q, Zhao J, Tian F. Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice. Int J Mol Sci. 2023;24. 10.3390/ijms24076721
- Xu X, Wu J, Jin Y, Huang K, Zhang Y, et al. Both and Its Postbiotics Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, Association with Modulating Inflammation and Intestinal Microbiota. Nutrients. 2023;15. 10.3390/nu15061484
- Lee JE, Lee E. The Probiotic Effects of the 28-7 Strain Isolated from Nuruk in a DSS-Induced Colitis Mouse Model. J Microbiol Biotechnol. 2022;32:877. 10.4014/jmb.2206.06035
- Gao H, Li Y, Sun J, Xu H, Wang M, et al. Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways. Oxid Med Cell Longev. 2021;2021:1622375. 10.1155/2021/1622375
- Mu Z, Yang Y, Xia Y, Wang F, Sun Y, et al. Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota. Food Funct. 2021;12:8386. 10.1039/d1fo01314a
- Liu CH, Chang JH, Chang YC, Mou KY. Treatment of murine colitis by Saccharomyces boulardii secreting atrial natriuretic peptide. J Mol Med (Berl). 2020;98:1675. 10.1007/s00109-020-01987-8
- Wang C, Li W, Wang H, Ma Y, Zhao X, et al. Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota. BMC Microbiol. 2019;19:246. 10.1186/s12866-019-1610-8
- Lam S, Zuo T, Ho M, Chan FKL, Chan PKS, et al. Review article: fungal alterations in inflammatory bowel diseases. Aliment Pharmacol Ther. 2019;50:1159. 10.1111/apt.15523
- Dong JP, Zheng Y, Wu T, He Q, Teng GG, et al. Protective effect of Saccharomyces boulardii on intestinal mucosal barrier of dextran sodium sulfate-induced colitis in mice. Chin Med J (Engl). 2019;132:1951. 10.1097/CM9.0000000000000364
