Last update
3/12/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.5
USERS' SCORE
Moderately Good
Based on 64 Reviews
7.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
9
We investigated the effects of brewer's yeast cell wall (BYC) on constipation in male rats induced by a medication called loperamide. In our findings, rats that received BYC showed significantly better defecation compared to those on a non-fiber diet or a cellulose-based diet. This improvement also included higher fecal water content and volatile fatty acids in the cecal contents. These results suggest that BYC can be beneficial in alleviating constipation by enhancing fermentation and water retention in the digestive system.
Read More
8
EpiCor modulates gut microbiome effects
We explored how EpiCor fermentate, derived from yeast, could help alleviate gastrointestinal discomfort and constipation. Through a randomized, double-blind, placebo-controlled study with 80 participants, we tracked changes in symptoms and bowel movements over six weeks.
Results showed that while EpiCor did modify the gut microbiome, any improvements in constipation symptoms were modest. Interestingly, the treatment seemed to encourage a quicker transit time for digestion, possibly changing the balance of gut bacteria. Overall, EpiCor may have some benefits, but its effects were not as significant as anticipated.
Results showed that while EpiCor did modify the gut microbiome, any improvements in constipation symptoms were modest. Interestingly, the treatment seemed to encourage a quicker transit time for digestion, possibly changing the balance of gut bacteria. Overall, EpiCor may have some benefits, but its effects were not as significant as anticipated.
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9
We evaluated the effectiveness of probiotics, including strains like Lactobacillus rhamnosus and Saccharomyces boulardii, in preventing antibiotic-associated diarrhea (AAD) in children. Our review covered 23 diverse studies involving nearly 4,000 young participants.
The results were promising: probiotics reduced the incidence of AAD from 19% to 8%. While results were generally optimistic, with no serious side effects reported, moderate evidence suggests further studies are needed before fully endorsing probiotics for all pediatric patients.
The results were promising: probiotics reduced the incidence of AAD from 19% to 8%. While results were generally optimistic, with no serious side effects reported, moderate evidence suggests further studies are needed before fully endorsing probiotics for all pediatric patients.
Read More
Most Useful Reviews
9
Addresses constipation
127 people found this helpful
Your gut will appreciate this supplement. It eliminates constipation and stops bloating effectively.
Read More
0
Increased discomfort
10 people found this helpful
With my leaky gut and SIBO, I was hopeful about this probiotic, but it worsened my gassy stomach and led to constipation. I realised I needed to avoid some ingredients, as they aggravated my condition.
Read More
10
Life-changing experience
9 people found this helpful
SB+MOS has truly changed my life, thanks to recommendations from over sixty others on a medical site. I struggled with medications that caused gut issues like constipation and bloating. After trying this probiotic, I noticed immediate improvements. It not only normalised my gut toxins quickly but also resolved my medication-related problems entirely. I never expected such a positive outcome! The convenience of not needing refrigeration is an added benefit. I plan to incorporate it into my daily routine moving forward.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.5
- All Researches
9
We evaluated the effectiveness of probiotics, including strains like Lactobacillus rhamnosus and Saccharomyces boulardii, in preventing antibiotic-associated diarrhea (AAD) in children. Our review covered 23 diverse studies involving nearly 4,000 young participants.
The results were promising: probiotics reduced the incidence of AAD from 19% to 8%. While results were generally optimistic, with no serious side effects reported, moderate evidence suggests further studies are needed before fully endorsing probiotics for all pediatric patients.
The results were promising: probiotics reduced the incidence of AAD from 19% to 8%. While results were generally optimistic, with no serious side effects reported, moderate evidence suggests further studies are needed before fully endorsing probiotics for all pediatric patients.
Read More
9
We explored the effects of Saccharomyces cerevisiae on patients suffering from Irritable Bowel Syndrome (IBS). In a four-week study with thirty participants, we found that daily 500 mg doses of this yeast led to significant reductions in abdominal pain and improvements in overall quality of life.
Results showed pain scores decreased dramatically, and all quality of life measures improved after treatment. This suggests that Saccharomyces cerevisiae could be an effective option for those looking to alleviate IBS symptoms.
Results showed pain scores decreased dramatically, and all quality of life measures improved after treatment. This suggests that Saccharomyces cerevisiae could be an effective option for those looking to alleviate IBS symptoms.
Read More
9
TRANSITECH improves bowel movement frequency
We examined how TRANSITECH, a food supplement made from plants and lactic ferments, affects constipation in healthy adults. Over a 10-day period, participants took either TRANSITECH or a placebo.
After monitoring their bowel movements, colonic transit time (CTT), and bloating, we found that TRANSITECH significantly increased their bowel movements and improved transit times without causing discomfort.
Impressively, these benefits continued even after participants stopped using the supplement.
After monitoring their bowel movements, colonic transit time (CTT), and bloating, we found that TRANSITECH significantly increased their bowel movements and improved transit times without causing discomfort.
Impressively, these benefits continued even after participants stopped using the supplement.
Read More
9
We investigated the effects of brewer's yeast cell wall (BYC) on constipation in male rats induced by a medication called loperamide. In our findings, rats that received BYC showed significantly better defecation compared to those on a non-fiber diet or a cellulose-based diet. This improvement also included higher fecal water content and volatile fatty acids in the cecal contents. These results suggest that BYC can be beneficial in alleviating constipation by enhancing fermentation and water retention in the digestive system.
Read More
8
We examined how Saccharomyces boulardii, a probiotic, can help patients experiencing constipation and other symptoms of dysbiosis. Over a two-year period, 209 patients were treated; those given this probiotic showed significant improvements.
Most reported a reduction in stool frequency and alleviation of discomfort, such as flatulence and abdominal pain. In fact, 92.9% of the 141 patients in the main treatment group experienced a noticeable improvement after the treatment course.
Overall, the findings suggest that Saccharomyces boulardii can effectively enhance intestinal health in individuals affected by gastrointestinal disorders, including constipation.
Most reported a reduction in stool frequency and alleviation of discomfort, such as flatulence and abdominal pain. In fact, 92.9% of the 141 patients in the main treatment group experienced a noticeable improvement after the treatment course.
Overall, the findings suggest that Saccharomyces boulardii can effectively enhance intestinal health in individuals affected by gastrointestinal disorders, including constipation.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 64 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Addresses constipation
127 people found this helpful
Your gut will appreciate this supplement. It eliminates constipation and stops bloating effectively.
Read More
0
Increased discomfort
10 people found this helpful
With my leaky gut and SIBO, I was hopeful about this probiotic, but it worsened my gassy stomach and led to constipation. I realised I needed to avoid some ingredients, as they aggravated my condition.
Read More
10
Life-changing experience
9 people found this helpful
SB+MOS has truly changed my life, thanks to recommendations from over sixty others on a medical site. I struggled with medications that caused gut issues like constipation and bloating. After trying this probiotic, I noticed immediate improvements. It not only normalised my gut toxins quickly but also resolved my medication-related problems entirely. I never expected such a positive outcome! The convenience of not needing refrigeration is an added benefit. I plan to incorporate it into my daily routine moving forward.
Read More
9
Post-antibiotic recovery
5 people found this helpful
This probiotic helped me recover my digestive system after antibiotics, addressing mild constipation effectively while supporting a healthy microbiome.
Read More
9
Relieves constipation
5 people found this helpful
My 82-year-old mother has been struggling with constipation and a heavy stomach. This product has effectively helped with gas. She expressed her happiness and satisfaction. I took one tablet before a meal; it's easy to swallow and doesn't taste like a capsule. The packaging is meticulous, and I stored it in the fridge during summer. The quality and ingredients seem top-notch.
Read More
Frequently Asked Questions
9
Constipation improvement
4 people found this helpful
This amazing probiotic has resolved my persistent constipation issues. I also dealt with a Yersinia infection, and I believe this product has aided my recovery. After three months of therapy, I'm feeling much better.
9
Addresses constipation
127 people found this helpful
Your gut will appreciate this supplement. It eliminates constipation and stops bloating effectively.
0
Increased discomfort
10 people found this helpful
With my leaky gut and SIBO, I was hopeful about this probiotic, but it worsened my gassy stomach and led to constipation. I realised I needed to avoid some ingredients, as they aggravated my condition.
8
We examined how Saccharomyces boulardii, a probiotic, can help patients experiencing constipation and other symptoms of dysbiosis. Over a two-year period, 209 patients were treated; those given this probiotic showed significant improvements.
Most reported a reduction in stool frequency and alleviation of discomfort, such as flatulence and abdominal pain. In fact, 92.9% of the 141 patients in the main treatment group experienced a noticeable improvement after the treatment course.
Overall, the findings suggest that Saccharomyces boulardii can effectively enhance intestinal health in individuals affected by gastrointestinal disorders, including constipation.
Most reported a reduction in stool frequency and alleviation of discomfort, such as flatulence and abdominal pain. In fact, 92.9% of the 141 patients in the main treatment group experienced a noticeable improvement after the treatment course.
Overall, the findings suggest that Saccharomyces boulardii can effectively enhance intestinal health in individuals affected by gastrointestinal disorders, including constipation.
8
We examined the effectiveness of Saccharomyces boulardii as an add-on therapy for treating Helicobacter pylori and its impact on constipation.
Our analysis included 18 trials with over 3,500 patients. The results showed that S. boulardii not only helped boost H. pylori eradication rates but also reduced the incidence of constipation.
Overall, S. boulardii appears beneficial as it increases treatment success while decreasing side effects, making it a promising option for those undergoing H. pylori therapy.
Our analysis included 18 trials with over 3,500 patients. The results showed that S. boulardii not only helped boost H. pylori eradication rates but also reduced the incidence of constipation.
Overall, S. boulardii appears beneficial as it increases treatment success while decreasing side effects, making it a promising option for those undergoing H. pylori therapy.
4
We explored the effectiveness of Saccharomyces boulardii in treating childhood functional constipation in a trial involving 187 children. These kids were divided into three groups: lactulose monotherapy, combination therapy, and Saccharomyces boulardii monotherapy.
By week 12, the success rates for bowel movements were significantly higher in the lactulose and combination groups compared to the monotherapy group. However, we found that Saccharomyces boulardii's effectiveness did not exceed that of lactulose alone, as it had a higher rate of required medication changes.
Overall, the findings suggest that probiotics like Saccharomyces boulardii may not be the primary recommended treatment for this condition.
By week 12, the success rates for bowel movements were significantly higher in the lactulose and combination groups compared to the monotherapy group. However, we found that Saccharomyces boulardii's effectiveness did not exceed that of lactulose alone, as it had a higher rate of required medication changes.
Overall, the findings suggest that probiotics like Saccharomyces boulardii may not be the primary recommended treatment for this condition.
References
- Tang S, Li J, Li Y, Du H, Zhu W, et al. Effects of Saccharomyces boulardii on microbiota composition and metabolite levels in the small intestine of constipated mice. BMC Microbiol. 2024;24:493. 10.1186/s12866-024-03647-0
- Chen Y, Teng T, Su Y, Chen WZ. The effect of supplementing with on bismuth quadruple therapy for eradicating : a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2024;11:1344702. 10.3389/fmed.2024.1344702
- Lee KJ, Ryoo E, Lee YM, Yoon JM, Jang HJ, et al. and Lactulose for Childhood Functional Constipation: A Multicenter Randomized Controlled Trial. J Neurogastroenterol Motil. 2022;28:454. 10.5056/jnm21130
- Kvit AD, Tutka MM, Laba OV, Kunovskiy VV. APPLICATION OF THE SACCHAROMYCES BOULARDII PROBIOTIC COMPLEX IN THE CORRECTION OF INTRAINTESTINAL HOMEOSTASIS IN PATIENTS WITH DYSBIOTIC DISORDERS DUE TO ANTIBIOTIC THERAPY. Wiad Lek. 2021;74:1655. PubMed
- García-Collinot G, Madrigal-Santillán EO, Martínez-Bencomo MA, Carranza-Muleiro RA, Jara LJ, et al. Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis. Dig Dis Sci. 2020;65:1134. 10.1007/s10620-019-05830-0
- Zhou BG, Chen LX, Li B, Wan LY, Ai YW. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis. Helicobacter. 2019;24:e12651. 10.1111/hel.12651
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. 10.1007/s12602-018-9401-3
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD004827.pub4
- Zhao HM, Ou-Yang HJ, Duan BP, Xu B, Chen ZY, et al. [Clinical effect of triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori infection in children]. Zhongguo Dang Dai Er Ke Za Zhi. 2014;16:230. PubMed
- Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40:492. 10.12669/pjms.40.3.8349
- Mourey F, Decherf A, Jeanne JF, Clément-Ziza M, Grisoni ML, et al. I-3856 in irritable bowel syndrome with predominant constipation. World J Gastroenterol. 2022;28:2509. 10.3748/wjg.v28.i22.2509
- Chen Z, Lin S, Jiang Y, Liu L, Jiang J, et al. Effects of Bread Yeast Cell Wall Beta-Glucans on Mice with Loperamide-Induced Constipation. J Med Food. 2019;22:1009. 10.1089/jmf.2019.4407
- Lim JM, Kim YD, Song CH, Park SJ, Park DC, et al. Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats. BMC Complement Altern Med. 2019;19:143. 10.1186/s12906-019-2557-x
- Pinheiro I, Robinson L, Verhelst A, Marzorati M, Winkens B, et al. A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complement Altern Med. 2017;17:441. 10.1186/s12906-017-1948-0
- Cayzeele-Decherf A, Pélerin F, Leuillet S, Douillard B, Housez B, et al. CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23:336. 10.3748/wjg.v23.i2.336
- Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United European Gastroenterol J. 2016;4:353. 10.1177/2050640615602571
- Alexandre V, Bertin C, Boubaya M, Airinei G, Bouchoucha M, et al. Randomized clinical trial: efficacy of a food supplement, TRANSITECH, on healthy individuals with mild intermittent constipation. Eur J Gastroenterol Hepatol. 2016;28:1087. 10.1097/MEG.0000000000000672
- Nakamura T, Agata K, Mizutani M, Iino H. Effects of brewer's yeast cell wall on constipation and defecation in experimentally constipated rats. Biosci Biotechnol Biochem. 2001;65:774. PubMed
Data last updated:
