Last update
3/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
USERS' SCORE
Moderately Good
Based on 51 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Saccharomyces boulardii(an S. cerevisiae Strain)
250 mg(5 Billion CFU)
†
MOS Yeast Fraction(Min. 35% Manno-oligosaccharides [MOS]) (S. cerevisiae)
200 mg
†
Top Medical Research Studies
8
We analyzed data from two clinical trials involving 579 individuals with Irritable Bowel Syndrome (IBS) to determine how CNCM I-3856 affects symptoms like bloating.
Our findings revealed that during the second month of supplementation, participants experienced significant reductions in both abdominal pain and bloating—up to 14.9% compared to those taking a placebo.
While intestinal symptoms improved, there were no significant differences observed between groups at the end of treatment. However, stool consistency was notably better in those taking CNCM I-3856.
Our findings revealed that during the second month of supplementation, participants experienced significant reductions in both abdominal pain and bloating—up to 14.9% compared to those taking a placebo.
While intestinal symptoms improved, there were no significant differences observed between groups at the end of treatment. However, stool consistency was notably better in those taking CNCM I-3856.
Read More
9
We looked into how probiotics, like Saccharomyces boulardii, can help prevent antibiotic-associated diarrhea (AAD) in children. Involving 23 studies with nearly 4,000 participants, our findings indicate a significant benefit from probiotics, with AAD occurring in 8% of the probiotic group versus 19% in the control group.
It appears that probiotics, particularly certain strains, can help keep children's gut health intact during antibiotic treatments. While no serious side effects were recorded, some mild issues like bloating were noted. Overall, moderate evidence supports using these probiotics to ward off AAD.
It appears that probiotics, particularly certain strains, can help keep children's gut health intact during antibiotic treatments. While no serious side effects were recorded, some mild issues like bloating were noted. Overall, moderate evidence supports using these probiotics to ward off AAD.
Read More
8
Probiotic treatment resolved infection
We examined a case involving a 41-year-old man who suffered from cramps, bloating, and watery diarrhea after drinking non-potable water. While initial tests ruled out gluten intolerance and other infectious agents, a deeper analysis eventually identified the presence of Blastocystis hominis. This protozoan is known to be associated with chronic intestinal issues and can be waterborne. Remarkably, treatment with the probiotic Saccharomyces boulardii seemed to effectively resolve the infection. This suggests that Saccharomyces boulardii might offer a beneficial approach for managing similar cases.
Read More
Most Useful Reviews
9
Bloating symptoms gone
263 people found this helpful
When S. boulardii is the right one, it's all you need. This probiotic stands out for gut inflammation. After my doctor reduced my supplements list, I noticed my bloating, gas, and GERD disappeared. Three weeks after eliminating junk probiotics and fibre, everything normalised.
Read More
7.5
Fungal support
23 people found this helpful
Excellent for treating fungal infections and effective for easing children's bloating.
Read More
10
Helped Crohn's symptoms
17 people found this helpful
I used to use Florastor, which was expensive, but researched to find similar strains. This brand has significantly assisted me with bloating, gas, and abdominal discomfort from Crohn's Disease. I take two daily, and it’s the best supplement ever!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.1
- All Researches
9
We looked into how probiotics, like Saccharomyces boulardii, can help prevent antibiotic-associated diarrhea (AAD) in children. Involving 23 studies with nearly 4,000 participants, our findings indicate a significant benefit from probiotics, with AAD occurring in 8% of the probiotic group versus 19% in the control group.
It appears that probiotics, particularly certain strains, can help keep children's gut health intact during antibiotic treatments. While no serious side effects were recorded, some mild issues like bloating were noted. Overall, moderate evidence supports using these probiotics to ward off AAD.
It appears that probiotics, particularly certain strains, can help keep children's gut health intact during antibiotic treatments. While no serious side effects were recorded, some mild issues like bloating were noted. Overall, moderate evidence supports using these probiotics to ward off AAD.
Read More
8
Probiotics significantly reduce bloating
We explored the effectiveness of the probiotic supplement Saccharomyces boulardii in reducing bloating and gastric pain among airline pilots suffering from chronic non-atrophic gastritis.
Over four weeks, participants were divided into groups receiving different doses of the probiotic or undergoing watchful waiting.
The results showed that both probiotic doses significantly improved symptoms compared to the control group, but only the high-dose led to notable changes in certain serum markers.
Overall, this suggests that Saccharomyces boulardii could help ease bloating and gastric discomfort in situations where these issues are common.
Over four weeks, participants were divided into groups receiving different doses of the probiotic or undergoing watchful waiting.
The results showed that both probiotic doses significantly improved symptoms compared to the control group, but only the high-dose led to notable changes in certain serum markers.
Overall, this suggests that Saccharomyces boulardii could help ease bloating and gastric discomfort in situations where these issues are common.
Read More
8
Saccharomyces boulardii aids bloating relief
In this clinical trial, we evaluated the impact of Saccharomyces boulardii on patients with small intestinal bacterial overgrowth (SIBO) related to systemic sclerosis (SSc).
We examined the effects of S. boulardii alone, with metronidazole, or in combination for two months.
Results showed that both S. boulardii and the combination treatment significantly reduced gastrointestinal symptoms, including bloating, while metronidazole alone had limited success.
Overall, S. boulardii proves beneficial, giving hope to those suffering from related discomfort.
We examined the effects of S. boulardii alone, with metronidazole, or in combination for two months.
Results showed that both S. boulardii and the combination treatment significantly reduced gastrointestinal symptoms, including bloating, while metronidazole alone had limited success.
Overall, S. boulardii proves beneficial, giving hope to those suffering from related discomfort.
Read More
8
Probiotic treatment resolved infection
We examined a case involving a 41-year-old man who suffered from cramps, bloating, and watery diarrhea after drinking non-potable water. While initial tests ruled out gluten intolerance and other infectious agents, a deeper analysis eventually identified the presence of Blastocystis hominis. This protozoan is known to be associated with chronic intestinal issues and can be waterborne. Remarkably, treatment with the probiotic Saccharomyces boulardii seemed to effectively resolve the infection. This suggests that Saccharomyces boulardii might offer a beneficial approach for managing similar cases.
Read More
8
We explored how probiotics might help prevent antibiotic-associated diarrhea (AAD) in children. By analyzing 23 studies involving almost 4,000 young participants, we found that probiotics significantly reduced AAD incidence compared to placebo or no treatment.
Specifically, AAD occurred in 8% of children receiving probiotics versus 19% in the control groups. We noted that Lactobacillus rhamnosus and Saccharomyces boulardii were among the most effective strains.
While adverse events were mild and rare, further research is needed regarding other probiotic strains, especially for at-risk children.
Specifically, AAD occurred in 8% of children receiving probiotics versus 19% in the control groups. We noted that Lactobacillus rhamnosus and Saccharomyces boulardii were among the most effective strains.
While adverse events were mild and rare, further research is needed regarding other probiotic strains, especially for at-risk children.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 51 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Bloating symptoms gone
263 people found this helpful
When S. boulardii is the right one, it's all you need. This probiotic stands out for gut inflammation. After my doctor reduced my supplements list, I noticed my bloating, gas, and GERD disappeared. Three weeks after eliminating junk probiotics and fibre, everything normalised.
Read More
7.5
Fungal support
23 people found this helpful
Excellent for treating fungal infections and effective for easing children's bloating.
Read More
10
Helped Crohn's symptoms
17 people found this helpful
I used to use Florastor, which was expensive, but researched to find similar strains. This brand has significantly assisted me with bloating, gas, and abdominal discomfort from Crohn's Disease. I take two daily, and it’s the best supplement ever!
Read More
9
Normalised stool
10 people found this helpful
An excellent probiotic; this is not the first time I have used it. It helps normalise my stool, which is vital for me. Bloating has vanished, and my intestines have cleared. Thus far, this is the best probiotic I've ever tried!
Read More
9
Stomach comfort
5 people found this helpful
This product has provided comfort to my stomach. I often suffer from gas and bloating, but it has resolved these issues effectively.
Read More
Frequently Asked Questions
8
Probiotics significantly reduce bloating
We explored the effectiveness of the probiotic supplement Saccharomyces boulardii in reducing bloating and gastric pain among airline pilots suffering from chronic non-atrophic gastritis.
Over four weeks, participants were divided into groups receiving different doses of the probiotic or undergoing watchful waiting.
The results showed that both probiotic doses significantly improved symptoms compared to the control group, but only the high-dose led to notable changes in certain serum markers.
Overall, this suggests that Saccharomyces boulardii could help ease bloating and gastric discomfort in situations where these issues are common.
Over four weeks, participants were divided into groups receiving different doses of the probiotic or undergoing watchful waiting.
The results showed that both probiotic doses significantly improved symptoms compared to the control group, but only the high-dose led to notable changes in certain serum markers.
Overall, this suggests that Saccharomyces boulardii could help ease bloating and gastric discomfort in situations where these issues are common.
8
Saccharomyces boulardii aids bloating relief
In this clinical trial, we evaluated the impact of Saccharomyces boulardii on patients with small intestinal bacterial overgrowth (SIBO) related to systemic sclerosis (SSc).
We examined the effects of S. boulardii alone, with metronidazole, or in combination for two months.
Results showed that both S. boulardii and the combination treatment significantly reduced gastrointestinal symptoms, including bloating, while metronidazole alone had limited success.
Overall, S. boulardii proves beneficial, giving hope to those suffering from related discomfort.
We examined the effects of S. boulardii alone, with metronidazole, or in combination for two months.
Results showed that both S. boulardii and the combination treatment significantly reduced gastrointestinal symptoms, including bloating, while metronidazole alone had limited success.
Overall, S. boulardii proves beneficial, giving hope to those suffering from related discomfort.
7
Saccharomyces boulardii reduces bloating effects
We evaluated the effects of the probiotic Saccharomyces boulardii on bloating in patients undergoing treatment for H. pylori infection. In a randomized controlled trial, 160 adults were divided into two groups: one received standard antibiotics along with Saccharomyces boulardii, while the other was treated with antibiotics alone.
Although the addition of the probiotic resulted in significantly fewer side effects, including bloating, it did not lead to a notable improvement in eradicating H. pylori. This suggests that while Saccharomyces boulardii may help with discomfort, it doesn't enhance the overall success of H. pylori treatment.
Although the addition of the probiotic resulted in significantly fewer side effects, including bloating, it did not lead to a notable improvement in eradicating H. pylori. This suggests that while Saccharomyces boulardii may help with discomfort, it doesn't enhance the overall success of H. pylori treatment.
7
Yeast treatment shows mixed results
We investigated the effects of EpiCor fermentate on gastrointestinal discomfort and constipation, focusing on bloating. In a randomized double-blind trial, eighty participants tracked their symptoms over six weeks, comparing a yeast-based treatment to a placebo. While the results showed that EpiCor could positively influence gut microbiome composition and improve constipation symptoms, there was no significant direct benefit reported for bloating relief. So, while EpiCor can help with certain bowel issues, its effectiveness may not extend to all gastrointestinal discomforts.
References
- Li M, Xie Y. Efficacy and safety of as an adjuvant therapy for the eradication of : a meta-analysis. Front Cell Infect Microbiol. 2025;15:1441185. 10.3389/fcimb.2025.1441185
- Minoretti P, Liaño Riera M, Santiago Sáez A, Gómez Serrano M, García Martín Á. Probiotic Supplementation With Saccharomyces boulardii and Enterococcus faecium Improves Gastric Pain and Bloating in Airline Pilots With Chronic Non-atrophic Gastritis: An Open-Label Study. Cureus. 2024;16:e52502. 10.7759/cureus.52502
- García-Collinot G, Madrigal-Santillán EO, Martínez-Bencomo MA, Carranza-Muleiro RA, Jara LJ, et al. Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis. Dig Dis Sci. 2020;65:1134. 10.1007/s10620-019-05830-0
- Angelici MC, Nardis C, Scarpelli R, Ade P. Blastocystis hominis transmission by non-potable water: a case report in Italy. New Microbiol. 2018;41:173. PubMed
- Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, et al. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol. 2017;73:1199. 10.1007/s00228-017-2291-6
- Hayes SR, Vargas AJ. Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea. Explore (NY). 2016;12:463. 10.1016/j.explore.2016.08.015
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. 10.1002/14651858.CD004827.pub4
- Zojaji H, Ghobakhlou M, Rajabalinia H, Ataei E, Jahani Sherafat S, et al. The efficacy and safety of adding the probiotic Saccharomyces boulardiito standard triple therapy for eradication of H.pylori: a randomized controlled trial. Gastroenterol Hepatol Bed Bench. 2013;6:S99. PubMed
- Polese B, Nicolai E, Genovese D, Verlezza V, La Sala CN, et al. Postprandial Gastrointestinal Function Differs after Acute Administration of Sourdough Compared with Brewer's Yeast Bakery Products in Healthy Adults. J Nutr. 2018;148:202. 10.1093/jn/nxx049
- Pinheiro I, Robinson L, Verhelst A, Marzorati M, Winkens B, et al. A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complement Altern Med. 2017;17:441. 10.1186/s12906-017-1948-0
- Cayzeele-Decherf A, Pélerin F, Leuillet S, Douillard B, Housez B, et al. CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23:336. 10.3748/wjg.v23.i2.336
- Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United European Gastroenterol J. 2016;4:353. 10.1177/2050640615602571
- Pineton de Chambrun G, Neut C, Chau A, Cazaubiel M, Pelerin F, et al. A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Dig Liver Dis. 2015;47:119. 10.1016/j.dld.2014.11.007
- Moya D, Calsamiglia S, Ferret A, Blanch M, Fandiño JI, et al. Effects of dietary changes and yeast culture (Saccharomyces cerevisiae) on rumen microbial fermentation of Holstein heifers. J Anim Sci. 2009;87:2874. 10.2527/jas.2008-1446
- Treem WR, McAdams L, Stanford L, Kastoff G, Justinich C, et al. Sacrosidase therapy for congenital sucrase-isomaltase deficiency. J Pediatr Gastroenterol Nutr. 1999;28:137. PubMed
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