Last update
4/12/2026
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Infographics
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Probiotic Blend
134 mg (1 Billion CFU§)
†
Lactobacillus rhamnosus (GR-1®)
Lactobacillus reuteri (RC-14®)
Top Medical Research Studies
9
We examined how Lactobacillus rhamnosus SP1 impacts acne through a 12-week study involving 20 adults. Participants were split into two groups: one received a liquid probiotic supplement, while the other got a placebo. Notably, those in the probiotic group showed significant improvements in skin gene expression linked to insulin signalling and had a higher chance of being rated as improved by physicians. Our findings suggest that this probiotic not only alters critical skin genes but also visibly enhances adult acne.
Read More
8
We explored how oral intake of Lactobacillus plantarum CCFM8661 affects acne, using a mouse model to examine its effects on skin inflammation and hormone production. Our findings revealed that live L. plantarum significantly reduced acne-related skin inflammation and regulated hormone levels, likely benefiting skin lipid metabolism. In contrast, inactivated L. plantarum showed limited effects on inflammation. Both forms of the probiotic positively influenced gut health, which may also play a role in managing acne. Overall, the evidence suggests that live Lactobacillus may offer a promising avenue for acne treatment.
Read More
8
Lactobacillus aids mild acne treatment
We investigated the effects of lactobacillus plantarum, a beneficial bacteria, on acne treatment. Clinical studies showed that when applied in a 5% solution, lactobacillus extract significantly reduced erythema and improved the skin barrier, which in turn led to smaller acne lesions. However, the lower concentration of 1% did not show these benefits. Overall, the findings suggest that lactobacillus could be a viable option for treating mild acne.
Read More
Most Useful Reviews
10
Acne improved significantly
4 people found this helpful
Maxi volume. This is my third purchase of this product. Previously, I took smaller jars, but during a promotion, I decided to buy a larger one. It lasts a long time with just one capsule per day. It works effectively; my acne on the face has cleared up, and my skin has improved. The most important aspect of FemoFlora is that it contains 100% lactobacilli.
Read More
9
Significant acne reduction
Excellent! As I continued to ingest lactic acid bacteria, I noticed a significant reduction in my acne.
Read More
8
Effective for chin acne
This is a regularly consumed product. I typically suffer from severe PMS, so I have been taking it alongside gamma-linolenic acid for two months, and I've noticed significant improvements in my chin acne.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7
- All Researches
9
We examined how Lactobacillus rhamnosus SP1 impacts acne through a 12-week study involving 20 adults. Participants were split into two groups: one received a liquid probiotic supplement, while the other got a placebo. Notably, those in the probiotic group showed significant improvements in skin gene expression linked to insulin signalling and had a higher chance of being rated as improved by physicians. Our findings suggest that this probiotic not only alters critical skin genes but also visibly enhances adult acne.
Read More
9
We explored whether tiny particles derived from a beneficial Lactobacillus bacteria could tackle acne from multiple angles. Using both laboratory tests and acne-prone mice, we found that these extracellular vesicles significantly reduced redness, swelling, and the acne-causing bacteria P. acnes.
The particles contained nine proteins with direct anti-acne properties, including enzymes that break down bacterial cell walls and regulate oils. Beyond killing bacteria, they also protected the skin's healthy microbiota balance and triggered beneficial changes in immune and metabolic pathways. This multi-pronged approach suggests probiotic-derived particles could offer a safer, more effective alternative to traditional acne treatments.
The particles contained nine proteins with direct anti-acne properties, including enzymes that break down bacterial cell walls and regulate oils. Beyond killing bacteria, they also protected the skin's healthy microbiota balance and triggered beneficial changes in immune and metabolic pathways. This multi-pronged approach suggests probiotic-derived particles could offer a safer, more effective alternative to traditional acne treatments.
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8
We evaluated how effective probiotics, specifically lactobacillus, might be for treating acne. Analyzing numerous studies revealed that these probiotics can help reduce acne lesions and improve skin health. Interestingly, both oral and topical applications showed promising results, sometimes even matching conventional treatments like antibiotics.
However, we also noticed that responses to specific probiotic strains varied, and some participants experienced rare side effects. Overall, our findings suggest that while probiotics could offer a natural treatment option, further research is essential to establish the best practices for use.
However, we also noticed that responses to specific probiotic strains varied, and some participants experienced rare side effects. Overall, our findings suggest that while probiotics could offer a natural treatment option, further research is essential to establish the best practices for use.
Read More
8
We examined how lactobacillus might improve acne vulgaris through changes in gut bacteria and tryptophan metabolism. Using a rat model that mimicked human gut conditions, we introduced gut microbiota from both healthy individuals and acne patients.
Our findings showed that lactobacillus significantly reduced acne-like symptoms by lowering inflammation and promoting beneficial bacteria. It also enhanced tryptophan metabolites linked to skin health, suggesting its potential as a natural treatment option.
Our findings showed that lactobacillus significantly reduced acne-like symptoms by lowering inflammation and promoting beneficial bacteria. It also enhanced tryptophan metabolites linked to skin health, suggesting its potential as a natural treatment option.
Read More
8
We explored how oral intake of Lactobacillus plantarum CCFM8661 affects acne, using a mouse model to examine its effects on skin inflammation and hormone production. Our findings revealed that live L. plantarum significantly reduced acne-related skin inflammation and regulated hormone levels, likely benefiting skin lipid metabolism. In contrast, inactivated L. plantarum showed limited effects on inflammation. Both forms of the probiotic positively influenced gut health, which may also play a role in managing acne. Overall, the evidence suggests that live Lactobacillus may offer a promising avenue for acne treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Acne improved significantly
4 people found this helpful
Maxi volume. This is my third purchase of this product. Previously, I took smaller jars, but during a promotion, I decided to buy a larger one. It lasts a long time with just one capsule per day. It works effectively; my acne on the face has cleared up, and my skin has improved. The most important aspect of FemoFlora is that it contains 100% lactobacilli.
Read More
9
Significant acne reduction
Excellent! As I continued to ingest lactic acid bacteria, I noticed a significant reduction in my acne.
Read More
8
Effective for chin acne
This is a regularly consumed product. I typically suffer from severe PMS, so I have been taking it alongside gamma-linolenic acid for two months, and I've noticed significant improvements in my chin acne.
Read More
2
No noticeable effect
I initially consumed it for chin acne, but it doesn't seem to have worked for me… The requirement for refrigeration is also inconvenient.
Read More
Frequently Asked Questions
8
Effective for chin acne
This is a regularly consumed product. I typically suffer from severe PMS, so I have been taking it alongside gamma-linolenic acid for two months, and I've noticed significant improvements in my chin acne.
2
No noticeable effect
I initially consumed it for chin acne, but it doesn't seem to have worked for me… The requirement for refrigeration is also inconvenient.
10
Acne improved significantly
4 people found this helpful
Maxi volume. This is my third purchase of this product. Previously, I took smaller jars, but during a promotion, I decided to buy a larger one. It lasts a long time with just one capsule per day. It works effectively; my acne on the face has cleared up, and my skin has improved. The most important aspect of FemoFlora is that it contains 100% lactobacilli.
9
Significant acne reduction
Excellent! As I continued to ingest lactic acid bacteria, I noticed a significant reduction in my acne.
7
Probiotics enhance acne treatment
We conducted a randomized controlled trial with 80 moderate acne patients, where one group received doxycycline plus probiotics, while the other received only doxycycline. Our findings suggested that adding probiotics improved acne treatment outcomes.
Specifically, the combination therapy showed enhanced effectiveness on acne located on the forehead, chin, and nose. This indicates that probiotics can be a beneficial addition to conventional acne treatments, making it an appealing option for those struggling with this skin condition.
Specifically, the combination therapy showed enhanced effectiveness on acne located on the forehead, chin, and nose. This indicates that probiotics can be a beneficial addition to conventional acne treatments, making it an appealing option for those struggling with this skin condition.
7
We explored how the probiotic strain Lactobacillus reuteri DSM 17938 affects skin health, particularly in reducing acne and inflammation. Our study looked at both live bacteria and their lysate in ex vivo skin models to see their impact on inflammation and skin barrier function.
We found that both forms reduced inflammatory markers and improved skin barrier function. However, the live strain notably showed antimicrobial properties against acne-causing bacteria, while the lysate did not. Overall, L. reuteri appears promising for skin health, but its direct effects on acne need further research.
We found that both forms reduced inflammatory markers and improved skin barrier function. However, the live strain notably showed antimicrobial properties against acne-causing bacteria, while the lysate did not. Overall, L. reuteri appears promising for skin health, but its direct effects on acne need further research.
8
We explored how oral intake of Lactobacillus plantarum CCFM8661 affects acne, using a mouse model to examine its effects on skin inflammation and hormone production. Our findings revealed that live L. plantarum significantly reduced acne-related skin inflammation and regulated hormone levels, likely benefiting skin lipid metabolism. In contrast, inactivated L. plantarum showed limited effects on inflammation. Both forms of the probiotic positively influenced gut health, which may also play a role in managing acne. Overall, the evidence suggests that live Lactobacillus may offer a promising avenue for acne treatment.
7
Probiotic lotion effectively treats acne
We conducted a study to see how effective a probiotic-derived lotion from Lactobacillus paracasei is for treating mild to moderate acne compared to benzoyl peroxide. Patients applied either the probiotic lotion or 2.5% benzoyl peroxide, and we assessed their acne conditions over four weeks.
Results showed that both treatments reduced acne lesions and redness significantly. However, there was no notable difference between the two treatments in effectiveness. Patients using the probiotic lotion experienced fewer side effects, making it a gentle alternative for acne care.
Results showed that both treatments reduced acne lesions and redness significantly. However, there was no notable difference between the two treatments in effectiveness. Patients using the probiotic lotion experienced fewer side effects, making it a gentle alternative for acne care.
8
Lactobacillus aids mild acne treatment
We investigated the effects of lactobacillus plantarum, a beneficial bacteria, on acne treatment. Clinical studies showed that when applied in a 5% solution, lactobacillus extract significantly reduced erythema and improved the skin barrier, which in turn led to smaller acne lesions. However, the lower concentration of 1% did not show these benefits. Overall, the findings suggest that lactobacillus could be a viable option for treating mild acne.
8
Probiotics show promise for acne
We aimed to understand how lactobacillus, combined with topical treatments, impacts acne-prone skin. Over three months, 20 participants took a daily probiotic and applied a topical treatment.
We noticed that clinically visible non-inflammatory lesions decreased from 11.5 to 7.3, suggesting positive effects. Additionally, imaging techniques revealed decreased microscopic acne features, which may not be observable through simple clinical assessments.
This research shows that acne-prone skin responds well to treatment, highlighting lactobacillus as a potential player in managing acne.
We noticed that clinically visible non-inflammatory lesions decreased from 11.5 to 7.3, suggesting positive effects. Additionally, imaging techniques revealed decreased microscopic acne features, which may not be observable through simple clinical assessments.
This research shows that acne-prone skin responds well to treatment, highlighting lactobacillus as a potential player in managing acne.
References
- Sutema IAMP, Latarissa IR, Widowati IGAR, Sartika CR, Ciptasari NWE, et al. Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results. J Exp Pharmacol. 2025;17:1. 10.2147/JEP.S498769
- Atefi N, Mohammadi M, Bodaghabadi M, Mehrali M, Behrangi E, et al. Evaluating the Effectiveness of Probiotic Supplementation in Combination With Doxycycline for the Treatment of Moderate Acne: A Randomized Double-Blind Controlled Clinical Trial. J Cosmet Dermatol. 2025;24:e16614. 10.1111/jocd.16614
- Huang Y, Huang Y, Xia D, Liu L, Xiong X, et al. ameliorates acne vulgaris in SD rats changes in gut microbiota and associated tryptophan metabolism. Front Immunol. 2023;14:1293048. 10.3389/fimmu.2023.1293048
- Cao Q, Guo J, Chang S, Huang Z, Luo Q. Gut microbiota and acne: A Mendelian randomization study. Skin Res Technol. 2023;29:e13473. 10.1111/srt.13473
- Ai J, Ma W, Pan Z, Mao B, Tang X, et al. Ameliorative effect of Lactobacillus plantarum CCFM8661 on oleic acid-induced acne: integrated gut microbiota link to acne pathogenesis. J Sci Food Agric. 2024;104:328. 10.1002/jsfa.12921
- Manfredini M, Sticchi A, Lippolis N, Pedroni G, Giovani M, et al. Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation. J Clin Med. 2023;12. 10.3390/jcm12144787
- Sathikulpakdee S, Kanokrungsee S, Vitheejongjaroen P, Kamanamool N, Udompataikul M, et al. Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial. J Cosmet Dermatol. 2022;21:5092. 10.1111/jocd.14971
- Lebeer S, Oerlemans EFM, Claes I, Henkens T, Delanghe L, et al. Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli. Cell Rep Med. 2022;3:100521. 10.1016/j.xcrm.2022.100521
- Kim MJ, Kim KP, Choi E, Yim JH, Choi C, et al. Effects of CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2021;13. 10.3390/nu13041368
- Cha H, Kim SK, Kook M, Yi TH. Lactobacillus paraplantarum THG-G10 as a potential anti-acne agent with anti-bacterial and anti-inflammatory activities. Anaerobe. 2020;64:102243. 10.1016/j.anaerobe.2020.102243
- Khmaladze I, Butler É, Fabre S, Gillbro JM. Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin. Exp Dermatol. 2019;28:822. 10.1111/exd.13950
- Deidda F, Amoruso A, Nicola S, Graziano T, Pane M, et al. New Approach in Acne Therapy: A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S78. 10.1097/MCG.0000000000001053
- Fabbrocini G, Bertona M, Picazo Ó, Pareja-Galeano H, Monfrecola G, et al. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes. 2016;7:625. PubMed
- Kwon HH, Yoon JY, Park SY, Min S, Suh DH. Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study. Dermatology. 2014;229:102. 10.1159/000362491
- Jung GW, Tse JE, Guiha I, Rao J. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg. 2013;17:114. PubMed
- Muizzuddin N, Maher W, Sullivan M, Schnittger S, Mammone T. Physiological effect of a probiotic on skin. J Cosmet Sci. 2012;63:385. PubMed
- Liu K, Zhang Z, Su Y, Ma X, Wang J, et al. Lactobacillus-derived extracellular vesicles provide multi-target acne treatment by enriched proteins and skin microbiota protection. J Nanobiotechnology. 2026. 10.1186/s12951-026-04291-8
- Abedin ZU, Shah A, Mazhar S, Khan SM, Aamir AB, et al. Lactobacillus-Based Microbiome Therapy for Acne Vulgaris: A GRADE Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Cosmet Dermatol. 2026;25:e70792. 10.1111/jocd.70792
- Tjiu JW, Lu CF. Oral Probiotics in : A Systematic Review and Meta-Analysis of Double-Blind Randomized Clinical Trials. Medicina (Kaunas). 2025;61. 10.3390/medicina61122152
- Shirani M, Bagherniya M, Sadeghi O, Ghasemi Tehrani H, Eskandari MH, et al. Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal status, oxidative stress, and clinical symptoms in women with polycystic ovary syndrome: a randomized clinical trial. Nutr J. 2025;24:175. 10.1186/s12937-025-01240-3
