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SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.6
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Turmeric nanovesicles aid obesity treatment
Development and Evaluation of Reconstructed Nanovesicles from Turmeric for Multifaceted Obesity Intervention.
Strong connection to turmeric use
We explored the potential of turmeric in challenging obesity, driven by its natural properties and numerous health benefits. Our focus was on a newly developed formulation called "Reconstructed Turmeric-derived Nanovesicles" (Rec-tNVs), which aimed to enhance the effects of curcumin, the active component of turmeric.
By using advanced techniques, we increased the curcumin content significantly in these nanovesicles, allowing us to measure their impact more effectively. The Rec-tNVs showed a remarkable capacity to promote fat breakdown and prevent fat creation in fat cells, while also encouraging the conversion of fat cells to a more metabolically active form.
In rigorous tests involving high-fat diet mouse models, we observed weight reductions of about 18.68% and 14.56% with intragastric and subcutaneous delivery of the Rec-tNVs, respectively, over four weeks. Importantly, these results were better than what we saw with free curcumin treatment alone, suggesting that these nanovesicles could target fat tissues effectively and influence overall metabolism and gut health.
This study highlights the multi-dimensional benefits of turmeric and opens doors for new plant-based treatments for obesity. It's an exciting step forward in the quest for safer weight management solutions.
By using advanced techniques, we increased the curcumin content significantly in these nanovesicles, allowing us to measure their impact more effectively. The Rec-tNVs showed a remarkable capacity to promote fat breakdown and prevent fat creation in fat cells, while also encouraging the conversion of fat cells to a more metabolically active form.
In rigorous tests involving high-fat diet mouse models, we observed weight reductions of about 18.68% and 14.56% with intragastric and subcutaneous delivery of the Rec-tNVs, respectively, over four weeks. Importantly, these results were better than what we saw with free curcumin treatment alone, suggesting that these nanovesicles could target fat tissues effectively and influence overall metabolism and gut health.
This study highlights the multi-dimensional benefits of turmeric and opens doors for new plant-based treatments for obesity. It's an exciting step forward in the quest for safer weight management solutions.
Read More
9
Turmeric improves obesity indicators
Consumption of dietary turmeric promotes fat browning and thermogenesis in association with gut microbiota regulation in high-fat diet-fed mice.
High relevance for obesity research
We explored the potential benefits of dietary turmeric powder in combating obesity in mice fed a high-fat diet. Over a period of 12 weeks, groups of high-fat diet (HFD)-fed C57BL/6J mice were given turmeric powder, which made up 8% of their diet, while others did not receive any supplementation.
The results were promising: turmeric significantly improved the metabolic issues commonly associated with obesity. We observed an increase in the development of beige fat and activation of brown adipose tissue, leading to enhanced nonshivering thermogenesis, which is the body's way of burning calories to generate heat.
Our analysis revealed that turmeric also supported healthier gut microbiota by countering the disruptions caused by a high-fat diet. This included increased levels of beneficial microbes and higher production of short-chain fatty acids and succinate, both of which are linked to improved metabolic functions.
We found a clear connection between turmeric's effects on fat browning and changes in the gut microbiome, suggesting that dietary turmeric could be a valuable addition to strategies aimed at obesity prevention. Overall, these findings highlight turmeric's potential in promoting a healthier weight through multiple biological pathways.
The results were promising: turmeric significantly improved the metabolic issues commonly associated with obesity. We observed an increase in the development of beige fat and activation of brown adipose tissue, leading to enhanced nonshivering thermogenesis, which is the body's way of burning calories to generate heat.
Our analysis revealed that turmeric also supported healthier gut microbiota by countering the disruptions caused by a high-fat diet. This included increased levels of beneficial microbes and higher production of short-chain fatty acids and succinate, both of which are linked to improved metabolic functions.
We found a clear connection between turmeric's effects on fat browning and changes in the gut microbiome, suggesting that dietary turmeric could be a valuable addition to strategies aimed at obesity prevention. Overall, these findings highlight turmeric's potential in promoting a healthier weight through multiple biological pathways.
Read More
9
Fermented turmeric combats obesity
Modulatory Effects of -Fermented Turmeric on Metabolic Dysregulation and Gut Microbiota in High-Fat Diet-Induced Obesity in Mice.
Study confirms turmeric's antiobesity effects
We set out to understand how turmeric, specifically when fermented, affects obesity. In a carefully designed study, we used high-fat diet-induced obese mice to explore the impact of both fermented turmeric (FT) and unfermented turmeric (UT) over 16 weeks.
Our findings revealed that the fermentation process actually reduced the curcuminoid content in turmeric, but FT showed remarkable benefits. Not only did it suppress weight gain, but it also reduced fat in the liver and around vital organs. Interestingly, FT displayed better results than UT in managing these obesity-related factors.
We observed that FT played a role in regulating fat cell growth and inflammation while enhancing the body's ability to burn fat. It also improved insulin sensitivity by activating important signaling pathways related to insulin in visceral fat tissue.
Lastly, FT influenced the gut microbiome positively, boosting beneficial bacteria and short-chain fatty acid producers that are known to be good for overall health. This suggests that the effects of fermented turmeric might be a significant means through which it supports weight management and metabolic health.
Our findings revealed that the fermentation process actually reduced the curcuminoid content in turmeric, but FT showed remarkable benefits. Not only did it suppress weight gain, but it also reduced fat in the liver and around vital organs. Interestingly, FT displayed better results than UT in managing these obesity-related factors.
We observed that FT played a role in regulating fat cell growth and inflammation while enhancing the body's ability to burn fat. It also improved insulin sensitivity by activating important signaling pathways related to insulin in visceral fat tissue.
Lastly, FT influenced the gut microbiome positively, boosting beneficial bacteria and short-chain fatty acid producers that are known to be good for overall health. This suggests that the effects of fermented turmeric might be a significant means through which it supports weight management and metabolic health.
Read More
Most Useful Reviews
8.8
Reduces inflammation
The benefit of curcumin is its ability to reduce chronic inflammation, which can lead to metabolic disorders, including obesity. It also positively affects arthritis patients by alleviating joint swelling. Regular use of curcumin notably decreases the risk of liver diseases and mitigates symptoms of conditions like hepatitis, diabetes, and periodontitis.
Read More
8.8
Metabolic support
Turmeric benefits include reducing chronic inflammation that can lead to metabolic disorders and obesity. It also helps arthritis sufferers by decreasing joint swelling and lowers the risk of liver disease while alleviating symptoms of hepatitis and other conditions.
Read More
8
Anti-inflammatory properties
The curcuminoids in turmeric provide excellent anti-inflammatory benefits, making it advisable for various disorders, including obesity, Crohn's disease, and arthritis.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.6
9
Tetrahydrocurcumin mitigates liver fat
Tetrahydrocurcumin Alleviates Metabolic Dysfunction-Associated Steatohepatitis in Mice by Regulating Serum Lipids, Bile Acids, and Gut Microbiota.
Promising findings for THC use
We investigated the effects of Tetrahydrocurcumin (THC) on metabolic dysfunction-related liver conditions in mice. The study involved feeding C57BL/6 mice a methionine-choline-deficient diet for eight weeks to create a model of metabolic dysfunction known as MASH. We compared the impacts of THC with a positive control, obeticholic acid, to see how well THC could alleviate the harmful effects of this diet.
Our findings indicated that THC significantly reduced oxidative stress and fat buildup in the liver. Additionally, it brought down liver triglyceride levels while improving overall liver health in the treated mice. Importantly, THC appeared to correct 34 different abnormalities in lipid levels caused by the diet, leading to changes in gut bacteria that are beneficial for health.
We saw an increase in the diversity and abundance of good bacteria in the intestines, which can aid in metabolic processes. THC also helped lower the levels of certain harmful bile acids in the serum. At the molecular level, THC downregulated genes related to fat production in the liver while enhancing those that aid in bile acid secretion.
Overall, we observed that THC potentially lessens the effects of diet-induced MASH by inhibiting fat synthesis, regulating bile acid levels, and promoting healthy gut flora. This study uncovers new mechanisms by which THC may be effective and suggests future directions for anti-MASH drug development, supporting the screening of clinical biomarkers for personalized diagnosis and treatment options.
Our findings indicated that THC significantly reduced oxidative stress and fat buildup in the liver. Additionally, it brought down liver triglyceride levels while improving overall liver health in the treated mice. Importantly, THC appeared to correct 34 different abnormalities in lipid levels caused by the diet, leading to changes in gut bacteria that are beneficial for health.
We saw an increase in the diversity and abundance of good bacteria in the intestines, which can aid in metabolic processes. THC also helped lower the levels of certain harmful bile acids in the serum. At the molecular level, THC downregulated genes related to fat production in the liver while enhancing those that aid in bile acid secretion.
Overall, we observed that THC potentially lessens the effects of diet-induced MASH by inhibiting fat synthesis, regulating bile acid levels, and promoting healthy gut flora. This study uncovers new mechanisms by which THC may be effective and suggests future directions for anti-MASH drug development, supporting the screening of clinical biomarkers for personalized diagnosis and treatment options.
Read More
9
Curcumin aids in obesity management
Curcumin Mitigates Gut Dysbiosis and Enhances Gut Barrier Function to Alleviate Metabolic Dysfunction in Obese, Aged Mice.
Positive effects on obesity observed
We looked into how curcumin, the active component found in turmeric, can help tackle obesity, particularly in older mice struggling with a high-fat, high-sugar diet. The study involved aging male mice, divided into groups to receive different diets—some with curcumin and some without—over both short and extended periods.
Our findings were promising. By supplementing with curcumin, these mice were able to avoid the typical weight gain and metabolic issues associated with poor diets. We observed significant improvements in the makeup of their gut microbiota, with a notable increase in beneficial bacteria, while harmful types saw a decrease. This positive shift contributed to better gut integrity and reduced inflammation.
Additionally, curcumin seemed to help the liver by positively influencing gene expressions related to bile acid management. This suggests that curcumin could be an effective dietary intervention for improving gut health and combating obesity, particularly in those impacted by age-related factors. Overall, these results highlight the potential benefits turmeric may offer as a nutrition strategy in managing obesity.
Our findings were promising. By supplementing with curcumin, these mice were able to avoid the typical weight gain and metabolic issues associated with poor diets. We observed significant improvements in the makeup of their gut microbiota, with a notable increase in beneficial bacteria, while harmful types saw a decrease. This positive shift contributed to better gut integrity and reduced inflammation.
Additionally, curcumin seemed to help the liver by positively influencing gene expressions related to bile acid management. This suggests that curcumin could be an effective dietary intervention for improving gut health and combating obesity, particularly in those impacted by age-related factors. Overall, these results highlight the potential benefits turmeric may offer as a nutrition strategy in managing obesity.
Read More
9
Curcumin enhances exercise for obesity
Impact of exercise intervention with or without curcumin supplementation on body fat composition, glucose, and lipid metabolism in obese adults: A meta-analysis.
Partial relevance due to study focus
We investigated how curcumin, a compound found in turmeric, affects body composition and metabolic health in obese adults when combined with exercise. By evaluating seven randomized controlled trials, we were able to compare two groups: those who engaged in exercise alone and those who incorporated curcumin into their routine.
Our analysis included 72 men and 111 women, showing that participants in the curcumin plus exercise group had a notable reduction in body fat percentage. The numbers indicated a significant advantage for those who took curcumin, pointing to a strong potential for curcumin to enhance the effects of exercise on obesity.
This finding suggests that combining curcumin supplementation with physical activity could offer a more effective strategy for managing weight. Overall, it seems that incorporating turmeric into our fitness journey might provide benefits worth exploring further.
Our analysis included 72 men and 111 women, showing that participants in the curcumin plus exercise group had a notable reduction in body fat percentage. The numbers indicated a significant advantage for those who took curcumin, pointing to a strong potential for curcumin to enhance the effects of exercise on obesity.
This finding suggests that combining curcumin supplementation with physical activity could offer a more effective strategy for managing weight. Overall, it seems that incorporating turmeric into our fitness journey might provide benefits worth exploring further.
Read More
9
Curcumin alleviates colitis in obesity
Curcumin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice.
Significant insight but complex interactions
We explored the potential of curcumin, a compound found in turmeric, in managing the effects of ulcerative colitis linked to obesity. Our study involved inducing colitis in obese mice using dextran sulfate sodium (DSS) and then treating them with curcumin at a dosage of 100 mg per kg for 14 days.
The results were promising. We observed that curcumin significantly alleviated the symptoms of colitis in the obese mice. This treatment led to weight gain, improved survival rates, and a reduced disease activity index. Additionally, curcumin helped in the elongation of the colon, decreased weight of the colon, and improved both ulcer formation as well as inflammatory cell infiltration within the colonic tissues.
Beyond these improvements, curcumin positively influenced lipid metabolism and adjusted the gut microbiota composition. It also enhanced the integrity of the intestinal lining and boosted the body's ability to withstand oxidative stress. Notably, we noted a stabilization in the levels of memory T cells and a favorable shift in the expression of inflammatory cytokines, alongside the suppression of the JAK2/STAT signaling pathway in the affected colonic tissues.
Overall, our findings suggest that curcumin may offer a comprehensive approach to mitigate the complications of colitis in obese individuals, by addressing multiple underlying mechanisms.
The results were promising. We observed that curcumin significantly alleviated the symptoms of colitis in the obese mice. This treatment led to weight gain, improved survival rates, and a reduced disease activity index. Additionally, curcumin helped in the elongation of the colon, decreased weight of the colon, and improved both ulcer formation as well as inflammatory cell infiltration within the colonic tissues.
Beyond these improvements, curcumin positively influenced lipid metabolism and adjusted the gut microbiota composition. It also enhanced the integrity of the intestinal lining and boosted the body's ability to withstand oxidative stress. Notably, we noted a stabilization in the levels of memory T cells and a favorable shift in the expression of inflammatory cytokines, alongside the suppression of the JAK2/STAT signaling pathway in the affected colonic tissues.
Overall, our findings suggest that curcumin may offer a comprehensive approach to mitigate the complications of colitis in obese individuals, by addressing multiple underlying mechanisms.
Read More
9
Turmeric nanovesicles aid obesity treatment
Development and Evaluation of Reconstructed Nanovesicles from Turmeric for Multifaceted Obesity Intervention.
Strong connection to turmeric use
We explored the potential of turmeric in challenging obesity, driven by its natural properties and numerous health benefits. Our focus was on a newly developed formulation called "Reconstructed Turmeric-derived Nanovesicles" (Rec-tNVs), which aimed to enhance the effects of curcumin, the active component of turmeric.
By using advanced techniques, we increased the curcumin content significantly in these nanovesicles, allowing us to measure their impact more effectively. The Rec-tNVs showed a remarkable capacity to promote fat breakdown and prevent fat creation in fat cells, while also encouraging the conversion of fat cells to a more metabolically active form.
In rigorous tests involving high-fat diet mouse models, we observed weight reductions of about 18.68% and 14.56% with intragastric and subcutaneous delivery of the Rec-tNVs, respectively, over four weeks. Importantly, these results were better than what we saw with free curcumin treatment alone, suggesting that these nanovesicles could target fat tissues effectively and influence overall metabolism and gut health.
This study highlights the multi-dimensional benefits of turmeric and opens doors for new plant-based treatments for obesity. It's an exciting step forward in the quest for safer weight management solutions.
By using advanced techniques, we increased the curcumin content significantly in these nanovesicles, allowing us to measure their impact more effectively. The Rec-tNVs showed a remarkable capacity to promote fat breakdown and prevent fat creation in fat cells, while also encouraging the conversion of fat cells to a more metabolically active form.
In rigorous tests involving high-fat diet mouse models, we observed weight reductions of about 18.68% and 14.56% with intragastric and subcutaneous delivery of the Rec-tNVs, respectively, over four weeks. Importantly, these results were better than what we saw with free curcumin treatment alone, suggesting that these nanovesicles could target fat tissues effectively and influence overall metabolism and gut health.
This study highlights the multi-dimensional benefits of turmeric and opens doors for new plant-based treatments for obesity. It's an exciting step forward in the quest for safer weight management solutions.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
8.8
Reduces inflammation
The benefit of curcumin is its ability to reduce chronic inflammation, which can lead to metabolic disorders, including obesity. It also positively affects arthritis patients by alleviating joint swelling. Regular use of curcumin notably decreases the risk of liver diseases and mitigates symptoms of conditions like hepatitis, diabetes, and periodontitis.
Read More
8.8
Metabolic support
Turmeric benefits include reducing chronic inflammation that can lead to metabolic disorders and obesity. It also helps arthritis sufferers by decreasing joint swelling and lowers the risk of liver disease while alleviating symptoms of hepatitis and other conditions.
8
Anti-inflammatory properties
The curcuminoids in turmeric provide excellent anti-inflammatory benefits, making it advisable for various disorders, including obesity, Crohn's disease, and arthritis.
