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SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8
USERS' SCORE
Good
Based on 53 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9.5
Vitamin B6 improves anemia outcomes
Recurrent sideroblastic anemia during pregnancy.
Significant effect of vitamin B6
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
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9.5
VB6 vital for symptomatic anemia
Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy for Parkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts.
Highlights significance of VB6
We observed that Vitamin B6 (VB6) plays a crucial role in preventing certain types of anemia, particularly in individuals undergoing treatment for Parkinson's disease. In this case, a 75-year-old man who was receiving levodopa/carbidopa intestinal gel therapy developed severe VB6 deficiency anemia. This condition is characterized by microcytic, hypochromic, and sideroblastic blood profiles, which can resemble myelodysplastic syndrome.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
Read More
9
Vitamin B12 effectively treats anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Highlights vitamin B12's significance
We observed a compelling case surrounding the impact of vitamin B12 on anemia, particularly in a 62-year-old man facing severe deficiencies due to factors like drug use, hepatitis C, smoking, and alcoholism. Initially, this patient presented with symptoms such as fatigue, fever, and confusion, raising concerns about more critical conditions like thrombotic thrombocytopenic purpura (TTP). Laboratory tests indicated severe pancytopenia and signs of hemolysis, making the situation quite alarming.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
However, further investigation revealed that the root cause was a significant deficiency of vitamin B12 coupled with folate. This discovery shifted our focus toward treatment strategies that addressed the underlying deficiency rather than applying unnecessary and invasive procedures like plasmapheresis. Upon administering vitamin B12 injections, we witnessed a refreshing turnaround as the patient's blood counts began to normalize progressively, along with an alleviation of symptoms.
This case emphasizes the necessity for healthcare providers to consider vitamin B12 deficiency when diagnosing patients presenting with hemolytic anemia and thrombocytopenia. By doing so, unnecessary treatments can be avoided, paving the way for a swift recovery through proper vitamin supplementation.
Read More
Most Useful Reviews
8.8
Supports energy production
Excellent composition! I take these vitamins daily, finding them delicious and effective against anaemia. They support energy and biochemical processes. I highly recommend them, especially since they're hard to find elsewhere.
Read More
9.5
Improves absorption rates
This is a good quality product. The combination of Methylfolate and B12 in active forms tastes great and is effective. I find that taking it sublingually helps with the absorption of B12, supporting my recovery from anaemia. I recommend it.
Read More
9.5
Corrects anaemia effectively
I take these occasionally to address my anaemia and low cholesterol. After starting this supplement, my blood test results improved significantly, particularly my hemoglobin levels. This has been much more effective than exercise or diet alone.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8
9.5
Vitamin B6 improves anemia outcomes
Recurrent sideroblastic anemia during pregnancy.
Significant effect of vitamin B6
We observed a compelling case involving a 32-year-old pregnant woman who experienced severe anemia during her pregnancy. This specific type of anemia, known as sideroblastic anemia, is quite rare in expectant mothers. The patient had been feeling weak and had heart palpitations for two weeks when she came to the emergency room.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Testing revealed she had an alarming hemoglobin level of just 4.2 g/dl, indicating severe anemia, along with a notably low reticulocyte count. What made this case particularly interesting was her history of recurrent anemia, which occurred exclusively during her pregnancies.
Upon examining her bone marrow, doctors found numerous ring sideroblasts, which confirmed the diagnosis of sideroblastic anemia. Further investigation uncovered extremely low levels of pyridoxine, or vitamin B6, in her system. After administering vitamin B6 replacement therapy, her hemoglobin levels improved significantly without the need for blood transfusions, highlighting the vitamin’s role in managing this type of anemia during pregnancy.
Read More
9.5
VB6 vital for symptomatic anemia
Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy for Parkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts.
Highlights significance of VB6
We observed that Vitamin B6 (VB6) plays a crucial role in preventing certain types of anemia, particularly in individuals undergoing treatment for Parkinson's disease. In this case, a 75-year-old man who was receiving levodopa/carbidopa intestinal gel therapy developed severe VB6 deficiency anemia. This condition is characterized by microcytic, hypochromic, and sideroblastic blood profiles, which can resemble myelodysplastic syndrome.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
The effects of the levodopa/carbidopa treatment were significant because the metabolism of levodopa relies heavily on VB6. Furthermore, the medication carbidopa has an adverse effect—it binds to and deactivates VB6, worsening the deficiency. Fortunately, our findings highlight that the symptoms of VB6 deficiency anemia can be effectively resolved with simple oral supplementation of pyridoxal phosphate hydrate.
This case underlines the necessity of recognizing VB6 deficiency anemia as a potential cause of anemia in patients receiving levodopa/carbidopa, distinguishing it from more serious conditions like myelodysplastic syndrome. Awareness of this link can lead to better diagnosis and treatment of anemia in these patients, emphasizing the importance of monitoring Vitamin B6 levels during treatment.
Read More
9.5
Nutrition education reduces anemia
Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study.
Effectiveness in anemia reduction
We observed the influence of nutrition education and iron-folic acid (IFA) supplementation on the levels of anemia among pregnant women in Butajira, Ethiopia. Through a quasi-experimental design over three months, we provided pregnant women with health education based on the Health Belief Model, alongside IFA supplements over a six-week period.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
Read More
9.5
Folate's limited role in anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Moderate connection to folate research
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Read More
9.5
Vitamin B12 aids anemia recovery
Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review.
Moderate relevance of vitamin B12
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 53 Reviews
8.8
10
Folic acid necessity
With low iron and increased homocysteine during pregnancy, it’s vital to take folic acid in a chelated form, especially if you have absorption issues. Using this alongside iron helped me manage my anaemia effectively during pregnancy.
9.5
Improves absorption rates
This is a good quality product. The combination of Methylfolate and B12 in active forms tastes great and is effective. I find that taking it sublingually helps with the absorption of B12, supporting my recovery from anaemia. I recommend it.
9.5
Corrects anaemia effectively
I take these occasionally to address my anaemia and low cholesterol. After starting this supplement, my blood test results improved significantly, particularly my hemoglobin levels. This has been much more effective than exercise or diet alone.
9.5
Convenient and effective
Initially, I didn’t notice this product, but after realising its benefits—active forms of folic acid and B12—I’ve had great results with my anaemia. This sublingual method ensures quick absorption into the bloodstream, effectively improving my mood.
9.5
Boosts energy levels
This excellent quality product raises my B12 levels efficiently. It aids in detoxification and helps tackle anaemia while improving my mood. I highly recommend it.
