Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.5
USERS' SCORE
Good
Based on 15 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
2
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
Read More
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
Most Useful Reviews
9
Cognitive function enhanced
2 people found this helpful
This product combines active forms of vitamins to support DNA synthesis, neurotransmitter function, and amino acid metabolism. It is beneficial for brain activity, red blood cell formation, and cognitive functions. Additionally, it helps to alleviate depression and normalise hormones.
Read More
10
Resolves antidepressant need
I utilise these vitamins to manage my MTHFR condition. The active B-12 and folate have allowed me to discontinue antidepressants and addressed my depression effectively. I highly recommend this product for similar needs!
Read More
9
Decreased symptoms noted
After a blood test revealed folate deficiency, I began taking this regularly about six years ago, addressing severe joint pains, weight loss, and depression. After 45 and menopause, metabolism alters, which can lead to symptoms of aging. These vitamins have significantly helped me!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.5
- All Researches
9.5
We explored a remarkable case of a 58-year-old cancer patient who exhibited depressive symptoms potentially linked to thiamine deficiency (TD). Initially suspected of having major depressive disorder, her condition transformed dramatically after receiving intravenous thiamine.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
Within an hour of treatment, her distressing symptoms—palpitations, dyspnea, and suicidal thoughts—significantly improved. This observation underscores the importance of considering TD as a reversible cause when patients present with depression-like symptoms, especially in serious cases involving cancer.
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9.5
We explored the connections between mental health conditions, like depression and stress, and the risk of developing gastric cancer. In this study, we looked at 82 patients with gastric cancer compared to 95 healthy individuals, measuring their mental health using a Depression-Anxiety-Stress Scale. We also examined what they ate through a food frequency questionnaire that included 168 items.
Our findings showed a notable association between depression and stress with higher odds of gastric cancer. Notably, when we analyzed dietary factors in relation to depression, we found that vitamin B6 had a protective effect. Specifically, in individuals experiencing depression, higher levels of vitamin B6 correlated with a significantly lower likelihood of facing depressive symptoms.
While this points to vitamin B6's potential benefits, it’s important to note that it wasn't tested in isolation from other dietary influences. Therefore, while we observed promising links between vitamin B6 and improved mental health, the impact of a diverse diet as a whole cannot be overlooked. Future studies are essential to better understand the specific impacts of nutrients like vitamin B6 on mental health and, subsequently, on conditions like gastric cancer.
Our findings showed a notable association between depression and stress with higher odds of gastric cancer. Notably, when we analyzed dietary factors in relation to depression, we found that vitamin B6 had a protective effect. Specifically, in individuals experiencing depression, higher levels of vitamin B6 correlated with a significantly lower likelihood of facing depressive symptoms.
While this points to vitamin B6's potential benefits, it’s important to note that it wasn't tested in isolation from other dietary influences. Therefore, while we observed promising links between vitamin B6 and improved mental health, the impact of a diverse diet as a whole cannot be overlooked. Future studies are essential to better understand the specific impacts of nutrients like vitamin B6 on mental health and, subsequently, on conditions like gastric cancer.
Read More
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.
The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.
Read More
9
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cognitive function enhanced
2 people found this helpful
This product combines active forms of vitamins to support DNA synthesis, neurotransmitter function, and amino acid metabolism. It is beneficial for brain activity, red blood cell formation, and cognitive functions. Additionally, it helps to alleviate depression and normalise hormones.
Read More
10
Resolves antidepressant need
I utilise these vitamins to manage my MTHFR condition. The active B-12 and folate have allowed me to discontinue antidepressants and addressed my depression effectively. I highly recommend this product for similar needs!
Read More
9
Decreased symptoms noted
After a blood test revealed folate deficiency, I began taking this regularly about six years ago, addressing severe joint pains, weight loss, and depression. After 45 and menopause, metabolism alters, which can lead to symptoms of aging. These vitamins have significantly helped me!
Read More
9
Hormonal levels normalised
The supplement regulates hormonal levels, stabilises the nervous system, alleviates depression, and improves cognitive functions, which I took on the recommendation of my endocrinologist.
Read More
9
Promotes energy levels
This vitamin significantly boosts my energy and quality ingredients. It's particularly effective for depression by aiding serotonin uptake. Research supports its positive effects, making it a reliable option for those facing similar challenges.
Read More
Frequently Asked Questions
7
Promotes stable mood
After being diagnosed with a deficiency, I began to take B12. It has significantly stabilised my mood and lowered my depression risk, as this vitamin plays a role in serotonin production. I'm pleased with the results and keep taking it regularly.
10
Resolves antidepressant need
I utilise these vitamins to manage my MTHFR condition. The active B-12 and folate have allowed me to discontinue antidepressants and addressed my depression effectively. I highly recommend this product for similar needs!
9
Decreased symptoms noted
After a blood test revealed folate deficiency, I began taking this regularly about six years ago, addressing severe joint pains, weight loss, and depression. After 45 and menopause, metabolism alters, which can lead to symptoms of aging. These vitamins have significantly helped me!
7.5
Supports brain health
This vitamin combination supports DNA synthesis and neurotransmitter production, essential for brain health. B12 aids in DNA production, while methylfolate is crucial for hormone formation, enhancing mood and work capacity, and alleviating depression. I took one tablet daily and have been very pleased with the outcomes.
9
Hormonal levels normalised
The supplement regulates hormonal levels, stabilises the nervous system, alleviates depression, and improves cognitive functions, which I took on the recommendation of my endocrinologist.
9
Promotes energy levels
This vitamin significantly boosts my energy and quality ingredients. It's particularly effective for depression by aiding serotonin uptake. Research supports its positive effects, making it a reliable option for those facing similar challenges.
6
Convenient delivery noted
Fast delivery! The speed of delivery was impressive, arriving in Florianópolis within 7 days. I intend to supplement with lithium for my depression. Great cost benefit—I have already ordered two bottles.
8
This study examined how dietary vitamin B6 and plasma levels of pyridoxal 5’-phosphate relate to depression in US adults. We analyzed data from nearly 25,000 people over five years, revealing that those with the highest vitamin B6 intake and plasma levels experienced a lower risk of depression.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
Although these results are promising and suggest the benefits of a vitamin B6-rich diet, we also noted that further randomized controlled trials are needed to better understand the effects of vitamin B6 supplementation on mood.
8
We conducted a study to explore whether vitamin B6 supplementation can help reduce symptoms of depression in college women who are using oral contraceptives. This group often faces a risk of lower vitamin B6 levels, which is important for maintaining a positive mood.
The trial was meticulously designed as a randomized, double-blind crossover study involving eight healthy participants aged 18-25 who consistently used birth control for at least a year. Over a span of 12 weeks, these women were given either a daily dose of 100 mg of vitamin B6 or a placebo, in two four-week treatment phases, separated by a washout period.
We found that after taking the vitamin B6 supplements, participants experienced a 20% reduction in their depression scores according to the Beck Depression Inventory-II. In contrast, those on the placebo saw their scores rise by 11%. While the Profile of Mood States scores weren’t significantly affected, our findings support the potential benefits of vitamin B6 in improving mood and tackling depression in young women on oral contraceptives.
Overall, this study adds to the growing evidence that vitamin B6 may play a positive role in mental health, particularly for those affected by hormonal contraceptives.
The trial was meticulously designed as a randomized, double-blind crossover study involving eight healthy participants aged 18-25 who consistently used birth control for at least a year. Over a span of 12 weeks, these women were given either a daily dose of 100 mg of vitamin B6 or a placebo, in two four-week treatment phases, separated by a washout period.
We found that after taking the vitamin B6 supplements, participants experienced a 20% reduction in their depression scores according to the Beck Depression Inventory-II. In contrast, those on the placebo saw their scores rise by 11%. While the Profile of Mood States scores weren’t significantly affected, our findings support the potential benefits of vitamin B6 in improving mood and tackling depression in young women on oral contraceptives.
Overall, this study adds to the growing evidence that vitamin B6 may play a positive role in mental health, particularly for those affected by hormonal contraceptives.
9
We explored the effects of vitamin B6, or pyridoxine, on depression in a study using mice. In this research, several doses of pyridoxine (12.5, 25, and 50 mg/kg) were administered to observe changes in behavior related to depression. Notably, we found that the highest dose of 50 mg/kg significantly reduced the immobility time in tests designed to measure depressive-like behavior, such as the tail suspension test and the forced swim test.
Our findings revealed an interesting mechanism behind these effects. Treatment with pyridoxine increased serotonin levels, a neurotransmitter often associated with mood regulation, while decreasing brain nitrite levels. However, we also examined the role of nitric oxide and its related pathway in enhancing pyridoxine's antidepressant effect. We noticed that certain substances, like L-Arginine (a nitric oxide donor) and sildenafil (which boosts cyclic GMP), seemed to counteract the positive effects of vitamin B6, while a nitric oxide/sGC inhibitor, methylene blue, amplified its benefits.
Overall, our study suggests that vitamin B6 could exert antidepressant-like effects by modulating serotonin levels in the brain and interacting with nitric oxide signaling pathways. This offers exciting potential for broader applications in managing depression, warranting further exploration in future studies.
Our findings revealed an interesting mechanism behind these effects. Treatment with pyridoxine increased serotonin levels, a neurotransmitter often associated with mood regulation, while decreasing brain nitrite levels. However, we also examined the role of nitric oxide and its related pathway in enhancing pyridoxine's antidepressant effect. We noticed that certain substances, like L-Arginine (a nitric oxide donor) and sildenafil (which boosts cyclic GMP), seemed to counteract the positive effects of vitamin B6, while a nitric oxide/sGC inhibitor, methylene blue, amplified its benefits.
Overall, our study suggests that vitamin B6 could exert antidepressant-like effects by modulating serotonin levels in the brain and interacting with nitric oxide signaling pathways. This offers exciting potential for broader applications in managing depression, warranting further exploration in future studies.
4
We reviewed several studies that looked into how vitamin B12 supplementation might help with depression and mental health issues. By systematically searching major databases, we identified a total of 287 articles and selected five that rigorously assessed the effects of B12 alone and alongside other B vitamins like folic acid and B6.
The results were mixed, showing that while some groups benefited from these vitamins, overall evidence was inconclusive. Notably, some studies indicated that combining vitamin B12 with folic acid and B6 could effectively prevent post-stroke depression. However, many trials examined specific populations, highlighting that B12 may be especially helpful for certain high-risk groups rather than a one-size-fits-all solution.
In conclusion, while the findings are promising for some, we need more research to determine how vitamin B12 supplementation could be beneficial for broader mental health improvement. Overall, vitamin B12’s role in treating depression is still a topic that requires further exploration.
The results were mixed, showing that while some groups benefited from these vitamins, overall evidence was inconclusive. Notably, some studies indicated that combining vitamin B12 with folic acid and B6 could effectively prevent post-stroke depression. However, many trials examined specific populations, highlighting that B12 may be especially helpful for certain high-risk groups rather than a one-size-fits-all solution.
In conclusion, while the findings are promising for some, we need more research to determine how vitamin B12 supplementation could be beneficial for broader mental health improvement. Overall, vitamin B12’s role in treating depression is still a topic that requires further exploration.
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
References
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- Caro-Ramírez JY, Bazán LO, Piro OE, Echeverría GA, Jori K, et al. Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection. J Inorg Biochem. 2025;267:112857. doi:10.1016/j.jinorgbio.2025.112857
- Siddique A, Khokhar MM, Waheed A, Naeem U, Aziz SA. Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder. BMC Pharmacol Toxicol. 2025;26:14. doi:10.1186/s40360-025-00846-x
- Lu J, Mao H, Tan Y, Luo G. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010. Brain Behav. 2024;14:e70128. doi:10.1002/brb3.70128
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. doi:10.1016/j.bcp.2023.115832
- Abdel Rasheed NO, Shiha NA, Mohamed SS, Ibrahim WW. SIRT1/PARP-1/NLRP3 cascade as a potential target for niacin neuroprotective effect in lipopolysaccharide-induced depressive-like behavior in mice. Int Immunopharmacol. 2023;123:110720. doi:10.1016/j.intimp.2023.110720
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. doi:10.1017/S1478951523001128
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Tuo LJ, Song XY, Zhu YY, He HN, Song YP, et al. Gestational folic acid supplement prevents vitamin D deficiency-induced depression-like behavior by reversing cortical DNA hypomethylation in adult offspring. J Steroid Biochem Mol Biol. 2023;231:106313. doi:10.1016/j.jsbmb.2023.106313
- Pan LA, Segreti AM, Wrobleski J, Shaw A, Hyland K, et al. Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior. Psychol Med. 2023;53:6046. doi:10.1017/S0033291722003233
- Rajasekar R, VanderMolen J, Barnhart K, Anguilim N. Dietary intake with supplementation of vitamin D, vitamin B6, and magnesium on depressive symptoms: a public health perspective. Front Public Health. 2024;12:1369666. doi:10.3389/fpubh.2024.1369666
- Vahid F, Rahmani W, Davoodi SH, Bohn T. Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients. 2023;15. doi:10.3390/nu15234981
- Mesripour A, Golchin S. Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice. Iran J Psychiatry. 2022;17:208. doi:10.18502/ijps.v17i2.8911
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. doi:10.1002/hup.2852
- Noah L, Morel V, Bertin C, Pouteau E, Macian N, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022;14. doi:10.3390/nu14091863
- C Curtin A, Johnston CS. Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial. J Diet Suppl. 2023;20:550. doi:10.1080/19390211.2022.2030843
- Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial. Int J Prev Med. 2021;12:136. doi:10.4103/ijpvm.IJPVM_240_19
- Maratha S, Sharma V, Walia V. Possible involvement of NO-sGC-cGMP signaling in the antidepressant like effect of pyridoxine in mice. Metab Brain Dis. 2022;37:173. doi:10.1007/s11011-021-00858-6
- Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
- Wu Y, Li S, Wang W, Zhang D. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023;93:142. doi:10.1024/0300-9831/a000720
- Yang Y, Qi H, Zhang J, Jia J, Yang Y, et al. Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database. Front Nutr. 2025;12:1505700. doi:10.3389/fnut.2025.1505700
- Guo Q, Wang Y, Guo L, Xu K, Shang S. Association of serum total folate and serum vitamin D concentrations with W-shape in depressed older adults with cognitive dysfunction: A cross-sectional observational study. Clin Nutr ESPEN. 2025;65:50. doi:10.1016/j.clnesp.2024.11.021
- Xiong Y, Zhou G, Zhou L, Guo M, Lu H. Serum molecules of the folate-driven one-carbon cycle as indicators of depressive tendencies in the elderly. Heliyon. 2024;10:e36980. doi:10.1016/j.heliyon.2024.e36980
- Liu M, Wang G, Jiang C. Independent and combined effect of serum copper and folate on depression: cross-sectional data from the NHANES 2011-2016. Front Nutr. 2024;11:1389480. doi:10.3389/fnut.2024.1389480
- Gao S, Khalid A, Amini-Salehi E, Radkhah N, Jamilian P, et al. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses. Food Sci Nutr. 2024;12:3806. doi:10.1002/fsn3.4073
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. doi:10.1093/hmg/ddae079
- Lv P, Xiang F, Zhang S, Lei D, Zhou C, et al. Valeriana jatamansi jones improves depressive behavior in CUMS mice by modulating vitamin B12-related ileal homeostasis. J Ethnopharmacol. 2025;342:119392. doi:10.1016/j.jep.2025.119392
- Alzahrani H. Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. Cureus. 2024;16:e73350. doi:10.7759/cureus.73350
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Hui J, Zhang N, Kang M, Gou Y, Liu C, et al. Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16132042
- Harikaran S, Basu S, Mukherjee MP, Kar R, Nair S, et al. Vitamin B12 and homocysteine in patients with major depressive disorder. J Family Med Prim Care. 2024;13:2049. doi:10.4103/jfmpc.jfmpc_1460_23
- Gao Y, Yang J, Sun H, Zhou H. Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trial. BMC Oral Health. 2024;24:603. doi:10.1186/s12903-024-04318-2
- Cruz-Rodríguez J, Canals-Sans J, Hernández-Martínez C, Arija V. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study. J Reprod Infant Psychol. 2024. doi:10.1080/02646838.2024.2324043
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
- Tan Y, Zhou L, Gu K, Xie C, Wang Y, et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023;21:617. doi:10.9758/cpn.22.1040
