Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
Read More
9
We explored the effects of vitamin B12 treatment on neuropathy through the case of a 41-year-old woman who had been struggling with balance and coordination issues for two years. Her medical evaluations revealed megaloblastic anemia due to vitamin B12 deficiency, alongside significant nerve damage identified through electromyography.
Imaging scans highlighted long T2 signal areas in the spinal cord and cerebellum, which pointed to subacute combined degeneration of the spinal cord. Fortunately, after receiving vitamin B12 supplements, we observed noticeable improvements in her limb strength, diet, and consciousness, with her muscle strength returning to grade IV in both lower limbs.
This case underscores the importance of early intervention for those exhibiting symptoms of neuropathy. It serves as a reminder that regular check-ups, including the evaluation for autoimmune gastritis, can help in the early identification of vitamin B12 deficiencies that may lead to irreversible nerve damage.
Imaging scans highlighted long T2 signal areas in the spinal cord and cerebellum, which pointed to subacute combined degeneration of the spinal cord. Fortunately, after receiving vitamin B12 supplements, we observed noticeable improvements in her limb strength, diet, and consciousness, with her muscle strength returning to grade IV in both lower limbs.
This case underscores the importance of early intervention for those exhibiting symptoms of neuropathy. It serves as a reminder that regular check-ups, including the evaluation for autoimmune gastritis, can help in the early identification of vitamin B12 deficiencies that may lead to irreversible nerve damage.
Read More
8
We explored the impact of nitrous oxide (N2O) use on neurological health, particularly focusing on how vitamin B12 treatment can play a crucial role in neuropathy. In two reported cases, individuals who had abused nitrous oxide displayed symptoms of progressive paresthesia, gait issues, and weakness, appearing similar to Guillain-Barré Syndrome.
Upon further investigation, both patients were found to have vitamin B12 deficiencies, which led to a condition known as myeloneuropathy. Using magnetic resonance imaging and electrodiagnostic studies, doctors were able to identify the damage caused by prolonged nitrous oxide exposure.
Fortunately, we observed that symptoms began to improve with vitamin B12 supplementation and the cessation of nitrous oxide use. This demonstrates that addressing vitamin B12 deficiencies can potentially reverse the neurological complications arising from nitrous oxide toxicity if treatment is prompt and effective.
Given the increasing recreational use of nitrous oxide and its associated risks, we believe it’s vital for healthcare providers to consider this as a possible cause of neuropathy or myelopathy in patients, especially when symptoms appear unusual in nature.
Upon further investigation, both patients were found to have vitamin B12 deficiencies, which led to a condition known as myeloneuropathy. Using magnetic resonance imaging and electrodiagnostic studies, doctors were able to identify the damage caused by prolonged nitrous oxide exposure.
Fortunately, we observed that symptoms began to improve with vitamin B12 supplementation and the cessation of nitrous oxide use. This demonstrates that addressing vitamin B12 deficiencies can potentially reverse the neurological complications arising from nitrous oxide toxicity if treatment is prompt and effective.
Given the increasing recreational use of nitrous oxide and its associated risks, we believe it’s vital for healthcare providers to consider this as a possible cause of neuropathy or myelopathy in patients, especially when symptoms appear unusual in nature.
Read More
Most Useful Reviews
9
Instant relief
10 people found this helpful
My doctor prescribed an expensive medication for neuropathy in my feet, which I couldn't afford. I discovered similar ingredients available on Amazon and found instant relief, not just from foot numbness but my Tinnitus vanished too. Later, we found a pre-made product with the same quantities as the original formulation. It is effective and affordable, and I love it!
Read More
2
Improved mood
4 people found this helpful
I was out of my 5000mcg for about a week, and my muscle twitches returned, so I tried this product hoping for other benefits. Although it does taste better than expected and did not cause jitters, I ended up experiencing severe insomnia. While it improved my mood and energy levels, it failed to help with my peripheral neuropathy, prompting me to return to the 5000mcg, which alleviates my neuropathy and insomnia.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.9
- All Researches
9
We aimed to investigate how paclitaxel-induced peripheral neuropathy affects salivary glands in rats and whether using a vitamin B/ATP complex could help. After inducing neuropathy with paclitaxel, we treated the animals with vitamin B for nine days.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
Read More
9
We observed a study that aimed to explore the effectiveness of vitamin B12 therapy compared to steroid treatment for improving extraocular movements in patients suffering from diabetic cranial nerve palsy, a type of nerve injury related to diabetes. The study involved 50 participants who were divided into two groups. One group received steroid injections, while the other group was treated with vitamin B12.
After the treatment, which was followed for 10 days, the researchers assessed the improvement in eye movements using a specific test. The results were telling: those who received vitamin B12 showed a greater enhancement in their eye movements compared to those treated with steroids. The improvement noted in the vitamin group was statistically significant, suggesting that vitamin B12 may play an essential role in supporting recovery from diabetic neuropathy.
Notably, the average age of participants was around 60 years, and many had poorly controlled diabetes, emphasizing the importance of managing blood sugar levels in diabetic patients. This research highlights the potential of vitamin B12 not just in treating symptoms, but in addressing underlying nutritional deficiencies, which may help enhance the quality of life for individuals with diabetic complications.
After the treatment, which was followed for 10 days, the researchers assessed the improvement in eye movements using a specific test. The results were telling: those who received vitamin B12 showed a greater enhancement in their eye movements compared to those treated with steroids. The improvement noted in the vitamin group was statistically significant, suggesting that vitamin B12 may play an essential role in supporting recovery from diabetic neuropathy.
Notably, the average age of participants was around 60 years, and many had poorly controlled diabetes, emphasizing the importance of managing blood sugar levels in diabetic patients. This research highlights the potential of vitamin B12 not just in treating symptoms, but in addressing underlying nutritional deficiencies, which may help enhance the quality of life for individuals with diabetic complications.
Read More
9
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
Read More
9
We observed a fascinating case involving an 11-month-old girl facing persistent seizures and developmental challenges. After trying numerous medications without success, tests revealed she had megaloblastic anemia and macrocytic anemia. Due to the unusual combination of her symptoms, we suspected a genetic condition related to vitamin B12 absorption.
Upon conducting whole exome sequencing, we discovered a novel mutation in the FUT2 gene, which affects how the body processes vitamin B12. Most notably, our findings confirmed that her neurological issues were connected to a deficiency in this vital vitamin.
When we initiated treatment with intramuscular hydroxocobalamin, there was a significant improvement in her condition, including a noticeable decrease in seizure frequency. This case underscores the crucial role that vitamin B12 plays in brain health and development, especially in young children.
It highlights the importance of genetic testing to uncover treatable causes in similar cases of refractory developmental and epileptic encephalopathy. Swift diagnosis and appropriate treatment can lead to remarkable recoveries, making this an encouraging story for those affected by such rare conditions.
Upon conducting whole exome sequencing, we discovered a novel mutation in the FUT2 gene, which affects how the body processes vitamin B12. Most notably, our findings confirmed that her neurological issues were connected to a deficiency in this vital vitamin.
When we initiated treatment with intramuscular hydroxocobalamin, there was a significant improvement in her condition, including a noticeable decrease in seizure frequency. This case underscores the crucial role that vitamin B12 plays in brain health and development, especially in young children.
It highlights the importance of genetic testing to uncover treatable causes in similar cases of refractory developmental and epileptic encephalopathy. Swift diagnosis and appropriate treatment can lead to remarkable recoveries, making this an encouraging story for those affected by such rare conditions.
Read More
9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Instant relief
10 people found this helpful
My doctor prescribed an expensive medication for neuropathy in my feet, which I couldn't afford. I discovered similar ingredients available on Amazon and found instant relief, not just from foot numbness but my Tinnitus vanished too. Later, we found a pre-made product with the same quantities as the original formulation. It is effective and affordable, and I love it!
Read More
2
Improved mood
4 people found this helpful
I was out of my 5000mcg for about a week, and my muscle twitches returned, so I tried this product hoping for other benefits. Although it does taste better than expected and did not cause jitters, I ended up experiencing severe insomnia. While it improved my mood and energy levels, it failed to help with my peripheral neuropathy, prompting me to return to the 5000mcg, which alleviates my neuropathy and insomnia.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Cuyubamba O, Braga CP, Swift D, Stickney JT, Viel C. The Combination of Neurotropic Vitamins B1, B6, and B12 Enhances Neural Cell Maturation and Connectivity Superior to Single B Vitamins. Cells. 2025;14. doi:10.3390/cells14070477
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Artiukhov AV, Solovjeva ON, Balashova NV, Sidorova OP, Graf AV, et al. Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes. Biochemistry (Mosc). 2024;89:1161. doi:10.1134/S0006297924070010
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. doi:10.11604/pamj.2024.47.164.43048
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. doi:10.1177/03795721241226886
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. doi:10.59556/japi.72.0493
- Tykhonovych K, Kryvoruchko T, Nikitina N, Berehovyi S, Neporada K. CORRECTION OF PATHOLOGICAL CHANGES IN SALIVARY GLANDS OF ANIMALS WITH PACLITAXEL-INDUCED NEUROPATHY. Exp Oncol. 2024;46:38. doi:10.15407/exp-oncology.2024.01.038
- Park KJ, Choi E, Jung IY, Kim ST. Pharmacologic management of trigeminal nerve injury after endodontic treatment: A retrospective analysis. J Oral Rehabil. 2024;51:1737. doi:10.1111/joor.13765
- Renting L, Zwart NRK, Ueland PM, McCann A, Ulvik A, et al. Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy. BMJ Oncol. 2024;3:e000462. doi:10.1136/bmjonc-2024-000462
- Hu S, Brown-Kunin S, Martin P, Wang Y. Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report. BMC Neurol. 2025;25:54. doi:10.1186/s12883-025-04069-9
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. doi:10.7759/cureus.75656
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. doi:10.1111/1753-0407.70045
- Kyaw KY, Lwin MT, Lwin ZT. Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report. Cureus. 2024;16:e74383. doi:10.7759/cureus.74383
- Kulkantrakorn K, Chunhachatrachai P, Kulkantrakorn W. Nitrous oxide abuse and associated neurological diseases. BMC Neurol. 2024;24:461. doi:10.1186/s12883-024-03966-9
- Bandara P, Wijenayake W, Fernando S, Padeniya P, Mettananda S. Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report. BMC Pediatr. 2024;24:622. doi:10.1186/s12887-024-05106-1
- Hotta K, Mano Y. Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma. J Pharmacol Toxicol Methods. 2024;129:107552. doi:10.1016/j.vascn.2024.107552
- Pino S, Vega E, Fragoso M, Salazar G. Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report. Cureus. 2024;16:e63003. doi:10.7759/cureus.63003
- Zhu M, Yu C, Xu Z, Zhang H, Huang H. Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report. Medicine (Baltimore). 2024;103:e37605. doi:10.1097/MD.0000000000037605
