Last update
4/1/2026
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Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
MethylSulfonylMethane (MSM)
1,000 mg
†
Top Medical Research Studies
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Read More
Most Useful Reviews
9
Menopause support
This is good for osteoporosis and essential during menopause.
Read More
9
Walking freely
Excellent for osteoporosis! My mother, who struggled to walk due to multiple fractures sustained in a traffic accident, takes MSM and now walks freely.
Read More
6
Nails improvement
6 people found this helpful
Sulfur is sulfur; I bought it specifically for my mother, who is 67 and suffers from several ailments, including osteoporosis. Due to serious intestinal issues, she opens the capsule and takes half a dose of 500 mg. Since starting this medication alongside calcium citrate, boswellia, and silicon, her nails have stopped separating, the traumatic foot injury (a stretch and bone fracture) is strengthening, and her pain has reduced. The only downside is that her intestines do not tolerate this sulfur well.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Menopause support
This is good for osteoporosis and essential during menopause.
Read More
9
Walking freely
Excellent for osteoporosis! My mother, who struggled to walk due to multiple fractures sustained in a traffic accident, takes MSM and now walks freely.
Read More
6
Nails improvement
6 people found this helpful
Sulfur is sulfur; I bought it specifically for my mother, who is 67 and suffers from several ailments, including osteoporosis. Due to serious intestinal issues, she opens the capsule and takes half a dose of 500 mg. Since starting this medication alongside calcium citrate, boswellia, and silicon, her nails have stopped separating, the traumatic foot injury (a stretch and bone fracture) is strengthening, and her pain has reduced. The only downside is that her intestines do not tolerate this sulfur well.
Read More
7.5
Mobility improvement
1 people found this helpful
I give this to my mother, who has osteoporosis. She also takes glucosamine and chondroitin occasionally. I am pleased with the results; at 80 and after a femoral neck fracture, she can now walk on her own.
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7.5
Collagen production
1 people found this helpful
This organic sulfur product aids in collagen production. Just one pill a day, preferably with glucosamine, ginkgo biloba, and vitamin D, is sufficient for those experiencing weakness, osteoporosis, or knee issues.
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Frequently Asked Questions
9
Walking freely
Excellent for osteoporosis! My mother, who struggled to walk due to multiple fractures sustained in a traffic accident, takes MSM and now walks freely.
7.5
Mobility improvement
1 people found this helpful
I give this to my mother, who has osteoporosis. She also takes glucosamine and chondroitin occasionally. I am pleased with the results; at 80 and after a femoral neck fracture, she can now walk on her own.
7.5
Collagen production
1 people found this helpful
This organic sulfur product aids in collagen production. Just one pill a day, preferably with glucosamine, ginkgo biloba, and vitamin D, is sufficient for those experiencing weakness, osteoporosis, or knee issues.
7.5
Osteoporosis improvement
My mother has a bad knee, but her condition improved after taking this. Her osteoporosis has also significantly improved, though I believe this is likely due to the treatment.
9
Prevention effectiveness
An excellent drug for preventing osteoporosis and for collagen production.
9
Menopause support
This is good for osteoporosis and essential during menopause.
8
We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.
Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.
References
- Kim DN, Joung YH, Darvin P, Kang DY, Sp N, et al. Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. Mol Med Rep. 2016;14:460. 10.3892/mmr.2016.5274
Data last updated:
