Last update
3/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc L-Methionine Sulfate)
15 mg
136%
Copper (as Gluconate)
1 mg
111%
Top Medical Research Studies
9
We constructed a mouse model of ulcerative colitis, a painful condition caused by inflammation in the intestines, to investigate how zinc hyaluronate (ZnHA) could help. Our goal was to explore whether ZnHA could effectively alleviate symptoms commonly associated with this disease, such as weight loss, diarrhea, and bleeding.
Our findings were encouraging. We observed that ZnHA reduced the levels of key inflammatory markers, helping to calm the immune response in the affected areas. Specifically, it decreased markers like tumor necrosis factor-α and interleukin-6, while boosting protective factors like interleukin-10.
Additionally, we examined the impact of ZnHA on gut bacteria and found that it promoted the production of beneficial short-chain fatty acids, which are crucial for gut health. This treatment also seemed to strengthen the intestinal barrier by enhancing the expression of proteins that help keep gut cells tightly bound together.
Overall, these results suggest that zinc could play a significant role in managing ulcerative colitis by reducing inflammation and supporting a healthy gut environment. Our research offers promising insights into using zinc hyaluronate as a potential treatment for this challenging condition.
Our findings were encouraging. We observed that ZnHA reduced the levels of key inflammatory markers, helping to calm the immune response in the affected areas. Specifically, it decreased markers like tumor necrosis factor-α and interleukin-6, while boosting protective factors like interleukin-10.
Additionally, we examined the impact of ZnHA on gut bacteria and found that it promoted the production of beneficial short-chain fatty acids, which are crucial for gut health. This treatment also seemed to strengthen the intestinal barrier by enhancing the expression of proteins that help keep gut cells tightly bound together.
Overall, these results suggest that zinc could play a significant role in managing ulcerative colitis by reducing inflammation and supporting a healthy gut environment. Our research offers promising insights into using zinc hyaluronate as a potential treatment for this challenging condition.
Read More
4
We explored the relationship between serum zinc levels and various clinical features in patients suffering from inflammatory bowel disease (IBD), specifically focusing on Crohn's disease and ulcerative colitis. Our study included 37 patients with Crohn’s disease and 64 with ulcerative colitis, where we measured serum zinc concentrations and analyzed patient characteristics, blood test values, disease activity, and endoscopic scores.
A notable finding was that a significant number of patients experienced hypozincemia, with 45.9% of Crohn's patients and 29.7% of those with ulcerative colitis having low zinc levels. We observed a weak negative correlation between zinc levels and disease activity, indicated by the Crohn’s Disease Activity Index and C-reactive protein levels in Crohn's patients. Similarly, in ulcerative colitis patients, there was a weak negative correlation with the white blood cell count.
Interestingly, lower zinc concentrations were seen in ulcerative colitis patients with higher Mayo endoscopic scores, reflecting more severe disease activity. Additionally, serum zinc showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index, suggesting that zinc levels might influence overall nutritional status in these patients.
Overall, while our study highlighted the importance of monitoring zinc levels due to their association with disease activity and nutritional parameters, we found no direct evidence that zinc treatment significantly improves symptoms of colitis.
A notable finding was that a significant number of patients experienced hypozincemia, with 45.9% of Crohn's patients and 29.7% of those with ulcerative colitis having low zinc levels. We observed a weak negative correlation between zinc levels and disease activity, indicated by the Crohn’s Disease Activity Index and C-reactive protein levels in Crohn's patients. Similarly, in ulcerative colitis patients, there was a weak negative correlation with the white blood cell count.
Interestingly, lower zinc concentrations were seen in ulcerative colitis patients with higher Mayo endoscopic scores, reflecting more severe disease activity. Additionally, serum zinc showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index, suggesting that zinc levels might influence overall nutritional status in these patients.
Overall, while our study highlighted the importance of monitoring zinc levels due to their association with disease activity and nutritional parameters, we found no direct evidence that zinc treatment significantly improves symptoms of colitis.
Read More
Most Useful Reviews
9
Effective supplement quality
I bought this product to assist with my Colitis condition. The quality, packaging, and size of this supplement are as advertised.
Read More
9
Pain significantly reduced
53 people found this helpful
I started researching and was impressed with what I found. I experienced severe pain in my right hip and lower back that came suddenly. While looking for information, I read about colostrum and decided to try Jarrow Colostrum because I trust the brand. On my day off, I took three upon delivery and rested. When I awoke four hours later, the pain had disappeared by 90%. After using it consistently for over thirty days, I can confidently say that colostrum is miraculous. The pain is now gone, and my mother with colitis flare-ups has also benefited, feeling better than she has in years.
Read More
7.5
Improved intestinal health
I purchased this to improve my Colitis. The ingestion of zinc, magnesium, and vitamin D enhances my intestinal health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
- All Researches
9
We constructed a mouse model of ulcerative colitis, a painful condition caused by inflammation in the intestines, to investigate how zinc hyaluronate (ZnHA) could help. Our goal was to explore whether ZnHA could effectively alleviate symptoms commonly associated with this disease, such as weight loss, diarrhea, and bleeding.
Our findings were encouraging. We observed that ZnHA reduced the levels of key inflammatory markers, helping to calm the immune response in the affected areas. Specifically, it decreased markers like tumor necrosis factor-α and interleukin-6, while boosting protective factors like interleukin-10.
Additionally, we examined the impact of ZnHA on gut bacteria and found that it promoted the production of beneficial short-chain fatty acids, which are crucial for gut health. This treatment also seemed to strengthen the intestinal barrier by enhancing the expression of proteins that help keep gut cells tightly bound together.
Overall, these results suggest that zinc could play a significant role in managing ulcerative colitis by reducing inflammation and supporting a healthy gut environment. Our research offers promising insights into using zinc hyaluronate as a potential treatment for this challenging condition.
Our findings were encouraging. We observed that ZnHA reduced the levels of key inflammatory markers, helping to calm the immune response in the affected areas. Specifically, it decreased markers like tumor necrosis factor-α and interleukin-6, while boosting protective factors like interleukin-10.
Additionally, we examined the impact of ZnHA on gut bacteria and found that it promoted the production of beneficial short-chain fatty acids, which are crucial for gut health. This treatment also seemed to strengthen the intestinal barrier by enhancing the expression of proteins that help keep gut cells tightly bound together.
Overall, these results suggest that zinc could play a significant role in managing ulcerative colitis by reducing inflammation and supporting a healthy gut environment. Our research offers promising insights into using zinc hyaluronate as a potential treatment for this challenging condition.
Read More
4
We explored the relationship between serum zinc levels and various clinical features in patients suffering from inflammatory bowel disease (IBD), specifically focusing on Crohn's disease and ulcerative colitis. Our study included 37 patients with Crohn’s disease and 64 with ulcerative colitis, where we measured serum zinc concentrations and analyzed patient characteristics, blood test values, disease activity, and endoscopic scores.
A notable finding was that a significant number of patients experienced hypozincemia, with 45.9% of Crohn's patients and 29.7% of those with ulcerative colitis having low zinc levels. We observed a weak negative correlation between zinc levels and disease activity, indicated by the Crohn’s Disease Activity Index and C-reactive protein levels in Crohn's patients. Similarly, in ulcerative colitis patients, there was a weak negative correlation with the white blood cell count.
Interestingly, lower zinc concentrations were seen in ulcerative colitis patients with higher Mayo endoscopic scores, reflecting more severe disease activity. Additionally, serum zinc showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index, suggesting that zinc levels might influence overall nutritional status in these patients.
Overall, while our study highlighted the importance of monitoring zinc levels due to their association with disease activity and nutritional parameters, we found no direct evidence that zinc treatment significantly improves symptoms of colitis.
A notable finding was that a significant number of patients experienced hypozincemia, with 45.9% of Crohn's patients and 29.7% of those with ulcerative colitis having low zinc levels. We observed a weak negative correlation between zinc levels and disease activity, indicated by the Crohn’s Disease Activity Index and C-reactive protein levels in Crohn's patients. Similarly, in ulcerative colitis patients, there was a weak negative correlation with the white blood cell count.
Interestingly, lower zinc concentrations were seen in ulcerative colitis patients with higher Mayo endoscopic scores, reflecting more severe disease activity. Additionally, serum zinc showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index, suggesting that zinc levels might influence overall nutritional status in these patients.
Overall, while our study highlighted the importance of monitoring zinc levels due to their association with disease activity and nutritional parameters, we found no direct evidence that zinc treatment significantly improves symptoms of colitis.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective supplement quality
I bought this product to assist with my Colitis condition. The quality, packaging, and size of this supplement are as advertised.
Read More
9
Pain significantly reduced
53 people found this helpful
I started researching and was impressed with what I found. I experienced severe pain in my right hip and lower back that came suddenly. While looking for information, I read about colostrum and decided to try Jarrow Colostrum because I trust the brand. On my day off, I took three upon delivery and rested. When I awoke four hours later, the pain had disappeared by 90%. After using it consistently for over thirty days, I can confidently say that colostrum is miraculous. The pain is now gone, and my mother with colitis flare-ups has also benefited, feeling better than she has in years.
Read More
7.5
Improved intestinal health
I purchased this to improve my Colitis. The ingestion of zinc, magnesium, and vitamin D enhances my intestinal health.
Read More
Frequently Asked Questions
9
Effective supplement quality
I bought this product to assist with my Colitis condition. The quality, packaging, and size of this supplement are as advertised.
7.5
Improved intestinal health
I purchased this to improve my Colitis. The ingestion of zinc, magnesium, and vitamin D enhances my intestinal health.
9
We constructed a mouse model of ulcerative colitis, a painful condition caused by inflammation in the intestines, to investigate how zinc hyaluronate (ZnHA) could help. Our goal was to explore whether ZnHA could effectively alleviate symptoms commonly associated with this disease, such as weight loss, diarrhea, and bleeding.
Our findings were encouraging. We observed that ZnHA reduced the levels of key inflammatory markers, helping to calm the immune response in the affected areas. Specifically, it decreased markers like tumor necrosis factor-α and interleukin-6, while boosting protective factors like interleukin-10.
Additionally, we examined the impact of ZnHA on gut bacteria and found that it promoted the production of beneficial short-chain fatty acids, which are crucial for gut health. This treatment also seemed to strengthen the intestinal barrier by enhancing the expression of proteins that help keep gut cells tightly bound together.
Overall, these results suggest that zinc could play a significant role in managing ulcerative colitis by reducing inflammation and supporting a healthy gut environment. Our research offers promising insights into using zinc hyaluronate as a potential treatment for this challenging condition.
Our findings were encouraging. We observed that ZnHA reduced the levels of key inflammatory markers, helping to calm the immune response in the affected areas. Specifically, it decreased markers like tumor necrosis factor-α and interleukin-6, while boosting protective factors like interleukin-10.
Additionally, we examined the impact of ZnHA on gut bacteria and found that it promoted the production of beneficial short-chain fatty acids, which are crucial for gut health. This treatment also seemed to strengthen the intestinal barrier by enhancing the expression of proteins that help keep gut cells tightly bound together.
Overall, these results suggest that zinc could play a significant role in managing ulcerative colitis by reducing inflammation and supporting a healthy gut environment. Our research offers promising insights into using zinc hyaluronate as a potential treatment for this challenging condition.
4
We explored the relationship between serum zinc levels and various clinical features in patients suffering from inflammatory bowel disease (IBD), specifically focusing on Crohn's disease and ulcerative colitis. Our study included 37 patients with Crohn’s disease and 64 with ulcerative colitis, where we measured serum zinc concentrations and analyzed patient characteristics, blood test values, disease activity, and endoscopic scores.
A notable finding was that a significant number of patients experienced hypozincemia, with 45.9% of Crohn's patients and 29.7% of those with ulcerative colitis having low zinc levels. We observed a weak negative correlation between zinc levels and disease activity, indicated by the Crohn’s Disease Activity Index and C-reactive protein levels in Crohn's patients. Similarly, in ulcerative colitis patients, there was a weak negative correlation with the white blood cell count.
Interestingly, lower zinc concentrations were seen in ulcerative colitis patients with higher Mayo endoscopic scores, reflecting more severe disease activity. Additionally, serum zinc showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index, suggesting that zinc levels might influence overall nutritional status in these patients.
Overall, while our study highlighted the importance of monitoring zinc levels due to their association with disease activity and nutritional parameters, we found no direct evidence that zinc treatment significantly improves symptoms of colitis.
A notable finding was that a significant number of patients experienced hypozincemia, with 45.9% of Crohn's patients and 29.7% of those with ulcerative colitis having low zinc levels. We observed a weak negative correlation between zinc levels and disease activity, indicated by the Crohn’s Disease Activity Index and C-reactive protein levels in Crohn's patients. Similarly, in ulcerative colitis patients, there was a weak negative correlation with the white blood cell count.
Interestingly, lower zinc concentrations were seen in ulcerative colitis patients with higher Mayo endoscopic scores, reflecting more severe disease activity. Additionally, serum zinc showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index, suggesting that zinc levels might influence overall nutritional status in these patients.
Overall, while our study highlighted the importance of monitoring zinc levels due to their association with disease activity and nutritional parameters, we found no direct evidence that zinc treatment significantly improves symptoms of colitis.
References
- Zhang L, Fu X, Li J, Xiao W, Xiong X, et al. Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice. J Microbiol Biotechnol. 2025;35:e2408050. 10.4014/jmb.2408.08050
- Omatsu T, Takagi T, Yasuda T, Nakahata Y, Hayashi S, et al. The association between serum zinc level and clinical features in patients with inflammatory bowel disease. J Clin Biochem Nutr. 2025;76:50. 10.3164/jcbn.24-64
Data last updated:
