Last update
3/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.4
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Red Yeast Rice (Monascus purpureus)
1,200 mg
†
Coenzyme Q10 (Ubiquinone)
100 mg
†
Top Medical Research Studies
4
We conducted a study to examine how coenzyme Q10, in its reduced form known as ubiquinol, might affect constipation in individuals dealing with daily abdominal discomfort. Using a robust, double-blind, randomized control design, we enlisted forty-one patients who experienced either constipation or diarrhea. Participants were split evenly into two groups, with one receiving 150 mg of ubiquinol each day for twelve weeks, while the other group received a placebo.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
Read More
9.5
We observed a fascinating case involving a patient with maternally inherited diabetes and deafness (MIDD) who experienced chronic intestinal pseudo obstruction. This condition, while not commonly reported in MIDD patients, illustrates the broader impact of the condition on various bodily systems.
Interestingly, despite most gastrointestinal symptoms like constipation and diarrhea being more prevalent, the introduction of Coenzyme Q10 as a treatment option led to a resolution of the pseudo obstruction. This finding gives us promising insights into how Coenzyme Q10 can aid in gastrointestinal health, particularly for patients facing complex mitochondrial disorders.
Although the report focuses on intestinal pseudo obstruction rather than constipation explicitly, the positive outcome from Coenzyme Q10 suggests it may play a supportive role in managing related gastrointestinal symptoms. By further exploring this connection, we can better understand the potential benefits of Coenzyme Q10 in similar clinical settings.
Interestingly, despite most gastrointestinal symptoms like constipation and diarrhea being more prevalent, the introduction of Coenzyme Q10 as a treatment option led to a resolution of the pseudo obstruction. This finding gives us promising insights into how Coenzyme Q10 can aid in gastrointestinal health, particularly for patients facing complex mitochondrial disorders.
Although the report focuses on intestinal pseudo obstruction rather than constipation explicitly, the positive outcome from Coenzyme Q10 suggests it may play a supportive role in managing related gastrointestinal symptoms. By further exploring this connection, we can better understand the potential benefits of Coenzyme Q10 in similar clinical settings.
Read More
Most Useful Reviews
9
No constipation side-effect
Excellent! It’s very effective and doesn’t cause constipation like other treatments. I’m awaiting analysis to check my cholesterol.
Read More
0
Worsened constipation
I purchased this as the side effects of statins were severe, yet it unfortunately made my constipation worse.
Read More
2
Occasional constipation
1 people found this helpful
I found it effective and have reduced my intake from two pills to one. After some time, my cholesterol levels have normalised when tested. However, I occasionally experience constipation the following day after taking it at night, though I am unsure if it is just a personal issue.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.8
- All Researches
9.5
We observed a fascinating case involving a patient with maternally inherited diabetes and deafness (MIDD) who experienced chronic intestinal pseudo obstruction. This condition, while not commonly reported in MIDD patients, illustrates the broader impact of the condition on various bodily systems.
Interestingly, despite most gastrointestinal symptoms like constipation and diarrhea being more prevalent, the introduction of Coenzyme Q10 as a treatment option led to a resolution of the pseudo obstruction. This finding gives us promising insights into how Coenzyme Q10 can aid in gastrointestinal health, particularly for patients facing complex mitochondrial disorders.
Although the report focuses on intestinal pseudo obstruction rather than constipation explicitly, the positive outcome from Coenzyme Q10 suggests it may play a supportive role in managing related gastrointestinal symptoms. By further exploring this connection, we can better understand the potential benefits of Coenzyme Q10 in similar clinical settings.
Interestingly, despite most gastrointestinal symptoms like constipation and diarrhea being more prevalent, the introduction of Coenzyme Q10 as a treatment option led to a resolution of the pseudo obstruction. This finding gives us promising insights into how Coenzyme Q10 can aid in gastrointestinal health, particularly for patients facing complex mitochondrial disorders.
Although the report focuses on intestinal pseudo obstruction rather than constipation explicitly, the positive outcome from Coenzyme Q10 suggests it may play a supportive role in managing related gastrointestinal symptoms. By further exploring this connection, we can better understand the potential benefits of Coenzyme Q10 in similar clinical settings.
Read More
4
We conducted a study to examine how coenzyme Q10, in its reduced form known as ubiquinol, might affect constipation in individuals dealing with daily abdominal discomfort. Using a robust, double-blind, randomized control design, we enlisted forty-one patients who experienced either constipation or diarrhea. Participants were split evenly into two groups, with one receiving 150 mg of ubiquinol each day for twelve weeks, while the other group received a placebo.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
No constipation side-effect
Excellent! It’s very effective and doesn’t cause constipation like other treatments. I’m awaiting analysis to check my cholesterol.
Read More
0
Worsened constipation
I purchased this as the side effects of statins were severe, yet it unfortunately made my constipation worse.
Read More
2
Occasional constipation
1 people found this helpful
I found it effective and have reduced my intake from two pills to one. After some time, my cholesterol levels have normalised when tested. However, I occasionally experience constipation the following day after taking it at night, though I am unsure if it is just a personal issue.
Read More
Frequently Asked Questions
9
No constipation side-effect
Excellent! It’s very effective and doesn’t cause constipation like other treatments. I’m awaiting analysis to check my cholesterol.
0
Worsened constipation
I purchased this as the side effects of statins were severe, yet it unfortunately made my constipation worse.
2
Occasional constipation
1 people found this helpful
I found it effective and have reduced my intake from two pills to one. After some time, my cholesterol levels have normalised when tested. However, I occasionally experience constipation the following day after taking it at night, though I am unsure if it is just a personal issue.
4
We conducted a study to examine how coenzyme Q10, in its reduced form known as ubiquinol, might affect constipation in individuals dealing with daily abdominal discomfort. Using a robust, double-blind, randomized control design, we enlisted forty-one patients who experienced either constipation or diarrhea. Participants were split evenly into two groups, with one receiving 150 mg of ubiquinol each day for twelve weeks, while the other group received a placebo.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.
On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.
9.5
We observed a fascinating case involving a patient with maternally inherited diabetes and deafness (MIDD) who experienced chronic intestinal pseudo obstruction. This condition, while not commonly reported in MIDD patients, illustrates the broader impact of the condition on various bodily systems.
Interestingly, despite most gastrointestinal symptoms like constipation and diarrhea being more prevalent, the introduction of Coenzyme Q10 as a treatment option led to a resolution of the pseudo obstruction. This finding gives us promising insights into how Coenzyme Q10 can aid in gastrointestinal health, particularly for patients facing complex mitochondrial disorders.
Although the report focuses on intestinal pseudo obstruction rather than constipation explicitly, the positive outcome from Coenzyme Q10 suggests it may play a supportive role in managing related gastrointestinal symptoms. By further exploring this connection, we can better understand the potential benefits of Coenzyme Q10 in similar clinical settings.
Interestingly, despite most gastrointestinal symptoms like constipation and diarrhea being more prevalent, the introduction of Coenzyme Q10 as a treatment option led to a resolution of the pseudo obstruction. This finding gives us promising insights into how Coenzyme Q10 can aid in gastrointestinal health, particularly for patients facing complex mitochondrial disorders.
Although the report focuses on intestinal pseudo obstruction rather than constipation explicitly, the positive outcome from Coenzyme Q10 suggests it may play a supportive role in managing related gastrointestinal symptoms. By further exploring this connection, we can better understand the potential benefits of Coenzyme Q10 in similar clinical settings.
References
- Suzuki S, Gotoda T, Kusano C, Ikehara H, Miyakoshi Y, et al. Effect of Ubiquinol Intake on Defecation Frequency and Stool Form: A Prospective, Double-Blinded, Randomized Control Study. J Med Food. 2019;22:81. 10.1089/jmf.2018.4233
- Bergamin CS, Rolim LC, Dib SA, Moisés RS. Unusual occurrence of intestinal pseudo obstruction in a patient with maternally inherited diabetes and deafness (MIDD) and favorable outcome with coenzyme Q10. Arq Bras Endocrinol Metabol. 2008;52:1345. PubMed
Data last updated:
