' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.3
USERS' SCORE
Excellent
Based on 5 Reviews
9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 ethosomal gel for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Focuses on vitamin D3 efficacy
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
9
Vitamin D's role in psoriasis treatment
Vitamins for the Management of Nail Disease: A Literature Review.
Study highlights vitamin D's efficacy
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
8
Effective topical psoriasis treatments
A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis.
Direct focus on vitamin D usage
We explored the effectiveness of topical treatments for chronic plaque psoriasis, particularly focusing on calcipotriol, an active form of vitamin D, and methotrexate. In a study involving 60 patients, we divided them into two groups: one receiving calcipotriol and the other methotrexate. Over two months, we assessed their progress based on the psoriasis area severity index (PASI) scores, measuring the severity of their condition at the start, four weeks in, and eight weeks later.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Read More
Most Useful Reviews
9
Improved immunity
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
Read More
9.5
Psoriasis improvement
I realised I was vitamin D deficient for quite a while. I've suffered from psoriasis and psoriatic arthritis. After starting vitamin D, the psoriasis on my scalp has nearly vanished. I haven’t needed to use topical steroids or pain relief for my arthritis since taking it. I wish my doctors had mentioned this association sooner!
Read More
9.3
Enhanced wellbeing
These vitamins are great. After Covid, my energy disappeared and I discovered my vitamin D level was very low. Within a week of taking these, I felt more energetic and my digestive issues improved. I've noticed less pain and my psoriasis has decreased. I believe vitamin D is crucial for everyone’s wellbeing.
Read More
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Culturelle Probiotics
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Solgar Naturally Sourced Vitamin E
SCIENTIFIC SCORE
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Solgar Biotin
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.3
9
Vitamin D's role in psoriasis treatment
Vitamins for the Management of Nail Disease: A Literature Review.
Study highlights vitamin D's efficacy
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
8
Vitamin D3 ethosomal gel for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Focuses on vitamin D3 efficacy
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
8
Phototherapy benefits psoriasis treatment
The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease.
Moderately relevant to vitamin D
We investigated how phototherapy, specifically narrowband-ultraviolet B (NB-UVB), affects vitamin D levels and inflammatory markers in patients with psoriasis and atopic dermatitis. The study involved thirty adults—twenty with psoriasis and ten with atopic dermatitis—who underwent NB-UVB treatment.
After therapy, we observed changes in vitamin D-binding protein (DBP) and high-sensitivity C-reactive protein (hsCRP), both of which indicate systemic inflammation. Interestingly, DBP levels decreased in psoriasis patients following treatment. However, the drop in hsCRP levels—while noticed in both groups—wasn't statistically significant.
We also saw improvements in disease severity, as measured by established scales, alongside increases in vitamin D levels. Sub-analyses showed that patients with vitamin D deficiency or insufficiency tended to respond better to NB-UVB therapy compared to those who were vitamin D sufficient.
Overall, our findings suggest that phototherapy may offer not only skin benefits but also a systemic anti-inflammatory effect, primarily in psoriasis patients.
After therapy, we observed changes in vitamin D-binding protein (DBP) and high-sensitivity C-reactive protein (hsCRP), both of which indicate systemic inflammation. Interestingly, DBP levels decreased in psoriasis patients following treatment. However, the drop in hsCRP levels—while noticed in both groups—wasn't statistically significant.
We also saw improvements in disease severity, as measured by established scales, alongside increases in vitamin D levels. Sub-analyses showed that patients with vitamin D deficiency or insufficiency tended to respond better to NB-UVB therapy compared to those who were vitamin D sufficient.
Overall, our findings suggest that phototherapy may offer not only skin benefits but also a systemic anti-inflammatory effect, primarily in psoriasis patients.
Read More
8
Effective topical psoriasis treatments
A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis.
Direct focus on vitamin D usage
We explored the effectiveness of topical treatments for chronic plaque psoriasis, particularly focusing on calcipotriol, an active form of vitamin D, and methotrexate. In a study involving 60 patients, we divided them into two groups: one receiving calcipotriol and the other methotrexate. Over two months, we assessed their progress based on the psoriasis area severity index (PASI) scores, measuring the severity of their condition at the start, four weeks in, and eight weeks later.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Read More
7
Vitamin D enhances psoriasis treatment
Dual-Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self-Locking Microneedles.
Combines vitamin D with advanced therapy
We explored an innovative approach to treating psoriasis by combining vitamin D, specifically Calcipotriol, with a targeted delivery method. This study combined a self-locking microneedle patch loaded with Deucravacitinib, a Tyrosine Kinase 2 inhibitor, alongside Calcipotriol, which helps manage skin cell proliferation.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 5 Reviews
9
9.5
Psoriasis improvement
I realised I was vitamin D deficient for quite a while. I've suffered from psoriasis and psoriatic arthritis. After starting vitamin D, the psoriasis on my scalp has nearly vanished. I haven’t needed to use topical steroids or pain relief for my arthritis since taking it. I wish my doctors had mentioned this association sooner!
Read More
9.3
Enhanced wellbeing
These vitamins are great. After Covid, my energy disappeared and I discovered my vitamin D level was very low. Within a week of taking these, I felt more energetic and my digestive issues improved. I've noticed less pain and my psoriasis has decreased. I believe vitamin D is crucial for everyone’s wellbeing.
Read More
9
Improved immunity
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
Read More
8.8
Psoriasis relief
In a good dosage, this vitamin D is excellent. It has helped with my psoriasis flare-up.
8.8
Ongoing treatment
I take vitamin D for psoriasis as I work from home and lack sunlight exposure. I’ve heard D3 is good for psoriasis, so I will continue taking it.
