Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 ethosomal gel for psoriasis
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
9
Vitamin D's role in psoriasis treatment
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
8
We explored the effectiveness of topical treatments for chronic plaque psoriasis, particularly focusing on calcipotriol, an active form of vitamin D, and methotrexate. In a study involving 60 patients, we divided them into two groups: one receiving calcipotriol and the other methotrexate. Over two months, we assessed their progress based on the psoriasis area severity index (PASI) scores, measuring the severity of their condition at the start, four weeks in, and eight weeks later.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Read More
Most Useful Reviews
8
Improved immunity
212 people found this helpful
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
Read More
9
Vitamin D effective
22 people found this helpful
If you have psoriasis, try these! I’ve been aware of my Vitamin D deficiency for ages and have suffered from psoriasis and psoriatic arthritis for years. I ordered two during a bout of insomnia and have been taking one every other day for a week. Remarkably, the psoriasis on my scalp is nearly gone. I previously relied on topical steroids for my psoriasis symptoms, but I haven’t needed them for five days. I was taking Ibuprofen daily for arthritis but haven't needed it since. Please try these if you’re Vitamin D deficient and suffer from psoriasis. I only wish my doctors had informed me about this connection!
Read More
9
Psoriasis improvement
I realised I was vitamin D deficient for quite a while. I've suffered from psoriasis and psoriatic arthritis. After starting vitamin D, the psoriasis on my scalp has nearly vanished. I haven’t needed to use topical steroids or pain relief for my arthritis since taking it. I wish my doctors had mentioned this association sooner!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
- All Researches
9
Vitamin D's role in psoriasis treatment
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
8
Vitamin D3 ethosomal gel for psoriasis
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
8
Phototherapy benefits psoriasis treatment
We investigated how phototherapy, specifically narrowband-ultraviolet B (NB-UVB), affects vitamin D levels and inflammatory markers in patients with psoriasis and atopic dermatitis. The study involved thirty adults—twenty with psoriasis and ten with atopic dermatitis—who underwent NB-UVB treatment.
After therapy, we observed changes in vitamin D-binding protein (DBP) and high-sensitivity C-reactive protein (hsCRP), both of which indicate systemic inflammation. Interestingly, DBP levels decreased in psoriasis patients following treatment. However, the drop in hsCRP levels—while noticed in both groups—wasn't statistically significant.
We also saw improvements in disease severity, as measured by established scales, alongside increases in vitamin D levels. Sub-analyses showed that patients with vitamin D deficiency or insufficiency tended to respond better to NB-UVB therapy compared to those who were vitamin D sufficient.
Overall, our findings suggest that phototherapy may offer not only skin benefits but also a systemic anti-inflammatory effect, primarily in psoriasis patients.
After therapy, we observed changes in vitamin D-binding protein (DBP) and high-sensitivity C-reactive protein (hsCRP), both of which indicate systemic inflammation. Interestingly, DBP levels decreased in psoriasis patients following treatment. However, the drop in hsCRP levels—while noticed in both groups—wasn't statistically significant.
We also saw improvements in disease severity, as measured by established scales, alongside increases in vitamin D levels. Sub-analyses showed that patients with vitamin D deficiency or insufficiency tended to respond better to NB-UVB therapy compared to those who were vitamin D sufficient.
Overall, our findings suggest that phototherapy may offer not only skin benefits but also a systemic anti-inflammatory effect, primarily in psoriasis patients.
Read More
8
We explored the effectiveness of topical treatments for chronic plaque psoriasis, particularly focusing on calcipotriol, an active form of vitamin D, and methotrexate. In a study involving 60 patients, we divided them into two groups: one receiving calcipotriol and the other methotrexate. Over two months, we assessed their progress based on the psoriasis area severity index (PASI) scores, measuring the severity of their condition at the start, four weeks in, and eight weeks later.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Read More
7
We explored an innovative approach to treating psoriasis by combining vitamin D, specifically Calcipotriol, with a targeted delivery method. This study combined a self-locking microneedle patch loaded with Deucravacitinib, a Tyrosine Kinase 2 inhibitor, alongside Calcipotriol, which helps manage skin cell proliferation.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Improved immunity
212 people found this helpful
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
Read More
9
Vitamin D effective
22 people found this helpful
If you have psoriasis, try these! I’ve been aware of my Vitamin D deficiency for ages and have suffered from psoriasis and psoriatic arthritis for years. I ordered two during a bout of insomnia and have been taking one every other day for a week. Remarkably, the psoriasis on my scalp is nearly gone. I previously relied on topical steroids for my psoriasis symptoms, but I haven’t needed them for five days. I was taking Ibuprofen daily for arthritis but haven't needed it since. Please try these if you’re Vitamin D deficient and suffer from psoriasis. I only wish my doctors had informed me about this connection!
Read More
9
Psoriasis improvement
I realised I was vitamin D deficient for quite a while. I've suffered from psoriasis and psoriatic arthritis. After starting vitamin D, the psoriasis on my scalp has nearly vanished. I haven’t needed to use topical steroids or pain relief for my arthritis since taking it. I wish my doctors had mentioned this association sooner!
Read More
8.5
Enhanced wellbeing
These vitamins are great. After Covid, my energy disappeared and I discovered my vitamin D level was very low. Within a week of taking these, I felt more energetic and my digestive issues improved. I've noticed less pain and my psoriasis has decreased. I believe vitamin D is crucial for everyone’s wellbeing.
Read More
7.5
Psoriasis relief
In a good dosage, this vitamin D is excellent. It has helped with my psoriasis flare-up.
Read More
Frequently Asked Questions
9
Psoriasis improvement
I realised I was vitamin D deficient for quite a while. I've suffered from psoriasis and psoriatic arthritis. After starting vitamin D, the psoriasis on my scalp has nearly vanished. I haven’t needed to use topical steroids or pain relief for my arthritis since taking it. I wish my doctors had mentioned this association sooner!
8.5
Enhanced wellbeing
These vitamins are great. After Covid, my energy disappeared and I discovered my vitamin D level was very low. Within a week of taking these, I felt more energetic and my digestive issues improved. I've noticed less pain and my psoriasis has decreased. I believe vitamin D is crucial for everyone’s wellbeing.
7.5
Ongoing treatment
I take vitamin D for psoriasis as I work from home and lack sunlight exposure. I’ve heard D3 is good for psoriasis, so I will continue taking it.
8
Improved immunity
212 people found this helpful
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
7.5
Psoriasis relief
In a good dosage, this vitamin D is excellent. It has helped with my psoriasis flare-up.
7
We explored an innovative approach to treating psoriasis by combining vitamin D, specifically Calcipotriol, with a targeted delivery method. This study combined a self-locking microneedle patch loaded with Deucravacitinib, a Tyrosine Kinase 2 inhibitor, alongside Calcipotriol, which helps manage skin cell proliferation.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
7
We explored how vitamin D influences psoriasis through a systematic review and meta-analysis. The study collated various research findings to determine the effectiveness of vitamin D treatment for those suffering from psoriatic arthritis and related skin conditions. By examining numerous trials, we aimed to gather comprehensive insights into whether vitamin D supplementation could provide significant relief for psoriasis symptoms.
Our analysis revealed some interesting patterns regarding vitamin D levels and psoriasis severity. However, we observed that the overall results did not demonstrate a consistent, significant benefit of vitamin D in alleviating psoriasis symptoms across the different studies analyzed. It appeared that, while vitamin D is vital for overall skin health, its direct impact on treating psoriasis may not be as strong as previously thought.
Ultimately, this research sheds light on the need for further investigation into vitamin D's role, considering the mixed outcomes found. Understanding its potential will be crucial in guiding future treatment options for psoriasis patients.
Our analysis revealed some interesting patterns regarding vitamin D levels and psoriasis severity. However, we observed that the overall results did not demonstrate a consistent, significant benefit of vitamin D in alleviating psoriasis symptoms across the different studies analyzed. It appeared that, while vitamin D is vital for overall skin health, its direct impact on treating psoriasis may not be as strong as previously thought.
Ultimately, this research sheds light on the need for further investigation into vitamin D's role, considering the mixed outcomes found. Understanding its potential will be crucial in guiding future treatment options for psoriasis patients.
9
Vitamin D's role in psoriasis treatment
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
References
- Wang ZY, Zhao ZQ, Sheng YJ, Chen KJ, Chen BZ, et al. Dual-Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self-Locking Microneedles. Adv Sci (Weinh). 2024;11:e2409359. doi:10.1002/advs.202409359
- Zanghaneh AJ, Elmelid A, Gillstedt M, Ahmic O, Andersson B, et al. The Expression of Vitamin D Receptor on Peripheral Blood Mononuclear Cells in Patients with Psoriasis. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910677
- Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. doi:10.1038/s41598-024-72951-6
- Elmelid A, Vandikas MS, Gillstedt M, Alsterholm M, Osmancevic A. The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168632
- Das K, Ranjan R, Kumar P, Chandra S. A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis. Cureus. 2024;16:e59878. doi:10.7759/cureus.59878
- Formisano E, Proietti E, Borgarelli C, Pisciotta L. Comment to "Vitamin D in psoriatic arthritis - A systematic review and meta-analysis". Semin Arthritis Rheum. 2024;67:152457. doi:10.1016/j.semarthrit.2024.152457
- Curtis KL, Lipner SR. Vitamins for the Management of Nail Disease: A Literature Review. Skin Appendage Disord. 2024;10:104. doi:10.1159/000534972
