Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 48 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin (as d-Biotin)
330 mcg
1,100%
Alpha Lipoic Acid (Thioctic Acid)
300 mg
†
Top Medical Research Studies
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
3
We investigated whether alpha-lipoic acid (ALA) could improve symptoms of diabetic peripheral neuropathy (DPN). Our review included three randomized trials with over 800 participants, with treatment durations ranging from six to 48 months.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Read More
Most Useful Reviews
9
Pain relief
46 people found this helpful
Alpha Lipoic Sustain works GREAT! I take it to alleviate pain from idiopathic peripheral neuropathy. Prescription Lyrica didn't work well and caused side effects, muddling my thoughts! Alpha Lipoic Sustain is effective, and I take about 1,200 mg (or 4 tablets daily) without any side effects. Jarrow seems to be the best among the alpha lipoic acids I've tried.
Read More
10
Best for neuropathy
22 people found this helpful
Pain relief! Jarrow is the best Alpha Lipoic on the market. The 300 mg sustained release provides all-day coverage. Nothing works as well for neuropathy as ALA. Note: this will lower blood sugar - if you're diabetic, be sure to test.
Read More
9
Sleeplessness alleviated
15 people found this helpful
Wonderful product! I purchased these after reading numerous reviews on how they assisted individuals with diabetic neuropathy. My feet were severely affected, and I struggled to sleep. I was willing to try anything due to my desperation. I tried these pills, and they began working almost immediately! I can finally sleep without the foot pain! THANK YOU JARROW FOR A WONDERFUL PRODUCT AND A GOOD NIGHT'S SLEEP!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
8
Alpha-lipoic acid and neuropathy insights
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
8
We explored the impact of genome sequencing on diagnosing and treating SLC5A6-related neuropathy. In this study, we observed that thirteen individuals with specific genetic variants experienced various symptoms, including childhood-onset peripheral motor neuropathy.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Read More
User Reviews
USERS' SCORE
Good
Based on 48 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief
46 people found this helpful
Alpha Lipoic Sustain works GREAT! I take it to alleviate pain from idiopathic peripheral neuropathy. Prescription Lyrica didn't work well and caused side effects, muddling my thoughts! Alpha Lipoic Sustain is effective, and I take about 1,200 mg (or 4 tablets daily) without any side effects. Jarrow seems to be the best among the alpha lipoic acids I've tried.
Read More
10
Best for neuropathy
22 people found this helpful
Pain relief! Jarrow is the best Alpha Lipoic on the market. The 300 mg sustained release provides all-day coverage. Nothing works as well for neuropathy as ALA. Note: this will lower blood sugar - if you're diabetic, be sure to test.
Read More
9
Sleeplessness alleviated
15 people found this helpful
Wonderful product! I purchased these after reading numerous reviews on how they assisted individuals with diabetic neuropathy. My feet were severely affected, and I struggled to sleep. I was willing to try anything due to my desperation. I tried these pills, and they began working almost immediately! I can finally sleep without the foot pain! THANK YOU JARROW FOR A WONDERFUL PRODUCT AND A GOOD NIGHT'S SLEEP!
Read More
9
Improved quality of life
14 people found this helpful
Neuropathy Treatment. Although I have never been diabetic, I developed neuropathy in my feet and hands. The tingling and numbness in my feet seriously affected my quality of life, making shoes uncomfortable. My doctors prescribed Gabapentin, which helped significantly but still left me with quality of life issues. I began taking this about 5 months ago and experienced immediate positive results. Most tingling is gone, and numbness has reduced significantly. Now, the feet are no longer a major issue, mostly just an annoyance. After starting with 300 mg twice a day, I tried doubling the dose for further improvement, but returned to my original dosis as there was no change. Remarkably, my skin's condition improved, with others commenting on its softness.
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8.5
Great improvements
11 people found this helpful
I use Alpha Lipoic Acid for my neuropathy with significant improvements. The sustained release allows me to enjoy the benefits longer, taking it once in the morning and again in the evening. This is one supplement I would not do without. I choose Jarrow for its quality.
Read More
Frequently Asked Questions
9
Sleeplessness alleviated
15 people found this helpful
Wonderful product! I purchased these after reading numerous reviews on how they assisted individuals with diabetic neuropathy. My feet were severely affected, and I struggled to sleep. I was willing to try anything due to my desperation. I tried these pills, and they began working almost immediately! I can finally sleep without the foot pain! THANK YOU JARROW FOR A WONDERFUL PRODUCT AND A GOOD NIGHT'S SLEEP!
9
Immediate effect observed
6 people found this helpful
I received ALA Sustain 300 on my brother's advice for tingling in my feet from Type 2 diabetes. It worked immediately! I then offered some to my daughter, who has Type 1 and suffers from significant discomfort in her feet, ankles, and hands. It worked immediately for her too. I will be ordering more bottles soon. Thank you for a product that genuinely helps without side effects.
7.5
Pain intensity decreased
11 people found this helpful
With neuropathy and Type 2 diabetes, my husband has type 2 diabetes mellitus alongside this painful form of neuropathy. Alpha lipoic acid serves two functions: it reduces protein glycation and protects the myelin sheath of the nerve from further damage. After two months of taking one in the morning and evening, the pain became less intense, and his glycated hemoglobin dropped from 8 to 6. Additionally, it is convenient that the 2-in-1 formula is enhanced by biotin. All feels good.
7.5
Significant pain relief
1 people found this helpful
This has made a real improvement in my nerve pain. No more pinching or biting sensations. Along with the reduction of neuropathy, I'm no longer limping from plantar fasciitis pain. I no longer need over-the-counter pain medications either. I will purchase this again!
7
Alleviates burning pain
2 people found this helpful
I believe it helps alleviate the burning and pain in my legs caused by peripheral neuropathy.
8
Improved overall wellness
This was recommended to me by a physician due to neuropathy from shingles. This product not only helped with that but also stabilised my glucose levels. The biotin in this product also enhances the appearance of my skin, nails, and hair. I have been using it for over a year now.
9
Improves foot condition
1 people found this helpful
This is a fantastic product. I am taking it for peripheral neuropathy and plantar fasciitis. With consistent use, my left foot has significantly improved. This formula is a timed-release and includes Biotin, which ensures it remains effective since Alpha lipoic and biotin work in the same pathway. I trust Jarrow formulas.
9
Best for neuropathy
4 people found this helpful
Absolutely the best for diabetic neuropathy symptoms. I take 1200 mgs a day, and the timed release is most effective.
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
7
Alpha-lipoic acid shows promise
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
References
- Csiha S, Hernyák M, Molnár Á, Lőrincz H, Katkó M, et al. Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy. Biomedicines. 2025;13. doi:10.3390/biomedicines13020438
- Abuali SM, Frasca DJ. Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy. Am Fam Physician. 2025;111:119.
- Walimbe AS, Waskow E, Mackay L, Miller M, Gijavanekar C, et al. Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency. Am J Med Genet A. 2025. doi:10.1002/ajmg.a.64014
- Hernyák M, Tóth LI, Csiha S, Molnár Á, Lőrincz H, et al. Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy. Int J Mol Sci. 2024;25. doi:10.3390/ijms252413276
- Pingali U, Sravanasandya P, Mekala P, Yareeda S, Sireesha K, et al. A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin. J Postgrad Med. 2024;70:191. doi:10.4103/jpgm.jpgm_310_24
- Wang Q, Xie H, Wang Z, Huang R, Xu M, et al. Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials. Pharm Biol. 2024;62:833. doi:10.1080/13880209.2024.2422084
- Pingali U, Kammila S, Mekala P, Yareeda S, Penugonda S. A Study to Evaluate the Effect of Alpha-Lipoic Acid on Neuropathic Symptoms in Diabetic Neuropathy Patients on Gabapentin or Pregabalin. Cureus. 2024;16:e70299. doi:10.7759/cureus.70299
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Aldendail CF, Chen P, Dibble HS, Baute Penry V. A Comprehensive Review of Safety, Efficacy, and Indications for the Use of Alpha-Lipoic Acid and Acetyl-L-Carnitine in Neuropathic Pain. Integr Med (Encinitas). 2024;23:32.
- Riley LG, Sabui S, Said HM, Niaz A, Girisha KM, et al. Genome sequencing enables diagnosis and treatment of SLC5A6 neuropathy. Eur J Hum Genet. 2024;32:947. doi:10.1038/s41431-024-01641-8
- Ran GL, Li YP, Lu LC, Lan SH. Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials. J Diabetes Complications. 2024;38:108691. doi:10.1016/j.jdiacomp.2024.108691
- Prado MB, Adiao KJB. Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis. Can J Diabetes. 2024;48:233. doi:10.1016/j.jcjd.2024.01.007
- Lee DW, Park HC, Kim DH. Protective effect of alpha-lipoic acid and epalrestat on oxaliplatin-induced peripheral neuropathy in zebrafish. Muscle Nerve. 2024;69:498. doi:10.1002/mus.28047
- Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206 Suppl 1:110764. doi:10.1016/j.diabres.2023.110764
- Baicus C, Purcarea A, von Elm E, Delcea C, Furtunescu FL. Alpha-lipoic acid for diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2024;1:CD012967. doi:10.1002/14651858.CD012967.pub2
- Li Y, Jia Y. Effect of miR-146a polymorphism on lipoic acid therapy in patients with T2DM peripheral polyneuropthy. Cell Mol Biol (Noisy-le-grand). 2023;69:38. doi:10.14715/cmb/2023.69.12.7
