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SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 19 Reviews
8.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin (as d-Biotin)
330 mcg
1,100%
Alpha Lipoic Acid (Thioctic Acid)
300 mg
†
Top Medical Research Studies
8
Alpha-lipoic acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Direct effect on T2DM neuropathy
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
7
Alpha-lipoic acid shows promise
Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy.
Highly relevant to neuropathy treatment
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
Read More
8
Alpha-lipoic acid and neuropathy insights
Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency.
Moderate relevance to neuropathy treatment
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
Most Useful Reviews
9.5
Pain relief
Alpha Lipoic Sustain works GREAT! I take it to alleviate pain from idiopathic peripheral neuropathy. Prescription Lyrica didn't work well and caused side effects, muddling my thoughts! Alpha Lipoic Sustain is effective, and I take about 1,200 mg (or 4 tablets daily) without any side effects. Jarrow seems to be the best among the alpha lipoic acids I've tried.
Read More
10
Best for neuropathy
Pain relief! Jarrow is the best Alpha Lipoic on the market. The 300 mg sustained release provides all-day coverage. Nothing works as well for neuropathy as ALA. Note: this will lower blood sugar - if you're diabetic, be sure to test.
Read More
9.5
Improved quality of life
Neuropathy Treatment. Although I have never been diabetic, I developed neuropathy in my feet and hands. The tingling and numbness in my feet seriously affected my quality of life, making shoes uncomfortable. My doctors prescribed Gabapentin, which helped significantly but still left me with quality of life issues. I began taking this about 5 months ago and experienced immediate positive results. Most tingling is gone, and numbness has reduced significantly. Now, the feet are no longer a major issue, mostly just an annoyance. After starting with 300 mg twice a day, I tried doubling the dose for further improvement, but returned to my original dosis as there was no change. Remarkably, my skin's condition improved, with others commenting on its softness.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
8
Alpha-lipoic acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Direct effect on T2DM neuropathy
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
8
Alpha-lipoic acid and neuropathy insights
Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency.
Moderate relevance to neuropathy treatment
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
7
Alpha-lipoic acid shows promise
Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy.
Highly relevant to neuropathy treatment
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.6
10
Neuropathy improvement
Helps my neuropathy!! My neurologist at the Cleveland Clinic said ALA would assist my neuropathy. It works!!
10
Best for neuropathy
Pain relief! Jarrow is the best Alpha Lipoic on the market. The 300 mg sustained release provides all-day coverage. Nothing works as well for neuropathy as ALA. Note: this will lower blood sugar - if you're diabetic, be sure to test.
9.5
Improved quality of life
Neuropathy Treatment. Although I have never been diabetic, I developed neuropathy in my feet and hands. The tingling and numbness in my feet seriously affected my quality of life, making shoes uncomfortable. My doctors prescribed Gabapentin, which helped significantly but still left me with quality of life issues. I began taking this about 5 months ago and experienced immediate positive results. Most tingling is gone, and numbness has reduced significantly. Now, the feet are no longer a major issue, mostly just an annoyance. After starting with 300 mg twice a day, I tried doubling the dose for further improvement, but returned to my original dosis as there was no change. Remarkably, my skin's condition improved, with others commenting on its softness.
Read More
9.5
Effective extended release
Been taking this for over a year now because it works! I love the extended release dosage for neuropathy pain (combined with vitamin B1). Additionally, I appreciate that Jarrow's products are third-party verified for potency.
9.5
Pain relief
Alpha Lipoic Sustain works GREAT! I take it to alleviate pain from idiopathic peripheral neuropathy. Prescription Lyrica didn't work well and caused side effects, muddling my thoughts! Alpha Lipoic Sustain is effective, and I take about 1,200 mg (or 4 tablets daily) without any side effects. Jarrow seems to be the best among the alpha lipoic acids I've tried.
Read More
