We conducted a nested case-control study within a large cohort to understand how levels of taurine, S-adenosylmethionine (SAM), and cysteine in our blood are related to cancer risk, particularly among Chinese adults. Our analysis included 1,391 cancer cases matched with 1,391 controls, providing a robust framework for our findings.
Our results showed that higher levels of taurine in the blood could reduce overall cancer risk, particularly for digestive cancers. This is an exciting discovery as it suggests that taurine might play a protective role. On the contrary, elevated levels of SAM appeared linked to an increased risk of digestive cancers.
Using advanced statistical models, we identified complex interactions among taurine, SAM, and cysteine. Notably, we observed a significant overall negative association between the combination of these amino acids and cancer risk, highlighting the intricate balance these compounds maintain in our metabolism.
Overall, while taurine seems to confer some protective benefits, the specific metabolic relationships and their implications for treatment and prevention strategies need further exploration. Our findings could pave the way for new approaches in cancer prevention.
Read More
8
Taurine's potential in CRC diagnosis
Systematic Review and Meta-Analysis: Taurine and Its Association With Colorectal Carcinoma.
We conducted an in-depth exploration of taurine's relationship with colorectal cancer (CRC) through a systematic review of existing studies. Our investigation looked at various research studies to gather insights into how taurine levels relate to cancer.
We discovered a significant association between higher taurine levels and the presence of CRC. Specifically, findings indicated that taurine concentrations were elevated in CRC patient samples, particularly in blood. More importantly, taurine showed potential as a diagnostic marker, which could help to distinguish between benign and malignant conditions in patients at differing stages of cancer.
Despite these promising results, it’s worth noting that there was considerable variability in some outcomes across different studies. This highlights the need for further research to clarify taurine’s role, but our analysis suggests an overall trend indicating that increased taurine may be linked to greater odds of developing CRC.
As we continue to look into the connection between taurine and colorectal cancer, it opens up exciting possibilities for future diagnostics and treatments that leverage our understanding of metabolic changes associated with this disease.
Read More
7
Taurine's mixed effects on cancer
Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment.
We set out to understand the role of taurine, a naturally occurring acid in our bodies, in lung cancer development. Previous findings indicated that elevated taurine levels were present in lung cancer patients, prompting us to investigate its impact more closely.
Through our research involving mouse models, RNA sequencing, and stable transfection techniques, we observed significant insights into how taurine may affect lung cancer progression. We analyzed tissue samples from non-small cell lung cancer patients to enhance our findings and help clarify the relationship between taurine and cancer.
Our results suggest that while taurine may be a potential biomarker, its effects can differ based on the patient's age and immune status. For younger lung cancer patients, taurine-rich drinks could potentially pose risks, while older or immune-deficient patients may benefit from such treatments. Overall, the specific mechanisms of taurine’s impact on cancer progress warrant further exploration and suggest careful consideration for future treatments.
Read More
Most Useful Reviews
9
Cancer prevention
This product prevents the onset of cancer and reduces blood glucose levels. It assists in the formation and restoration of the retina within the eyes after injuries and helps to normalise blood pressure. The quality is exceptional, and the dosage is excellent.
Read More
9
Strong antioxidant
This supplement is a potent antioxidant that helps prevent the progression of cancer. It effectively lowers blood glucose levels and is involved in the formation of the retina, aiding recovery in case of injuries.
Read More
9
Excellent cancer prevention
This is a powerful natural antioxidant that combats oxidative processes in the body, alkalising and promoting cardiovascular health. It serves as an excellent preventive measure against cancer!
We investigated how taurine, an important amino acid, influences the effectiveness of 5-fluorouracil (5-FU), a common chemotherapy drug used to treat colon cancer. In our study, we chemically induced cancer in rats and then treated them with taurine for eight days while observing their colon tissues.
Our findings revealed concerning trends among the different treatment groups. While the control group showed 80% of adenocarcinoma cases, those who received only 5-FU had 70%, and those on taurine alone reported 50%. Remarkably, no adenocarcinoma was found in the group treated with both 5-FU and taurine, suggesting a powerful synergy.
Additionally, we noted that while inflammatory responses and certain gene expressions remained similar across the cancer-induced groups, the expression of a critical protein (APC/β-catenin) increased in the combination group. This suggests that taking taurine might help harness the strengths of 5-FU while lowering potential adverse effects.
Despite some encouraging evidence, we did not observe any significant improvement in inflammation or gene markers typically associated with cancer. However, using taurine appears to normalize some concerning results linked directly to treatment with 5-FU. Overall, the combination shows potential for enhancing treatment outcomes in colon cancer.
Read More
8
Taurine's protective role in cancer
Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study.
We conducted a nested case-control study within a large cohort to understand how levels of taurine, S-adenosylmethionine (SAM), and cysteine in our blood are related to cancer risk, particularly among Chinese adults. Our analysis included 1,391 cancer cases matched with 1,391 controls, providing a robust framework for our findings.
Our results showed that higher levels of taurine in the blood could reduce overall cancer risk, particularly for digestive cancers. This is an exciting discovery as it suggests that taurine might play a protective role. On the contrary, elevated levels of SAM appeared linked to an increased risk of digestive cancers.
Using advanced statistical models, we identified complex interactions among taurine, SAM, and cysteine. Notably, we observed a significant overall negative association between the combination of these amino acids and cancer risk, highlighting the intricate balance these compounds maintain in our metabolism.
Overall, while taurine seems to confer some protective benefits, the specific metabolic relationships and their implications for treatment and prevention strategies need further exploration. Our findings could pave the way for new approaches in cancer prevention.
Read More
8
Taurine metabolism impact on cancer
Taurine Synthesis by 2-Aminoethanethiol Dioxygenase as a Vulnerable Metabolic Alteration in Pancreatic Cancer.
We conducted a thorough investigation into how taurine, an amino acid, relates to pancreatic ductal adenocarcinoma (PDAC). Our study involved analyzing 54 pairs of tumor and matching normal pancreatic tissues using advanced metabolomics. We found that taurine levels in PDAC tissues were 2.51 times higher compared to normal tissues.
To confirm these findings, we used immunohistochemistry (IHC) on additional samples, which demonstrated a similar increase in taurine. Through bioinformatics, we identified 2-aminoethanethiol dioxygenase (ADO) as a crucial gene influencing taurine metabolism. Further IHC analysis confirmed elevated levels of ADO in PDAC tissues, indicating a potential link between ADO and tumor behavior.
Excitingly, we observed that the ADO-Taurine axis was associated with key clinical outcomes like disease-free survival and cancer recurrence. In experiments where we knocked down ADO, we noticed reduced cancer cell growth, suggesting that taurine metabolism could impact tumor progression. Overall, our findings point to elevated taurine synthesis in PDAC driven by ADO, presenting a promising target for future cancer therapies and a possible prognostic marker for patients.
Read More
8
Taurine's potential in CRC diagnosis
Systematic Review and Meta-Analysis: Taurine and Its Association With Colorectal Carcinoma.
We conducted an in-depth exploration of taurine's relationship with colorectal cancer (CRC) through a systematic review of existing studies. Our investigation looked at various research studies to gather insights into how taurine levels relate to cancer.
We discovered a significant association between higher taurine levels and the presence of CRC. Specifically, findings indicated that taurine concentrations were elevated in CRC patient samples, particularly in blood. More importantly, taurine showed potential as a diagnostic marker, which could help to distinguish between benign and malignant conditions in patients at differing stages of cancer.
Despite these promising results, it’s worth noting that there was considerable variability in some outcomes across different studies. This highlights the need for further research to clarify taurine’s role, but our analysis suggests an overall trend indicating that increased taurine may be linked to greater odds of developing CRC.
As we continue to look into the connection between taurine and colorectal cancer, it opens up exciting possibilities for future diagnostics and treatments that leverage our understanding of metabolic changes associated with this disease.
Read More
8
Taurine mitigates irinotecan muscle damage
Taurine Protects Irinotecan-induced Muscle Dysfunction by Modulating Oxidative Stress and Endoplasmic Reticulum Stress in Human Skeletal Muscle Cells.
We explored the effects of taurine, a conditionally essential amino acid known for its antioxidant properties, on muscle dysfunction caused by irinotecan, a common chemotherapy drug for metastatic colorectal cancer. Our aim was to determine whether taurine could mitigate the negative impact of irinotecan on human skeletal muscle cells (HSkMCs).
We conducted experiments by treating these muscle cells with irinotecan while some were pre-treated with taurine. We carefully monitored how these treatments affected cell viability, toxicity, and the ability of the cells to differentiate into muscle fibers. Our findings revealed some encouraging results: taurine significantly improved cell viability, reduced toxicity, and preserved the cells' capability to differentiate, which had been compromised by irinotecan.
Remarkably, taurine also seemed to help counteract the oxidative stress and endoplasmic reticulum stress triggered by irinotecan. This suggests that taurine might be a valuable ally in enhancing muscle health for patients undergoing cancer treatment, potentially easing symptoms of cancer cachexia, which often arises due to chemotherapy-induced muscle dysfunction.
This product prevents the onset of cancer and reduces blood glucose levels. It assists in the formation and restoration of the retina within the eyes after injuries and helps to normalise blood pressure. The quality is exceptional, and the dosage is excellent.
Read More
9
Strong antioxidant
This supplement is a potent antioxidant that helps prevent the progression of cancer. It effectively lowers blood glucose levels and is involved in the formation of the retina, aiding recovery in case of injuries.
Read More
9
Excellent cancer prevention
This is a powerful natural antioxidant that combats oxidative processes in the body, alkalising and promoting cardiovascular health. It serves as an excellent preventive measure against cancer!
Read More
4
Prevents liver damage
Taurine appears to enhance heart function and exercise capacity in individuals with CHF. Although its benefits for the body are varied, many studies lack sufficient evidence. While it is evident that taurine acts as a hepatoprotector, its effectiveness against cholesterol accumulation remains uncertain. Early studies indicate that taurine may improve liver function in hepatitis patients and help prevent kidney and liver damage from cancer drugs. Furthermore, taurine usage in liver cirrhosis may reduce blood pressure in the vein supplying the liver. However, it's unclear if this leads to fewer complications. Though numerous studies affirm taurine's benefits for the heart, its impact on diabetics is still not fully understood, suggesting it poses no worry for insulin levels.
Read More
4
Supports detoxification
This supplement has facilitated healthy detoxification and mitigated the risk of toxin-related health issues such as liver damage or cancer. It is particularly beneficial for those exposed to environmental toxins or individuals looking to maintain effective detoxification through dietary supplements.
Cancer is a complex group of diseases characterized by uncontrolled growth and spread of abnormal cells in the body. These cells can form tumors, invade nearby tissues, and metastasize to other parts of the body via the bloodstream or lymphatic system. While cancer can affect nearly any part of the body, it is classified into various types, including carcinomas, sarcomas, leukemia, and lymphomas, each originating from different types of cells. Risk factors for developing cancer can include genetic predisposition, lifestyle choices such as smoking and diet, environmental exposures, and certain infections.
Diagnosis typically involves medical imaging, biopsies, and a thorough review of personal and family health histories. Treatment options vary widely depending on the type and stage of cancer and may include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapies. Early detection is crucial and can significantly improve treatment outcomes, leading to better survival rates. As awareness and research continue to advance, new methods for prevention, detection, and treatment of cancer are consistently being developed, offering hope to those affected by this challenging disease.
L-Taurine is a sulfonic acid and an amino acid often categorized as a conditionally essential amino acid due to its important roles in various bodily functions. Unlike most amino acids, L-Taurine is not used to synthesize proteins but is critical for several physiological processes, including bile salt formation, osmoregulation, and antioxidant defense. It’s naturally found in high concentrations in the brain, muscles, heart, and blood, playing a vital role in cardiovascular health and the maintenance of neurological function.
L-Taurine is often included in dietary supplements and energy drinks due to its potential benefits, such as enhancing exercise performance, improving recovery, and supporting overall energy levels. While the body can produce taurine from other amino acids like cysteine, some people may choose to supplement with it, particularly athletes or those seeking additional health benefits. As always, it's important to consult with a healthcare provider before starting any new supplement regimen to ensure safety and appropriateness for your individual health needs.
Scientific research suggests that taurine, an amino acid, may have varying effects on different types of cancer. A nested case-control study indicated that higher levels of taurine in the blood are associated with a reduced overall cancer risk, particularly for digestive cancers ([1]). On the other hand, investigations into pancreatic ductal adenocarcinoma demonstrated that taurine levels were significantly elevated in cancerous tissues compared to normal tissues, hinting at a complex relationship where taurine synthesis may play a role in tumor behavior ([2]).
Furthermore, a systematic review established a strong correlation between elevated taurine levels and colorectal cancer, suggesting that taurine could serve as a potential diagnostic marker ([3]). Moreover, studies on treatment effects have shown that taurine might improve outcomes in chemotherapy settings, enhancing the effectiveness of drugs like 5-fluorouracil while reducing potential side effects ([7]). However, the dual roles of taurine in various cancers showcase the need for ongoing research to fully understand its benefits and risks, as its impact can vary widely depending on the cancer type and individual patient conditions ([8]).
Users have reported various improvements in their health conditions after using the products reviewed. For instance, multiple users highlighted the supplement's effectiveness in lowering blood glucose levels, which can be particularly beneficial for individuals managing diabetes. One review noted that the product "effectively lowers blood glucose levels" and is involved in "the formation and restoration of the retina" Read Review. Moreover, several users emphasized its role in cancer prevention, suggesting that the supplement acts as a potent antioxidant and a preventive measure against the progression of cancer, enhancing overall health Read Review.
Additionally, improvements in cardiovascular and detoxification health have also been frequently mentioned. One user stated that the supplement provides "healthy detoxification" and helps mitigate the risk of toxin-related health issues, like liver damage and cancer Read Review. Others indicated its positive impact on heart function and blood pressure regulation, reinforcing its significance for cardiovascular health Read Review. However, while these findings are promising, individual results can vary, and it’s essential to consult healthcare professionals before starting any new supplement regimen.
Users have reported positive experiences when combining this supplement with other supplements, particularly in the context of managing cancer. For instance, one user emphasized that this supplement acts as a potent antioxidant, suggesting that it aids in preventing the progression of cancer when paired with other health-supportive supplements Read Review. Furthermore, another review noted that the supplement promotes healthy detoxification, helping mitigate risks related to toxin exposure that may exacerbate cancer risks Read Review.
Additionally, users highlighted the combination of this supplement with taurine, particularly for its cardiovascular benefits and potential to lower blood sugar levels. One user outlined taurine's ability to reduce cancer risk while enhancing heart function, suggesting that this combination could provide a multifaceted approach in managing health concerns Read Review. However, users also indicated that while such combinations could be beneficial, one should consult with healthcare professionals to tailor supplement regimens appropriately.
9
Strong antioxidant
This supplement is a potent antioxidant that helps prevent the progression of cancer. It effectively lowers blood glucose levels and is involved in the formation of the retina, aiding recovery in case of injuries.
9
Excellent cancer prevention
This is a powerful natural antioxidant that combats oxidative processes in the body, alkalising and promoting cardiovascular health. It serves as an excellent preventive measure against cancer!
4
Supports detoxification
This supplement has facilitated healthy detoxification and mitigated the risk of toxin-related health issues such as liver damage or cancer. It is particularly beneficial for those exposed to environmental toxins or individuals looking to maintain effective detoxification through dietary supplements.
4
Prevents cancer development
Taurine is a naturally occurring amino acid in tissues and organs, poised to be a promising treatment for heart and vascular diseases. It protects the cardiovascular system as a potent antioxidant while reducing cancer risk, lowering blood sugar levels, normalising pressure, and preventing atherosclerosis. Additionally, it regulates sodium, potassium, and calcium levels, which are crucial for heart function, while stimulating blood flow and metabolic processes within the heart.
8
Taurine's protective role in cancer
Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study.
We conducted a nested case-control study within a large cohort to understand how levels of taurine, S-adenosylmethionine (SAM), and cysteine in our blood are related to cancer risk, particularly among Chinese adults. Our analysis included 1,391 cancer cases matched with 1,391 controls, providing a robust framework for our findings.
Our results showed that higher levels of taurine in the blood could reduce overall cancer risk, particularly for digestive cancers. This is an exciting discovery as it suggests that taurine might play a protective role. On the contrary, elevated levels of SAM appeared linked to an increased risk of digestive cancers.
Using advanced statistical models, we identified complex interactions among taurine, SAM, and cysteine. Notably, we observed a significant overall negative association between the combination of these amino acids and cancer risk, highlighting the intricate balance these compounds maintain in our metabolism.
Overall, while taurine seems to confer some protective benefits, the specific metabolic relationships and their implications for treatment and prevention strategies need further exploration. Our findings could pave the way for new approaches in cancer prevention.
8
Taurine metabolism impact on cancer
Taurine Synthesis by 2-Aminoethanethiol Dioxygenase as a Vulnerable Metabolic Alteration in Pancreatic Cancer.
We conducted a thorough investigation into how taurine, an amino acid, relates to pancreatic ductal adenocarcinoma (PDAC). Our study involved analyzing 54 pairs of tumor and matching normal pancreatic tissues using advanced metabolomics. We found that taurine levels in PDAC tissues were 2.51 times higher compared to normal tissues.
To confirm these findings, we used immunohistochemistry (IHC) on additional samples, which demonstrated a similar increase in taurine. Through bioinformatics, we identified 2-aminoethanethiol dioxygenase (ADO) as a crucial gene influencing taurine metabolism. Further IHC analysis confirmed elevated levels of ADO in PDAC tissues, indicating a potential link between ADO and tumor behavior.
Excitingly, we observed that the ADO-Taurine axis was associated with key clinical outcomes like disease-free survival and cancer recurrence. In experiments where we knocked down ADO, we noticed reduced cancer cell growth, suggesting that taurine metabolism could impact tumor progression. Overall, our findings point to elevated taurine synthesis in PDAC driven by ADO, presenting a promising target for future cancer therapies and a possible prognostic marker for patients.
8
Taurine's potential in CRC diagnosis
Systematic Review and Meta-Analysis: Taurine and Its Association With Colorectal Carcinoma.
We conducted an in-depth exploration of taurine's relationship with colorectal cancer (CRC) through a systematic review of existing studies. Our investigation looked at various research studies to gather insights into how taurine levels relate to cancer.
We discovered a significant association between higher taurine levels and the presence of CRC. Specifically, findings indicated that taurine concentrations were elevated in CRC patient samples, particularly in blood. More importantly, taurine showed potential as a diagnostic marker, which could help to distinguish between benign and malignant conditions in patients at differing stages of cancer.
Despite these promising results, it’s worth noting that there was considerable variability in some outcomes across different studies. This highlights the need for further research to clarify taurine’s role, but our analysis suggests an overall trend indicating that increased taurine may be linked to greater odds of developing CRC.
As we continue to look into the connection between taurine and colorectal cancer, it opens up exciting possibilities for future diagnostics and treatments that leverage our understanding of metabolic changes associated with this disease.
9.5
Taurine enhances 5-FU effectiveness
Synergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model.
We investigated how taurine, an important amino acid, influences the effectiveness of 5-fluorouracil (5-FU), a common chemotherapy drug used to treat colon cancer. In our study, we chemically induced cancer in rats and then treated them with taurine for eight days while observing their colon tissues.
Our findings revealed concerning trends among the different treatment groups. While the control group showed 80% of adenocarcinoma cases, those who received only 5-FU had 70%, and those on taurine alone reported 50%. Remarkably, no adenocarcinoma was found in the group treated with both 5-FU and taurine, suggesting a powerful synergy.
Additionally, we noted that while inflammatory responses and certain gene expressions remained similar across the cancer-induced groups, the expression of a critical protein (APC/β-catenin) increased in the combination group. This suggests that taking taurine might help harness the strengths of 5-FU while lowering potential adverse effects.
Despite some encouraging evidence, we did not observe any significant improvement in inflammation or gene markers typically associated with cancer. However, using taurine appears to normalize some concerning results linked directly to treatment with 5-FU. Overall, the combination shows potential for enhancing treatment outcomes in colon cancer.
7
Taurine's complex effects on cancer
Unveiling the role of taurine and SLC6A6 in tumor immune evasion: Implications for gastric cancer therapy.
Our investigation focuses on how taurine, an amino acid, influences cancer, particularly in the context of gastric cancer (GC). We learned that taurine has a surprising dual role when it comes to tumor behavior—it helps tumors grow in immunodeficient mice but actually inhibits growth in immunocompetent mice. This finding highlights that the immune system plays a crucial part in determining how effective taurine can be against cancer.
By scrutinizing the mechanisms at play, we found that taurine affects CD8 T cells, which are essential for immune responses against tumors. Rather than directly attacking tumor cells, taurine seems to enhance the ability of these immune cells to act against cancer. We identified the SP1-SLC6A6 axis as an important pathway involved in chemotherapy-induced immune evasion, showing how metabolic changes within the tumor environment can impact treatment outcomes.
While our study reveals significant insights into taurine's effects, we also emphasize the need for a deeper understanding of its potential as a biomarker and treatment target for gastric cancer. It’s a complex relationship, and while taurine could play a valuable role, more research is needed to fully realize its therapeutic possibilities.
References
Liu C, Liu T, Wei Y, Shi J, Deng L, et al. Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study. Front Pharmacol. 2024;15:1507125. doi:10.3389/fphar.2024.1507125
Nam H, Lee W, Lee YJ, Kim JM, Jung KH, et al. Taurine Synthesis by 2-Aminoethanethiol Dioxygenase as a Vulnerable Metabolic Alteration in Pancreatic Cancer. Biomol Ther (Seoul). 2025;33:143. doi:10.4062/biomolther.2024.086
Sinha A, Griffith L, Acharjee A. Systematic Review and Meta-Analysis: Taurine and Its Association With Colorectal Carcinoma. Cancer Med. 2024;13:e70424. doi:10.1002/cam4.70424
Chen CI, Chen YC, Kao YK, Chen CH, Yang PW, et al. Taurine Protects Irinotecan-induced Muscle Dysfunction by Modulating Oxidative Stress and Endoplasmic Reticulum Stress in Human Skeletal Muscle Cells. Anticancer Res. 2024;44:5371. doi:10.21873/anticanres.17364
Das J, Singh TA, Lalruatsangi R, Sil PC. Synthesis of nanohybrid consisting of taurine derived carbon dots and nanoceria for anticancer applications. Toxicol Rep. 2024;13:101794. doi:10.1016/j.toxrep.2024.101794
Lawore DC, Jena S, Berard AR, Birse K, Lamont A, et al. Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites. bioRxiv. 2024. doi:10.1101/2024.10.10.616351
Jornada DH, Boreski D, Chiba DE, Ligeiro D, Luz MAM, et al. Synergistic Enhancement of 5-Fluorouracil Chemotherapeutic Efficacy by Taurine in Colon Cancer Rat Model. Nutrients. 2024;16. doi:10.3390/nu16183047
Shentu J, Su X, Yu Y, Duan S. Unveiling the role of taurine and SLC6A6 in tumor immune evasion: Implications for gastric cancer therapy. Int J Biochem Cell Biol. 2024;176:106661. doi:10.1016/j.biocel.2024.106661
Liang TL, Pan HD, Yan PY, Mi JN, Liu XC, et al. Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment. J Adv Res. 2024. doi:10.1016/j.jare.2024.09.005