Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Glutamine
1,000 mg
†
Top Medical Research Studies
8
Our exploration delves into how early life stress affects anxiety and social behavior, particularly through the role of l-glutamine. We found that maternal separation in mice led to reduced levels of amino acid transporters in the gut, which in turn caused lower glutamine levels in the bloodstream. This was significant since glutamine is vital for brain functions, including the production of key neurotransmitters that influence mood and behavior.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
Read More
4
We explored the effects of heat stress on anxiety responses in male rats, particularly focusing on the role of l-glutamine in altering these responses. In the study, the rats were exposed to high temperatures for two hours, which resulted in noticeable physiological changes, such as weight loss and increased body temperature.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Read More
9
In our study, we investigated how l-glutamine, when paired with curcumin and a probiotic, affects anxiety in a mouse model designed to mimic anxiety-depressive disorders. We put six-month-old mice through chronic unpredictable mild stress (CUMS) for three weeks to induce emotional disturbances. After this stress period, we administered curcumin, glutamine, and the probiotic—either alone or in combination—to see if they could alleviate anxiety and depressive-like behaviors.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
Read More
Most Useful Reviews
9
Significant improvement
141 people found this helpful
Simply the BEST supplement for IBS that I have ever taken! After suffering with IBS-C for over 10 years and undergoing numerous tests that returned normal results, the impact on my diet, sleep, anxiety, and travel enjoyment was profound. Following a bout of food poisoning, I became extremely sensitive to various foods. Despite trying many supplements, only L-glutamine made a significant difference for me. This product has alleviated my digestive issues and, unexpectedly, helped with my sleep and overall well-being. I began to feel better right away and I'm astonished that such a reasonably priced supplement could yield such remarkable results.
Read More
9
Effective for anxiety
3 people found this helpful
I've been using inositol for over six years to manage my anxiety. Mixing it into water and sipping throughout the day works well for me. Its sweet flavour without sugar makes it enjoyable. This brand is my go-to due to its affordability and consistency.
Read More
7
Regular bowel movements
194 people found this helpful
Practically overnight, I became intolerant to lactose, gluten, and suffered malabsorption and severe anxiety. Quick trips to the bathroom became more routine after starting this supplement. Avoiding gluten and antibiotics seems to greatly improve my IBS symptoms as well as stress reactions. Despite the pressure to take antibiotics for a minor infection which caused a flare-up, I have since stabilised with the right supplements. As I've adjusted my diet and continued the supplements, I barely experience any IBS issues anymore and feel remarkably better.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
- All Researches
9
In our study, we investigated how l-glutamine, when paired with curcumin and a probiotic, affects anxiety in a mouse model designed to mimic anxiety-depressive disorders. We put six-month-old mice through chronic unpredictable mild stress (CUMS) for three weeks to induce emotional disturbances. After this stress period, we administered curcumin, glutamine, and the probiotic—either alone or in combination—to see if they could alleviate anxiety and depressive-like behaviors.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
Read More
8
Our exploration delves into how early life stress affects anxiety and social behavior, particularly through the role of l-glutamine. We found that maternal separation in mice led to reduced levels of amino acid transporters in the gut, which in turn caused lower glutamine levels in the bloodstream. This was significant since glutamine is vital for brain functions, including the production of key neurotransmitters that influence mood and behavior.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
Read More
8
Probiotics and L-glutamine improve anxiety
To delve into how l-glutamine affects anxiety, we examined a multi-strain probiotic formulation alongside l-glutamine in a study designed for animals subjected to stressors, such as maternal separation and unpredictable mild stress. These stressors created anxiety- and depression-like behaviors in the Sprague-Dawley rats used in our research.
Throughout six weeks, we administered a total of ten billion cfu of the probiotic formulation, combined with l-glutamine, via drinking water. The behavioral assessments we conducted—like tests for forced swimming, preferencing sucrose, and exploring open areas—helped us understand the impact of the treatment on rats' anxiety levels.
Remarkably, the treatment with the multi-strain probiotics and l-glutamine appeared to significantly improve the rats' behavior after they were stressed. While the probiotics were shown to play a critical role, the specific impact of l-glutamine alone in this context couldn't be fully isolated, as it was always paired with the probiotics.
Overall, we observed that the combination treatment successfully reversed certain mood-related issues linked to stress. However, the exact influence of l-glutamine on its own remains uncertain. The findings position the combined approach as a potential avenue for improving anxiety symptoms related to chronic stress.
Throughout six weeks, we administered a total of ten billion cfu of the probiotic formulation, combined with l-glutamine, via drinking water. The behavioral assessments we conducted—like tests for forced swimming, preferencing sucrose, and exploring open areas—helped us understand the impact of the treatment on rats' anxiety levels.
Remarkably, the treatment with the multi-strain probiotics and l-glutamine appeared to significantly improve the rats' behavior after they were stressed. While the probiotics were shown to play a critical role, the specific impact of l-glutamine alone in this context couldn't be fully isolated, as it was always paired with the probiotics.
Overall, we observed that the combination treatment successfully reversed certain mood-related issues linked to stress. However, the exact influence of l-glutamine on its own remains uncertain. The findings position the combined approach as a potential avenue for improving anxiety symptoms related to chronic stress.
Read More
4
We explored the effects of heat stress on anxiety responses in male rats, particularly focusing on the role of l-glutamine in altering these responses. In the study, the rats were exposed to high temperatures for two hours, which resulted in noticeable physiological changes, such as weight loss and increased body temperature.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
141 people found this helpful
Simply the BEST supplement for IBS that I have ever taken! After suffering with IBS-C for over 10 years and undergoing numerous tests that returned normal results, the impact on my diet, sleep, anxiety, and travel enjoyment was profound. Following a bout of food poisoning, I became extremely sensitive to various foods. Despite trying many supplements, only L-glutamine made a significant difference for me. This product has alleviated my digestive issues and, unexpectedly, helped with my sleep and overall well-being. I began to feel better right away and I'm astonished that such a reasonably priced supplement could yield such remarkable results.
Read More
9
Effective for anxiety
3 people found this helpful
I've been using inositol for over six years to manage my anxiety. Mixing it into water and sipping throughout the day works well for me. Its sweet flavour without sugar makes it enjoyable. This brand is my go-to due to its affordability and consistency.
Read More
7
Regular bowel movements
194 people found this helpful
Practically overnight, I became intolerant to lactose, gluten, and suffered malabsorption and severe anxiety. Quick trips to the bathroom became more routine after starting this supplement. Avoiding gluten and antibiotics seems to greatly improve my IBS symptoms as well as stress reactions. Despite the pressure to take antibiotics for a minor infection which caused a flare-up, I have since stabilised with the right supplements. As I've adjusted my diet and continued the supplements, I barely experience any IBS issues anymore and feel remarkably better.
Read More
8
Helps anxiety symptoms
11 people found this helpful
This product genuinely assists with anxiety, racing thoughts, IBS, and cravings. After experiencing awful digestive issues, particularly after alcohol, I started taking glutamine, and my digestion improved remarkably. No more racing thoughts or uncomfortable sensations in my head. I now feel more focused and my anxiety symptoms have lessened significantly.
Read More
7.5
Eases anxiety
I purchased these for my parents to take daily. They contain amino acids that everyone needs, and they help to alleviate anxiety while boosting the immune system. My parents appear to have no issues with this supplement.
Read More
Frequently Asked Questions
7.5
Eases anxiety
I purchased these for my parents to take daily. They contain amino acids that everyone needs, and they help to alleviate anxiety while boosting the immune system. My parents appear to have no issues with this supplement.
8
Our exploration delves into how early life stress affects anxiety and social behavior, particularly through the role of l-glutamine. We found that maternal separation in mice led to reduced levels of amino acid transporters in the gut, which in turn caused lower glutamine levels in the bloodstream. This was significant since glutamine is vital for brain functions, including the production of key neurotransmitters that influence mood and behavior.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
9
In our study, we investigated how l-glutamine, when paired with curcumin and a probiotic, affects anxiety in a mouse model designed to mimic anxiety-depressive disorders. We put six-month-old mice through chronic unpredictable mild stress (CUMS) for three weeks to induce emotional disturbances. After this stress period, we administered curcumin, glutamine, and the probiotic—either alone or in combination—to see if they could alleviate anxiety and depressive-like behaviors.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
8
Probiotics and L-glutamine improve anxiety
To delve into how l-glutamine affects anxiety, we examined a multi-strain probiotic formulation alongside l-glutamine in a study designed for animals subjected to stressors, such as maternal separation and unpredictable mild stress. These stressors created anxiety- and depression-like behaviors in the Sprague-Dawley rats used in our research.
Throughout six weeks, we administered a total of ten billion cfu of the probiotic formulation, combined with l-glutamine, via drinking water. The behavioral assessments we conducted—like tests for forced swimming, preferencing sucrose, and exploring open areas—helped us understand the impact of the treatment on rats' anxiety levels.
Remarkably, the treatment with the multi-strain probiotics and l-glutamine appeared to significantly improve the rats' behavior after they were stressed. While the probiotics were shown to play a critical role, the specific impact of l-glutamine alone in this context couldn't be fully isolated, as it was always paired with the probiotics.
Overall, we observed that the combination treatment successfully reversed certain mood-related issues linked to stress. However, the exact influence of l-glutamine on its own remains uncertain. The findings position the combined approach as a potential avenue for improving anxiety symptoms related to chronic stress.
Throughout six weeks, we administered a total of ten billion cfu of the probiotic formulation, combined with l-glutamine, via drinking water. The behavioral assessments we conducted—like tests for forced swimming, preferencing sucrose, and exploring open areas—helped us understand the impact of the treatment on rats' anxiety levels.
Remarkably, the treatment with the multi-strain probiotics and l-glutamine appeared to significantly improve the rats' behavior after they were stressed. While the probiotics were shown to play a critical role, the specific impact of l-glutamine alone in this context couldn't be fully isolated, as it was always paired with the probiotics.
Overall, we observed that the combination treatment successfully reversed certain mood-related issues linked to stress. However, the exact influence of l-glutamine on its own remains uncertain. The findings position the combined approach as a potential avenue for improving anxiety symptoms related to chronic stress.
References
- Zhu J, Zhong Z, Shi L, Huang L, Lin C, et al. Gut microbiota mediate early life stress-induced social dysfunction and anxiety-like behaviors by impairing amino acid transport at the gut. Gut Microbes. 2024;16:2401939. doi:10.1080/19490976.2024.2401939
- Faucher P, Dries A, Mousset PY, Leboyer M, Dore J, et al. Synergistic effects of GG, glutamine, and curcumin on chronic unpredictable mild stress-induced depression in a mouse model. Benef Microbes. 2022;13:253. doi:10.3920/BM2021.0188
- Dandekar MP, Palepu MSK, Satti S, Jaiswal Y, Singh AA, et al. Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome-Brain Activity in Rats. ACS Chem Neurosci. 2022;13:1948. doi:10.1021/acschemneuro.2c00143
- Belity T, Horowitz M, Hoffman JR, Epstein Y, Bruchim Y, et al. Heat-Stress Preconditioning Attenuates Behavioral Responses to Psychological Stress: The Role of HSP-70 in Modulating Stress Responses. Int J Mol Sci. 2022;23. doi:10.3390/ijms23084129
