Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Glutamine
1,000 mg
†
Top Medical Research Studies
9
Targeted treatment for colon cancer
We focused on the potential of l-glutamine-conjugated organotin(IV) compounds as a targeted treatment for colorectal cancer. These compounds were tested in laboratory settings against human colon cancer cell lines, revealing marked cytotoxic effects.
Through our observations, we noted that these compounds were capable of inducing cell cycle arrest and promoting apoptosis, which are key processes in halting cancer cell growth. When applied in an experimental model of colon cancer, they effectively reduced tumor sizes and volume while selectively accumulating in the colon with minimal toxicity.
Importantly, our findings suggest that these glutamine-linked compounds not only exhibit strong anti-tumor activity but also address the issue of systemic toxicity often seen with traditional therapies. Overall, we believe these compounds could potentially serve as promising candidates in the fight against colon cancer.
Through our observations, we noted that these compounds were capable of inducing cell cycle arrest and promoting apoptosis, which are key processes in halting cancer cell growth. When applied in an experimental model of colon cancer, they effectively reduced tumor sizes and volume while selectively accumulating in the colon with minimal toxicity.
Importantly, our findings suggest that these glutamine-linked compounds not only exhibit strong anti-tumor activity but also address the issue of systemic toxicity often seen with traditional therapies. Overall, we believe these compounds could potentially serve as promising candidates in the fight against colon cancer.
8
Efficacy of L-glutaminase in cancer
We explored the effects of L-glutaminase, produced by Klebsiella pneumoniae AS KP 23, on cancer cells. This enzyme is noteworthy because cancer cells often rely heavily on glutamine to grow and survive. By targeting and breaking down glutamine, L-glutaminase serves as a promising approach to inhibit cancer cell proliferation.
Our study demonstrated that purified L-glutaminase not only impacted normal cells but also showed significant anticancer activity against various cancer cell lines. Specifically, we found that this enzyme effectively reduced the growth of hepatocellular and breast cancer cells. Its stability across different pH levels and temperatures enhances its potential as a viable treatment option.
With previous research highlighting the importance of glutamine in cancer metabolism, the activation of L-glutaminase presents a compelling strategy for cancer therapy. This reinforces the potential of L-glutaminase as an alternative to traditional chemotherapy, providing a new avenue for the development of cancer treatments that might improve patient outcomes.
Our study demonstrated that purified L-glutaminase not only impacted normal cells but also showed significant anticancer activity against various cancer cell lines. Specifically, we found that this enzyme effectively reduced the growth of hepatocellular and breast cancer cells. Its stability across different pH levels and temperatures enhances its potential as a viable treatment option.
With previous research highlighting the importance of glutamine in cancer metabolism, the activation of L-glutaminase presents a compelling strategy for cancer therapy. This reinforces the potential of L-glutaminase as an alternative to traditional chemotherapy, providing a new avenue for the development of cancer treatments that might improve patient outcomes.
8
Impact of l-glutamine on gliomas
Our study focused on how l-glutamine impacts cancer cells, particularly in relation to IDH1 mutations, which are commonly seen in certain types of brain tumors. We observed that these mutations lead to changes in metabolism that can disrupt normal cell function.
Interestingly, we found that low levels of a key enzyme, oxoglutarate dehydrogenase (OGDH), are found in IDH-mutated gliomas and astrocytes, which decreased levels of α-ketoglutarate. This metabolic shift ended up affecting the development of astrocytes, inhibiting their maturation and contributing to structural problems in the brain.
When we looked at l-glutamine, it appeared to help increase α-ketoglutarate levels, especially when used alongside an IDH-mutant inhibitor. This combination seemed to enhance the differentiation of glioma cells, showing potential for using l-glutamine as part of treatment strategies for these challenging tumors.
Overall, while l-glutamine alone may not show direct benefits, its ability to boost α-ketoglutarate levels when paired with specific inhibitors suggests that it could play a role in future treatments for IDH-mutated gliomas.
Interestingly, we found that low levels of a key enzyme, oxoglutarate dehydrogenase (OGDH), are found in IDH-mutated gliomas and astrocytes, which decreased levels of α-ketoglutarate. This metabolic shift ended up affecting the development of astrocytes, inhibiting their maturation and contributing to structural problems in the brain.
When we looked at l-glutamine, it appeared to help increase α-ketoglutarate levels, especially when used alongside an IDH-mutant inhibitor. This combination seemed to enhance the differentiation of glioma cells, showing potential for using l-glutamine as part of treatment strategies for these challenging tumors.
Overall, while l-glutamine alone may not show direct benefits, its ability to boost α-ketoglutarate levels when paired with specific inhibitors suggests that it could play a role in future treatments for IDH-mutated gliomas.
Most Useful Reviews
7.5
Aids cancer prevention
193 people found this helpful
An important nutraceutical for health and healing. I prefer this brand of L-glutamine for its cost savings and pleasant taste. I take 6 grams daily on an empty stomach to promote digestive health, maintain muscle mass, and as a cancer preventive. L-glutamine is vital for athletes and those recovering from disease. Research shows that cancer cells consume L-glutamine, impacting healthy cells' survival. Supplementing helps counter the negative nitrogen balance that can occur in cancer patients, preventing cachexia, which often threatens those with cancer.
9
Relief from neuropathy
8 people found this helpful
This product is great for anyone suffering from peripheral neuropathy. My neighbour shared their leftovers with us while my boyfriend was undergoing chemotherapy, which induced tingling and sensitivity in his hands and feet. As a cancer survivor, the neighbour recommended this product, which truly worked for my boyfriend. We shared the information with several patients at the infusion centre, and many of them found relief as well.
9
Increased energy
I bought it for my mum, a breast cancer survivor, and this supplement provides her with more energy. It’s a fantastic product.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
Targeted treatment for colon cancer
We focused on the potential of l-glutamine-conjugated organotin(IV) compounds as a targeted treatment for colorectal cancer. These compounds were tested in laboratory settings against human colon cancer cell lines, revealing marked cytotoxic effects.
Through our observations, we noted that these compounds were capable of inducing cell cycle arrest and promoting apoptosis, which are key processes in halting cancer cell growth. When applied in an experimental model of colon cancer, they effectively reduced tumor sizes and volume while selectively accumulating in the colon with minimal toxicity.
Importantly, our findings suggest that these glutamine-linked compounds not only exhibit strong anti-tumor activity but also address the issue of systemic toxicity often seen with traditional therapies. Overall, we believe these compounds could potentially serve as promising candidates in the fight against colon cancer.
Through our observations, we noted that these compounds were capable of inducing cell cycle arrest and promoting apoptosis, which are key processes in halting cancer cell growth. When applied in an experimental model of colon cancer, they effectively reduced tumor sizes and volume while selectively accumulating in the colon with minimal toxicity.
Importantly, our findings suggest that these glutamine-linked compounds not only exhibit strong anti-tumor activity but also address the issue of systemic toxicity often seen with traditional therapies. Overall, we believe these compounds could potentially serve as promising candidates in the fight against colon cancer.
8
Efficacy of L-glutaminase in cancer
We explored the effects of L-glutaminase, produced by Klebsiella pneumoniae AS KP 23, on cancer cells. This enzyme is noteworthy because cancer cells often rely heavily on glutamine to grow and survive. By targeting and breaking down glutamine, L-glutaminase serves as a promising approach to inhibit cancer cell proliferation.
Our study demonstrated that purified L-glutaminase not only impacted normal cells but also showed significant anticancer activity against various cancer cell lines. Specifically, we found that this enzyme effectively reduced the growth of hepatocellular and breast cancer cells. Its stability across different pH levels and temperatures enhances its potential as a viable treatment option.
With previous research highlighting the importance of glutamine in cancer metabolism, the activation of L-glutaminase presents a compelling strategy for cancer therapy. This reinforces the potential of L-glutaminase as an alternative to traditional chemotherapy, providing a new avenue for the development of cancer treatments that might improve patient outcomes.
Our study demonstrated that purified L-glutaminase not only impacted normal cells but also showed significant anticancer activity against various cancer cell lines. Specifically, we found that this enzyme effectively reduced the growth of hepatocellular and breast cancer cells. Its stability across different pH levels and temperatures enhances its potential as a viable treatment option.
With previous research highlighting the importance of glutamine in cancer metabolism, the activation of L-glutaminase presents a compelling strategy for cancer therapy. This reinforces the potential of L-glutaminase as an alternative to traditional chemotherapy, providing a new avenue for the development of cancer treatments that might improve patient outcomes.
8
Impact of l-glutamine on gliomas
Our study focused on how l-glutamine impacts cancer cells, particularly in relation to IDH1 mutations, which are commonly seen in certain types of brain tumors. We observed that these mutations lead to changes in metabolism that can disrupt normal cell function.
Interestingly, we found that low levels of a key enzyme, oxoglutarate dehydrogenase (OGDH), are found in IDH-mutated gliomas and astrocytes, which decreased levels of α-ketoglutarate. This metabolic shift ended up affecting the development of astrocytes, inhibiting their maturation and contributing to structural problems in the brain.
When we looked at l-glutamine, it appeared to help increase α-ketoglutarate levels, especially when used alongside an IDH-mutant inhibitor. This combination seemed to enhance the differentiation of glioma cells, showing potential for using l-glutamine as part of treatment strategies for these challenging tumors.
Overall, while l-glutamine alone may not show direct benefits, its ability to boost α-ketoglutarate levels when paired with specific inhibitors suggests that it could play a role in future treatments for IDH-mutated gliomas.
Interestingly, we found that low levels of a key enzyme, oxoglutarate dehydrogenase (OGDH), are found in IDH-mutated gliomas and astrocytes, which decreased levels of α-ketoglutarate. This metabolic shift ended up affecting the development of astrocytes, inhibiting their maturation and contributing to structural problems in the brain.
When we looked at l-glutamine, it appeared to help increase α-ketoglutarate levels, especially when used alongside an IDH-mutant inhibitor. This combination seemed to enhance the differentiation of glioma cells, showing potential for using l-glutamine as part of treatment strategies for these challenging tumors.
Overall, while l-glutamine alone may not show direct benefits, its ability to boost α-ketoglutarate levels when paired with specific inhibitors suggests that it could play a role in future treatments for IDH-mutated gliomas.
8
In our exploration of the effects of glutamine metabolism on cancer, we focused on a novel treatment involving a glutamine antagonist known as JHU083. This study utilized immunocompetent mouse models to better understand how this treatment interacts with the immune cells present in tumors, particularly in gynecological cancers.
We found that JHU083 works not only by targeting cancer cells that are dependent on glutamine but also by modifying the immune landscape around tumors. Specifically, the treatment suppressed a type of immune cell called M2 macrophages, which are known to promote tumor growth. This change led to a more immune-stimulating environment, favoring M1 macrophages that can help fight the cancer.
Our findings highlight the importance of considering the immune microenvironment when evaluating cancer treatments. We observed a significant shift in the balance of macrophages due to the treatment, suggesting that targeting glutamine metabolism could be a promising strategy for cancer therapy. By rethinking how we approach tumor metabolism, we open the door to potentially more effective cancer treatments that also leverage the body's immune response.
We found that JHU083 works not only by targeting cancer cells that are dependent on glutamine but also by modifying the immune landscape around tumors. Specifically, the treatment suppressed a type of immune cell called M2 macrophages, which are known to promote tumor growth. This change led to a more immune-stimulating environment, favoring M1 macrophages that can help fight the cancer.
Our findings highlight the importance of considering the immune microenvironment when evaluating cancer treatments. We observed a significant shift in the balance of macrophages due to the treatment, suggesting that targeting glutamine metabolism could be a promising strategy for cancer therapy. By rethinking how we approach tumor metabolism, we open the door to potentially more effective cancer treatments that also leverage the body's immune response.
7
We explored the impact of l-glutamine, an amino acid abundant in our body, on cancer treatment and immune responses. Glutamine plays a vital role in providing building blocks for rapidly dividing cancer cells, which often ramp up their uptake of this nutrient to fuel their growth.
Our investigation highlights how cancer cells reprogram their metabolism to prioritize glutamine. But it’s not just the cancer cells that are affected; immune cells also utilize glutamine for various functions, including fighting off cancer. Recent successes in cancer immunotherapy have prompted us to look deeper into how glutamine metabolism influences immune cell behavior within the cancer microenvironment.
One particularly noteworthy finding is that oral supplementation of glutamine can enhance the immune function in cancer patients. This can potentially improve their responses to chemotherapy and radiation, leading to better outcomes overall. We noted that while the existing research sheds light on this relationship, more targeted studies would be beneficial to fully understand the nuances of glutamine’s role in cancer therapy.
Overall, we recognize the unique importance of glutamine in both cancer cells and immune function, positioning it as a potential target for future therapies. However, the nuances of its effects and interactions with other treatments require further exploration.
Our investigation highlights how cancer cells reprogram their metabolism to prioritize glutamine. But it’s not just the cancer cells that are affected; immune cells also utilize glutamine for various functions, including fighting off cancer. Recent successes in cancer immunotherapy have prompted us to look deeper into how glutamine metabolism influences immune cell behavior within the cancer microenvironment.
One particularly noteworthy finding is that oral supplementation of glutamine can enhance the immune function in cancer patients. This can potentially improve their responses to chemotherapy and radiation, leading to better outcomes overall. We noted that while the existing research sheds light on this relationship, more targeted studies would be beneficial to fully understand the nuances of glutamine’s role in cancer therapy.
Overall, we recognize the unique importance of glutamine in both cancer cells and immune function, positioning it as a potential target for future therapies. However, the nuances of its effects and interactions with other treatments require further exploration.
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Aids cancer prevention
193 people found this helpful
An important nutraceutical for health and healing. I prefer this brand of L-glutamine for its cost savings and pleasant taste. I take 6 grams daily on an empty stomach to promote digestive health, maintain muscle mass, and as a cancer preventive. L-glutamine is vital for athletes and those recovering from disease. Research shows that cancer cells consume L-glutamine, impacting healthy cells' survival. Supplementing helps counter the negative nitrogen balance that can occur in cancer patients, preventing cachexia, which often threatens those with cancer.
9
Relief from neuropathy
8 people found this helpful
This product is great for anyone suffering from peripheral neuropathy. My neighbour shared their leftovers with us while my boyfriend was undergoing chemotherapy, which induced tingling and sensitivity in his hands and feet. As a cancer survivor, the neighbour recommended this product, which truly worked for my boyfriend. We shared the information with several patients at the infusion centre, and many of them found relief as well.
9
Increased energy
I bought it for my mum, a breast cancer survivor, and this supplement provides her with more energy. It’s a fantastic product.
7.5
Improved symptoms
A family member underwent chemotherapy for cancer, experiencing side effects like oral mucosa damage and diarrhoea. After taking this product, the symptoms significantly improved, the appetite increased, and the individual felt more energetic.
7.5
Reduces TPN reliance
38 people found this helpful
I suffered radiation damage from cancer treatment affecting my nutrient absorption. After using Glutamine packets while hospitalised, I researched its benefits for my condition. I began taking this product, mixing it into my juice every morning. Since starting it, I have reduced my reliance on TPN from nightly to just three days a week, and I have maintained my weight, allowing me to eat properly and improving my digestion. The Glutamine is clearly beneficial as I previously needed TPN nightly to sustain my weight.
Frequently Asked Questions
7.5
Improved symptoms
A family member underwent chemotherapy for cancer, experiencing side effects like oral mucosa damage and diarrhoea. After taking this product, the symptoms significantly improved, the appetite increased, and the individual felt more energetic.
9
Increased energy
I bought it for my mum, a breast cancer survivor, and this supplement provides her with more energy. It’s a fantastic product.
6
Affordable support
1 people found this helpful
My family suffers from cancer and has purchased other costly products before. This one is much more affordable, and I hope it will benefit my family members undergoing chemotherapy. Previously, I bought powder forms of a product, which didn’t taste very pleasant. This one is granular; although you need to take more tablets, it's convenient to swallow.
8
Efficacy of L-glutaminase in cancer
We explored the effects of L-glutaminase, produced by Klebsiella pneumoniae AS KP 23, on cancer cells. This enzyme is noteworthy because cancer cells often rely heavily on glutamine to grow and survive. By targeting and breaking down glutamine, L-glutaminase serves as a promising approach to inhibit cancer cell proliferation.
Our study demonstrated that purified L-glutaminase not only impacted normal cells but also showed significant anticancer activity against various cancer cell lines. Specifically, we found that this enzyme effectively reduced the growth of hepatocellular and breast cancer cells. Its stability across different pH levels and temperatures enhances its potential as a viable treatment option.
With previous research highlighting the importance of glutamine in cancer metabolism, the activation of L-glutaminase presents a compelling strategy for cancer therapy. This reinforces the potential of L-glutaminase as an alternative to traditional chemotherapy, providing a new avenue for the development of cancer treatments that might improve patient outcomes.
Our study demonstrated that purified L-glutaminase not only impacted normal cells but also showed significant anticancer activity against various cancer cell lines. Specifically, we found that this enzyme effectively reduced the growth of hepatocellular and breast cancer cells. Its stability across different pH levels and temperatures enhances its potential as a viable treatment option.
With previous research highlighting the importance of glutamine in cancer metabolism, the activation of L-glutaminase presents a compelling strategy for cancer therapy. This reinforces the potential of L-glutaminase as an alternative to traditional chemotherapy, providing a new avenue for the development of cancer treatments that might improve patient outcomes.
7
We explored the impact of l-glutamine, an amino acid abundant in our body, on cancer treatment and immune responses. Glutamine plays a vital role in providing building blocks for rapidly dividing cancer cells, which often ramp up their uptake of this nutrient to fuel their growth.
Our investigation highlights how cancer cells reprogram their metabolism to prioritize glutamine. But it’s not just the cancer cells that are affected; immune cells also utilize glutamine for various functions, including fighting off cancer. Recent successes in cancer immunotherapy have prompted us to look deeper into how glutamine metabolism influences immune cell behavior within the cancer microenvironment.
One particularly noteworthy finding is that oral supplementation of glutamine can enhance the immune function in cancer patients. This can potentially improve their responses to chemotherapy and radiation, leading to better outcomes overall. We noted that while the existing research sheds light on this relationship, more targeted studies would be beneficial to fully understand the nuances of glutamine’s role in cancer therapy.
Overall, we recognize the unique importance of glutamine in both cancer cells and immune function, positioning it as a potential target for future therapies. However, the nuances of its effects and interactions with other treatments require further exploration.
Our investigation highlights how cancer cells reprogram their metabolism to prioritize glutamine. But it’s not just the cancer cells that are affected; immune cells also utilize glutamine for various functions, including fighting off cancer. Recent successes in cancer immunotherapy have prompted us to look deeper into how glutamine metabolism influences immune cell behavior within the cancer microenvironment.
One particularly noteworthy finding is that oral supplementation of glutamine can enhance the immune function in cancer patients. This can potentially improve their responses to chemotherapy and radiation, leading to better outcomes overall. We noted that while the existing research sheds light on this relationship, more targeted studies would be beneficial to fully understand the nuances of glutamine’s role in cancer therapy.
Overall, we recognize the unique importance of glutamine in both cancer cells and immune function, positioning it as a potential target for future therapies. However, the nuances of its effects and interactions with other treatments require further exploration.
9
Targeted treatment for colon cancer
We focused on the potential of l-glutamine-conjugated organotin(IV) compounds as a targeted treatment for colorectal cancer. These compounds were tested in laboratory settings against human colon cancer cell lines, revealing marked cytotoxic effects.
Through our observations, we noted that these compounds were capable of inducing cell cycle arrest and promoting apoptosis, which are key processes in halting cancer cell growth. When applied in an experimental model of colon cancer, they effectively reduced tumor sizes and volume while selectively accumulating in the colon with minimal toxicity.
Importantly, our findings suggest that these glutamine-linked compounds not only exhibit strong anti-tumor activity but also address the issue of systemic toxicity often seen with traditional therapies. Overall, we believe these compounds could potentially serve as promising candidates in the fight against colon cancer.
Through our observations, we noted that these compounds were capable of inducing cell cycle arrest and promoting apoptosis, which are key processes in halting cancer cell growth. When applied in an experimental model of colon cancer, they effectively reduced tumor sizes and volume while selectively accumulating in the colon with minimal toxicity.
Importantly, our findings suggest that these glutamine-linked compounds not only exhibit strong anti-tumor activity but also address the issue of systemic toxicity often seen with traditional therapies. Overall, we believe these compounds could potentially serve as promising candidates in the fight against colon cancer.
References
- Abdel-Hafez LJ, Elariny EYT, Ibrahim AE, Abdel-Haliem MEF. L-glutaminase synthesis by Klebsiella pneumoniae (AS KP 23) isolated from clinical strain, and its efficacy against human hepatocellular and breast cancer cell lines. BMC Microbiol. 2025;25:62. doi:10.1186/s12866-025-03773-3
- Zhao Y, Yang Y, Yang R, Sun C, Gao X, et al. IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbing α-ketoglutarate-related metabolism and epigenetic modification. Life Metab. 2024;3:loae002. doi:10.1093/lifemeta/loae002
- Li T, Akhtarkhavari S, Chang TY, Shen YA, Yang J, et al. Inhibition of Glutamine Metabolism Suppresses Tumor Progression through Remodeling of the Macrophage Immune Microenvironment. bioRxiv. 2025. doi:10.1101/2025.01.10.632174
- Nan D, Yao W, Huang L, Liu R, Chen X, et al. Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets. Cell Commun Signal. 2025;23:45. doi:10.1186/s12964-024-02018-6
- Sharma S, Kaur V, Duhan P, Singh R, Agnihotri N. Evaluation of Anticancer Activity of Novel and Tumor-Targeted Glutamine-Conjugated Organotin(IV) Compounds in Colorectal Cancer─An In Vitro and In Vivo Study. J Med Chem. 2025;68:2593. doi:10.1021/acs.jmedchem.4c01728
