Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 1 Vegetarian capsule
Amount Per Serving
%DV
Bio-Quercetin® Proprietary Blend providing 35% quercetin (10 mg) [from Japanese sophora concentrate flower bud)], 30% galactomannans (8 mg) [from fenugreek (seed)]
30 mg
**
Top Medical Research Studies
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
We explored the effects of quercetin, a plant flavonoid, on KON oral cancer cells. Our aim was to understand how quercetin could potentially fight cancer by assessing its anti-growth, anti-migrative, and anti-invasive properties. Using various assays, we treated KON cells with quercetin and observed its impact on their viability compared to normal fibroblast cells.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
Read More
8
Quercetin reduces oral cancer cell viability
We explored the effects of quercetin, a natural flavonoid, on oral cancer during a systematic review of existing studies. Our investigation included a thorough screening process, where we analyzed 193 articles and selected 18 that met our inclusion criteria.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Read More
Most Useful Reviews
7.5
Potential cancer protection
96 people found this helpful
Quercetin is scientifically proven to possess antioxidant and anti-inflammatory properties, potentially aiding in reducing inflammation, killing cancer cells, and controlling blood sugar levels. Research suggests it may help protect against certain cancers, including leukemia and lung cancer, and its neuroprotective properties could benefit brain health. Overall, quercetin shows promise in both the treatment and prevention of various forms of cancer.
Read More
7.5
Holistic cancer support
29 people found this helpful
Part of a good holistic anti-cancer regimen. This complements our holistic cancer protocol.
Read More
7.5
Promotes detoxification
5 people found this helpful
Quercetin addresses arthritis, asthma and other inflammatory conditions while effectively combating viral infections. By boosting the immune system, it promotes detoxification enzymes that eliminate carcinogens, which is vital in various types of cancer. Quercetin also supports cerebral circulation, notably in Alzheimer's disease, and helps prevent skin and eye aging.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
- All Researches
9.5
Quercetin enhances cancer treatment efficacy
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Read More
9
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Read More
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
Quercetin combats cancer drug resistance
We explored the potential of quercetin, a natural compound found in various fruits and vegetables, in combating resistance to the cancer drug trastuzumab, particularly in patients with HER2-positive gastric cancer. Our study investigated how quercetin, as part of a mixture known as Jian Pi Hua Tan Fang (JPHTF), could enhance the effectiveness of this treatment.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Read More
9
Our research delved into the effects of quercetin, a flavonoid commonly found in plants, on hepatocellular carcinoma (HCC), a prevalent form of liver cancer. We focused on the role of the Farnesoid X receptor (FXR), which is crucial for maintaining liver health and metabolism. By investigating how quercetin influences the glycolysis pathway through FXR signaling, we sought to uncover its anti-cancer properties.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Potential cancer protection
96 people found this helpful
Quercetin is scientifically proven to possess antioxidant and anti-inflammatory properties, potentially aiding in reducing inflammation, killing cancer cells, and controlling blood sugar levels. Research suggests it may help protect against certain cancers, including leukemia and lung cancer, and its neuroprotective properties could benefit brain health. Overall, quercetin shows promise in both the treatment and prevention of various forms of cancer.
Read More
7.5
Holistic cancer support
29 people found this helpful
Part of a good holistic anti-cancer regimen. This complements our holistic cancer protocol.
Read More
7.5
Promotes detoxification
5 people found this helpful
Quercetin addresses arthritis, asthma and other inflammatory conditions while effectively combating viral infections. By boosting the immune system, it promotes detoxification enzymes that eliminate carcinogens, which is vital in various types of cancer. Quercetin also supports cerebral circulation, notably in Alzheimer's disease, and helps prevent skin and eye aging.
Read More
7
Neutralises cancer cells
1 people found this helpful
The quality of this bioavailable quercetin is excellent. It aids blood vessels and capillaries, and since taking this supplement, the bruising on my body has improved significantly. It also acts as an antioxidant that neutralises cancer cells. The capsules are small, making them easy to swallow.
Read More
7.5
Excellent antioxidant
Quercetin, a natural flavonoid, offers exceptional antioxidant and anti-inflammatory effects. Studies indicate it protects cells from oxidative stress, enhances immunity, boosts blood vessel health, and possesses anticancer and antiviral properties. Its benefits have made it a popular topic in biomedical research.
Read More
Frequently Asked Questions
7
Neutralises cancer cells
1 people found this helpful
The quality of this bioavailable quercetin is excellent. It aids blood vessels and capillaries, and since taking this supplement, the bruising on my body has improved significantly. It also acts as an antioxidant that neutralises cancer cells. The capsules are small, making them easy to swallow.
7.5
Reduces cancer risk
This is a fantastic product to include in my anti-allergic protocol and for liver detoxification! It reduces inflammation, alleviates allergy symptoms, and lowers the risk of developing cancer. Additionally, it helps to prevent degenerative brain diseases and lowers blood pressure. Other benefits include slowing down the ageing process, enhancing physical endurance, and normalising blood sugar levels, preventing the development of diabetes. Quercetin's numerous qualities make it an essential supplement.
7.5
Promotes detoxification
5 people found this helpful
Quercetin addresses arthritis, asthma and other inflammatory conditions while effectively combating viral infections. By boosting the immune system, it promotes detoxification enzymes that eliminate carcinogens, which is vital in various types of cancer. Quercetin also supports cerebral circulation, notably in Alzheimer's disease, and helps prevent skin and eye aging.
6
Good for cancer prevention
Following positive reviews, I purchased this for cancer prevention. I plan to buy it again.
7.5
Excellent antioxidant
Quercetin, a natural flavonoid, offers exceptional antioxidant and anti-inflammatory effects. Studies indicate it protects cells from oxidative stress, enhances immunity, boosts blood vessel health, and possesses anticancer and antiviral properties. Its benefits have made it a popular topic in biomedical research.
9.5
Quercetin enhances cancer treatment efficacy
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
9
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
8
Quercetin may aid prostate cancer treatment
We delved into the potential healing properties of Quercetin, a natural compound that may help combat prostate cancer (PCa). Our approach involved several innovative techniques, including network pharmacology, molecular docking, and molecular dynamics simulation to uncover how Quercetin interacts with cancer-related proteins.
By examining various bioinformatics resources, we identified a set of key genes related to both Quercetin and PCa, ultimately narrowing it down to 11 crucial genes. Through further analysis, we discovered six hub genes that could play significant roles in the effectiveness of Quercetin’s therapeutic properties.
Our findings revealed that Quercetin may induce apoptosis—meaning it can trigger cancer cell death—suppress metastasis, and inhibit processes related to tumor growth. We found that it influences oxidative stress and the immune response within the tumor environment. Additionally, the molecular docking studies indicated that Quercetin forms stable interactions with the identified target proteins.
The promising results suggest that Quercetin could be a valuable addition to cancer treatment strategies; however, further experimental research is essential before we can confirm these benefits in clinical settings.
By examining various bioinformatics resources, we identified a set of key genes related to both Quercetin and PCa, ultimately narrowing it down to 11 crucial genes. Through further analysis, we discovered six hub genes that could play significant roles in the effectiveness of Quercetin’s therapeutic properties.
Our findings revealed that Quercetin may induce apoptosis—meaning it can trigger cancer cell death—suppress metastasis, and inhibit processes related to tumor growth. We found that it influences oxidative stress and the immune response within the tumor environment. Additionally, the molecular docking studies indicated that Quercetin forms stable interactions with the identified target proteins.
The promising results suggest that Quercetin could be a valuable addition to cancer treatment strategies; however, further experimental research is essential before we can confirm these benefits in clinical settings.
9
Quercetin combats cancer drug resistance
We explored the potential of quercetin, a natural compound found in various fruits and vegetables, in combating resistance to the cancer drug trastuzumab, particularly in patients with HER2-positive gastric cancer. Our study investigated how quercetin, as part of a mixture known as Jian Pi Hua Tan Fang (JPHTF), could enhance the effectiveness of this treatment.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
8
We investigated how quercetin, a natural flavonoid found in fruits and vegetables, can impact breast cancer treatment. This study highlights the significant health challenges posed by breast cancer, a condition affecting millions of women globally.
Quercetin is known for its various health benefits, including its potential anti-cancer effects. By employing a strategy called network pharmacology, we identified specific genes that quercetin targets in breast cancer cells. Through insightful analysis using various online tools, we pinpointed eight key genes related to quercetin's effectiveness.
Our findings suggest that quercetin interacts positively with these genes, showing promising binding affinities. This interaction indicates that quercetin could play a role in halting cancer cell growth, promoting programmed cell death (apoptosis), and reducing metastasis—the spread of cancer to other parts of the body.
Despite its potential, quercetin does face challenges like low bioavailability, meaning our bodies may not absorb it efficiently. However, there are ways to enhance its delivery through modifications or special formulations, such as nanoparticles.
In conclusion, quercetin emerges as a potential natural therapy for breast cancer, enhancing the prospects for future clinical applications and research into its benefits.
Quercetin is known for its various health benefits, including its potential anti-cancer effects. By employing a strategy called network pharmacology, we identified specific genes that quercetin targets in breast cancer cells. Through insightful analysis using various online tools, we pinpointed eight key genes related to quercetin's effectiveness.
Our findings suggest that quercetin interacts positively with these genes, showing promising binding affinities. This interaction indicates that quercetin could play a role in halting cancer cell growth, promoting programmed cell death (apoptosis), and reducing metastasis—the spread of cancer to other parts of the body.
Despite its potential, quercetin does face challenges like low bioavailability, meaning our bodies may not absorb it efficiently. However, there are ways to enhance its delivery through modifications or special formulations, such as nanoparticles.
In conclusion, quercetin emerges as a potential natural therapy for breast cancer, enhancing the prospects for future clinical applications and research into its benefits.
References
- Verma M, Yadav K, Parihar R, Dutta D, Chaudhuri S, et al. Active tumor targeting by core-shell PDMS-HA nanoparticles with sequential delivery of doxorubicin and quercetin to overcome P-glycoprotein efflux pump. Nanoscale. 2025;17:5033. doi:10.1039/d4nr03040k
- Wang J, Yang JH, Xiong D, Chen L. Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma. Hum Exp Toxicol. 2025;44:9603271251323753. doi:10.1177/09603271251323753
- Saadh MJ, Ahmed HH, Chandra M, Al-Hussainy AF, Hamid JA, et al. Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis. Cancer Cell Int. 2025;25:66. doi:10.1186/s12935-025-03694-1
- Mukherjee S, Banik SK, Chakraborty S, Das T, Choudhury MD, et al. Bryophyllum pinnatum Induces p53-Dependent Apoptosis of Colorectal Cancer Cells via Increased Intracellular ROS and G2/M Cell-Cycle Arrest In Vitro and Validated in Silico by Molecular Docking. Cell Biol Int. 2025. doi:10.1002/cbin.70004
- Alsaab J, Sarawi WS, Alhusaini AM, Hasan IH, Alturaif S, et al. Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways. Food Chem Toxicol. 2025;199:115341. doi:10.1016/j.fct.2025.115341
- Sun J, Sha M, Zhou J, Huang Y. Quercetin affects apoptosis and autophagy in pediatric acute myeloid leukaemia cells by inhibiting PI3K/AKT signaling pathway activation through regulation of miR-224-3p/PTEN axis. BMC Cancer. 2025;25:318. doi:10.1186/s12885-025-13709-9
- Han S, Yi YW, Kim H, Lee MY, Choi H, et al. Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells. Biomed Pharmacother. 2025;184:117930. doi:10.1016/j.biopha.2025.117930
- Martínez-Esquivias F, Guzmán-Flores JM, Pech-Santiago EO, Guerrero-Barrera AL, Delgadillo-Aguirre CK, et al. Therapeutic Role of Quercetin in Prostate Cancer: A Study of Network Pharmacology, Molecular Docking, and Dynamics Simulation. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01697-3
- Chuang CH, Tai YA, Wu TJ, Ho YJ, Yeh SL. Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling. Front Nutr. 2025;12:1530132. doi:10.3389/fnut.2025.1530132
- Singh T, Rastogi M, Thakur K. Network pharmacology and in silico approach to study the mechanism of quercetin against breast cancer. In Silico Pharmacol. 2025;13:22. doi:10.1007/s40203-025-00306-8
- Hu J, Bu W, Ding Y, Li X, Zhang B, et al. Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2-Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation. Immun Inflamm Dis. 2025;13:e70154. doi:10.1002/iid3.70154
- Zhong W, Chen T, Chen L, Xing Y, Lin H, et al. Crippled Hepatocarcinogenesis Inhibition of Quercetin in Glycolysis Pathway with Hepatic Farnesoid X Receptor Deficiency. Curr Pharm Des. 2025. doi:10.2174/0113816128342642250111055339
- Qiu C, Xia F, Tu Q, Tang H, Liu Y, et al. Multimodal lung cancer theranostics via manganese phosphate/quercetin particle. Mol Cancer. 2025;24:43. doi:10.1186/s12943-025-02242-9
- Tubtimsri S, Chuenbarn T, Manmuan S. Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells. BMC Complement Med Ther. 2025;25:34. doi:10.1186/s12906-025-04782-5
- Wen C, Tang J, Wu M, Liu H, Lin X, et al. Preparation, characterization, and stability of pectin-whey protein isolate-based nanoparticles with mitochondrial targeting ability. Int J Biol Macromol. 2025;301:140383. doi:10.1016/j.ijbiomac.2025.140383
- Wang G, Wang D, Xia L, Lian J, Zhang Q, et al. Metal-Phenolic Nanomedicines Targeting Fatty Acid Metabolic Reprogramming to Overcome Immunosuppression in Radiometabolic Cancer Therapy. ACS Appl Mater Interfaces. 2025;17:7478. doi:10.1021/acsami.4c21028
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