Overview
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Magnesium (as ZumXR® magnesium oxide, magnesium citrate)
250 mg
60%
Top Medical Research Studies
8
Magnesium treats anxiety in MS
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
7
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
5
Magnesium's effects on anxiety examined
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
Most Useful Reviews
9
Perfect for sleep
49 people found this helpful
I began taking magnesium due to anxiety that disrupted my sleep. Regular supplements would wear off too quickly, but this time-release version has worked wonders. I fall asleep easily and stay asleep for a full night. It proved equally effective as a more expensive brand. Although I forgot my supplement during a vacation and noticed a slight decline in my sleep quality, I was not faced with withdrawal symptoms.
9
Less anxiety, more energy
4 people found this helpful
With this, I feel so much better and can do much more. I have significantly less anxiety and fewer troubles with falling asleep.
9
Sleep like a baby
2 people found this helpful
THE BEST MAGNESIUM EVER! I've tried about five different brands, and this one is the best. One capsule at night helps me sleep soundly without nightmares or side effects. It also effectively addresses anxiety and enhances my mood.
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.9
- All Researches
9
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
8
Magnesium's role in anxiety treatment
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
8
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.
Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.
This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.
This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
8
Magnesium treats anxiety in MS
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Perfect for sleep
49 people found this helpful
I began taking magnesium due to anxiety that disrupted my sleep. Regular supplements would wear off too quickly, but this time-release version has worked wonders. I fall asleep easily and stay asleep for a full night. It proved equally effective as a more expensive brand. Although I forgot my supplement during a vacation and noticed a slight decline in my sleep quality, I was not faced with withdrawal symptoms.
9
Less anxiety, more energy
4 people found this helpful
With this, I feel so much better and can do much more. I have significantly less anxiety and fewer troubles with falling asleep.
9
Sleep like a baby
2 people found this helpful
THE BEST MAGNESIUM EVER! I've tried about five different brands, and this one is the best. One capsule at night helps me sleep soundly without nightmares or side effects. It also effectively addresses anxiety and enhances my mood.
7.5
Major improvement
15 people found this helpful
After realising I was deficient in magnesium, which was affecting my sleep, anxiety, and muscle issues, I found this product to be a game changer. After just a few days of use, I noticed considerable improvements. I now wake up ready to tackle the day, feeling more flexible and energetic. The relief from my anxiety and insomnia is tangible, and I wouldn’t want to go back.
7.5
Improved anxiety relief
5 people found this helpful
An excellent tool! Magnesium is very useful for those over 50. Recently, I often felt anxiety, palpitations, headaches, and insomnia, along with occasional joint pain. After two weeks of taking it, I noticed improvements. My husband and I both enjoy the results. It's excellent for normalising the nervous system and maintaining youthfulness in the body!
Frequently Asked Questions
7.5
Better sleep quality
3 people found this helpful
Recently at work, I started feeling very tired, and my sleep was disturbed, leading to mood swings, anxiety, and irritability. I began taking magnesium before bed and felt the difference immediately. My sleep quality improved, and I found it easier to rise in the morning.
7.5
Improved anxiety relief
5 people found this helpful
An excellent tool! Magnesium is very useful for those over 50. Recently, I often felt anxiety, palpitations, headaches, and insomnia, along with occasional joint pain. After two weeks of taking it, I noticed improvements. My husband and I both enjoy the results. It's excellent for normalising the nervous system and maintaining youthfulness in the body!
9
Less anxiety, more energy
4 people found this helpful
With this, I feel so much better and can do much more. I have significantly less anxiety and fewer troubles with falling asleep.
9
Sleep like a baby
2 people found this helpful
THE BEST MAGNESIUM EVER! I've tried about five different brands, and this one is the best. One capsule at night helps me sleep soundly without nightmares or side effects. It also effectively addresses anxiety and enhances my mood.
7.5
Relaxation and wellbeing
Excellent! Life Extension Magnesium Extender is a remarkable product that I’ve used to support my health. It helps me relax and manage daily stress. Since I started taking it, I’ve experienced improved sleep quality and decreased anxiety levels. The vegetarian capsules are easy to swallow and well tolerated. I highly recommend this product for those seeking an effective health supplement.
9
Stress relief from magnesium
2 people found this helpful
I take magnesium after dinner, and it effectively alleviates my irritability and anxiety. According to my beautician, magnesium deficiency can lead to facial swelling, so my friends and I are taking it to wake up looking beautiful!
7
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.
Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.
Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.
Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.
Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.
Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
7
Magnesium may ease anxiety symptoms
This study aimed to explore how magnesium, when combined with vitamins and herbs, affects anxiety levels in individuals experiencing chronic stress. In a well-structured, randomized controlled trial, participants were given either a magnesium-rich supplement or a placebo for 28 days.
After conducting functional MRI scans, we noticed significant changes in brain activation patterns related to stress and pain perception in those taking the magnesium supplement. Specifically, over the course of the month, there was a notable reduction in anxiety levels as measured by the Depression Anxiety Stress Scale.
Participants reported feeling less stressed and more resilient in facing daily challenges. Our findings suggest that magnesium supplementation may offer a complementary approach to managing anxiety, particularly for those suffering from chronic stress.
After conducting functional MRI scans, we noticed significant changes in brain activation patterns related to stress and pain perception in those taking the magnesium supplement. Specifically, over the course of the month, there was a notable reduction in anxiety levels as measured by the Depression Anxiety Stress Scale.
Participants reported feeling less stressed and more resilient in facing daily challenges. Our findings suggest that magnesium supplementation may offer a complementary approach to managing anxiety, particularly for those suffering from chronic stress.
5
Magnesium's effects on anxiety examined
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
References
- Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
- Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. doi:10.3390/microorganisms12071429
- Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. doi:10.7759/cureus.59317
- Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. doi:10.5152/alphapsychiatry.2024.231342
- Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. doi:10.23736/S0375-9393.24.17868-6
- Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. doi:10.1080/01616412.2024.2352234
- Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. doi:10.3390/life14030306
- Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. doi:10.1038/s41591-023-02705-w
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. doi:10.3389/fnut.2023.1211321
- Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. doi:10.1080/1354750X.2023.2246104
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
- Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. doi:10.3390/metabo13010073
