' 
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg
625%
Vitamin K activity from:Vitamin K1 (as phytonadione)Vitamin K2 (as menaquinone-4)Vitamin K2 (as trans menaquinone-7)
2,100 mcg1,000 mcg1,000 mcg100 mcg
1,750%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Study emphasizes isolated effects
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
9
Iodine treatment aids recurrent cancer
Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes.
Focuses on iodine's specific effect.
We observed a compelling case where a biodegradable hydrogel spacer was used alongside iodine-125 brachytherapy to treat recurrent prostate cancer. This innovative approach involved placing the spacer to create space between the prostate and the rectum, which significantly reduced radiation exposure to healthy tissues during the treatment.
Following initial external beam radiotherapy in 2015, the patient showed signs of local recurrence by 2022. To address this, the treatment plan included not just the iodine-125 brachytherapy but also the hydrogel spacer, which was placed in January 2024 just before the radiation treatment. Six months later, we noted a remarkable drop in the patient’s prostate-specific antigen (PSA) levels, indicating a positive response to the treatment.
This case showcases the potential benefits of using iodine treatment in combination with advanced techniques like hydrogel spacers. The results suggest that this method not only improves the effectiveness of therapy but also ensures higher safety by protecting adjacent tissues from unnecessary radiation damage. Overall, we find this integration of technology highly beneficial for managing recurrent cancer challenges.
Following initial external beam radiotherapy in 2015, the patient showed signs of local recurrence by 2022. To address this, the treatment plan included not just the iodine-125 brachytherapy but also the hydrogel spacer, which was placed in January 2024 just before the radiation treatment. Six months later, we noted a remarkable drop in the patient’s prostate-specific antigen (PSA) levels, indicating a positive response to the treatment.
This case showcases the potential benefits of using iodine treatment in combination with advanced techniques like hydrogel spacers. The results suggest that this method not only improves the effectiveness of therapy but also ensures higher safety by protecting adjacent tissues from unnecessary radiation damage. Overall, we find this integration of technology highly beneficial for managing recurrent cancer challenges.
Read More
Most Useful Reviews
9.5
Supports immunity enhancement
This is one of the best manufacturers of vitamin D. It promotes muscle tone, increases immunity, supports thyroid function and normal blood clotting, and aids in restoring the protective sheaths around nerves. It also regulates blood pressure and heart rate while preventing cancer cell growth. I recommend taking it year-round at a dosage of 1000, ensuring sufficient levels in the body. Remember, vitamin D has a cumulative effect, so there's no fear of overdose when paired with vitamin K, which reduces liver strain.
Read More
8.8
Reduces cancer growth
Vitamin D helps the body absorb calcium and phosphorus, essential for bone growth. Besides its building function, it performs a protective role by decreasing cancer cell growth, aiding the immune system against infections, and lessening inflammation. It is also crucial for the normal functioning of the neuromuscular, endocrine, and immune systems.
Read More
8.8
Effective for cancer
I have been using this as part of my regimen for cancer treatment, and so far, everything is going well. My vitamin D levels have improved after years of consistent use, proving effective for my health regime.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.5
- All Researches
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
9
Cu-Cy-I Nanoparticles Show Promise
Iodinated Copper-Cysteamine Nanoparticles as Radiosensitizers for Tumor Radiotherapy.
Relevance score indicates mixed impact
We explored the potential of iodinated copper-cysteamine (Cu-Cy-I) nanoparticles to enhance cancer treatment when combined with X-ray therapy. The study specifically focused on how these nanoparticles could improve the effectiveness of radiotherapy by increasing the generation of reactive oxygen species (ROS) in tumor cells. This increase in ROS leads to more significant DNA damage in cancer cells, making them more susceptible to radiation treatment.
Our findings revealed that when 4T1 tumor cells were treated with Cu-Cy-I nanoparticles alongside X-ray irradiation, there was a notable improvement in tumor cell killing compared to X-ray treatment alone. Additionally, in mouse models with breast carcinoma, the combination treatment led to better tumor growth inhibition and extended survival time for the mice.
However, we acknowledge that the effectiveness of the iodine component in the nanoparticles at lower doses was not verified in this study. The results suggest that Cu-Cy-I nanoparticles have promise as radiosensitizers in cancer therapy, but more research is needed, particularly regarding the synthesis of smaller nanoparticles for further evaluation.
Our findings revealed that when 4T1 tumor cells were treated with Cu-Cy-I nanoparticles alongside X-ray irradiation, there was a notable improvement in tumor cell killing compared to X-ray treatment alone. Additionally, in mouse models with breast carcinoma, the combination treatment led to better tumor growth inhibition and extended survival time for the mice.
However, we acknowledge that the effectiveness of the iodine component in the nanoparticles at lower doses was not verified in this study. The results suggest that Cu-Cy-I nanoparticles have promise as radiosensitizers in cancer therapy, but more research is needed, particularly regarding the synthesis of smaller nanoparticles for further evaluation.
Read More
9
Iodine enhances lung cancer treatment
Efficacy and safety of immune checkpoint inhibitors combined with iodine-125 seed implantation in driver gene-negative non-small cell lung cancer: a retrospective cohort study.
Combination therapy studied for efficacy
We conducted a retrospective study focusing on patients with driver gene-negative non-small cell lung cancer (NSCLC) to explore the effectiveness of iodine-125 (I) seed implantation when paired with immune checkpoint inhibitors (ICIs) and chemotherapy (CT). In our analysis of 95 patients, we compared two groups: one treated with I seed implantation alongside ICIs and CT, and the other treated with conventional radiotherapy (RT) with the same additional therapies.
Our primary goal was to assess the median progression-free survival (mPFS), alongside secondary outcomes that included the one- and two-year progression-free survival rates, as well as the occurrence of adverse events related to treatments. The results were promising: patients who received iodine treatment experienced longer survival times and reported fewer adverse effects compared to those undergoing traditional RT.
The findings suggest that Iodine-125 seed implantation could be a more advantageous option for treating this specific type of lung cancer, offering a precision approach that minimizes damage to healthy lung tissue. This less invasive method could provide patients with a better quality of life while still tackling the disease effectively.
Our primary goal was to assess the median progression-free survival (mPFS), alongside secondary outcomes that included the one- and two-year progression-free survival rates, as well as the occurrence of adverse events related to treatments. The results were promising: patients who received iodine treatment experienced longer survival times and reported fewer adverse effects compared to those undergoing traditional RT.
The findings suggest that Iodine-125 seed implantation could be a more advantageous option for treating this specific type of lung cancer, offering a precision approach that minimizes damage to healthy lung tissue. This less invasive method could provide patients with a better quality of life while still tackling the disease effectively.
Read More
9
Iodine treatment aids recurrent cancer
Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes.
Focuses on iodine's specific effect.
We observed a compelling case where a biodegradable hydrogel spacer was used alongside iodine-125 brachytherapy to treat recurrent prostate cancer. This innovative approach involved placing the spacer to create space between the prostate and the rectum, which significantly reduced radiation exposure to healthy tissues during the treatment.
Following initial external beam radiotherapy in 2015, the patient showed signs of local recurrence by 2022. To address this, the treatment plan included not just the iodine-125 brachytherapy but also the hydrogel spacer, which was placed in January 2024 just before the radiation treatment. Six months later, we noted a remarkable drop in the patient’s prostate-specific antigen (PSA) levels, indicating a positive response to the treatment.
This case showcases the potential benefits of using iodine treatment in combination with advanced techniques like hydrogel spacers. The results suggest that this method not only improves the effectiveness of therapy but also ensures higher safety by protecting adjacent tissues from unnecessary radiation damage. Overall, we find this integration of technology highly beneficial for managing recurrent cancer challenges.
Following initial external beam radiotherapy in 2015, the patient showed signs of local recurrence by 2022. To address this, the treatment plan included not just the iodine-125 brachytherapy but also the hydrogel spacer, which was placed in January 2024 just before the radiation treatment. Six months later, we noted a remarkable drop in the patient’s prostate-specific antigen (PSA) levels, indicating a positive response to the treatment.
This case showcases the potential benefits of using iodine treatment in combination with advanced techniques like hydrogel spacers. The results suggest that this method not only improves the effectiveness of therapy but also ensures higher safety by protecting adjacent tissues from unnecessary radiation damage. Overall, we find this integration of technology highly beneficial for managing recurrent cancer challenges.
Read More
9
Iodine peptides show cancer treatment promise
Experimental study of iodine-131 labeling of a novel tumor-targeting peptide, TFMP-Y4, in the treatment of hepatocellular carcinoma with internal irradiation.
Study relevant but not definitive
We explored the effectiveness of iodine-labeled peptides, specifically I-TFMP-Y4 and I-Caerin 1.1, in treating hepatocellular carcinoma, a common type of liver cancer. Our study included in vitro experiments where we assessed how these peptides affected the growth of liver cancer cells, as well as in vivo tests using a hormone-treated nude mouse model.
We found that both I-Caerin 1.1 and I-TFMP-Y4 were effective at inhibiting the proliferation of Hepg2 cells, which are a model for liver cancer. Interestingly, while I-Caerin 1.1 showed a significant impact, we observed that TFMP-Y4 alone did not inhibit the liver cancer cells, suggesting its effectiveness might rely on its pairing with Iodine.
Additionally, we noted that I-TFMP-Y4 has the potential to lessen adverse reactions during treatment compared to I-Caerin 1.1. This finding is particularly important as it may improve the safety profile of the treatment, making it more acceptable for patients undergoing therapy.
We found that both I-Caerin 1.1 and I-TFMP-Y4 were effective at inhibiting the proliferation of Hepg2 cells, which are a model for liver cancer. Interestingly, while I-Caerin 1.1 showed a significant impact, we observed that TFMP-Y4 alone did not inhibit the liver cancer cells, suggesting its effectiveness might rely on its pairing with Iodine.
Additionally, we noted that I-TFMP-Y4 has the potential to lessen adverse reactions during treatment compared to I-Caerin 1.1. This finding is particularly important as it may improve the safety profile of the treatment, making it more acceptable for patients undergoing therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Supports immunity enhancement
This is one of the best manufacturers of vitamin D. It promotes muscle tone, increases immunity, supports thyroid function and normal blood clotting, and aids in restoring the protective sheaths around nerves. It also regulates blood pressure and heart rate while preventing cancer cell growth. I recommend taking it year-round at a dosage of 1000, ensuring sufficient levels in the body. Remember, vitamin D has a cumulative effect, so there's no fear of overdose when paired with vitamin K, which reduces liver strain.
Read More
8.8
Reduces cancer growth
Vitamin D helps the body absorb calcium and phosphorus, essential for bone growth. Besides its building function, it performs a protective role by decreasing cancer cell growth, aiding the immune system against infections, and lessening inflammation. It is also crucial for the normal functioning of the neuromuscular, endocrine, and immune systems.
Read More
8.8
Effective for cancer
I have been using this as part of my regimen for cancer treatment, and so far, everything is going well. My vitamin D levels have improved after years of consistent use, proving effective for my health regime.
8.8
Strong supplement choice
This product is excellent, incorporating K1, K2, and Vitamin D3, aiding calcium absorption while possessing anti-inflammatory properties. It has demonstrated a capacity to reduce cancer cell growth. K2 directs calcium to the bones, ensuring proper absorption, while K1 supports blood clotting and overall heart health.
Read More
8.8
Helpful for cancer history
I use this supplement due to previously low vitamin D levels, managing to boost it significantly. I have observed my levels rise through lab results, confirming its effectiveness. The inclusion of iodine and vitamin K offers added benefits, particularly vital for anyone with a cancer history.
Read More
