Overview
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
N-acetyl-L-cysteine
600 mg
**
Top Medical Research Studies
8
We explored the effect of rutecarpine, a natural compound from Chinese herbs, on non-small cell lung cancer (NSCLC) and how n-acetyl-l-cysteine (NAC) interacts with this treatment. Our study showed that rutecarpine can trigger cell death and reduce the growth of cancer cells, primarily by promoting the production of reactive oxygen species (ROS) that lead to mitochondrial dysfunction.
Importantly, we observed that when cells were exposed to NAC, it was able to suppress this ROS production, suggesting that NAC might mitigate some of rutecarpine’s cancer-fighting effects. We also noted that rutecarpine activated the STING pathway and increased the levels of immune signals, which could boost the body's immune response against the tumor.
However, while NAC plays a protective role by dampening excess ROS, it’s clear that rutecarpine’s ability to combat NSCLC is more pronounced when NAC is not present. In in vivo studies, rutecarpine not only slowed tumor growth significantly, but also elevated the presence of active CD8 T cells, enhancing antitumor immunity. This shows promise for rutecarpine as a potential treatment for lung cancer, albeit with a nuanced interaction with NAC that requires further exploration.
Importantly, we observed that when cells were exposed to NAC, it was able to suppress this ROS production, suggesting that NAC might mitigate some of rutecarpine’s cancer-fighting effects. We also noted that rutecarpine activated the STING pathway and increased the levels of immune signals, which could boost the body's immune response against the tumor.
However, while NAC plays a protective role by dampening excess ROS, it’s clear that rutecarpine’s ability to combat NSCLC is more pronounced when NAC is not present. In in vivo studies, rutecarpine not only slowed tumor growth significantly, but also elevated the presence of active CD8 T cells, enhancing antitumor immunity. This shows promise for rutecarpine as a potential treatment for lung cancer, albeit with a nuanced interaction with NAC that requires further exploration.
Read More
8
We explored how n-acetyl-l-cysteine (NAC) interacts with cancer treatments, especially concerning pancreatic ductal adenocarcinoma (PDAC). In a recent study assessing the effects of BIX01294, a G9a histone methyltransferase inhibitor, we discovered intriguing insights into cellular responses. While BIX demonstrated a significant ability to inhibit the growth of PDAC cells, it also triggered apoptosis, or programmed cell death.
What's particularly fascinating is the role NAC played in this context. Our findings revealed that the addition of NAC substantially rescued PDAC cells from the effects of BIX-induced apoptosis. This suggests that NAC may have protective properties against certain cancer therapies, especially those that impact a cell's redox balance.
Although direct claims about NAC's effectiveness as a standalone cancer treatment were not established in this study, its capability to mitigate the adverse effects of BIX on cell death highlights its potential in cancer therapy adjuncts. Moving forward, it will be essential to further investigate NAC's role and refine its application in cancer treatments to better understand its benefits.
What's particularly fascinating is the role NAC played in this context. Our findings revealed that the addition of NAC substantially rescued PDAC cells from the effects of BIX-induced apoptosis. This suggests that NAC may have protective properties against certain cancer therapies, especially those that impact a cell's redox balance.
Although direct claims about NAC's effectiveness as a standalone cancer treatment were not established in this study, its capability to mitigate the adverse effects of BIX on cell death highlights its potential in cancer therapy adjuncts. Moving forward, it will be essential to further investigate NAC's role and refine its application in cancer treatments to better understand its benefits.
Read More
4
Our study focused on understanding how n-acetyl-l-cysteine (NAC) interacts with high-dose ascorbate in relation to endometrial cancer (EC) treatment. We observed that while high doses of ascorbate showed promising anti-cancer effects, NAC appeared to partially reverse these benefits.
Specifically, in experiments with EC cells, when NAC was introduced alongside ascorbate, some of the tumor-fighting properties of ascorbate were diminished. This suggests that while ascorbate has the potential to inhibit tumor growth and promote cell stress, NAC may interfere with this process.
We also found that the effectiveness of ascorbate was closely linked to the PTEN/AKT/mTOR pathway, which is often altered in endometrial cancer. Overall, our findings indicate that while NAC does have a role in this context, it may not necessarily provide a significant independent benefit against cancer on its own. Further exploration of these interactions will be essential to understand their full implications for treatment strategies.
Specifically, in experiments with EC cells, when NAC was introduced alongside ascorbate, some of the tumor-fighting properties of ascorbate were diminished. This suggests that while ascorbate has the potential to inhibit tumor growth and promote cell stress, NAC may interfere with this process.
We also found that the effectiveness of ascorbate was closely linked to the PTEN/AKT/mTOR pathway, which is often altered in endometrial cancer. Overall, our findings indicate that while NAC does have a role in this context, it may not necessarily provide a significant independent benefit against cancer on its own. Further exploration of these interactions will be essential to understand their full implications for treatment strategies.
Read More
Most Useful Reviews
9
Glutathione production improved
I wholeheartedly recommend this modified form of cysteine. It significantly boosts glutathione levels in the body, which is critical in fighting cancer and preventing ageing. Acetylcysteine's detoxifying ability is notable, and its effectiveness is widely recognised in both preventive and curative cardiology practices.
Read More
8
Quality of life enhanced
N-acetyl-L-cysteine is exemplary! It provides antioxidant protection, inhibits premature ageing, and serves as a preventive component against cancer. It alleviates fatigue and speeds up muscle recovery while also thinning phlegm and removing toxins from the body. It has positively impacted my recovery during illness and post-recovery.
Read More
9
Cancer suppression observed
7 people found this helpful
NAC is a remarkable amino acid and powerful antioxidant, functioning as a precursor to glutathione—a critical antioxidant for the body. It detoxifies chemicals effectively and serves as a strong cancer suppressant. I've experienced significant relief from abdominal issues after using NAC, whereas other medications failed. My nails have strengthened, and my hair appears healthier. Overall, I’m pleased!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
- All Researches
8
We explored the effect of rutecarpine, a natural compound from Chinese herbs, on non-small cell lung cancer (NSCLC) and how n-acetyl-l-cysteine (NAC) interacts with this treatment. Our study showed that rutecarpine can trigger cell death and reduce the growth of cancer cells, primarily by promoting the production of reactive oxygen species (ROS) that lead to mitochondrial dysfunction.
Importantly, we observed that when cells were exposed to NAC, it was able to suppress this ROS production, suggesting that NAC might mitigate some of rutecarpine’s cancer-fighting effects. We also noted that rutecarpine activated the STING pathway and increased the levels of immune signals, which could boost the body's immune response against the tumor.
However, while NAC plays a protective role by dampening excess ROS, it’s clear that rutecarpine’s ability to combat NSCLC is more pronounced when NAC is not present. In in vivo studies, rutecarpine not only slowed tumor growth significantly, but also elevated the presence of active CD8 T cells, enhancing antitumor immunity. This shows promise for rutecarpine as a potential treatment for lung cancer, albeit with a nuanced interaction with NAC that requires further exploration.
Importantly, we observed that when cells were exposed to NAC, it was able to suppress this ROS production, suggesting that NAC might mitigate some of rutecarpine’s cancer-fighting effects. We also noted that rutecarpine activated the STING pathway and increased the levels of immune signals, which could boost the body's immune response against the tumor.
However, while NAC plays a protective role by dampening excess ROS, it’s clear that rutecarpine’s ability to combat NSCLC is more pronounced when NAC is not present. In in vivo studies, rutecarpine not only slowed tumor growth significantly, but also elevated the presence of active CD8 T cells, enhancing antitumor immunity. This shows promise for rutecarpine as a potential treatment for lung cancer, albeit with a nuanced interaction with NAC that requires further exploration.
Read More
8
We explored how n-acetyl-l-cysteine (NAC) interacts with cancer treatments, especially concerning pancreatic ductal adenocarcinoma (PDAC). In a recent study assessing the effects of BIX01294, a G9a histone methyltransferase inhibitor, we discovered intriguing insights into cellular responses. While BIX demonstrated a significant ability to inhibit the growth of PDAC cells, it also triggered apoptosis, or programmed cell death.
What's particularly fascinating is the role NAC played in this context. Our findings revealed that the addition of NAC substantially rescued PDAC cells from the effects of BIX-induced apoptosis. This suggests that NAC may have protective properties against certain cancer therapies, especially those that impact a cell's redox balance.
Although direct claims about NAC's effectiveness as a standalone cancer treatment were not established in this study, its capability to mitigate the adverse effects of BIX on cell death highlights its potential in cancer therapy adjuncts. Moving forward, it will be essential to further investigate NAC's role and refine its application in cancer treatments to better understand its benefits.
What's particularly fascinating is the role NAC played in this context. Our findings revealed that the addition of NAC substantially rescued PDAC cells from the effects of BIX-induced apoptosis. This suggests that NAC may have protective properties against certain cancer therapies, especially those that impact a cell's redox balance.
Although direct claims about NAC's effectiveness as a standalone cancer treatment were not established in this study, its capability to mitigate the adverse effects of BIX on cell death highlights its potential in cancer therapy adjuncts. Moving forward, it will be essential to further investigate NAC's role and refine its application in cancer treatments to better understand its benefits.
Read More
7
We evaluated the effects of n-acetyl-l-cysteine (NAC) in the context of Atractylodes lancea DC. (ALD) research geared towards prostate cancer treatment. ALD has shown promise in inhibiting cancer cell growth and promoting apoptosis, particularly through a mechanism involving reactive oxygen species (ROS). Our exploration highlighted that NAC can influence ROS levels, indicating a possible interplay between NAC and ALD’s anticancer activities.
However, while NAC is commonly recognized for its antioxidant properties, the study did not pinpoint a clear and significant advantage of NAC specifically in the treatment of cancer when assessed in isolation. Instead, its effects were more pronounced when combined with ALD, suggesting a more complex relationship that requires further investigation.
Ultimately, our findings suggest that while NAC can modulate oxidative stress in cancer contexts, its standalone implications remain inconclusive. Further studies are needed to clarify its potential role in cancer treatment, particularly in conjunction with other therapeutic agents like ALD.
However, while NAC is commonly recognized for its antioxidant properties, the study did not pinpoint a clear and significant advantage of NAC specifically in the treatment of cancer when assessed in isolation. Instead, its effects were more pronounced when combined with ALD, suggesting a more complex relationship that requires further investigation.
Ultimately, our findings suggest that while NAC can modulate oxidative stress in cancer contexts, its standalone implications remain inconclusive. Further studies are needed to clarify its potential role in cancer treatment, particularly in conjunction with other therapeutic agents like ALD.
Read More
4
Our study focused on understanding how n-acetyl-l-cysteine (NAC) interacts with high-dose ascorbate in relation to endometrial cancer (EC) treatment. We observed that while high doses of ascorbate showed promising anti-cancer effects, NAC appeared to partially reverse these benefits.
Specifically, in experiments with EC cells, when NAC was introduced alongside ascorbate, some of the tumor-fighting properties of ascorbate were diminished. This suggests that while ascorbate has the potential to inhibit tumor growth and promote cell stress, NAC may interfere with this process.
We also found that the effectiveness of ascorbate was closely linked to the PTEN/AKT/mTOR pathway, which is often altered in endometrial cancer. Overall, our findings indicate that while NAC does have a role in this context, it may not necessarily provide a significant independent benefit against cancer on its own. Further exploration of these interactions will be essential to understand their full implications for treatment strategies.
Specifically, in experiments with EC cells, when NAC was introduced alongside ascorbate, some of the tumor-fighting properties of ascorbate were diminished. This suggests that while ascorbate has the potential to inhibit tumor growth and promote cell stress, NAC may interfere with this process.
We also found that the effectiveness of ascorbate was closely linked to the PTEN/AKT/mTOR pathway, which is often altered in endometrial cancer. Overall, our findings indicate that while NAC does have a role in this context, it may not necessarily provide a significant independent benefit against cancer on its own. Further exploration of these interactions will be essential to understand their full implications for treatment strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Glutathione production improved
I wholeheartedly recommend this modified form of cysteine. It significantly boosts glutathione levels in the body, which is critical in fighting cancer and preventing ageing. Acetylcysteine's detoxifying ability is notable, and its effectiveness is widely recognised in both preventive and curative cardiology practices.
Read More
8
Quality of life enhanced
N-acetyl-L-cysteine is exemplary! It provides antioxidant protection, inhibits premature ageing, and serves as a preventive component against cancer. It alleviates fatigue and speeds up muscle recovery while also thinning phlegm and removing toxins from the body. It has positively impacted my recovery during illness and post-recovery.
Read More
9
Cancer suppression observed
7 people found this helpful
NAC is a remarkable amino acid and powerful antioxidant, functioning as a precursor to glutathione—a critical antioxidant for the body. It detoxifies chemicals effectively and serves as a strong cancer suppressant. I've experienced significant relief from abdominal issues after using NAC, whereas other medications failed. My nails have strengthened, and my hair appears healthier. Overall, I’m pleased!
Read More
7.5
Antioxidant effects noted
1 people found this helpful
A powerful antioxidant effect on cells, protecting them from harmful free radicals, this supplement slows premature ageing and is an effective preventive measure against cancer. It alleviates fatigue and aids muscle recovery after exercise. I've been drinking it during and post-covid to assist my body in detoxifying during a critical time.
Read More
7.5
Immunity boost confirmed
4 people found this helpful
This supplement bolsters immunity effectively. Life Extension is of excellent quality, enhancing glutathione production in the liver to combat cancer. Its powerful antioxidant properties make it ideal for preventing respiratory diseases and aiding detoxification while stabilising blood sugar levels.
Read More
Frequently Asked Questions
8
Quality of life enhanced
N-acetyl-L-cysteine is exemplary! It provides antioxidant protection, inhibits premature ageing, and serves as a preventive component against cancer. It alleviates fatigue and speeds up muscle recovery while also thinning phlegm and removing toxins from the body. It has positively impacted my recovery during illness and post-recovery.
9
Cancer suppression observed
7 people found this helpful
NAC is a remarkable amino acid and powerful antioxidant, functioning as a precursor to glutathione—a critical antioxidant for the body. It detoxifies chemicals effectively and serves as a strong cancer suppressant. I've experienced significant relief from abdominal issues after using NAC, whereas other medications failed. My nails have strengthened, and my hair appears healthier. Overall, I’m pleased!
7.5
Antioxidant effects noted
1 people found this helpful
A powerful antioxidant effect on cells, protecting them from harmful free radicals, this supplement slows premature ageing and is an effective preventive measure against cancer. It alleviates fatigue and aids muscle recovery after exercise. I've been drinking it during and post-covid to assist my body in detoxifying during a critical time.
9
Glutathione production improved
I wholeheartedly recommend this modified form of cysteine. It significantly boosts glutathione levels in the body, which is critical in fighting cancer and preventing ageing. Acetylcysteine's detoxifying ability is notable, and its effectiveness is widely recognised in both preventive and curative cardiology practices.
7.5
Immunity boost confirmed
4 people found this helpful
This supplement bolsters immunity effectively. Life Extension is of excellent quality, enhancing glutathione production in the liver to combat cancer. Its powerful antioxidant properties make it ideal for preventing respiratory diseases and aiding detoxification while stabilising blood sugar levels.
References
- Shen X, Wang J, Kong W, John C, Deng B, et al. High-dose Ascorbate Exhibits Anti-proliferative and Anti-invasive Effects Dependent on PTEN/AKT/mTOR Pathway in Endometrial Cancer and . Int J Biol Sci. 2025;21:1545. doi:10.7150/ijbs.102079
- Jiang ZB, He QH, Kang LP, Jiang S, Liu JN, et al. Rutecarpine Suppresses Non-Small Cell Lung Cancer Progression Through Activating the STING Pathway and Elevating CD8+ T Cells. Chem Biol Drug Des. 2025;105:e70070. doi:10.1111/cbdd.70070
- Ahn CH, Myong JS, Ahmed KR, Rahman MA, Fahim MMH, et al. A pharmacoinformatic approach for studying DC's anticancer potential and control ROS-mediated apoptosis against prostate cancer cells. Front Oncol. 2025;15:1471110. doi:10.3389/fonc.2025.1471110
- Im SS, Seo J, You JE, Bang HW, Kim Y, et al. BIX01294 suppresses PDAC growth through inhibition of glutaminase-mediated glutathione dynamics. Mol Metab. 2025;94:102113. doi:10.1016/j.molmet.2025.102113
