Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
7
We investigated the impact of folic acid (FA) on anxiety and ovarian function in female mice exposed to radiation. By dividing the mice into groups treated with FA and others that weren’t, we observed that those receiving FA showed significantly reduced anxiety levels alongside improvements in ovarian health. The findings highlighted that FA not only supports reproductive performance by preserving ovarian function but may also help manage emotional symptoms linked to radiation exposure. This suggests that folic acid could be a beneficial aid for women undergoing radiation therapy.
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7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
Read More
Most Useful Reviews
9
Noticeable difference
13 people found this helpful
This product has significantly helped my family members suffering from anxiety, panic attacks, and depression, attributed to the MTHFR C677T double mutation. It’s truly worthwhile to incorporate it into our daily supplements.
Read More
9
Helpful for anxiety
1 people found this helpful
I've been taking it for depression and anxiety for years alongside other treatments. Nowadays, it’s the only supplement I take daily, and it does make a difference.
Read More
9
Essential for anxiety
This is a must-have if you are suffering from anxiety.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
- All Researches
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
8
We explored the effects of chlorzoxazone and folic acid on anxiety and cognitive functions in mice suffering from spinocerebellar ataxia type 3 (SCA3).
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
Read More
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
Read More
7
Folic acid alleviates nicotine withdrawal symptoms
We explored how folic acid (FA) could ease anxiety and depression in adolescent male rats going through nicotine withdrawal.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
Read More
7
We explored how folate supplementation might counteract anxiety-like behaviors caused by prenatal ethanol exposure in rodents. Administering folate alongside ethanol during crucial developmental days showed promising results.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Noticeable difference
13 people found this helpful
This product has significantly helped my family members suffering from anxiety, panic attacks, and depression, attributed to the MTHFR C677T double mutation. It’s truly worthwhile to incorporate it into our daily supplements.
Read More
9
Helpful for anxiety
1 people found this helpful
I've been taking it for depression and anxiety for years alongside other treatments. Nowadays, it’s the only supplement I take daily, and it does make a difference.
Read More
9
Essential for anxiety
This is a must-have if you are suffering from anxiety.
Read More
7.5
Increased balance noted
This product has been transformative. I'd always known the importance of folate but hadn't consumed enough. The tablets are easy to swallow, and being vegetarian is a plus. I noticed better energy and mood, which has improved my quality of life. The absence of artificial additives is a bonus. I’m committed to continuing with Optimized Folate and would recommend it to health-conscious individuals seeking to boost folate levels.
Read More
7.5
Effective support
9 people found this helpful
I purchased these in an effort to manage OCD and anxiety, and they have worked exceptionally well.
Read More
Frequently Asked Questions
7.5
Anxiety level improvement
After discovering I struggle to process folic acid, I tried methylfolate. I’ve honestly noticed a difference in my anxiety levels and I'm very satisfied with this brand, which offers good quality at a reasonable price.
7.5
Reduced reliance on medication
My mood and focus improved significantly, and I realised I felt less dependent on my antidepressants and anxiety medications, which is tremendous.
0
Avoid without guidance
1 people found this helpful
BEWARE methyl folate can cause intense anxiety and depression in some people. I am one of them, and it was absolutely dreadful. I would not recommend anyone take this without proper guidance from a health professional.
9
Helpful for anxiety
1 people found this helpful
I've been taking it for depression and anxiety for years alongside other treatments. Nowadays, it’s the only supplement I take daily, and it does make a difference.
7.5
Increased balance noted
This product has been transformative. I'd always known the importance of folate but hadn't consumed enough. The tablets are easy to swallow, and being vegetarian is a plus. I noticed better energy and mood, which has improved my quality of life. The absence of artificial additives is a bonus. I’m committed to continuing with Optimized Folate and would recommend it to health-conscious individuals seeking to boost folate levels.
6
Reduced PMS anxiety
1 people found this helpful
I took these for about six months but stopped due to breast sensitivity. However, they helped significantly with my PMS anxiety, and I felt great. I plan to try a lower potency next time I decide to use folate.
4
Increased anxiety noted
I bought this on the recommendation of my psychotherapist. I take it with an antidepressant for enhanced effectiveness, but I've experienced increased anxiety.
7.5
Anxiety and energy boost
Due to my MTHFR gene deficiency, I’ve noticed an improvement in my anxiety levels and increased energy since taking this product. The pricing is sensible compared to other brands, and the quality is good too.
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
7
Folic acid alleviates nicotine withdrawal symptoms
We explored how folic acid (FA) could ease anxiety and depression in adolescent male rats going through nicotine withdrawal.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
7
We explored how folate supplementation might counteract anxiety-like behaviors caused by prenatal ethanol exposure in rodents. Administering folate alongside ethanol during crucial developmental days showed promising results.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
7
We explored the impact of folic acid (FA) on anxiety and mood disorders, particularly in a mouse model that simulates early immune challenges.
Our findings suggest that FA treatment can significantly improve anxiety and depressive behaviors in adult mice, likely by reducing the activation of certain brain cells called glial cells.
Alongside these behavioral improvements, we noted reduced inflammation in the brain areas related to mood and stress. Importantly, the study highlights different ways FA functions in two types of glial cells and its potential as a treatment for mood disorders stemming from early neurodevelopmental issues.
Our findings suggest that FA treatment can significantly improve anxiety and depressive behaviors in adult mice, likely by reducing the activation of certain brain cells called glial cells.
Alongside these behavioral improvements, we noted reduced inflammation in the brain areas related to mood and stress. Importantly, the study highlights different ways FA functions in two types of glial cells and its potential as a treatment for mood disorders stemming from early neurodevelopmental issues.
References
- Ni WH, Wang K, Wang Y, Lu J, Lu CT, et al. Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats. Neuropharmacology. 2025;269:110352. 10.1016/j.neuropharm.2025.110352
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. 10.1093/hmg/ddae079
- Rezaei Moghadam M, Khoshrou A, Kakhki S, Hosseini SH, Shirinzadeh Feizabadi A, et al. Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats. Nicotine Tob Res. 2024;26:733. 10.1093/ntr/ntad227
- Marengo L, Barey A, Salguero A, Fabio MC, Cendán CM, et al. Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration. Dev Psychobiol. 2023;65:e22426. 10.1002/dev.22426
- Kakhki S, Goodarzi M, Abbaszade-Cheragheali A, Rajabi M, Masoumipour AH, et al. Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring. Int J Dev Neurosci. 2023;83:615. 10.1002/jdn.10289
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Zhang Q, Wei Z, Weng H, Chen Y, Zhang J, et al. Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice. Front Nutr. 2022;9:854655. 10.3389/fnut.2022.854655
- Ono T, Hino K, Kimura T, Uchimura Y, Ashihara T, et al. Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles. Congenit Anom (Kyoto). 2022;62:169. 10.1111/cga.12472
- Zhao T, Wu D, Du J, Liu G, Ji G, et al. Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation. Front Pharmacol. 2022;13:818423. 10.3389/fphar.2022.818423
- Eszlari N, Bruncsics B, Millinghoffer A, Hullam G, Petschner P, et al. Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake. Nutrients. 2021;13. 10.3390/nu13124396
- Zhang Q, Huang Q, Yao L, Liu W, Ruan J, et al. Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice. Front Pharmacol. 2021;12:701009. 10.3389/fphar.2021.701009
- Mahdavifar B, Hosseinzadeh M, Salehi-Abargouei A, Mirzaei M, Vafa M. Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. J Affect Disord. 2021;288:92. 10.1016/j.jad.2021.03.055
- de Carvalho J, Lerner A, Feingold D. Management of Hyperhomocysteinemia, Low Vitamin Levels, and Low Cortisol in Cannabis Users: A Report of 2 Cases. J Chiropr Med. 2022;21:322. 10.1016/j.jcm.2022.03.001
