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SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Addresses folic acid for anxiety relevance
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Read More
8
Folate shows potential in anxiety treatment
Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation.
Study focuses on folate's effects
This study investigated how folic acid (FA), a vitamin commonly recommended during pregnancy, can support mental health by reducing anxiety and depression symptoms. We looked at the effects of FA in a mouse model subjected to postnatal immune activation—an event known to increase the likelihood of developing neuropsychiatric disorders later in life.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
Read More
8
Folic acid aids anxiety treatment
A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice.
Study shows combined therapy benefits
A recent study explored how a combination of chlorzoxazone and folic acid can influence anxiety and cognitive functions. The research focused on SCA3-84Q mice, which exhibit anxiety, memory decline, and signs of low mood due to a genetic condition known as spinocerebellar ataxia type 3.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
Read More
Most Useful Reviews
9.5
Noticeable difference
This product has significantly helped my family members suffering from anxiety, panic attacks, and depression, attributed to the MTHFR C677T double mutation. It’s truly worthwhile to incorporate it into our daily supplements.
Read More
8.8
Effective support
I purchased these in an effort to manage OCD and anxiety, and they have worked exceptionally well.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Addresses folic acid for anxiety relevance
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Read More
8
Folic acid aids anxiety treatment
A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice.
Study shows combined therapy benefits
A recent study explored how a combination of chlorzoxazone and folic acid can influence anxiety and cognitive functions. The research focused on SCA3-84Q mice, which exhibit anxiety, memory decline, and signs of low mood due to a genetic condition known as spinocerebellar ataxia type 3.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
Read More
8
Folic acid eases withdrawal symptoms
Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats.
Moderate relevance due to treatment overlap
We explored the impact of folic acid (FA) on anxiety and depressive-like behaviors in adolescent male rats following nicotine withdrawal. In our study, we divided the rats into groups that received either a nicotine treatment or a vehicle control, then observed their behavior as they experienced withdrawal.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
Read More
8
Folate shows potential in anxiety treatment
Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation.
Study focuses on folate's effects
This study investigated how folic acid (FA), a vitamin commonly recommended during pregnancy, can support mental health by reducing anxiety and depression symptoms. We looked at the effects of FA in a mouse model subjected to postnatal immune activation—an event known to increase the likelihood of developing neuropsychiatric disorders later in life.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
Read More
7
Folate mitigates anxiety effects
Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration.
Moderate relevance for anxiety effects
We examined how folate treatment impacts anxiety in rats that had been exposed to ethanol during a critical developmental window. In this study, Wistar rat pups were given folate alongside ethanol during a key period equivalent to the third trimester in humans, aiming to alleviate the neurobehavioral impairments linked to prenatal ethanol exposure.
We tested the pups for signs of anxiety and exploratory behaviors as they grew. The findings revealed that while prenatal ethanol exposure did lead to some behavioral changes, such as reduced preference for sweets and increased shelter-seeking behavior, there was no significant enhancement of ethanol self-administration or major impacts on performance in standard anxiety tests. Importantly, the administration of folate markedly lessened some of the anxiety-related effects.
Overall, we found that while folate didn't completely erase the impact of prenatal ethanol exposure, it did offer some protective benefits. This suggests that folate could be a promising, low-risk treatment option to help manage anxiety symptoms linked to such developmental challenges.
We tested the pups for signs of anxiety and exploratory behaviors as they grew. The findings revealed that while prenatal ethanol exposure did lead to some behavioral changes, such as reduced preference for sweets and increased shelter-seeking behavior, there was no significant enhancement of ethanol self-administration or major impacts on performance in standard anxiety tests. Importantly, the administration of folate markedly lessened some of the anxiety-related effects.
Overall, we found that while folate didn't completely erase the impact of prenatal ethanol exposure, it did offer some protective benefits. This suggests that folate could be a promising, low-risk treatment option to help manage anxiety symptoms linked to such developmental challenges.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Noticeable difference
This product has significantly helped my family members suffering from anxiety, panic attacks, and depression, attributed to the MTHFR C677T double mutation. It’s truly worthwhile to incorporate it into our daily supplements.
8.8
Effective support
I purchased these in an effort to manage OCD and anxiety, and they have worked exceptionally well.
