Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin C (from ascorbic acid, camu-camu berry extract)
30 mg
33%
Quercetin (as quercetin dihydrate)
250 mg
**
Optimized Food Blend[onion (bulb) (extracts), bitter orange bioflavonoids (peel and fruit), apple (fruit)
220 mg
**
Camu-camu extract (wildcrafted berry)
50 mg
**
Top Medical Research Studies
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
We explored the effects of quercetin, a plant flavonoid, on KON oral cancer cells. Our aim was to understand how quercetin could potentially fight cancer by assessing its anti-growth, anti-migrative, and anti-invasive properties. Using various assays, we treated KON cells with quercetin and observed its impact on their viability compared to normal fibroblast cells.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
Read More
8
Quercetin reduces oral cancer cell viability
We explored the effects of quercetin, a natural flavonoid, on oral cancer during a systematic review of existing studies. Our investigation included a thorough screening process, where we analyzed 193 articles and selected 18 that met our inclusion criteria.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Read More
Most Useful Reviews
9
Reduces cancer risk
7 people found this helpful
Quercetin is a powerful antioxidant that has a strong healing effect on the body. It addresses efforts to combat diseases such as stroke and heart attack. The anti-inflammatory properties of quercetin benefit blood vessels, lower blood pressure, and help prevent atherosclerosis. Its antioxidant action reduces the risk of cardiovascular disease. Including foods, particularly fruits and vegetables, rich in quercetin in your diet can significantly lower the risk of dangerous diseases. Quercetin possesses strong anti-tumour properties and can inhibit the growth of new cancer cells. In larger doses, it may even eliminate cancer cells.
Read More
9
Promotes overall health
Good supplement! Quercetin is a powerful antioxidant that has a strong healing effect on the body. It is a potential solution for combating diseases such as stroke and heart attack. Its anti-inflammatory properties benefit blood vessels, lower pressure, and protect against atherosclerosis. The antioxidant action reduces the risk of cardiovascular disease. Quercetin also has notable anti-tumour properties and can inhibit the development of new cancer cells. In large amounts, it can eliminate cancer cells. I wish everyone health and peace!
Read More
7.5
Supports cancer treatment
1 people found this helpful
Life Extension's Optimised Quercetin supplement is a high-quality product that provides a potent dose of quercetin, a flavonoid antioxidant with several health benefits. Quercetin is known for its ability to support a healthy immune system, reduce inflammation, and promote cardiovascular health. It may also have anti-cancer properties and aid in healthy ageing.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
- All Researches
9.5
Quercetin enhances cancer treatment efficacy
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Read More
9
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Read More
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
Quercetin combats cancer drug resistance
We explored the potential of quercetin, a natural compound found in various fruits and vegetables, in combating resistance to the cancer drug trastuzumab, particularly in patients with HER2-positive gastric cancer. Our study investigated how quercetin, as part of a mixture known as Jian Pi Hua Tan Fang (JPHTF), could enhance the effectiveness of this treatment.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Read More
9
Our research delved into the effects of quercetin, a flavonoid commonly found in plants, on hepatocellular carcinoma (HCC), a prevalent form of liver cancer. We focused on the role of the Farnesoid X receptor (FXR), which is crucial for maintaining liver health and metabolism. By investigating how quercetin influences the glycolysis pathway through FXR signaling, we sought to uncover its anti-cancer properties.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces cancer risk
7 people found this helpful
Quercetin is a powerful antioxidant that has a strong healing effect on the body. It addresses efforts to combat diseases such as stroke and heart attack. The anti-inflammatory properties of quercetin benefit blood vessels, lower blood pressure, and help prevent atherosclerosis. Its antioxidant action reduces the risk of cardiovascular disease. Including foods, particularly fruits and vegetables, rich in quercetin in your diet can significantly lower the risk of dangerous diseases. Quercetin possesses strong anti-tumour properties and can inhibit the growth of new cancer cells. In larger doses, it may even eliminate cancer cells.
Read More
9
Promotes overall health
Good supplement! Quercetin is a powerful antioxidant that has a strong healing effect on the body. It is a potential solution for combating diseases such as stroke and heart attack. Its anti-inflammatory properties benefit blood vessels, lower pressure, and protect against atherosclerosis. The antioxidant action reduces the risk of cardiovascular disease. Quercetin also has notable anti-tumour properties and can inhibit the development of new cancer cells. In large amounts, it can eliminate cancer cells. I wish everyone health and peace!
Read More
7.5
Supports cancer treatment
1 people found this helpful
Life Extension's Optimised Quercetin supplement is a high-quality product that provides a potent dose of quercetin, a flavonoid antioxidant with several health benefits. Quercetin is known for its ability to support a healthy immune system, reduce inflammation, and promote cardiovascular health. It may also have anti-cancer properties and aid in healthy ageing.
Read More
7.5
Cancer prevention benefits
1 people found this helpful
This substance may help prevent cancer or inhibit the growth of cancerous tumours, contributing to resistance against several types, such as lung and prostate cancer. Additionally, it may promote brain cell health, potentially reducing the likelihood of diseases such as Alzheimer's and Parkinson's. It also helps resist free radicals that the body encounters from various sources, including cigarette smoke and radiation.
Read More
7.5
Essential for patients
Very good product, a must-have supplement for cancer patients.
Read More
Frequently Asked Questions
9
Reduces cancer risk
7 people found this helpful
Quercetin is a powerful antioxidant that has a strong healing effect on the body. It addresses efforts to combat diseases such as stroke and heart attack. The anti-inflammatory properties of quercetin benefit blood vessels, lower blood pressure, and help prevent atherosclerosis. Its antioxidant action reduces the risk of cardiovascular disease. Including foods, particularly fruits and vegetables, rich in quercetin in your diet can significantly lower the risk of dangerous diseases. Quercetin possesses strong anti-tumour properties and can inhibit the growth of new cancer cells. In larger doses, it may even eliminate cancer cells.
7.5
Supports cancer treatment
1 people found this helpful
Life Extension's Optimised Quercetin supplement is a high-quality product that provides a potent dose of quercetin, a flavonoid antioxidant with several health benefits. Quercetin is known for its ability to support a healthy immune system, reduce inflammation, and promote cardiovascular health. It may also have anti-cancer properties and aid in healthy ageing.
7.5
Essential for patients
Very good product, a must-have supplement for cancer patients.
7.5
Cancer prevention benefits
1 people found this helpful
This substance may help prevent cancer or inhibit the growth of cancerous tumours, contributing to resistance against several types, such as lung and prostate cancer. Additionally, it may promote brain cell health, potentially reducing the likelihood of diseases such as Alzheimer's and Parkinson's. It also helps resist free radicals that the body encounters from various sources, including cigarette smoke and radiation.
4
Enhances immunity
1 people found this helpful
Excellent! I took this to maintain immunity and prevent viral diseases. Quercetin combats infectious diseases, cardiovascular diseases, asthma, and arthritis, and reduces the risk of cancer. It also aids in zinc absorption.
9.5
Quercetin enhances cancer treatment efficacy
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
9
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
8
Quercetin reduces oral cancer cell viability
We explored the effects of quercetin, a natural flavonoid, on oral cancer during a systematic review of existing studies. Our investigation included a thorough screening process, where we analyzed 193 articles and selected 18 that met our inclusion criteria.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
9
Our research delved into the effects of quercetin, a flavonoid commonly found in plants, on hepatocellular carcinoma (HCC), a prevalent form of liver cancer. We focused on the role of the Farnesoid X receptor (FXR), which is crucial for maintaining liver health and metabolism. By investigating how quercetin influences the glycolysis pathway through FXR signaling, we sought to uncover its anti-cancer properties.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
References
- Verma M, Yadav K, Parihar R, Dutta D, Chaudhuri S, et al. Active tumor targeting by core-shell PDMS-HA nanoparticles with sequential delivery of doxorubicin and quercetin to overcome P-glycoprotein efflux pump. Nanoscale. 2025;17:5033. doi:10.1039/d4nr03040k
- Wang J, Yang JH, Xiong D, Chen L. Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma. Hum Exp Toxicol. 2025;44:9603271251323753. doi:10.1177/09603271251323753
- Saadh MJ, Ahmed HH, Chandra M, Al-Hussainy AF, Hamid JA, et al. Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis. Cancer Cell Int. 2025;25:66. doi:10.1186/s12935-025-03694-1
- Mukherjee S, Banik SK, Chakraborty S, Das T, Choudhury MD, et al. Bryophyllum pinnatum Induces p53-Dependent Apoptosis of Colorectal Cancer Cells via Increased Intracellular ROS and G2/M Cell-Cycle Arrest In Vitro and Validated in Silico by Molecular Docking. Cell Biol Int. 2025. doi:10.1002/cbin.70004
- Alsaab J, Sarawi WS, Alhusaini AM, Hasan IH, Alturaif S, et al. Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways. Food Chem Toxicol. 2025;199:115341. doi:10.1016/j.fct.2025.115341
- Sun J, Sha M, Zhou J, Huang Y. Quercetin affects apoptosis and autophagy in pediatric acute myeloid leukaemia cells by inhibiting PI3K/AKT signaling pathway activation through regulation of miR-224-3p/PTEN axis. BMC Cancer. 2025;25:318. doi:10.1186/s12885-025-13709-9
- Han S, Yi YW, Kim H, Lee MY, Choi H, et al. Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells. Biomed Pharmacother. 2025;184:117930. doi:10.1016/j.biopha.2025.117930
- Martínez-Esquivias F, Guzmán-Flores JM, Pech-Santiago EO, Guerrero-Barrera AL, Delgadillo-Aguirre CK, et al. Therapeutic Role of Quercetin in Prostate Cancer: A Study of Network Pharmacology, Molecular Docking, and Dynamics Simulation. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01697-3
- Chuang CH, Tai YA, Wu TJ, Ho YJ, Yeh SL. Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling. Front Nutr. 2025;12:1530132. doi:10.3389/fnut.2025.1530132
- Singh T, Rastogi M, Thakur K. Network pharmacology and in silico approach to study the mechanism of quercetin against breast cancer. In Silico Pharmacol. 2025;13:22. doi:10.1007/s40203-025-00306-8
- Hu J, Bu W, Ding Y, Li X, Zhang B, et al. Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2-Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation. Immun Inflamm Dis. 2025;13:e70154. doi:10.1002/iid3.70154
- Zhong W, Chen T, Chen L, Xing Y, Lin H, et al. Crippled Hepatocarcinogenesis Inhibition of Quercetin in Glycolysis Pathway with Hepatic Farnesoid X Receptor Deficiency. Curr Pharm Des. 2025. doi:10.2174/0113816128342642250111055339
- Qiu C, Xia F, Tu Q, Tang H, Liu Y, et al. Multimodal lung cancer theranostics via manganese phosphate/quercetin particle. Mol Cancer. 2025;24:43. doi:10.1186/s12943-025-02242-9
- Tubtimsri S, Chuenbarn T, Manmuan S. Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells. BMC Complement Med Ther. 2025;25:34. doi:10.1186/s12906-025-04782-5
- Wen C, Tang J, Wu M, Liu H, Lin X, et al. Preparation, characterization, and stability of pectin-whey protein isolate-based nanoparticles with mitochondrial targeting ability. Int J Biol Macromol. 2025;301:140383. doi:10.1016/j.ijbiomac.2025.140383
- Wang G, Wang D, Xia L, Lian J, Zhang Q, et al. Metal-Phenolic Nanomedicines Targeting Fatty Acid Metabolic Reprogramming to Overcome Immunosuppression in Radiometabolic Cancer Therapy. ACS Appl Mater Interfaces. 2025;17:7478. doi:10.1021/acsami.4c21028
- Velásquez Bravo A, Martínez Medina JJ, López Tevez LL, Restrepo AG, Huamaní ÁL, et al. Structural related oxidovanadium(IV)-flavonoid complexes. Influence on their anticancer effects. J Inorg Biochem. 2025;268:112915. doi:10.1016/j.jinorgbio.2025.112915
- Zhang J, Qi S, Du Y, Dai H, Liu N. Effect of quercetin on inhibiting gefitinib‑activated non‑small cell lung cancer‑induced cell pyroptosis in cardiomyocytes via modulating mitochondrial autophagy mediated by the SHP2/ROS/AMPK/XBP‑1/DJ‑1 signaling pathway. Oncol Rep. 2025;53. doi:10.3892/or.2025.8890
- Ramadan DR, Osman HA, Madhy SA, Teleb M, Darwish AI, et al. A tailored 4G -triazine-based dendrimer vehicle for quercetin endowed with MMP-2/9 inhibition and VEGF downregulation for targeting breast cancer progression and liver metastasis. RSC Adv. 2025;15:10426. doi:10.1039/d5ra01588j
- El Gendy SN, Elmotayam AK, Samir R, Ezzat MI, Abo-Elfadl MT, et al. Biotransformation of quercetin by Bacillus subtilis and anticancer activity evaluation: in vitro and in Silico. AMB Express. 2025;15:58. doi:10.1186/s13568-025-01860-2
- Wu J, Zhang J, Shu W, Feng W, Meng R, et al. Kitag. (Binpu-3) root extract inhibits tumor invasion via Notch signaling in and human breast cancer MDA-MB-231 cells. Front Pharmacol. 2025;16:1494545. doi:10.3389/fphar.2025.1494545
- Mukherjee A, Ghosh S, Ganguli S, Basu J, Basu B. Antiproliferative and Apoptotic Efficacy of Nano-PLGA Encapsulated Quercetin Molecules by Downregulation of Akt in K-ras Mutated NSCLC Cell Lines, A549 and H460. J Biochem Mol Toxicol. 2025;39:e70240. doi:10.1002/jbt.70240
- Siddiqui AJ, Elkahoui S, Alshammari AM, Patel M, Ghoniem AEM, et al. Mechanistic Insights into the Anticancer Potential of Willd. Against Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Study. Pharmaceuticals (Basel). 2025;18. doi:10.3390/ph18030433
- Hussein SA, Ababneh NA, Tarawneh N, Ismail MA, Awidi A, et al. Antitumor Effects of Quercetin and Luteolin in A375 Cutaneous Melanoma Cell Line Are Mediated by Upregulation of P-ERK, c-Myc, and the Upstream GPER. Life (Basel). 2025;15. doi:10.3390/life15030417
- Pawar CS, Balamurugan K, Baskar S, Prasad NR, Khan HA. Enhancing Chemosensitivity in Drug-Resistant Breast Cancer Cells Using β-Cyclodextrin-Loaded Quercetin and Doxorubicin Inclusion Complex via Modulating SRC/PI3K/Akt Pathway. Appl Biochem Biotechnol. 2025. doi:10.1007/s12010-025-05219-y
- Ma S, Zhang X, Zhu X, Yan K, Wang Q, et al. Dual-modality immune nano-activator harnessing Mn⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy. J Nanobiotechnology. 2025;23:248. doi:10.1186/s12951-025-03336-8
- Sun G, Wu Y, Li J, Yang M, Xu H, et al. Quercetin liposomes conjugated with hyaluronidase: An efficient drug delivery system to block pancreatic cancer. J Control Release. 2025;382:113642. doi:10.1016/j.jconrel.2025.113642
- Yang C, Ma H, Liang Z, Zhuang Y, Hu L, et al. Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer. Int J Biol Macromol. 2025;308:142272. doi:10.1016/j.ijbiomac.2025.142272
- Silva-Pinto PA, de Pontes JTC, Aguilar-Morón B, Canales CSC, Pavan FR, et al. Phytochemical insights into flavonoids in cancer: Mechanisms, therapeutic potential, and the case of quercetin. Heliyon. 2025;11:e42682. doi:10.1016/j.heliyon.2025.e42682
- Zafar M, Anwar S, Hussain MA, Iqbal N, Ali A, et al. Elucidation of -derived natural compounds in STAT 3 pathway against human cancer cells: and studies. Front Pharmacol. 2025;16:1507002. doi:10.3389/fphar.2025.1507002
- Tiburzi S, Lezcano V, Principe G, Montiel Schneider MG, Miravalles AB, et al. Quercetin-loaded magnetic nanoparticles: a promising tool for antitumor treatment in human breast cancer cells. J Drug Target. 2025. doi:10.1080/1061186X.2025.2477764
- Mehrabadi S. Quercetin's Potential Therapeutic Role in Human Colorectal Cancer: An Effective Strategy for Prevention and Treatment. Anticancer Agents Med Chem. 2025. doi:10.2174/0118715206354948250226103832
