5/13/2025
Last update
5/13/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 5 Reviews
7
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Zinc (as OptiZinc® zinc monomethionine, zinc citrate)
50 mg
455%
Top Medical Research Studies
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
Most Useful Reviews
9
Constipation resolved
Zinc in capsules is of top quality with good ingredients, and I noticed health improvements. The dosage is reasonable, and I noticed immediate benefits, including improved digestion. My microbiome became noticeably better, and my intestines began to function well; constipation passed. It supports immunity, acidity, and overall effectiveness.
Read More
6
Helps with constipation
Mushroom supplements are of good quality and support longevity. The ingredients are beneficial, with no smell or taste. They can aid in sleep, relieve stress, and stabilise mood. This superfood assists in detoxification, digestion, and even helps clear the stomach while addressing constipation issues.
Read More
4
Moderate constipation
My personal evaluation thus far is that the zinc caused me constipation, but there was no nausea. I only experienced nausea initially. I took it without breakfast, then waited until I had eaten, and everything was fine. I will finish the package and then reconsider.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Constipation resolved
Zinc in capsules is of top quality with good ingredients, and I noticed health improvements. The dosage is reasonable, and I noticed immediate benefits, including improved digestion. My microbiome became noticeably better, and my intestines began to function well; constipation passed. It supports immunity, acidity, and overall effectiveness.
Read More
6
Helps with constipation
Mushroom supplements are of good quality and support longevity. The ingredients are beneficial, with no smell or taste. They can aid in sleep, relieve stress, and stabilise mood. This superfood assists in detoxification, digestion, and even helps clear the stomach while addressing constipation issues.
Read More
4
Moderate constipation
My personal evaluation thus far is that the zinc caused me constipation, but there was no nausea. I only experienced nausea initially. I took it without breakfast, then waited until I had eaten, and everything was fine. I will finish the package and then reconsider.
Read More
0
Caused constipation
Didn't like it. Zinc caused terrible constipation for me and my mother, so we ultimately decided to throw it away.
Read More
2
Severe constipation
1 people found this helpful
I was prescribed zinc when diagnosed with Covid-19. Initially, I took Zinc Picolinate 22mg. Once it finished, I was left with this larger dosage, which was in capsule form and couldn't be divided. I began taking it every other day, but I experienced terrible constipation. Initially, I didn't associate it with the zinc, yet it affected my entire family. After suffering for two weeks, I decided to discontinue the zinc, even though I would prefer manufacturers produce more manageable dosages.
Read More
Frequently Asked Questions
9
Constipation resolved
Zinc in capsules is of top quality with good ingredients, and I noticed health improvements. The dosage is reasonable, and I noticed immediate benefits, including improved digestion. My microbiome became noticeably better, and my intestines began to function well; constipation passed. It supports immunity, acidity, and overall effectiveness.
2
Severe constipation
1 people found this helpful
I was prescribed zinc when diagnosed with Covid-19. Initially, I took Zinc Picolinate 22mg. Once it finished, I was left with this larger dosage, which was in capsule form and couldn't be divided. I began taking it every other day, but I experienced terrible constipation. Initially, I didn't associate it with the zinc, yet it affected my entire family. After suffering for two weeks, I decided to discontinue the zinc, even though I would prefer manufacturers produce more manageable dosages.
6
Helps with constipation
Mushroom supplements are of good quality and support longevity. The ingredients are beneficial, with no smell or taste. They can aid in sleep, relieve stress, and stabilise mood. This superfood assists in detoxification, digestion, and even helps clear the stomach while addressing constipation issues.
0
Caused constipation
Didn't like it. Zinc caused terrible constipation for me and my mother, so we ultimately decided to throw it away.
4
Moderate constipation
My personal evaluation thus far is that the zinc caused me constipation, but there was no nausea. I only experienced nausea initially. I took it without breakfast, then waited until I had eaten, and everything was fine. I will finish the package and then reconsider.
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
References
- Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.
