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SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8.2
USERS' SCORE
Good
Based on 41 Reviews
8.7
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
9.5
Selenium drug shows selective toxicity
Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.
Direct evaluation of selenium's efficacy
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
8
Gamma-tocopherol in cancer research
Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.
Strong focus on cancer effects
We examined the effects of gamma-tocopherol, a major form of vitamin E, on cancer treatment and prevention. This powerful antioxidant is noted for its ability to combat oxidative stress, which plays a significant role in the development and progression of various cancers.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
Read More
8
Selenium's role in lung cancer
Selenium-containing compounds, selenium nanoparticles and selenoproteins in the prevention and treatment of lung cancer.
Direct focus on lung cancer
We explored how selenium, a trace element, can play a role in preventing and treating lung cancer. This review focused on various forms of selenium, including sodium selenite, methylselenic acid, selenomethionine, and selenium nanoparticles.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
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Most Useful Reviews
8.8
Defence against cancer
Selenium is indispensable for maintaining health, based on its role in protecting against cancer through its antioxidant activity. A daily intake has notably increased my immune response and offers protection against harmful metals.
Read More
9.5
Cancer treatment benefits
Excellent! Selenium may have anti-cancer properties through its antioxidant effects and ability to enhance the immune system, aiding in cancer elimination at early stages. It's vital for women, as it accelerates thyroid hormone synthesis, normalises the function of over two hundred enzymes and hormones, slows skin ageing, boosts coenzyme Q-10 production, and positively impacts heart, joint and bone health.
Read More
9.5
Improves immunity
I’ve taken selenium for nearly six years since my father had lung adenocarcinoma. I learned that selenium has anti-tumour effects and chose this supplement. Everyone in my family takes it, and I feel it enhances our antioxidant capacity and immunity. We will continue to use it!
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8.2
9.5
Selenium drug shows selective toxicity
Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.
Direct evaluation of selenium's efficacy
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
9
Nanoparticles improve cancer therapies
Computer-Aided Design of Self-Assembled Nanoparticles to Enhance Cancer Chemoimmunotherapy via Dual-Modulation Strategy.
Combination treatments complicate isolation
This study focuses on the innovative use of self-assembled nanoparticles to improve cancer treatment, particularly for triple-negative breast cancer. By leveraging computer-aided strategies, researchers identified key properties that guide the creation of these nanoparticles.
We observed that vitamin E, when combined with hydroxychloroquine and bortezomib, resulted in a unique nanoparticle formulation. This formulation not only helps reduce harmful M2-type tumor-associated macrophages but also induces a process known as immunogenic cell death in tumor cells.
In experiments conducted on mouse models, the nanoparticles displayed promising results. They effectively decreased levels of regulatory T cells and transforming growth factor-β while enhancing the presence of cytotoxic T lymphocytes. Moreover, they inhibited the secretion of a pro-inflammatory factor known as Interleukin-6, which can contribute to tumor growth and poor immune response.
The combination of vitamin E and other compounds showcases a dual modulation approach, potentially reprogramming the tumor microenvironment to enhance chemotherapy combined with immunotherapy.
However, while the study highlights potential benefits, it also suggests that isolating vitamin E's effect in cancer treatment is challenging due to its application alongside other treatments.
We observed that vitamin E, when combined with hydroxychloroquine and bortezomib, resulted in a unique nanoparticle formulation. This formulation not only helps reduce harmful M2-type tumor-associated macrophages but also induces a process known as immunogenic cell death in tumor cells.
In experiments conducted on mouse models, the nanoparticles displayed promising results. They effectively decreased levels of regulatory T cells and transforming growth factor-β while enhancing the presence of cytotoxic T lymphocytes. Moreover, they inhibited the secretion of a pro-inflammatory factor known as Interleukin-6, which can contribute to tumor growth and poor immune response.
The combination of vitamin E and other compounds showcases a dual modulation approach, potentially reprogramming the tumor microenvironment to enhance chemotherapy combined with immunotherapy.
However, while the study highlights potential benefits, it also suggests that isolating vitamin E's effect in cancer treatment is challenging due to its application alongside other treatments.
Read More
9
Vitamin E reprograms immune cells
Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.
High relevance to cancer treatment
Our study delves into the innovative use of vitamin E as part of a lipid nanosystem to change the behavior of tumor-associated macrophages (TAMs). These immune cells typically foster a pro-cancer environment, and we aimed to see if reprogramming them could impact pancreatic cancer's progression and metastasis, particularly in the liver.
We found that treating M2-polarized macrophages with a nanoemulsion of vitamin E and sphingomyelin made them shift from a pro-tumor state to a more neutral or anti-tumor state. The treatment decreased markers associated with the M2 phenotype, which promotes cancer growth, and increased markers of the M1 phenotype that fight cancer. Notably, when we coupled this treatment with a drug that inhibits TGF-βR1, it led to reduced tumor growth and liver metastasis in models of pancreatic cancer.
This work underscores vitamin E's potential as a part of a broader therapeutic strategy aimed at reprogramming immune cells to better combat cancer. By targeting TAMs, we are opening new avenues for treatments that not only manage the primary tumors but also curb the spread of cancer to other organs, like the liver, which is vital for improving outcomes for patients dealing with aggressive forms of the disease.
We found that treating M2-polarized macrophages with a nanoemulsion of vitamin E and sphingomyelin made them shift from a pro-tumor state to a more neutral or anti-tumor state. The treatment decreased markers associated with the M2 phenotype, which promotes cancer growth, and increased markers of the M1 phenotype that fight cancer. Notably, when we coupled this treatment with a drug that inhibits TGF-βR1, it led to reduced tumor growth and liver metastasis in models of pancreatic cancer.
This work underscores vitamin E's potential as a part of a broader therapeutic strategy aimed at reprogramming immune cells to better combat cancer. By targeting TAMs, we are opening new avenues for treatments that not only manage the primary tumors but also curb the spread of cancer to other organs, like the liver, which is vital for improving outcomes for patients dealing with aggressive forms of the disease.
Read More
9
Vitamin E impacts cancer growth
Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity.
High relevance to cancer treatment
We observed that vitamin E succinate (VES) has the potential to serve as a tool for fighting cancer, particularly by targeting a protein called fat mass and obesity-associated protein (FTO), which plays a role in tumor growth. This study highlights how VES can act as a degrader of FTO, leading to its suppression, thereby hindering tumor progression and enhancing the effectiveness of immunotherapy.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
Read More
9
Vitamin E enhances cancer treatment
Combination therapy of Lapatinib/Letrozole-based protein-vitamin nanoparticles to enhance the therapeutic effectiveness in drug-resistant breast cancer.
Evaluates combination therapy effectiveness
In our exploration of breast cancer treatments, we investigated how nanoparticles infused with vitamin E could effectively deliver cancer medications. Our study specifically focused on drug-resistant HER2-positive breast cancer, which is challenging to treat due to its tendency to develop resistance to standard therapies.
We developed nanoparticles from human serum albumin linked with vitamin E, designed to encapsulate and deliver targeted cancer drugs. Through sophisticated methods, including infrared spectroscopy and cell viability assays, we confirmed that the nanoparticles efficiently bound the drugs and released them over time.
Our results revealed that combining these vitamin E-laden nanoparticles—specifically Lapatinib and Letrozole—in a carefully designed ratio led to a substantial reduction in tumor growth. This combination not only outperformed individual treatments but also proved effective in drug-resistant cell lines, showcasing the potential of vitamin E as a vehicle for enhancing cancer therapy.
Overall, while the study highlighted the promising role of vitamin E in this innovative drug delivery approach, it primarily emphasized the combined effects of the therapies rather than isolating vitamin E's impact alone.
We developed nanoparticles from human serum albumin linked with vitamin E, designed to encapsulate and deliver targeted cancer drugs. Through sophisticated methods, including infrared spectroscopy and cell viability assays, we confirmed that the nanoparticles efficiently bound the drugs and released them over time.
Our results revealed that combining these vitamin E-laden nanoparticles—specifically Lapatinib and Letrozole—in a carefully designed ratio led to a substantial reduction in tumor growth. This combination not only outperformed individual treatments but also proved effective in drug-resistant cell lines, showcasing the potential of vitamin E as a vehicle for enhancing cancer therapy.
Overall, while the study highlighted the promising role of vitamin E in this innovative drug delivery approach, it primarily emphasized the combined effects of the therapies rather than isolating vitamin E's impact alone.
Read More
User Reviews
USERS' SCORE
Good
Based on 41 Reviews
8.7
9.5
Supports youthfulness
Selenium significantly influences health, protecting cell membranes and neutralising toxins. It prevents cancer development and promotes healthy skin and reproductive functions. With added vitamin E, this complex enhances antioxidant protection and counters ageing. I find it invaluable in maintaining my vitality.
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9.5
Skin improvement
This selenium supplement has proven beneficial for my skin issues, quickly alleviating redness and swelling. Alongside vitamins and zinc, it provides an effective alternative to conventional treatments. I now regard it as essential for my health, particularly for liver protection and reducing cancer risks.
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9.5
Fights ageing
Selenium aids in combating premature ageing and supports glutathione peroxidase, which protects against oxidative damage and cancer. Food sources are often insufficient, hence this supplement is beneficial. Regular intake bolsters immunity, enhances heart health, and supports healthy cell division.
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9.5
Detox aid
Selenium significantly slows down ageing and combats cancer. Its detoxifying properties improve menstrual health and gastrointestinal function. I regularly buy this supplement, appreciating its wide range of benefits.
9.5
Cancer treatment benefits
Excellent! Selenium may have anti-cancer properties through its antioxidant effects and ability to enhance the immune system, aiding in cancer elimination at early stages. It's vital for women, as it accelerates thyroid hormone synthesis, normalises the function of over two hundred enzymes and hormones, slows skin ageing, boosts coenzyme Q-10 production, and positively impacts heart, joint and bone health.
Read More
