5/16/2025
Last update
5/16/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
125 mcg
625%
Top Medical Research Studies
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
Most Useful Reviews
9
Cancer risk reduction
4 people found this helpful
Vitamin D is the most potent steroid hormone and possesses exceptional anticancer properties. Achieving a blood vitamin D level of 50 ng/ml decreases cancer risk by 75% overall, breast cancer risk by 70%, and colon cancer risk by 67%. It’s crucial to increase vitamin D levels before illness, as starting post-symptoms has no effect on severity. A study from 2018 found that women with 25 (OH) D concentrations of 60 ng/ml or greater had an 80% lower risk of developing breast cancer compared to those with levels below 20 ng/ml. Vitamin D is vital for reducing cancer risks and should be maintained at optimal levels.
Read More
9
Cancer prevention
Vitamin D is essential, and I have been taking it for several years. It is beneficial in preventing cancer as well as aiding sleep. I take one daily alongside Omega 3. The packaging is good and it absorbs quickly, which I appreciate.
Read More
7.5
Consistent vitamin D
1 people found this helpful
Vitamin D from a reputable manufacturer! As it has recently been established, vitamin D functions as a hormone D, enhancing muscle tone and strengthening immunity. It's vital for thyroid function and normal blood clotting. Additionally, it aids in restoring protective sheaths around nerves and regulates blood pressure while preventing cancer cell growth. I recommend taking it year-round in a small daily dosage of 1000, provided levels in the body are adequate. Higher doses are necessary for restoration. Vitamin D has a cumulative effect, so overdose risk is minimal. If my review was useful, please give it a like!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
- All Researches
9
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
Read More
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
We explored the potential benefits of a vitamin D analog in treating prostate cancer, which is a major cause of cancer-related deaths among men. Our work focused on understanding how this vitamin D form impacts cancer resistance and the tumor microenvironment. We used the Pten mouse model to observe the therapeutic effects of the vitamin D analog.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
Read More
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
8
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cancer risk reduction
4 people found this helpful
Vitamin D is the most potent steroid hormone and possesses exceptional anticancer properties. Achieving a blood vitamin D level of 50 ng/ml decreases cancer risk by 75% overall, breast cancer risk by 70%, and colon cancer risk by 67%. It’s crucial to increase vitamin D levels before illness, as starting post-symptoms has no effect on severity. A study from 2018 found that women with 25 (OH) D concentrations of 60 ng/ml or greater had an 80% lower risk of developing breast cancer compared to those with levels below 20 ng/ml. Vitamin D is vital for reducing cancer risks and should be maintained at optimal levels.
Read More
9
Cancer prevention
Vitamin D is essential, and I have been taking it for several years. It is beneficial in preventing cancer as well as aiding sleep. I take one daily alongside Omega 3. The packaging is good and it absorbs quickly, which I appreciate.
Read More
7.5
Consistent vitamin D
1 people found this helpful
Vitamin D from a reputable manufacturer! As it has recently been established, vitamin D functions as a hormone D, enhancing muscle tone and strengthening immunity. It's vital for thyroid function and normal blood clotting. Additionally, it aids in restoring protective sheaths around nerves and regulates blood pressure while preventing cancer cell growth. I recommend taking it year-round in a small daily dosage of 1000, provided levels in the body are adequate. Higher doses are necessary for restoration. Vitamin D has a cumulative effect, so overdose risk is minimal. If my review was useful, please give it a like!
Read More
9
Restores vitamin levels
Replenishing vitamin D deficiency is crucial as it promotes muscle tone, boosts immunity, and is essential for thyroid function and blood clotting. It aids in restoring the protective sheath of nerves, regulates blood pressure, and most importantly, prevents the growth of cancer cells.
Read More
8
Bone growth support
Vitamin D ensures proper bone growth, preventing rickets and osteoporosis by regulating mineral metabolism. It promotes muscle tone, enhances immunity, and is essential for thyroid function and normal blood clotting. Additionally, it aids in restoring protective nerve membranes and regulates blood pressure. Vitamin D also inhibits cancer cell growth. Ongoing research into its effects on cognitive functionalities and mood disorders is promising. The quality of this product is good, the tablets are easy to swallow, and I have resolved my D3 deficiency.
Read More
Frequently Asked Questions
7.5
Effective and fast result
Wonderful! This product is effective. After four months of use, my blood test results reached maximum levels. When tested, my result was 86 compared to the standard range of 30-80. I would recommend this, but monitoring is important since various factors can affect results. Vitamin D positively impacts insulin resistance and metabolic functions, reducing the risk of cancer, enhancing resilience against SARS, and alleviating pain during childbirth. If this review was helpful, please leave a like.
7.5
Consistent vitamin D
1 people found this helpful
Vitamin D from a reputable manufacturer! As it has recently been established, vitamin D functions as a hormone D, enhancing muscle tone and strengthening immunity. It's vital for thyroid function and normal blood clotting. Additionally, it aids in restoring protective sheaths around nerves and regulates blood pressure while preventing cancer cell growth. I recommend taking it year-round in a small daily dosage of 1000, provided levels in the body are adequate. Higher doses are necessary for restoration. Vitamin D has a cumulative effect, so overdose risk is minimal. If my review was useful, please give it a like!
7.5
Prevents cancer risk
Since this is a product taken daily, its effects are subtle; however, vitamin D is reputedly beneficial in preventing cancer, dementia, and ageing. Therefore, I take it each day to avoid deficiency. Although there are numerous cheaper alternatives, I purchase this product with confidence in the quality of this company's offerings.
6
Supports overall health
Vitamin D is essential! It is particularly effective in adults and children, enhancing calcium absorption, boosting immune defence, and regulating nervous system functions. It also improves mood and brain performance, while reducing the risk of cancer. In adults, it prevents cardiovascular diseases, endocrine issues, osteoporosis, and multiple sclerosis.
6
Growth and immunity
This vitamin ensures normal bone growth, prevents rickets and osteoporosis through mineral regulation, promotes muscle tone, boosts immunity, and is necessary for the thyroid and blood clotting functions. It aids the body in restoring protective nerve membranes and is involved in blood pressure and heartbeat regulation, while inhibiting cancer cell growth.
9
Cancer prevention
Vitamin D is essential, and I have been taking it for several years. It is beneficial in preventing cancer as well as aiding sleep. I take one daily alongside Omega 3. The packaging is good and it absorbs quickly, which I appreciate.
9
Cancer risk reduction
4 people found this helpful
Vitamin D is the most potent steroid hormone and possesses exceptional anticancer properties. Achieving a blood vitamin D level of 50 ng/ml decreases cancer risk by 75% overall, breast cancer risk by 70%, and colon cancer risk by 67%. It’s crucial to increase vitamin D levels before illness, as starting post-symptoms has no effect on severity. A study from 2018 found that women with 25 (OH) D concentrations of 60 ng/ml or greater had an 80% lower risk of developing breast cancer compared to those with levels below 20 ng/ml. Vitamin D is vital for reducing cancer risks and should be maintained at optimal levels.
4
Improved health benefits
3 people found this helpful
Good formulation. No vitamin enhances health like vitamin D (vitamin D3 or cholecalciferol). Current research indicates that vitamin D may play a significant role in preventing SARS and upper respiratory infections. Numerous studies have highlighted that individuals with elevated vitamin D levels in their blood have a reduced risk of heart attack, breast cancer, colon cancer, multiple sclerosis, and diabetes. I purchased vitamin D3 for taken during the pandemic. The tablets are small and easy to swallow, and it's recommended to consume them with fatty foods. I took a high dosage: 5000 units. If my review was beneficial, please click Yes. Thank you!
8
We explored the potential benefits of a vitamin D analog in treating prostate cancer, which is a major cause of cancer-related deaths among men. Our work focused on understanding how this vitamin D form impacts cancer resistance and the tumor microenvironment. We used the Pten mouse model to observe the therapeutic effects of the vitamin D analog.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
5
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
9
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
7
Vitamin D3 contributes to cancer treatment
We explored the potential of vitamin D3 as part of a treatment combination with curcumin, examining its effects on human osteosarcoma cells. The study involved using calcium phosphate materials loaded with both curcumin and vitamin D3, which were then tested in a specific 3D-printed format designed to promote bone health.
Our observations indicated that as part of this combination, vitamin D3 plays a supportive role. We found that using these loaded materials improved the survival of bone-forming cells (osteoblasts) over an 11-day period. Additionally, the combination treatment significantly increased new bone formation when compared to control groups.
However, it's important to note that the study's focus on the dual impact of curcumin and vitamin D3 limits our ability to assess the isolated effects of vitamin D3 alone. The results showed a decrease in the proliferation of osteosarcoma cells, highlighting the potential anti-cancer properties of the treatment combination. Yet, these findings suggest that while vitamin D3 contributes positively, more research is needed to fully understand its effectiveness on its own.
Our observations indicated that as part of this combination, vitamin D3 plays a supportive role. We found that using these loaded materials improved the survival of bone-forming cells (osteoblasts) over an 11-day period. Additionally, the combination treatment significantly increased new bone formation when compared to control groups.
However, it's important to note that the study's focus on the dual impact of curcumin and vitamin D3 limits our ability to assess the isolated effects of vitamin D3 alone. The results showed a decrease in the proliferation of osteosarcoma cells, highlighting the potential anti-cancer properties of the treatment combination. Yet, these findings suggest that while vitamin D3 contributes positively, more research is needed to fully understand its effectiveness on its own.
7
We explored how vitamin D3 impacts cancer metabolism through an innovative chip-based solid-phase extraction mass spectrometry method. This approach allowed us to closely analyze the metabolic changes in both normal liver cells and cancer cells, providing a real-time view of how these processes work. With this technology, we could detect various metabolites at incredibly low concentrations, helping us form a clearer picture of cellular metabolism.
Our observations highlighted significant differences in metabolism between normal cells and cancerous ones, specifically noting increased glycolytic activity and higher lactate production in cancer cells. When we treated the cancer cells with 1,25-dihydroxyvitamin D3 (the active form of vitamin D3), we found that it suppressed glucose uptake and altered metabolic activity in one type of cancer cell, HCT116. This finding suggests that vitamin D3 could play a regulatory role in how cancer cells manage their energy and metabolize nutrients.
Overall, our study sheds light on the metabolic changes associated with cancer and points to vitamin D3 as a potential modulator of these processes. The insights gained could be valuable for developing new cancer therapies and understanding metabolic diseases better.
Our observations highlighted significant differences in metabolism between normal cells and cancerous ones, specifically noting increased glycolytic activity and higher lactate production in cancer cells. When we treated the cancer cells with 1,25-dihydroxyvitamin D3 (the active form of vitamin D3), we found that it suppressed glucose uptake and altered metabolic activity in one type of cancer cell, HCT116. This finding suggests that vitamin D3 could play a regulatory role in how cancer cells manage their energy and metabolize nutrients.
Overall, our study sheds light on the metabolic changes associated with cancer and points to vitamin D3 as a potential modulator of these processes. The insights gained could be valuable for developing new cancer therapies and understanding metabolic diseases better.
References
- Len-Tayon K, Metzger D, Laverny G. [New insights of vitamin D-based therapy for prostate cancer]. Med Sci (Paris). 2025;41:154. 10.1051/medsci/2025011
- Soni D, Tiwari A, Kushwah PS, Dubey S, Khan S. Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study. Cureus. 2025;17:e78283. 10.7759/cureus.78283
- Peixoto D, Ravasco JM, Blanco-Fernandez B, Veiga F, Concheiro A, et al. Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy. Mater Today Bio. 2025;31:101555. 10.1016/j.mtbio.2025.101555
- Xu N, Lin H, Ding X, Wang P, Lin JM. Isotope tracing-assisted chip-based solid-phase extraction mass spectrometry for monitoring metabolic changes and vitamin D3 regulation in cells. Talanta. 2025;288:127754. 10.1016/j.talanta.2025.127754
- Jo Y, Kushram P, Bose S. Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration. Biomater Sci. 2025. 10.1039/d4bm01188k
- Ezcurra-Hualde M, Zalba S, Bella Á, Arrizabalaga L, Risson A, et al. Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth. Front Immunol. 2025;16:1529007. 10.3389/fimmu.2025.1529007
- Wang L, Xu R, Wang M, Wang M, Su S, et al. Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors. Onco Targets Ther. 2025;18:129. 10.2147/OTT.S495066
- Evans H, Greenhough A, Perry L, Lasanta G, Gonzalez CM, et al. Hypoxia Compromises the Differentiation of Human Osteosarcoma Cells to CAR-R, a Hydroxylated Derivative of Lithocholic Acid and Potent Agonist of the Vitamin D Receptor. Int J Mol Sci. 2025;26. 10.3390/ijms26010365
- Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. 10.1248/cpb.c24-00598
- He W, Lv W, Liu L, Gong Y, Song K, et al. Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform. ACS Nano. 2024;18:35559. 10.1021/acsnano.4c13470
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16223960
- Maturana-Ramiìrez A, Aitken-Saavedra J, Rojas-Zúñiga G, Rojas-Alcayaga G, Espinoza-Santander I, et al. Hypovitaminosis D in patients with oral squamous cell carcinoma: Is a risk factor of developing this neoplasia?. Med Oral Patol Oral Cir Bucal. 2025;30:e24. 10.4317/medoral.26692
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial. Clin Nutr ESPEN. 2025;65:64. 10.1016/j.clnesp.2024.11.014
- García-Martínez JM, Chocarro-Calvo A, Martínez-Useros J, Regueira-Acebedo N, Fernández-Aceñero MJ, et al. SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells. Int J Biol Sci. 2024;20:5495. 10.7150/ijbs.95875
