Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
USERS' SCORE
Good
Based on 29 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
9
We explored the intriguing link between vitamin B12 deficiency and anemia, particularly through a rare condition known as pseudo-thrombotic microangiopathy. This condition mimics other thrombotic microangiopathies and could lead to unnecessary treatments such as plasmapheresis.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
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7
We sought to understand how effective vitamin B12 is in treating anemia in children. Our focus was on comparing two different methods of supplementation: parenteral (injections) and oral (pills). While previous studies in adults suggested both methods might have similar benefits, we found limited data for children, prompting our thorough investigation.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
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9
We explored the intriguing case of a 51-year-old man in Western Uganda who experienced lower limb weakness linked to pernicious anemia, a condition caused by vitamin B12 deficiency. His journey illustrates the importance of recognizing the signs of this often-overlooked autoimmune disease.
Initially presenting with macrocytic anemia, our patient had a history of similar symptoms seven years prior, which were treated for vitamin B12 deficiency. This time, additional tests confirmed that pernicious anemia was at play, allowing for targeted treatment.
After starting parenteral methylcobalamin therapy, he showed significant improvement in his symptoms. This case underscores that vitamin B12 is crucial not just for red blood cell production but also for neurological health, emphasizing the need for increased awareness and diagnosis of vitamin B12 deficiencies in resource-limited settings.
Initially presenting with macrocytic anemia, our patient had a history of similar symptoms seven years prior, which were treated for vitamin B12 deficiency. This time, additional tests confirmed that pernicious anemia was at play, allowing for targeted treatment.
After starting parenteral methylcobalamin therapy, he showed significant improvement in his symptoms. This case underscores that vitamin B12 is crucial not just for red blood cell production but also for neurological health, emphasizing the need for increased awareness and diagnosis of vitamin B12 deficiencies in resource-limited settings.
Read More
Most Useful Reviews
9
Visible results
123 people found this helpful
Bioactive form! This means that vitamins are well absorbed, even by those with malabsorption issues. It helps maintain red blood cell production within the normal range. I use it alongside iron for my anaemia. The results were visible within a month. The capsules are small and easy to swallow, even for children. I recommend it.
Read More
9
Fatigue resolved
22 people found this helpful
Folate is a form of vitamin B9. A lack of vitamin B12 often leads to a deficiency of folate. This complex is excellent; I take one tablet twice a day. After a month, my constant fatigue disappeared, and my stomach pain due to gastritis improved. My doctor recommended this for my anaemia. They have no taste and are easy to take. Highly recommended!
Read More
9
Improved B12 levels
16 people found this helpful
Excellent composition! This is the best active form of folate and B12, especially needed with anaemia. I’ll order again; the capsules are tiny and easy to swallow. My B12 level rose from 360 to 540, a fantastic result! I take it regularly. You won’t regret it, especially if you’re deficient in vitamin B12.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
- All Researches
9.5
We observed the influence of nutrition education and iron-folic acid (IFA) supplementation on the levels of anemia among pregnant women in Butajira, Ethiopia. Through a quasi-experimental design over three months, we provided pregnant women with health education based on the Health Belief Model, alongside IFA supplements over a six-week period.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
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9.5
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
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9.5
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
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9
We evaluated the effectiveness of a grassroots organization’s iron and folic acid (IFA) supplementation program aimed at improving anemia levels among school-age and adolescent females in India. The program implemented a peer network approach to educate young females about anemia and encourage compliance with supplementation.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Read More
9
Folate supplementation improves anemia
We conducted a study to understand how a school-based program offering weekly iron and folic acid supplements affects anemia, particularly focusing on the serum folate levels in adolescent girls aged 10 to 19 in the Sidama Region of Southern Ethiopia.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Read More
User Reviews
USERS' SCORE
Good
Based on 29 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Visible results
123 people found this helpful
Bioactive form! This means that vitamins are well absorbed, even by those with malabsorption issues. It helps maintain red blood cell production within the normal range. I use it alongside iron for my anaemia. The results were visible within a month. The capsules are small and easy to swallow, even for children. I recommend it.
Read More
9
Fatigue resolved
22 people found this helpful
Folate is a form of vitamin B9. A lack of vitamin B12 often leads to a deficiency of folate. This complex is excellent; I take one tablet twice a day. After a month, my constant fatigue disappeared, and my stomach pain due to gastritis improved. My doctor recommended this for my anaemia. They have no taste and are easy to take. Highly recommended!
Read More
9
Improved B12 levels
16 people found this helpful
Excellent composition! This is the best active form of folate and B12, especially needed with anaemia. I’ll order again; the capsules are tiny and easy to swallow. My B12 level rose from 360 to 540, a fantastic result! I take it regularly. You won’t regret it, especially if you’re deficient in vitamin B12.
Read More
9
Ferritin increased
12 people found this helpful
Small pinkish capsules are convenient to take. For better absorption, I take it separately from other supplements, one capsule daily after breakfast. Both B12 and B9 improve iron absorption, crucial for my latent anaemia. After two months, my ferritin level increased from 7 to 33, a significant achievement for me.
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9
General well-being improved
11 people found this helpful
My favourite form of vitamin B12! I take it as prescribed by my endocrinologist for AIT, hypothyroidism, and anaemia. It has significantly improved my overall well-being, and even the condition of my hair and nails has enhanced. I’m very pleased with the results!
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Frequently Asked Questions
9
Fatigue resolved
22 people found this helpful
Folate is a form of vitamin B9. A lack of vitamin B12 often leads to a deficiency of folate. This complex is excellent; I take one tablet twice a day. After a month, my constant fatigue disappeared, and my stomach pain due to gastritis improved. My doctor recommended this for my anaemia. They have no taste and are easy to take. Highly recommended!
9
Visible results
123 people found this helpful
Bioactive form! This means that vitamins are well absorbed, even by those with malabsorption issues. It helps maintain red blood cell production within the normal range. I use it alongside iron for my anaemia. The results were visible within a month. The capsules are small and easy to swallow, even for children. I recommend it.
9
Ferritin increased
12 people found this helpful
Small pinkish capsules are convenient to take. For better absorption, I take it separately from other supplements, one capsule daily after breakfast. Both B12 and B9 improve iron absorption, crucial for my latent anaemia. After two months, my ferritin level increased from 7 to 33, a significant achievement for me.
9
General well-being improved
11 people found this helpful
My favourite form of vitamin B12! I take it as prescribed by my endocrinologist for AIT, hypothyroidism, and anaemia. It has significantly improved my overall well-being, and even the condition of my hair and nails has enhanced. I’m very pleased with the results!
9
Fatigue relief
7 people found this helpful
A fantastic complex for anaemia, it alleviates fatigue effectively! Folate is a B9 form, and a deficiency in B12 leads to a folate shortage. I take one tablet twice daily; my fatigue disappeared after a month, and my metabolism improved. My doctor recommended it to address my anaemia. The tablets are tasteless and easy to swallow.
9
Essential nutrients
3 people found this helpful
An excellent product at a good price with active forms. Active folate and vitamin B12 are vital for many bodily functions. Methylcobalamin (B12) aids in blood creation and overall organ function. Folate is essential for red blood cell formation. Together, they combat anaemia effectively, and it is advisable to take them together.
9
Successful B12 increase
The best active folate and B12. Necessary for those with anemia. I will reorder as the tiny capsules are easy to swallow. My B12 levels improved significantly after use—great outcome!
7.5
B12 and B9 benefits
Great supplement in a convenient form with the right dosage, all in one capsule! B12 and B9 (folate) deficiencies can lead to anemia, not just a lack of iron.
7
Factors influencing supplement adherence
We conducted an unmatched case-control study in Bule Hora district, Southern Ethiopia, aiming to understand what factors affect pregnant women’s compliance with iron and folic acid supplementation. This is crucial because these supplements are recommended to help prevent anemia during pregnancy, a common issue in many areas including Ethiopia.
Our research included 115 cases of women who adhered to supplementation and 230 controls who did not. We focused on various influencers such as health care interactions, knowledge about anemia, and support from partners. Interestingly, we found that the likelihood of compliance increased with factors like being a first-time mother, attending antenatal care at least four times, receiving support from husbands, and having solid knowledge about anemia.
From our findings, it’s clear that enhancing support from partners and improving the overall frequency of health care contacts can significantly boost compliance with iron and folic acid supplementation. Sharing information about anemia with expectant mothers also plays a vital role in increasing adherence to these important health recommendations.
Our research included 115 cases of women who adhered to supplementation and 230 controls who did not. We focused on various influencers such as health care interactions, knowledge about anemia, and support from partners. Interestingly, we found that the likelihood of compliance increased with factors like being a first-time mother, attending antenatal care at least four times, receiving support from husbands, and having solid knowledge about anemia.
From our findings, it’s clear that enhancing support from partners and improving the overall frequency of health care contacts can significantly boost compliance with iron and folic acid supplementation. Sharing information about anemia with expectant mothers also plays a vital role in increasing adherence to these important health recommendations.
We conducted a study to investigate how supplementation with folate, along with iron, affects children suffering from mild-to-moderate anaemia. Over a 90-day period, we randomly assigned 1,300 children from rural India to receive either iron-folic acid with multiple micronutrients or iron-folic acid alone.
Our goal was to determine if the combination of these nutrients could boost haemoglobin levels and improve recovery rates from anaemia compared to just iron and folate. After the supplementation period, we found no significant difference in mean haemoglobin levels between the two groups.
In fact, around 80% of children in both groups were cured of anaemia, showing that adding multiple micronutrients did not provide additional benefits over iron-folic acid alone. This indicates that simply ensuring children adhere to iron-folic acid supplementation may be sufficient to effectively combat anaemia in this population.
Our goal was to determine if the combination of these nutrients could boost haemoglobin levels and improve recovery rates from anaemia compared to just iron and folate. After the supplementation period, we found no significant difference in mean haemoglobin levels between the two groups.
In fact, around 80% of children in both groups were cured of anaemia, showing that adding multiple micronutrients did not provide additional benefits over iron-folic acid alone. This indicates that simply ensuring children adhere to iron-folic acid supplementation may be sufficient to effectively combat anaemia in this population.
9
We explored a notable case involving an 86-year-old man who experienced symptoms linked to anemia, such as tingling in his hands and later developed a condition known as pancytopenia. Initially diagnosed with myelodysplastic syndrome after a bone marrow analysis, his case took a turn when further tests revealed unusually high levels of serum vitamin B12 despite other concerning indicators.
As we delved deeper into his condition, we discovered that he had elevated homocysteine levels and tested positive for an anti-intrinsic factor antibody. These elements played a crucial role, as they pointed toward pernicious anemia, which can complicate the interpretation of vitamin B12 levels. Remarkably, he also exhibited T-weighted hyperintense lesions on his spinal cord MRI, indicating subacute combined degeneration—a severe condition caused by vitamin B12 deficiency.
Treatment with mecobalamin, a form of vitamin B12 administered through intramuscular injections, ultimately proved beneficial. It improved his pancytopenia and resolved the MRI lesions, highlighting the effectiveness of vitamin B12 in managing anemia, especially in the context of pernicious anemia. However, this case also serves as a reminder that simply measuring vitamin B12 levels may not provide a complete picture; additional tests like serum homocysteine and anti-intrinsic factor antibodies are critical in these scenarios.
Overall, it’s essential to consider the broader implications of vitamin B12 treatment in anemia assessment, particularly when dealing with complex conditions like pernicious anemia.
As we delved deeper into his condition, we discovered that he had elevated homocysteine levels and tested positive for an anti-intrinsic factor antibody. These elements played a crucial role, as they pointed toward pernicious anemia, which can complicate the interpretation of vitamin B12 levels. Remarkably, he also exhibited T-weighted hyperintense lesions on his spinal cord MRI, indicating subacute combined degeneration—a severe condition caused by vitamin B12 deficiency.
Treatment with mecobalamin, a form of vitamin B12 administered through intramuscular injections, ultimately proved beneficial. It improved his pancytopenia and resolved the MRI lesions, highlighting the effectiveness of vitamin B12 in managing anemia, especially in the context of pernicious anemia. However, this case also serves as a reminder that simply measuring vitamin B12 levels may not provide a complete picture; additional tests like serum homocysteine and anti-intrinsic factor antibodies are critical in these scenarios.
Overall, it’s essential to consider the broader implications of vitamin B12 treatment in anemia assessment, particularly when dealing with complex conditions like pernicious anemia.
References
- Merga RT, Birhane M, Dhinsa M, Muleta B, Jemal J, et al. Determinants of compliance with iron-folic acid supplementation among pregnant mothers in Bule Hora district, Southern Ethiopia: unmatched case-control study. BMC Public Health. 2025;25:832. doi:10.1186/s12889-025-22005-x
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Weeks CJ, Mian M, Stokes M, Gold M, Shah A, et al. The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma. Hematol Rep. 2025;17. doi:10.3390/hematolrep17010005
- Taye M, Mohammed T, Taye W, Glagn M, Yihune M. Compliance with iron-folate supplementation among pregnant women in Southern Ethiopia: a multi-center cross-sectional study. Reprod Health. 2025;22:22. doi:10.1186/s12978-025-01944-z
- Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. doi:10.1038/s41598-025-87957-x
- Kant SB, Bashir R, Khan B, Shabbir NA, Nizami AA, et al. A Cross-Sectional Study of the Maternal Health Factors: The Interplay Between Breastfeeding Patterns, Gut Microbiota, Anemia, and Cardiovascular Risk in Lactating Mothers. Cureus. 2024;16:e76316. doi:10.7759/cureus.76316
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Kataria S, Kataria S, Chougule D, Bharti B, Rastogi A. Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India. Cureus. 2024;16:e75608. doi:10.7759/cureus.75608
- Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. doi:10.1177/03795721241304475
- Chillo SL, Woldesemayat EM, Dangisso MH. Intermittent versus daily oral iron folic acid supplementation and pregnancy outcome in low- and middle-income countries: a systematic review and meta-analysis of experimental studies. Reprod Health. 2025;22:2. doi:10.1186/s12978-024-01917-8
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. doi:10.7759/cureus.75257
- Contreras R, Méndez GP, Mujica J, Padilla C, Selamé ME, et al. [Paroxysmal Nocturnal Hemoglobinuria: A Rare but Treatable Cause of Acute Kidney Injury. Case Report]. Rev Med Chil. 2024;152:627. doi:10.4067/s0034-98872024000500627
- Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. doi:10.4103/ijph.ijph_844_23
- Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. doi:10.1021/acsami.4c15206
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. doi:10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. doi:10.1007/s13668-025-00622-7
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. doi:10.7759/cureus.75800
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. doi:10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. doi:10.3389/fnut.2024.1493593
