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SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
9
Nitrous oxide affects B12 levels
Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report.
Direct link to B12 treatment effectiveness
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
Read More
9
Effectiveness of B12 in neuropathy
Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report.
Directly addresses B12 treatment impact
We explored the effects of vitamin B12 treatment on neuropathy through the case of a 41-year-old woman who had been struggling with balance and coordination issues for two years. Her medical evaluations revealed megaloblastic anemia due to vitamin B12 deficiency, alongside significant nerve damage identified through electromyography.
Imaging scans highlighted long T2 signal areas in the spinal cord and cerebellum, which pointed to subacute combined degeneration of the spinal cord. Fortunately, after receiving vitamin B12 supplements, we observed noticeable improvements in her limb strength, diet, and consciousness, with her muscle strength returning to grade IV in both lower limbs.
This case underscores the importance of early intervention for those exhibiting symptoms of neuropathy. It serves as a reminder that regular check-ups, including the evaluation for autoimmune gastritis, can help in the early identification of vitamin B12 deficiencies that may lead to irreversible nerve damage.
Imaging scans highlighted long T2 signal areas in the spinal cord and cerebellum, which pointed to subacute combined degeneration of the spinal cord. Fortunately, after receiving vitamin B12 supplements, we observed noticeable improvements in her limb strength, diet, and consciousness, with her muscle strength returning to grade IV in both lower limbs.
This case underscores the importance of early intervention for those exhibiting symptoms of neuropathy. It serves as a reminder that regular check-ups, including the evaluation for autoimmune gastritis, can help in the early identification of vitamin B12 deficiencies that may lead to irreversible nerve damage.
Read More
8
Nitrous oxide-induced neuropathy recovery
Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report.
Supports vitamin B12's therapeutic role
We explored the impact of nitrous oxide (N2O) use on neurological health, particularly focusing on how vitamin B12 treatment can play a crucial role in neuropathy. In two reported cases, individuals who had abused nitrous oxide displayed symptoms of progressive paresthesia, gait issues, and weakness, appearing similar to Guillain-Barré Syndrome.
Upon further investigation, both patients were found to have vitamin B12 deficiencies, which led to a condition known as myeloneuropathy. Using magnetic resonance imaging and electrodiagnostic studies, doctors were able to identify the damage caused by prolonged nitrous oxide exposure.
Fortunately, we observed that symptoms began to improve with vitamin B12 supplementation and the cessation of nitrous oxide use. This demonstrates that addressing vitamin B12 deficiencies can potentially reverse the neurological complications arising from nitrous oxide toxicity if treatment is prompt and effective.
Given the increasing recreational use of nitrous oxide and its associated risks, we believe it’s vital for healthcare providers to consider this as a possible cause of neuropathy or myelopathy in patients, especially when symptoms appear unusual in nature.
Upon further investigation, both patients were found to have vitamin B12 deficiencies, which led to a condition known as myeloneuropathy. Using magnetic resonance imaging and electrodiagnostic studies, doctors were able to identify the damage caused by prolonged nitrous oxide exposure.
Fortunately, we observed that symptoms began to improve with vitamin B12 supplementation and the cessation of nitrous oxide use. This demonstrates that addressing vitamin B12 deficiencies can potentially reverse the neurological complications arising from nitrous oxide toxicity if treatment is prompt and effective.
Given the increasing recreational use of nitrous oxide and its associated risks, we believe it’s vital for healthcare providers to consider this as a possible cause of neuropathy or myelopathy in patients, especially when symptoms appear unusual in nature.
Read More
Most Useful Reviews
8.8
Improved B12 levels
This product appears to be effective. I’m on my fourth bottle now. Although I have absorption issues due to potential damage, I started on six a day. After three bottles, my B12 was tested at 436, and my folate at 18.9. I’ve had neuropathy from chronic anaemia, but while I'm no longer technically anaemic, my iron remains low. This supplement has significantly contributed to improving my overall health.
Read More
9.5
Reduced tingling sensation
I experience tingling in my feet from neuropathy. Doctors were unsure of the cause as I'm not diabetic. After trying various treatments, these supplements greatly alleviated the tingling and heaviness in my feet and legs. They truly are a great product.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
9
Vitamin B12 shows therapeutic potential
The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study.
Highly relevant to diabetic neuropathy
We observed a study that aimed to explore the effectiveness of vitamin B12 therapy compared to steroid treatment for improving extraocular movements in patients suffering from diabetic cranial nerve palsy, a type of nerve injury related to diabetes. The study involved 50 participants who were divided into two groups. One group received steroid injections, while the other group was treated with vitamin B12.
After the treatment, which was followed for 10 days, the researchers assessed the improvement in eye movements using a specific test. The results were telling: those who received vitamin B12 showed a greater enhancement in their eye movements compared to those treated with steroids. The improvement noted in the vitamin group was statistically significant, suggesting that vitamin B12 may play an essential role in supporting recovery from diabetic neuropathy.
Notably, the average age of participants was around 60 years, and many had poorly controlled diabetes, emphasizing the importance of managing blood sugar levels in diabetic patients. This research highlights the potential of vitamin B12 not just in treating symptoms, but in addressing underlying nutritional deficiencies, which may help enhance the quality of life for individuals with diabetic complications.
After the treatment, which was followed for 10 days, the researchers assessed the improvement in eye movements using a specific test. The results were telling: those who received vitamin B12 showed a greater enhancement in their eye movements compared to those treated with steroids. The improvement noted in the vitamin group was statistically significant, suggesting that vitamin B12 may play an essential role in supporting recovery from diabetic neuropathy.
Notably, the average age of participants was around 60 years, and many had poorly controlled diabetes, emphasizing the importance of managing blood sugar levels in diabetic patients. This research highlights the potential of vitamin B12 not just in treating symptoms, but in addressing underlying nutritional deficiencies, which may help enhance the quality of life for individuals with diabetic complications.
Read More
9
Nitrous oxide affects B12 levels
Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report.
Direct link to B12 treatment effectiveness
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
Read More
9
Vitamin B12's role in neuropathy
Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report.
Significant association with symptoms
We observed a fascinating case involving an 11-month-old girl facing persistent seizures and developmental challenges. After trying numerous medications without success, tests revealed she had megaloblastic anemia and macrocytic anemia. Due to the unusual combination of her symptoms, we suspected a genetic condition related to vitamin B12 absorption.
Upon conducting whole exome sequencing, we discovered a novel mutation in the FUT2 gene, which affects how the body processes vitamin B12. Most notably, our findings confirmed that her neurological issues were connected to a deficiency in this vital vitamin.
When we initiated treatment with intramuscular hydroxocobalamin, there was a significant improvement in her condition, including a noticeable decrease in seizure frequency. This case underscores the crucial role that vitamin B12 plays in brain health and development, especially in young children.
It highlights the importance of genetic testing to uncover treatable causes in similar cases of refractory developmental and epileptic encephalopathy. Swift diagnosis and appropriate treatment can lead to remarkable recoveries, making this an encouraging story for those affected by such rare conditions.
Upon conducting whole exome sequencing, we discovered a novel mutation in the FUT2 gene, which affects how the body processes vitamin B12. Most notably, our findings confirmed that her neurological issues were connected to a deficiency in this vital vitamin.
When we initiated treatment with intramuscular hydroxocobalamin, there was a significant improvement in her condition, including a noticeable decrease in seizure frequency. This case underscores the crucial role that vitamin B12 plays in brain health and development, especially in young children.
It highlights the importance of genetic testing to uncover treatable causes in similar cases of refractory developmental and epileptic encephalopathy. Swift diagnosis and appropriate treatment can lead to remarkable recoveries, making this an encouraging story for those affected by such rare conditions.
Read More
9
Methylcobalamin shows high bioavailability
Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma.
Relevant to neuropathy treatment
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
9
Vitamin B12's role in neuropathy
Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report.
Directly relates to neuropathy treatment
We observed an intriguing case of a 33-year-old female patient living with HIV who experienced progressive vision loss attributed to vitamin B12 deficiency. Prior to this, she had dealt with severe peripheral neuropathy, which was managed with vitamin B12 supplements for about three years. This connection raises the question of how vitamin B12 might affect neuropathy and overall nerve health.
Upon examination, the patient had severe vision impairment, showing no light perception in one eye and limited movement detection in the other. Tests indicated a significantly low serum vitamin B12 level, confirming a deficiency likely responsible for her optic neuritis—a rare outcome of this vitamin deficiency.
After her diagnosis, she underwent treatment that included corticosteroids followed by vitamin B12 injections. Remarkably, this treatment led to gradual improvement over five months, with the patient regaining her vision. This case underscores the importance of recognizing vitamin B12’s role in neurological health, particularly in individuals who experience nerve-related issues, including those with complicated medical histories like HIV.
Identifying vitamin B12 deficiency early can be crucial, especially since its ophthalmic symptoms might appear without typical blood-related signs. A high level of suspicion and timely intervention can lead to significant recoveries in such cases.
Upon examination, the patient had severe vision impairment, showing no light perception in one eye and limited movement detection in the other. Tests indicated a significantly low serum vitamin B12 level, confirming a deficiency likely responsible for her optic neuritis—a rare outcome of this vitamin deficiency.
After her diagnosis, she underwent treatment that included corticosteroids followed by vitamin B12 injections. Remarkably, this treatment led to gradual improvement over five months, with the patient regaining her vision. This case underscores the importance of recognizing vitamin B12’s role in neurological health, particularly in individuals who experience nerve-related issues, including those with complicated medical histories like HIV.
Identifying vitamin B12 deficiency early can be crucial, especially since its ophthalmic symptoms might appear without typical blood-related signs. A high level of suspicion and timely intervention can lead to significant recoveries in such cases.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Reduced tingling sensation
I experience tingling in my feet from neuropathy. Doctors were unsure of the cause as I'm not diabetic. After trying various treatments, these supplements greatly alleviated the tingling and heaviness in my feet and legs. They truly are a great product.
8.8
Improved B12 levels
This product appears to be effective. I’m on my fourth bottle now. Although I have absorption issues due to potential damage, I started on six a day. After three bottles, my B12 was tested at 436, and my folate at 18.9. I’ve had neuropathy from chronic anaemia, but while I'm no longer technically anaemic, my iron remains low. This supplement has significantly contributed to improving my overall health.
Read More
