Last update
5/16/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
9
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
Read More
9
We explored the effects of vitamin B12 treatment on neuropathy through the case of a 41-year-old woman who had been struggling with balance and coordination issues for two years. Her medical evaluations revealed megaloblastic anemia due to vitamin B12 deficiency, alongside significant nerve damage identified through electromyography.
Imaging scans highlighted long T2 signal areas in the spinal cord and cerebellum, which pointed to subacute combined degeneration of the spinal cord. Fortunately, after receiving vitamin B12 supplements, we observed noticeable improvements in her limb strength, diet, and consciousness, with her muscle strength returning to grade IV in both lower limbs.
This case underscores the importance of early intervention for those exhibiting symptoms of neuropathy. It serves as a reminder that regular check-ups, including the evaluation for autoimmune gastritis, can help in the early identification of vitamin B12 deficiencies that may lead to irreversible nerve damage.
Imaging scans highlighted long T2 signal areas in the spinal cord and cerebellum, which pointed to subacute combined degeneration of the spinal cord. Fortunately, after receiving vitamin B12 supplements, we observed noticeable improvements in her limb strength, diet, and consciousness, with her muscle strength returning to grade IV in both lower limbs.
This case underscores the importance of early intervention for those exhibiting symptoms of neuropathy. It serves as a reminder that regular check-ups, including the evaluation for autoimmune gastritis, can help in the early identification of vitamin B12 deficiencies that may lead to irreversible nerve damage.
Read More
8
We explored the impact of nitrous oxide (N2O) use on neurological health, particularly focusing on how vitamin B12 treatment can play a crucial role in neuropathy. In two reported cases, individuals who had abused nitrous oxide displayed symptoms of progressive paresthesia, gait issues, and weakness, appearing similar to Guillain-Barré Syndrome.
Upon further investigation, both patients were found to have vitamin B12 deficiencies, which led to a condition known as myeloneuropathy. Using magnetic resonance imaging and electrodiagnostic studies, doctors were able to identify the damage caused by prolonged nitrous oxide exposure.
Fortunately, we observed that symptoms began to improve with vitamin B12 supplementation and the cessation of nitrous oxide use. This demonstrates that addressing vitamin B12 deficiencies can potentially reverse the neurological complications arising from nitrous oxide toxicity if treatment is prompt and effective.
Given the increasing recreational use of nitrous oxide and its associated risks, we believe it’s vital for healthcare providers to consider this as a possible cause of neuropathy or myelopathy in patients, especially when symptoms appear unusual in nature.
Upon further investigation, both patients were found to have vitamin B12 deficiencies, which led to a condition known as myeloneuropathy. Using magnetic resonance imaging and electrodiagnostic studies, doctors were able to identify the damage caused by prolonged nitrous oxide exposure.
Fortunately, we observed that symptoms began to improve with vitamin B12 supplementation and the cessation of nitrous oxide use. This demonstrates that addressing vitamin B12 deficiencies can potentially reverse the neurological complications arising from nitrous oxide toxicity if treatment is prompt and effective.
Given the increasing recreational use of nitrous oxide and its associated risks, we believe it’s vital for healthcare providers to consider this as a possible cause of neuropathy or myelopathy in patients, especially when symptoms appear unusual in nature.
Read More
Most Useful Reviews
7.5
Improved B12 levels
60 people found this helpful
This product appears to be effective. I’m on my fourth bottle now. Although I have absorption issues due to potential damage, I started on six a day. After three bottles, my B12 was tested at 436, and my folate at 18.9. I’ve had neuropathy from chronic anaemia, but while I'm no longer technically anaemic, my iron remains low. This supplement has significantly contributed to improving my overall health.
Read More
9
Reduced tingling sensation
13 people found this helpful
I experience tingling in my feet from neuropathy. Doctors were unsure of the cause as I'm not diabetic. After trying various treatments, these supplements greatly alleviated the tingling and heaviness in my feet and legs. They truly are a great product.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8
- All Researches
9
Vitamin B12 improves vision loss
We examined a case of optic neuritis in a 33-year-old woman with HIV, who experienced sudden vision loss. Interestingly, she had a history of severe peripheral neuropathy treated with vitamin B12 tablets years earlier. As her treatment progressed, vitamin B12 injections were administered daily for 10 days, followed by monthly doses. Encouragingly, after five months of this treatment, she regained her sight.
This case highlights the importance of recognizing vitamin B12 deficiency, especially in patients with other health challenges, to prevent potentially serious complications.
This case highlights the importance of recognizing vitamin B12 deficiency, especially in patients with other health challenges, to prevent potentially serious complications.
Read More
9
We observed a study that aimed to explore the effectiveness of vitamin B12 therapy compared to steroid treatment for improving extraocular movements in patients suffering from diabetic cranial nerve palsy, a type of nerve injury related to diabetes. The study involved 50 participants who were divided into two groups. One group received steroid injections, while the other group was treated with vitamin B12.
After the treatment, which was followed for 10 days, the researchers assessed the improvement in eye movements using a specific test. The results were telling: those who received vitamin B12 showed a greater enhancement in their eye movements compared to those treated with steroids. The improvement noted in the vitamin group was statistically significant, suggesting that vitamin B12 may play an essential role in supporting recovery from diabetic neuropathy.
Notably, the average age of participants was around 60 years, and many had poorly controlled diabetes, emphasizing the importance of managing blood sugar levels in diabetic patients. This research highlights the potential of vitamin B12 not just in treating symptoms, but in addressing underlying nutritional deficiencies, which may help enhance the quality of life for individuals with diabetic complications.
After the treatment, which was followed for 10 days, the researchers assessed the improvement in eye movements using a specific test. The results were telling: those who received vitamin B12 showed a greater enhancement in their eye movements compared to those treated with steroids. The improvement noted in the vitamin group was statistically significant, suggesting that vitamin B12 may play an essential role in supporting recovery from diabetic neuropathy.
Notably, the average age of participants was around 60 years, and many had poorly controlled diabetes, emphasizing the importance of managing blood sugar levels in diabetic patients. This research highlights the potential of vitamin B12 not just in treating symptoms, but in addressing underlying nutritional deficiencies, which may help enhance the quality of life for individuals with diabetic complications.
Read More
9
We examined a remarkable case involving the effects of nitrous oxide (NO) on vitamin B12 levels and its neurological consequences. Nitrous oxide is not just a useful tool in medical and food industries; it is sometimes misused by young adults for recreational purposes. This misuse can lead to functional vitamin B12 deficiency, which in turn may result in serious neurological issues like peripheral neuropathy and subacute combined degeneration (SACD) of the spinal cord.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
In this specific case, we identified a functional B12 deficiency, characterized by borderline normal serum vitamin B12 levels, but with increased levels of methylmalonic acid and homocysteine—key indicators of vitamin deficiency. Remarkably, after administering intramuscular vitamin B12, we observed significant clinical improvement in the patient’s condition. This suggests that vitamin B12 treatment can be effective in reversing the neurological damage caused by nitrous oxide-induced deficiency.
Our findings highlight the importance of recognizing the neurological risks associated with nitrous oxide misuse and the potential for vitamin B12 treatment to alleviate serious symptoms in affected individuals.
Read More
9
We investigated how methylcobalamin, a form of vitamin B12, affects neuropathy by exploring its pharmacokinetics in rats. Our study utilized a straightforward method to assess the levels of methylcobalamin in the bloodstream using just a drop of plasma.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Under controlled conditions, we extracted methylcobalamin from rat plasma and developed an efficient assay using liquid chromatography and tandem mass spectrometry. The results showed that methylcobalamin was effectively quantified even at low concentrations, demonstrating the robustness of our approach.
We administered methylcobalamin through various routes—intravenous, intramuscular, and subcutaneous—to evaluate its bioavailability. Our findings revealed that methylcobalamin demonstrates high bioavailability, particularly after intramuscular and subcutaneous injections, significantly supporting its potential effectiveness in treating peripheral neuropathies.
Overall, this study suggests that methylcobalamin could be a valuable treatment option for neuropathy, providing a basis for further research into its benefits for those suffering from nerve-related conditions.
Read More
9
We explored the impact of vitamin B12 deficiency on neuropathy and cognitive function in elderly patients, particularly in the context of underlying health conditions. Two patients, a 71-year-old man and a 74-year-old woman, were observed for their severe fatigue, cognitive issues, and walking difficulties, all of which can be bewildering at their age.
The male patient, who had a history of intestinal surgery, had been receiving B12 injections yet still showed normal to high B12 levels. On the other hand, the female patient, who had multiple health concerns, presented with B12 deficiency despite having normal blood levels. Her diagnosis was confirmed through other markers, indicating that a deficiency might not always reflect in standard test results.
After treatment with frequent hydroxocobalamin injections, both patients exhibited notable improvements in cognitive and motor functions. This underlines the importance of being vigilant about vitamin B12 deficiency in older adults, even when test results appear normal. A keen focus on clinical signs and risk factors for B12 deficiency is essential for better management of neuropathy and cognitive issues in the elderly.
The male patient, who had a history of intestinal surgery, had been receiving B12 injections yet still showed normal to high B12 levels. On the other hand, the female patient, who had multiple health concerns, presented with B12 deficiency despite having normal blood levels. Her diagnosis was confirmed through other markers, indicating that a deficiency might not always reflect in standard test results.
After treatment with frequent hydroxocobalamin injections, both patients exhibited notable improvements in cognitive and motor functions. This underlines the importance of being vigilant about vitamin B12 deficiency in older adults, even when test results appear normal. A keen focus on clinical signs and risk factors for B12 deficiency is essential for better management of neuropathy and cognitive issues in the elderly.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved B12 levels
60 people found this helpful
This product appears to be effective. I’m on my fourth bottle now. Although I have absorption issues due to potential damage, I started on six a day. After three bottles, my B12 was tested at 436, and my folate at 18.9. I’ve had neuropathy from chronic anaemia, but while I'm no longer technically anaemic, my iron remains low. This supplement has significantly contributed to improving my overall health.
Read More
9
Reduced tingling sensation
13 people found this helpful
I experience tingling in my feet from neuropathy. Doctors were unsure of the cause as I'm not diabetic. After trying various treatments, these supplements greatly alleviated the tingling and heaviness in my feet and legs. They truly are a great product.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- Kang W, Zhang Y, Cui W, Meng H, Zhang D. Folic Acid Promotes Peripheral Nerve Injury Repair via Regulating DNM3-AKT Pathway Through Mediating Methionine Cycle Metabolism. Neuromolecular Med. 2025;27:23. 10.1007/s12017-025-08845-1
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. 10.1111/1753-0407.70045
- Brunt TM, van den Brink W, van Amsterdam J. Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?. Addiction. 2025;120:1046. 10.1111/add.16753
- Kuchmerovska T, Tykhonenko T, Yanitska L, Savosko S, Pryvrotska I. Nicotinamide and Nicotinoyl-Gamma-Aminobutyric Acid as Neuroprotective Agents Against Type 1 Diabetes-Induced Nervous System Impairments in Rats. Neurochem Res. 2024;50:1. 10.1007/s11064-024-04257-y
- Bandara P, Wijenayake W, Fernando S, Padeniya P, Mettananda S. Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report. BMC Pediatr. 2024;24:622. 10.1186/s12887-024-05106-1
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- Artiukhov AV, Solovjeva ON, Balashova NV, Sidorova OP, Graf AV, et al. Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes. Biochemistry (Mosc). 2024;89:1161. 10.1134/S0006297924070010
- Scharf K, Tang J, Jamall S, Baker N. Atypical presentation of Wernicke encephalopathy due to thiamine deficiency in a patient post sleeve gastrectomy. BMJ Case Rep. 2024;17. 10.1136/bcr-2024-261292
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. 10.11604/pamj.2024.47.164.43048
- Hu S, Brown-Kunin S, Martin P, Wang Y. Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report. BMC Neurol. 2025;25:54. 10.1186/s12883-025-04069-9
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. 10.7759/cureus.75656
- Kyaw KY, Lwin MT, Lwin ZT. Correlation Between Nitrous Oxide and Functional Vitamin B12 Deficiency Resulting in Subacute Combined Degeneration of the Spinal Cord: A Case Report. Cureus. 2024;16:e74383. 10.7759/cureus.74383
- Kulkantrakorn K, Chunhachatrachai P, Kulkantrakorn W. Nitrous oxide abuse and associated neurological diseases. BMC Neurol. 2024;24:461. 10.1186/s12883-024-03966-9
- Hotta K, Mano Y. Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma. J Pharmacol Toxicol Methods. 2024;129:107552. 10.1016/j.vascn.2024.107552
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. 10.1177/03795721241226886
- Pino S, Vega E, Fragoso M, Salazar G. Nitrous Oxide as an Emerging Cause of Subacute Combined Degeneration and Polyneuropathy: A Two-Case Report. Cureus. 2024;16:e63003. 10.7759/cureus.63003
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. 10.59556/japi.72.0493
- Zhu M, Yu C, Xu Z, Zhang H, Huang H. Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report. Medicine (Baltimore). 2024;103:e37605. 10.1097/MD.0000000000037605
